Research Laboratory on Urine, UO Nefrologia e Dialisi, Ospedale Maggiore, IRCCS, Milano, Italy
Correspondence and offprint requests to: G. B. Fogazzi, UO di Nefrologia e Dialisi, Ospedale Maggiore, IRCCS, Via Commenda 15, 20122 Milano, Italy. Email: fogazzi{at}policlinico.mi.it
Keywords: haematuria; anisocytes; poikilocytes; urinary erythrocyte morphology; urine sediment
Two main types of erythrocytes can be found in the urine, i.e. dysmorphic erythrocytes, which are a marker of glomerular bleeding, and isomorphic erythrocytes, which are a marker of urological disorders [1,2]. In addition, in patients with sickle cell disease, sickled erythrocytes can occasionally be seen [3].
Herein we describe another type of urinary red cells, to our knowledge never described before, which we found in a 39-year-old patient suffering from bilateral hydronephrosis caused by endometriosis and severe iron deficiency anaemia, haemoglobin 9.0 g/dl (n.v. 1418), serum iron 30 mcg/dl (n.v. 59158), and percent saturation of transferrin 6.7% (n.v. 3050).
The new type of urinary erythrocyte was found during an episode of gross haematuria after bilateral pyelostomy. The urine sediment contained too many isomorphic red cells to count. Intermingled with them were several erythrocytes of abnormal size and shape (Figure 1A), which were identical to the red cells found in peripheral blood (Figure 1B). The blood smear was prepared after a negative search for haemoglobin S and the finding at automatic complete blood cell count of a + anisocytosis (=variations in cell size), a +++ poikilocytosis (= variations in cell shape) and a +++ microcytosis (= small cells).
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Conflict of interest statement. None declared.
References
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