Timing of DAS28 in infliximab therapy: reply

P. Durez, F. Van den Bosch1, L. Corluy2, E. Veys1, L. De Clerck3, A. Peretz4, M. Malaise5, J.-P. Devogelaer, N. Vastesaeger6, A. Geldhof7 and R. Westhovens2

Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Rheumatology, Louvain, 1 University Hospital R.U. Ghent, Rheumatology, Ghent,2 University Hospitals K.U. Leuven, Rheumatology, Leuven,3 University Hospital Antwerp, University of Antwerp, Rheumatology, Antwerp,4 University Hospital Brugmann, Brussels, Rheumatology, Brussels,5 University Hospital Liège, Rheumatology, Liège,6 Schering Plough Belgium, Belgium and7 Centocor BV, Leiden, The Netherlands

Correspondence to: R. Westhovens. E-mail: rene.westhovens{at}uz.kuleuven.ac.be

We very much appreciate the careful reading by Armstrong and Bruce of our paper on dose adjustment in patients with rheumatoid arthritis not optimally responding to a standard dose of infliximab of 3 mg/kg every 8 weeks [1].

We agree with them that the time-point of measurement is crucial, and we support their interpretation on the results reported in the paper of Sidiropoulos et al. [2]. Of course the instrument for measuring disease activity or response is also crucial. We have already been interested in analysing the ‘mirror-image’ as defined in Armstrong and Bruce's letter to the Editor.

In a sub-analysis of a non-selected sub-group of 241 patients from our cohort, we analysed differences in response scoring, and these data were presented at the EULAR Stockholm Meeting in 2002 [3]. One hundred and seventy-five of the 241 patients were clinical responders as judged by the expert. Twenty-three of these 175 clinical responders were ACR non-responders but DAS responders, six of the 175 clinical responders were ACR responders but not DAS responders and 25 of the 175 were ACR and DAS28 non-responders. So, 54 of the 175 clinical responders or almost 31% of all patients continued the same dose although they did not fulfil one of the classical response criteria used in clinical trials, or even failed both.

At present we are performing a further in-depth analysis of our data to contribute to a better understanding of which measures to use in daily practice, aiming for treatment optimization.

P. Durez was a consultant for Schering Plough for this study. N. Vastesaeger is a Schering Plough employee. A. Geldhof is an employee of Centocor BV. R. Westhovens was a consultant for Schering Plough for this study. The other authors have declared no conflicts of interest.

References

  1. Durez P, Van den Bosch F, Corluy L et al. A dose adjustment in patients with rheumatoid arthritis not optimally responding to a standard dose of infliximab of 3 mg/kg every 8 weeks can be effective: a Belgian prospective study. Rheumatology 2005;44:465–8.[Abstract/Free Full Text]
  2. Sidiropoulos P, Bertsias G, Kritikos HD, Kouroumali H, Voudouris K, Boumpas DT. Infliximab treatment for rheumatoid arthritis, with dose titration based on the Disease Activity Score: dose adjustments are common but not always sufficient to assure sustained benefit. Ann Rheum Dis 2004;63:144–8.[Abstract/Free Full Text]
  3. Corluy L, Van den Bosch F, Van den Bossche N et al. Clinical response compared to DAS28 and ACR-response criteria in rheumatoid arthritis patients on Infliximab. Ann Rheum Dis 2002;61(Suppl. 1):195.[CrossRef]
Accepted 8 April 2005





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