1Department of Internal Medicine, Nagasaki Municipal Medical Center, 2Second Department of Pathology and 3Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Correspondence and offprint requests to: Yoshio Horita, MD, Department of Internal Medicine, Nagasaki Municipal Medical Center, 20-5 Fuchi-machi, Nagasaki 852-8012, Japan. Email: y-horita{at}h8.dion.ne.jp
Keywords: renal biopsy; renal medullary fibroma; renomedullary interstitial cell tumour
Case
A 51-year-old woman with asymptomatic proteinuria and haematuria was admitted for a renal biopsy. Upon admission, her blood pressure was 118/68 mmHg. Urinalysis revealed proteinuria 1+, blood 2+, but glucose-negative. A microscopic examination showed 01 white and 2030 red blood cells per high power field. Laboratory investigations showed serum total protein 6.8 g/dl, albumin 4.3 g/dl, sodium 141 mmol/l, potassium 3.8 mmol/l, creatinine 0.4 mg/dl, blood urea nitrogen 15.3 mg/dl, creatinine clearance 114 ml/min, 24 h urinary protein 0.43 g and haemoglobin 13.4 g/dl. An immunological screen and radiological studies were normal.
A renomedullary interstitial cell tumour was identified in the medulla of a renal biopsy specimen (Figure 1). Glomeruli were mostly normal by light microscopy. Immunofluorescence studies were negative and electron micrography of glomeruli did not reveal dense deposits.
|
Renomedullary interstitial cell tumour is a frequent incidental autopsy finding in the kidneys of patients >50 years of age [1]. These lesions are round to oval, unencapsulated, 7 mm in diameter (mean: 3 mm), pale grey to yellow and, because they are frequently located in the renal medulla, they often escape clinical detection. Lerman et al. [2], who found one or more such lesions in 30% of all autopsies, coined the name renomedullary interstitial cell tumour (renal medullary fibroma). Whether such tumours represent true neoplasms, hamartoma [1], scar response to unknown injury or simple hyperplasia with fibrosis of interstitial cells [2], remains unknown. Interstitial cells may play a humoral role in reducing blood pressure, but a relationship between the presence of those tumours and clinical hypertension has not been demonstrated [2].
Clinically evident renomedullary interstitial cell tumours are rare. Our patient was asymptomatic, with proteinuria and microhaematuria. Although standard methods using renal biopsy specimens did not find evidence of glomerulonephritis, proteinuria and haematuria might have been due to a renomedullary interstitial cell tumour in this case.
Conflict of interest statement. None declared.
References