Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Correspondence and offprint requests to: Professor Cheuk Chun Szeto, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Email: ccszeto{at}cuhk.edu.hk
Keywords: metastatic calcification; tumoural calcinosis
A 59-year-old Chinese patient had a history of end-stage renal disease secondary to glomerulonephritis and underwent peritoneal dialysis. Nine years after initiation of dialysis, he developed an enlarging tumour over his right wrist in the absence of antecedent trauma. Within 1 month of presentation, he was unable to use chopsticks because of the painful mass. At that time, his serum calcium and phosphate levels were 2.77 and 2.84 mmol/l, respectively (calcium x phosphate product 7.9 mmol2/l2), with a serum intact parathyroid hormone level (iPTH) of 12 pg/l (normal range 0.070.56 pg/l). Alkaline phosphatase level was normal. Plain radiograph showed a large mass of encapsulated amorphous calcium phosphate around his right wrist joint (Figure 1A). Bone erosion into the radial aspect of the trapezium by metastatic calcification (Figure 2) was evident radiologically.
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Instead of surgical excision, the mainstay of therapy should preferably be targeted at reducing the phosphate burden in the absence of an additional calcium load [1]. Aluminum-containing phosphate binders were prescribed to our patient, together with dietary advice and haemodialysis therapy. Of note, when our patient's calcium x phosphate product fell below 4.9 mmol2/l2 during the following 2 months, the size of his wrist swelling decreased markedly, accompanied by radiologic evidence of calcific deposits dissolution (Figure 1B).
Conflict of interest statement. None declared.
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