Cyclosporin A-induced remission of primary membranous glomerulonephritis in a child

Sir,

A 4-year-old boy presented with oedema and weight gain of 5 kg. There had been no preceding infections, vaccinations or medication. The family history includes the mothers mesangioproliferative glomerulonephritis.

Laboratory results showed decreased albumin (13 g/l) concentration. Calculated glomerular filtration rate was 125 ml/min/1.73 m2 and the U-albumin/U-creatinine ratio was 300 mg/mmol. The Na/K exchange after van de Walle [1] [U-K / (U-K + U-Na)] was 61%, indicating an underfill that changed to an overfill (15%) spontaneously. Hepatitis titres, ANAs, anti-DNS or other signs of infectious/autoimmunological diseases were not found. A malignancy was excluded. After diagnoses of nephrotic syndrome, treatment with prednisolone 60 mg/m2/day was started. Two days later, the Na/K-exchange represented an overfill (20%). Therefore, furosemide was administered. No remission was observed. A renal biopsy showed a membranous glomerulonephritis, stage I–II. Because of the family history, the treatment had been expanded to intravenous prednisolone 300 mg/m2 every 48 h plus oral prednisolone 40 mg on alternate days and cyclosporin A (CsA) microemulsion at a dosage of 150 mg/m2 with trough levels between 89 and 117 ng/ml before the result of the biopsy was known. A partial remission was achieved within 1 week. The U-albumin/U-creatinine ratio decreased to 50 mg/mmol, S-albumin was 37 g/l. Prednisolone was stopped 2 months later because of remission. After 12 months, no proteinuria was present under a maintenance therapy of CsA, which was discontinued at this timepoint. Two weeks later, nephrotic proteinuria started again. This time, CsA therapy (150 mg/m2) was initiated without steroids with trough levels between 85 and 122 ng/ml. A partial remission was achieved within 1 week and a complete remission after 2 weeks. The patient has now been asymptomatic for another year.

Membranous glomerulonephritis is predominantly a disease of mid-adult life. It is a rare disorder in children [2]. Contrary to in adults, relapsing courses are more frequent. The idiopathic disease is the most common subtype. An association with malignancies, rheumatoid arthritis, infections or drugs can be found in only few cases. As a development of renal failure in children is the exception, the natural course of the disease is usually with spontaneous remission [3]. If proteinuria or a deterioration of renal function occur, treatment with corticosteroids is the standard. If this is ineffective, a more aggressive approach, such as the method of Ponticelli et al. [4], might be used in adults. It remains unclear what is the best model for children.

Two studies show positive effects of CsA in membranous glomerulonephritis [5,6]. Treatment with CsA has been successful in children with a steroid-resistant nephrotic syndrome [7], but data about membranous glomerulonephritis have not been published yet.

CsA therapy might be an additional approach in steroid-resistant membranous glomerulonephritis. Due to the low numbers of patients, policy cannot be derived from evidence of randomized trials.

Conflict of interest statement. None declared.

Lars Pape1, Michael Mengel2, Gisela Offner1 and Jochen H.H. Ehrich1

1 Department of Pediatric Nephrology2 Department of Pathology Medical School of Hannover Germany Email: larspape{at}t-online.de

References

  1. van de Walle JG, Donckerwolcke RA, Greidanus TB, Joles JA, Koomans HA. Renal sodium handling in children with nephrotic relapse: relation to hypovolaemic symptoms. Nephrol Dial Transplant 1996; 11: 2202–2208[Abstract]
  2. Cameron JS. Membranous nephropathy in childhood and its treatment. Pediatr Nephrol 1990; 4: 193–198[ISI][Medline]
  3. Lewis EJ. Idiopathic membranous nephropathy—to treat or not to treat? N. Engl J Med 1993; 329: 127–129[Free Full Text]
  4. Ponticelli C, Zuccheli P, Passerini P et al. A randomized trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy. N Engl J Med 1989; 320: 8–13[Abstract]
  5. Yao X, Chen H, Wang Q et al. Cyclosporine A treatment for idiopathic membranous nephropathy. Chin Med J 2001; 114: 1305–1308[ISI][Medline]
  6. Cattran DC, Appel GB, Hebert LA et al. Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial. Kidney Int 2001; 59: 1484–1490[CrossRef][ISI][Medline]
  7. Singh A, Tejani C, Tejani A. One-center experience with cyclosporine in refractory nephrotic syndrome in children. Pediatr Nephrol 1990; 13: 26–32[CrossRef]




This Article
Extract
FREE Full Text (PDF)
Alert me when this article is cited
Alert me if a correction is posted
Services
Email this article to a friend
Similar articles in this journal
Similar articles in ISI Web of Science
Similar articles in PubMed
Alert me to new issues of the journal
Add to My Personal Archive
Download to citation manager
Disclaimer
Request Permissions
Google Scholar
Articles by Pape, L.
Articles by Ehrich, J. H.H.
PubMed
PubMed Citation
Articles by Pape, L.
Articles by Ehrich, J. H.H.