I am writing to you today to introduce this special issue of Molecular Endocrinology celebrating the 20th anniversary of cloning the genes for the nuclear receptor superfamily of transcription factors. We commence this issue with a series of invited historical perspective articles written by distinguished scientists and scholars who have made major contributions to the nuclear receptor field. We are grateful to these authorities for agreeing to undertake the truly difficult challenge of summarizing their laboratories contributions, which have been so important to molecular endocrinologists and to this field of research. It is critical to keep in mind that, although we celebrate the past twenty years since the cloning of the genes, the field of nuclear receptor action was vibrant and fully engaged in intense research efforts prior to that time. This early work on the physiology, biochemistry, and regulation of gene expression by the nuclear receptors contributed much of the groundwork for both the cloning of these receptor genes and todays appreciation for nuclear receptor signaling mechanisms.
In addition, this issue of Molecular Endocrinology is devoted to nuclear receptors and reflects our call for papers on the topic. Rest assured that all of these manuscripts have undergone the same rigorous peer-review process that is standard for Molecular Endocrinology. On behalf of all of the editors, I hope you enjoy this special issue.
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