Oral methotrexate: hazard of different tablet strengths

J. E. Dippy, D. A. Collins and E. J. Price

Princess Margaret Hospital, Okus Road, Swindon SN1 4JU, UK

SIR, We read the letter from Hordon et al. [1] with some interest. Our department recently had a patient who was inadvertently given 10 mg methotrexate tablets instead of 2.5 mg tablets and promptly consumed 60 mg instead of 15 mg. Fortunately, folinic acid rescue prevented a disaster. This was the second such experience of methotrexate tablet confusion. May we encourage people to write to the manufacturers on this issue, which does have a fairly obvious remedy, namely to make the appearance of the 2.5 and 10 mg tablets entirely different.

References

  1. Hordon LD, Le Gallez P, Isdale AH. Oral methotrexate: hazard of different tablet strengths. Rheumatology1999; 38:1304.[Free Full Text]
Accepted 10 January 2000





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