Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka and
1 Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
SIR, Antiphospholipid antibodies (aPL) are known to be related to other clinical manifestations, such as cardiac valve lesions and haemolytic anaemia, in addition to the major clinical features of antiphospholipid syndrome (APS), such as thrombosis, recurrent fetal loss and thrombocytopenia [1]. Recently, we encountered and reported on patients with reactive haemophagocytic syndrome (HPS) or hypopituitarism (Sheehan's syndrome), possibly induced by the presence of aPL [2, 3]. Patient 1 was a 27-yr-old woman who showed anaemia and severe thrombocytopenia (white cells 7.0x103/mm3; red cells 411x104/mm3; haemoglobin 7.0 g/dl; platelets 0.2x104 /mm3). aPL were detected in the immunological examination (Table 1). Clinical and laboratory examinations allowed us to exclude connective tissue diseases, such as systemic lupus erythematosus (SLE) and autoimmune haemolytic anaemia, and viral infections or malignancies as underlying disorders. Bone marrow smears showed an increase in mature-looking histiocytes scattered among the haematopoietic cells. The histiocytes showed marked phagocytosis of the haematopoietic cells, including megakaryocytes and erythroblasts. On the basis of these findings, the patient was diagnosed with HPS associated with the presence of aPL.
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Patient 3 was a 33-yr-old woman who complained of fatigue, failure to lactate and to resume menses after delivery. Hormonal examinations revealed low levels of adrenocorticotropic hormone (<5 pg/ml, normal range 952) and prolactin (<1.0 ng/ml, normal range 1.414.6) and magnetic resonance imaging examination disclosed empty sella of the hypophysis, which is a neuroradiological finding indicating pituitary necrosis. She showed positive reactions to aPL and thrombocytopenia (Table 1); however, it was not clear whether her thrombocytopenia was associated with HPS (as in the patients 1 and 2) because there was no bone marrow examination. There were no autoimmune connective tissue disorders noted after further investigation. Although it is difficult to prove directly the relationship between empty sella and thrombosis of pituitary vessels, she was thought to have Sheehan's syndrome associated with the presence of aPL. To date, adrenal insufficiency (Addison's disease), hyperthyroidism (Graves disease) and primary and secondary hypopituitarisms have been reported as aPL-related endocrine disorders [810]; however, our patient was the first reported case of Sheehan's syndrome associated with aPL. Although Sheehan's syndrome is thought to be induced by ischaemic hypophyseal necrosis induced by extensive blood loss associated with delivery, blood loss in this patient was not severe. APS and/or the presence of aPL may play an important role in the occurrence of such postparturient hypopituitarisms.
Recently, new criteria for the classification for APS were provided by Wilson et al. [11]. These criteria emphasize the importance of thrombosis and/or recurrent fetal loss but omit thrombocytopenia from the clinical criteria. The new laboratory criteria have more accurate specifications for detecting aPL in order to define the parameters for diagnosing APS, compared with previous criteria [12]. The laboratory findings of our three patients fulfilled the new criteria. However, the clinical findings did not meet the new criteria for diagnosing APS even though these patients were diagnosed with APS according to the previous criteria [12], because these patients have not developed any thrombosis affecting the deep veins or arteries, or recurrent fetal loss. This preliminary criterion for APS seems to be more suitable for confirming a diagnosis. On the other hand, the possibility of novel minor clinical symptoms associated with aPL, especially aPL according to the laboratory criteria given by Wilson et al. (such as those found in our patients), should not be overlooked, since aPL-related aetiological mechanisms, including the development of thrombosis, are not yet entirely clear. Further studies of additional associated features of APS should be encouraged.
Notes
Correspondence to: I. Sekigawa, Department of Medicine, Juntendo University Izu-Nagaoka Hospital, 1129 Nagaoka, Izu-Nagaoka-cho, Tagata-gun, Shizuoka 4102295, Japan
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