School of Health Related Professions, State University of New York at Buffalo, Buffalo, New York 14214
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ABSTRACT |
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Sainburg, R. L. and D. Kalakanis. Differences in Control of Limb Dynamics During Dominant and Nondominant Arm Reaching. J. Neurophysiol. 83: 2661-2675, 2000. This study compares the coordination patterns employed for the left and right arms during rapid targeted reaching movements. Six right-handed subjects reached to each of three targets, designed to elicit progressively greater amplitude interaction torques at the elbow joint. All targets required the same elbow excursion (20°), but different shoulder excursions (5, 10, and 15°, respectively). Movements were restricted to the shoulder and elbow and supported on a horizontal plane by a frictionless air-jet system. Subjects received visual feedback only of the final hand position with respect to the start and target locations. For motivation, points were awarded based on final position accuracy for movements completed within an interval of 400-600 ms. For all subjects, the right and left hands showed a similar time course of improvement in final position accuracy over repeated trials. After task adaptation, final position accuracy was similar for both hands; however, the hand trajectories and joint coordination patterns during the movements were systematically different. Right hand paths showed medial to lateral curvatures that were consistent in magnitude for all target directions, whereas the left hand paths had lateral to medial curvatures that increased in magnitude across the three target directions. Inverse dynamic analysis revealed substantial differences in the coordination of muscle and intersegmental torques for the left and right arms. Although left elbow muscle torque contributed largely to elbow acceleration, right arm coordination was characterized by a proximal control strategy, in which movement of both joints was primarily driven by the effects of shoulder muscles. In addition, right hand path direction changes were independent of elbow interaction torque impulse, indicating skillful coordination of muscle actions with intersegmental dynamics. In contrast, left hand path direction changes varied directly with elbow interaction torque impulse. These findings strongly suggest that distinct neural control mechanisms are employed for dominant and non dominant arm movements. However, whether interlimb differences in neural strategies are a consequence of asymmetric use of the two arms, or vice versa, is not yet understood. The implications for neural organization of voluntary movement control are discussed.
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INTRODUCTION |
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Handedness, the manual asymmetry characterized by
the tendency to favor one hand for performance of skilled unimanual
tasks, is an intriguing feature of human motor performance. To
investigate whether handedness is associated with asymmetries in neural
control, previous studies compared dominant and nondominant arm
performance during aimed movements. A number of studies showed that
dominant arm advantages in reaching accuracy were not evident during
"ballistic" (low precision, high speed) movements and only emerged
when the precision requirements of the experimental task increased
(Carson et al. 1993; Elliott et al. 1994
;
Flowers 1975
; Steingruber 1975
; Todor and Cisneros 1985
). Some studies attributed better
accuracy of the dominant arm, during higher precision movements, to
less trajectory "corrections" during the deceleration phase
(Carson et al. 1993
; Todor and Cisneros
1985
), whereas others attributed this accuracy advantage to
smaller errors in the initial acceleration phase of motion
(Annett et al. 1979
; Roy and Elliott
1986
). The former reports proposed a dominant arm advantage for
error correction mechanisms, whereas the latter proposed that movement
planning is more effective and consistent for the dominant arm. Studies that manipulated target information before movement onset reported longer reaction times for the dominant arm, further suggesting interlimb disparities in movement preparation (Carson
1992
; Carson et al. 1990
, 1995
;
Elliott et al. 1993
).
Recent studies investigating control of multijoint coordination have
indicated the importance of movement dynamics in understanding neural
control of reaching movements. To produce a desired trajectory, muscle
forces must be coordinated with both external forces, imposed by the
environment, and additional internal forces that arise from within the
musculoskeletal system. Internal forces include interaction forces
imposed on a given limb segment by motion of the attached segments, and
forces resulting from stretch and compression of noncontractile
tissues. Environmental forces include those arising from sources
external to the musculoskeletal system (i.e., gravity and contact with
objects). Previous reports have shown that, with practice, using the
dominant arm, subjects adapt to coriolis forces (Lackner and
Dizio 1994) and viscous forces applied to the hand by a
manipulandum (Gandolfo et al. 1996
; Goodbody and
Wolpert 1998
; Shadmehr and Mussa-Ivaldi 1994
).
The use of anticipatory mechanisms for this adaptation was evident from
the existence of "after effects," or hand path curvatures that
mirrored the direction and magnitude of previously applied forces. We
recently extended these findings by showing that control of interaction forces also relies on neural representations of musculoskeletal dynamics (Sainburg et al. 1999
). After adaptation to a
mass attached by an outrigger to the forearm, the position of the mass
was experimentally manipulated (thus changing the center of mass of the
forearm/mass segment) on random, "surprise" trials. During these
trials, the subjects continued to initiate movements with muscle torque
patterns appropriate to the previously adapted inertial condition.
Errors in initial movement direction were thus accurately predicted by an open-loop forward simulation. These studies provided evidence that
successful coordination of multisegment movements is dependent on
accurate neural representations of musculoskeletal and task-specific dynamics.
The purpose of this paper is to investigate dominant and nondominant
arm differences in interjoint coordination during targeted reaching
movements. We compare the performance of the dominant and nondominant
arm during rapid aimed reaching movements of six neurologically intact,
right-handed subjects. Both arms were supported in the horizontal plane
by an air-jet system, which eliminated the effects of gravity and
friction. Because motion of the arm was influenced by both muscle
forces and intersegmental forces, we separately analyzed these effects
as muscle torque and interaction torque (see Sainburg et al.
1999). To experimentally manipulate the intersegmental dynamic
contributions to limb movement, we presented three targets of varying
directions and distances, designed to require the same amount of elbow
motion (20°) but varying amounts of shoulder motion (5, 10, and
15°). Thus we were able to investigate the effects of interaction
torques on the control of voluntary reaching with the dominant and
nondominant arms.
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METHODS |
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Subjects and apparatus
Subjects were six, neurologically intact, right-handed adults (2 females, 4 males), 24-36 yr of age. All subjects scored 100 (laterality quotient) on the 10-item version of the Edinburgh inventory
(Oldfield 1971). All subjects provided informed consent before participation in this study, which was approved by the institutional review board of the State University of New York at
Buffalo. Figure 1 illustrates the
experimental setup. Subjects sat facing a computer screen with each arm
supported, over a horizontal table top at shoulder height, by a
frictionless air-jet system. All joints distal to the elbow were
immobilized using an air splint. The scapulae and trunk were
immobilized using a custom-fit butterfly-shaped chest restraint.
Precision, single turn, linear potentiometers (Beckman Instruments)
were used to monitor the elbow and shoulder joint angles, and data were
digitized using a Macintosh computer equipped with an A/D board
(National Instruments PCI-MIO-16XE-50). The experimental tasks and hand
position feedback were presented to the subjects using a second
computer. The position of the index finger was calculated from joint
angle data and limb segment lengths and was displayed as a screen
cursor. Vision of the arm and tabletop was blocked using a horizontal
screen. Computer algorithms for experiment control and data analysis
were custom written.
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Task
A starting circle (10 mm diam) was displayed on the lower part of the computer screen while one of three target circles (5 mm diam) was displayed on the top part of the screen (see Fig. 1). To control the rotational effects of upper arm motion on the forearm (interaction torque), we presented three targets that required the same elbow excursion (20°), but different shoulder excursions (target 1 = 5°, target 2 = 10°, target 3 = 15°). Between trials, the hand position was shown in real time as a screen cursor. Before each trial, subjects were to hold the cursor within the starting circle for 1 s. The trial was then initiated by an audiovisual signal at which time the cursor was blanked. Subjects were instructed to move their hand to the target using a single, uncorrected, rapid motion.
At the end of each trial, knowledge of results was provided in the form of a crosshair indicating final position. To motivate subjects, audiovisual feedback and points were awarded for accuracy when the movement occurred in a prescribed time window (400-600 ms). Movement initiation and termination were determined by analyzing the hand's tangential velocity profile. To account for small oscillations of the hand inside the starting circle, movement onset was defined to occur 10 ms before the last minimum (below 5% Vmax) prior to the maximum (Vmax) in the hand's tangential velocity profile. Final position was defined to occur 10 ms after the first minimum (below 5% Vmax) following the peak in tangential hand velocity (see Fig. 2), thus requiring subjects to perform rapid, uncorrected movements. Subjects moved one hand at a time, alternating hands every 12 trials. Each experimental session consisted of 240 trials, in which the targets were presented in a continuous sequence (target 1, target 2, target 3, target 1...). The order of target presentation was randomized between subjects. Because not all trials were successfully completed, our analysis includes 230 trials from each subject. For motivation, points were awarded based on accuracy.
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Kinematic analysis
The shoulder and elbow potentiometer signals were collected at
500 Hz, converted to joint angles, low-pass filtered at 20 Hz (3rd
order, no-lag Butterworth), and double differentiated to yield angular
velocity and acceleration values. Elbow () and shoulder (
) joint
angles are defined in Fig. 1.
Hand paths were calculated from joint angle data using the measured
length of the upper arm and the distance from the elbow to the index
finger (proximal metacarpophalangeal joint). The angular data were
transformed to a Cartesian coordinate system with the origin at the
shoulder (see Fig. 1). For direct comparison between left and right
hand trajectories, the left hand paths were converted to a
"right-hand" coordinate system. Thus the medial to lateral axis is
represented graphically from left to right for both hands (see Figs.
3 and 5A). Task accuracy was
measured as the distance between the final position and the center of
the target circle. Hand path "direction-change" was defined as the difference in direction () between the average velocity vectors calculated for the following two movement periods: 1)
movement initiation to time-of-peak tangential hand velocity
(Vmax) and 2) time-of-peak
tangential hand velocity (Vmax) to
movement termination. This measure provided a signed value indicating
the overall direction-change between the acceleration and deceleration
phases of motion (see Fig. 2).
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Kinetic analysis
To separately analyze the effects of intersegmental forces and
muscle forces on limb motion, we partitioned the terms of the equations
of motion into three main components: interaction torque, muscle
torque, and net torque. Interaction torque represents the rotational
effect of the forces due to the motion of the segments about the
joints. The muscle torque primarily represents the rotational effect of
muscle forces. Finally, the net torque is directly proportional to
joint acceleration, inversely proportional to limb inertia, and equal
to the combined muscle and interaction torques (see Sainburg et
al. 1999; Zajac and Gordon 1989
).
It is important to note that the computed muscle joint torque cannot be
considered a simple proxy for the neural activation of the muscles
acting at that joint. Muscle joint torque does not distinguish muscle
forces that counter one another during co-contraction, and it also
includes the passive effects of soft tissue deformation. Additionally,
the force generated by muscle to a given neural input signal is
dependent on muscle length, rate of muscle length change, and recent
activation history, whereas the contribution of muscle force to joint
torque changes with musculoskeletal geometry (Abbott and Wilkie
1953; Wilkie 1956
; Zajac 1989
).
Torques were computed and analyzed for the shoulder and elbow joints as detailed in the equations below.
Elbow joint torques
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Shoulder Joint Torques
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Symbols
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For these calculations, the aluminum rod attaching the shoulder
potentiometer to the elbow potentiometer was not considered because its
mass was only 0.052 kg. The inertia and mass of the forearm support
were 0.0247 kgm2 and 0.58 kg, respectively. Limb
segment inertia, center of mass, and mass were computed from regression
equations using subjects' body weight and measured limb segment
lengths (Winter 1990).
We quantified the contributions of muscle and interaction torques to motion using the following method. Intervals during which the interaction torque component acted in the same direction as the net torque were considered to contribute to a positive interaction torque impulse. Intervals during which the interaction torque component acted in the opposite direction to net torque were considered to contribute to a negative interaction torque impulse. All positive and negative integrals were summed to yield a single total interaction torque impulse for the entire movement. Muscle torque impulse was likewise computed as a contribution to net torque for the entire movement.
Statistical analysis
The individual measures used in this paper were analyzed in separate analyses of variance (ANOVAs). Post hoc comparison of cell means was done using the Bonferoni/Dunn method. We used a simple linear regression analysis to assess the relationships between specific data sets.
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RESULTS |
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Task learning
Final position error, hand path direction-change, and movement duration are shown in Fig. 3 for all trials, averaged across all subjects. Left and right arm data are grouped and plotted separately for comparison of performance between arms. Although movement duration remained relatively constant across the entire experimental session, movement accuracy improved during the 1st 55 trials performed with each hand, indicating task adaptation. For the following 60 trials, task accuracy remained relatively constant, as reflected by the asymptotic region of the plots (exponential fit) shown in Fig. 3. Left and right hand paths showed distinct curvatures, measured as direction-changes. The direction-changes of movements to targets 2 and 3 were opposite for the two arms, but remained relatively constant across the duration of task performance. The direction-change measured for movements to target 1 was also different for the two hands. Left arm movements to target 1 showed a clockwise shift in this measure before trial 55, remaining relatively constant across the final 60 trials. In the following sections, we compare performance of left and right arms for the last 60 trials performed with each hand, during which movement accuracy, duration, and direction-change remained relatively constant.
Hand kinematics
Figure 4 (top) shows left and right hand paths from two subjects for the 120 trials (60 for each hand) that followed task adaptation. Measures of accuracy and direction-change, averaged across all subjects, are shown below. Right and left hand paths are displayed in a "right-hand" coordinate system (see METHODS). The distributions in final position for the right and left hands are overlapping for targets 2 and 3, whereas the final positions for target 1 showed little overlap. Both hands showed similar final position errors (distance from the target). Across all subjects, the left hand was slightly more accurate (difference of means: 2.6 ± 2.0 mm, mean ± SE; Bonferoni/Dunn: P < 0.0043) for targets 2 and 3, whereas there was no significant interlimb difference in accuracy for target 1 (Bonferoni/Dunn: P = 0.9201; see Fig. 4B, right).
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The most striking finding, illustrated in Fig. 4, was the difference in the trajectories taken by the right and left hands to reach the targets. For the movements directed to targets 2 and 3, the right hand was initially directed medial to the target, subsequently curving lateral to reach its final position, whereas left hand movements were initiated lateral to the target, subsequently curving medial. These different coordination patterns were consistent across subjects as indicated by the plot of mean direction-change (see METHODS) in Fig. 4B, left. Across subjects, interlimb differences in direction-change were substantial for movements to all targets (Bonferoni/Dunn: P < 0.0001). For movements to target 1, both hands showed a medial to lateral direction-change (positive value); however, the left hand paths were significantly less curved (reduced direction-change, Bonferoni/Dunn: P < 0.0001).
Next, we examined whether these different hand path direction-changes
varied with the amount of shoulder excursion required for the different
targets. As greater amounts of shoulder excursion were required by the
task (targets 1-3, respectively), the left hand paths
showed progressively greater lateral to medial direction-changes. For
the left arm, the average direction-change measured for movements toward target 1 was 3.9 ± 1.0° (mean ± SE),
whereas that measured for movements to target 3 was
22.6 ± 2.6° (difference, 26.5°; Bonferoni/Dunn:
P < 0.0001). In contrast, the right hand paths showed
slight changes in curvature that varied with direction. For movements
toward target 1, the mean direction-change was 10.7 ± 2.0°, whereas that measured for movements to target 3 was
13.6 ± 2.0°, a small but significant difference (2.9°,
Bonferoni/Dunn: P = 0.0033).
Joint kinematics
Figure 5A shows representative trials made toward target 3 by subject 1. The different hand path curvatures illustrated in Fig. 5A (left) reflect different elbow and shoulder joint coordination patterns (Fig. 5A, right). For these particular trials, the shoulder displacement profiles were almost identical. However, the elbow profiles were quite different. Although both elbows reached similar final positions, the left elbow initially extended earlier than the right elbow. As a result, left elbow excursion at peak tangential hand velocity (Vmax) was larger. This resulted in a more lateral position of the left hand at Vmax. Although shoulder excursions were not always identical, interlimb differences in coordinative patterns were consistent across trials, directions, and subjects. Figure 5B shows the ratio of shoulder to elbow excursion (averaged across all subjects), measured at Vmax and at final position. Regardless of the target direction, the left hand showed substantially smaller excursion ratios at Vmax (Bonferoni/Dunn: P < 0.0001). This indicates that for a given shoulder excursion, elbow displacement was greater for the left arm. In contrast, at the final position, right and left joint excursion ratios were not significantly different for movements made to target 3 (Bonferoni/Dunn: P = 0.018) and were similar for movements made to target 2 (left mean, 0.74 ± 0.03; right mean, 0.76 ± 0.02). Consistent with these similarities in final joint ratios, the final positions of movements made to these targets had overlapping distributions (see Fig. 3). However, for movements made toward target 1, right arm and left arm joint ratios remained different (Bonferoni/Dunn: P < 0.0001), reflecting the segregated endpoint distributions for right and left hands displayed in Fig. 4.
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In summary, right and left arms showed similar accuracy in final position, however, not always with identical final configurations of the limb. Left and right hand trajectories were substantially different, with oppositely directed curvatures. These curvatures are direct indications of different interjoint coordination patterns employed by each arm. Compared to the right arm, left arm movements were systematically initiated with greater elbow extension for a given amount of shoulder flexion. The following sections examine the kinetic differences underlying these interjoint coordination patterns.
Joint kinetics
Figures 6 and 7 show representative trials made with the right and left arms, respectively, to targets 1 and 3 by subject 1. Hand paths are shown at the top, followed by joint angle, and joint torque profiles.
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In Fig. 6 (right arm) the hand paths in both directions show similar medial to lateral curvatures. As required by the task, elbow excursions are similar (24.3 and 25.0°, respectively), and shoulder excursions are different: target 3 greater than target 1 (6.4 and 17.2°, respectively). For both movements, shoulder motion is determined predominantly by muscle forces acting on the upper arm (interaction torque remains small relative to net torque). In contrast, interaction torques contribute substantially to elbow motion. This is evident especially during movement initiation toward target 3 where the muscle torque counters elbow joint acceleration. Although both movements are initiated with elbow extensor acceleration, as indicated by the net torque profiles, initial muscle torque acts in opposite directions for each movement. The target 1 movement is initiated with extensor muscle torque, whereas the target 3 movement is initiated with flexor muscle torque.
Figure 7 (left arm, target 1) shows that the left hand path is nearly straight and directed lateral to target 1, in contrast to the corresponding right arm movement (Fig. 6, left). The more lateral hand trajectory results from less shoulder flexion, which is reflected by lower net shoulder torque. This is because elbow and shoulder muscle torques, acting on the upper arm, counter one another. This reduced left shoulder motion, relative to the corresponding right arm movement, results in smaller elbow joint interaction torques. Consequently, elbow joint acceleration is determined almost entirely by muscle torque. This is in contrast with the right arm movement (Fig. 6), in which interaction torques at the elbow play a larger role in the acceleration of the joint.
Figure 7 (left arm, target 3) shows that the hand path is curved lateral to medial, opposite to that of the corresponding right arm movement (Fig. 6, right). This initial lateral deviation reflects greater left elbow extension in the early phase of motion (see RESULTS: Joint kinematics). During this part of the movement, shoulder net torque is similar for the two arms. However, the right arm movement is initiated with flexor elbow muscle torque (see Fig. 6, right column), while the left arm movement is initiated with extensor elbow muscle torque (Fig. 7, right column). As a result, left extensor net torque develops more rapidly, producing the early elbow joint extension that causes the initial lateral deviation in the left hand trajectory.
In summary, the examples in Figs. 6 and 7 illustrate distinct coordination strategies employed by each arm. For movements to target 1, right elbow and shoulder muscle torques acted synergistically to accelerate the upper arm, whereas elbow and shoulder muscle torques countered one another in accelerating the left upper arm. For both targets, interaction torques contributed more to elbow joint acceleration for the right arm than for the left arm.
Muscle and interaction torque contributions to net torque
The interlimb differences in torque strategies illustrated by the examples of Figs. 6 and 7 were consistent across all trials and all subjects. The stacked bar plots of Fig. 8 illustrate muscle and interaction torque impulse, measured as separate contributions to shoulder (left) and elbow (right) net torque (see METHODS). For this analysis, interaction torque impulse is considered positive when the interaction torque acts in the same direction (flexor or extensor) as the joint's net torque. Muscle torque impulse was computed in the same way (see METHODS). The mean ± SE, calculated across all trials for each subject, is plotted for each arm and target direction in Fig. 8. (Note: net joint torque is equal to the summed positive and negative bar plot height.)
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In general, right and left elbow joint net torques were similar, whereas right shoulder net torque was greater than left shoulder net torque. It should be noted that elbow net torque varies with elbow joint acceleration, whereas shoulder net torque varies with shoulder acceleration and elbow angle. Because left and right elbow displacements were different for movements to the same targets, differences in net shoulder joint torque values do not directly indicate differences in shoulder joint acceleration.
As expected by the design of the task (same net elbow excursion
required for all targets), elbow net torque impulse was similar across
all three target directions for both hands (all subjects: target
1, 0.61 ± 0.16 Nms, mean ± SD; target 2, 0.66 ± 0.14 Nms; target 3, 0.58 ± 0.15 Nms). In
contrast, shoulder net torque impulse increased substantially across
the three target directions, as successively more net shoulder joint
excursion was required for targets two and three, respectively (all
subjects, both arms: target 1, 0.260 ± 0.15 Nms,
mean ± SD; target 2, 0.695 ± 0.16 Nms;
target 3, 0.954 ± 0.22 Nms). The percentage change in
mean net shoulder torque impulse for movements to target 3 compared with that for movements to target 1 was 267%,
whereas the corresponding change in mean net elbow torque impulse was
4.9%. Furthermore, as greater shoulder motion was required by the
task, the contributions of elbow interaction torque to elbow net torque
increased substantially. For both hands, the mean elbow joint
interaction torque impulses were 0.179 ± 0.087 (SD) Nms for
target 1, 0.337 ± 0.101 Nms for target 2, and 0.461 ± 0.127 Nms for target 3. Thus mean elbow interaction torque impulse increased 2.5-fold for target 3 movements, compared with target 1 movements.
Regardless of the target, the contributions of elbow joint interaction torque impulse to net torque impulse was almost 20% greater for right arm movements, as compared with left arm movements (see Table 1 and Fig. 8). Elbow muscle torque, thus contributed substantially less toward acceleration of the right elbow, compared with acceleration of the left elbow, for movements to all three directions (Bonferoni/Dunn: P < 0.0001). For target 3 movements, in which elbow joint interaction torques were largest, right elbow muscle torque impulse contributed <7% to elbow net torque impulse, whereas left elbow muscle torque impulse contributed almost 30% to elbow net torque impulse. Thus for this direction, right elbow acceleration was determined almost entirely by interaction torque, whereas left elbow muscle torque contributed substantially more to acceleration of the left elbow joint (see Table 1). In summary, the right arm coordination strategy more extensively employed muscle torque at the shoulder to accelerate the elbow, indicating more effective utilization of interaction torques.
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Left elbow muscle torque not only contributed greater to elbow joint acceleration, but also to shoulder joint acceleration. It should be noted that muscles crossing the elbow joint produce equal and opposite forces on the distal upper arm and the proximal forearm. Thus elbow muscle torque directly affects both elbow and shoulder joint acceleration. For all directions, left elbow muscle torque impulse contributed greater than twice as much to shoulder joint net torque impulse than did right elbow muscle torque impulse (Bonferoni/Dunn: P < 0.0001; see Table 2 and Fig. 8). Thus for the left arm, elbow joint muscle torque contributed greater to motion at both joints. In contrast, for the right arm, elbow and shoulder joint acceleration was determined to a greater extent by shoulder muscle torque.
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Dependence of hand path direction-changes on intersegmental dynamics
We examined the extent to which the hand path direction-changes, made by the right and left arms, were dependent on interaction torque impulse. Figure 9 shows sample scatter plots of our measure of hand path direction-change plotted against interaction torque impulse (calculated across the entire movement, as a contribution to net torque) from subject 1 data (left), and regression coefficients for all subject data (right). For all subjects, left hand direction-change was highly dependent on interaction torque impulse. However, variation in right hand direction-change could not be accounted for by variation in interaction torque impulse. Thus right arm hand path shape was independent of direction-dependent variations in interaction torques, whereas left arm hand path shape varied directly with interaction torques. This is consistent with the fact that the left hand path direction-changes varied with target direction, becoming greater as more shoulder excursion was required by the target, whereas the right hand path direction-changes did not (see Fig. 4). We reasoned that the right arm controller must have accounted for interaction forces, to specify muscle actions that combine with these forces such that the shape of the hand path was not dependent on their magnitude. Such independence of hand path shape from direction-dependent variations in interaction torque implies greater control of the hand trajectory for the dominant arm.
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DISCUSSION |
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This study examined the coordination patterns employed for the left and right arms during rapid targeted reaching movements made by right-handed subjects. Movements were made to each of three targets, designed to elicit progressively greater amplitude interaction torques at the elbow joint. Subjects received visual feedback only of the final hand position with respect to the target location, whereas points were awarded based on final position accuracy for movements made within an interval of 400-600 ms. For all subjects, the right and left hands showed a similar time course of improvement in final position accuracy over repeated trials. After task adaptation, final position accuracy was similar for both hands; however, the hand trajectories and joint coordination patterns during the movement were systematically different. The trajectories of both hands were not straight but exhibited oppositely directed curvatures. Right hand paths showed similar medial to lateral curvatures for all target directions. The left hand paths had lateral to medial curvatures, which increased in magnitude as greater shoulder excursions were required.
Kinetic analysis revealed differences in the control strategies employed for the left and right arms. For movements requiring substantial shoulder excursions (targets 2 and 3), right arm coordination was characterized by a control strategy, in which movement of both joints was primarily driven by the effects of shoulder muscle actions. In contrast, motion of the left elbow and shoulder joints was substantially effected by elbow muscles through direct actions on the upper arm and forearm segments. In other words, interaction torques contributed more to the acceleration of the right elbow than the left elbow. Furthermore, the direction-changes (curvatures) of the right hand paths were independent, whereas those of the left hand paths were dependent, on variations in elbow joint interaction torque impulse.
Right (dominant) arm control
Our findings for the right arm are consistent with previous
reports that demonstrated that adaptation to task-specific dynamics occurs through the development of internal representations of the
applied loads. During practice under particular viscous, coriolis, and
inertial loading conditions (Gandolfo et al. 1996;
Goodbody and Wolpert 1998
; Lackner and Dizio
1994
; Sainburg et al. 1999
; Shadmehr and
Mussa-Ivaldi 1994
), the CNS develops internal models of the
applied forces that are used to predict musculoskeletal and
environmental dynamics for planning subsequent movements. In the
current study, the independence of dominant hand path shape from
interaction torque indicates skillful coordination of muscle actions
with intersegmental dynamics and indicates accurate predictions of
those interactions. For example, during target 3 movements, extension of the right elbow was initiated with flexor, or near zero,
elbow muscle torque, exemplifying the anticipation of extensor interaction torque before movement initiation (see Fig. 6, target 3). Such predictions are requisite to achieving variable control over the hand trajectory under different task conditions. In contrast, nondominant hand path shape deviated directly with interaction torque
amplitude, indicating less accurate predictions of those interactions.
Consistent with this finding, Hore et al. (1996)
recently demonstrated that dominant arm advantages in throwing accuracy
are related to more consistent timing of finger extension relative to
proximal limb motion, indicating interlimb differences in the
coordination of proximal and distal joints. Our findings extend those
of Hore, suggesting that dominant arm advantages for interjoint
coordination result from more accurate predictions of the effects of
intersegmental dynamics during movement planning. Our results are thus
consistent with the anecdotal observation that the dominant arm can
achieve more varied and flexible control over movement trajectories, as
required for accurate drawing, writing, and ball throwing.
Left (nondominant) arm control
It appears contradictory that the two limbs achieved similar final
position accuracy, whereas the left arm demonstrated less effective
control of intersegmental dynamics. However, it has previously been
proposed that control of limb trajectory and posture is implemented by
distinct mechanisms (Gottlieb 1996; Hirayama et
al. 1993
). Hirayama demonstrated the plausibility of such
control using a two-phase model to implement a simulation, in which
movement was initiated through a forward dynamic controller
(open-looped), whereas final position was achieved by increasing joint
stiffness about an equilibrium posture (coactivation of antagonist
muscles). Gottlieb (1996)
elaborated a similar,
three-element model, in which each component of control can be
differentially weighted depending on the current demands of the task.
According to this model, initial trajectory features result from
open-loop mechanisms (
), based on internal representations of task
dynamics. The second element (
) defines feedback mediated control,
largely effecting limb compliance. The third element (
) describes
active modulation of the feedback elements. If task dynamics are
incompletely or incorrectly modeled by the controller, the effects of
feedback can be amplified by way of the
command, thereby increasing
joint viscosity as well as stiffness about a desired trajectory. This will reduce potential path deviations due to inaccurate predictions of
impending mechanical interactions. In this particular case, control
would mimic that described by the equilibrium point hypotheses, because
joint torque will emerge largely as a function of the difference
between the muscle lengths for the current and the desired limb
positions (Bizzi 1987
; Bizzi and Abend
1983
; Bizzi et al. 1976
,
1982
; Feldman 1986
; Flash
1987
; Polit and Bizzi 1979
). Under such
conditions, the trajectory would be expected to deviate with
task-specific inertial dynamics, such as interaction torques. As the
limb slows down and approaches the final position, the
command
becomes dominant, and feedback-mediated increases in joint stiffness
and viscosity substantially reduce potential path deviations and errors
in final position. This type of mechanism may explain the behavior of
the nondominant arm in the current study for which trajectory
deviations, but not final position errors, varied with the magnitude of
interaction torques.
Distinct neural mechanisms for right and left arm movements
The distinct coordination patterns observed for the left and right
arms are not likely to have resulted from differences in peripheral
factors, such as muscle strength or distribution of muscle fiber types.
Such differences would be expected to alter the rate of change of
muscle force generation (Burke 1981; Enoka 1988
). However, our results show interlimb differences in the relative timing, magnitude, and direction of muscle torques at the
shoulder and elbow that are more likely to result from differences in
neural activation. For example, substantial differences in the
direction of muscle torque occurred at movement initiation. Target 1 movements were consistently initiated with extensor
muscle torque at the left shoulder, but with flexor muscle torque at the right shoulder (see Figs. 6-8). Similarly, for target 3 movements, right elbow extension was initiated with flexor (or near
zero) elbow muscle torque, whereas left elbow extension was initiated with substantial extensor muscle torque (see Figs. 6-8). Furthermore, the magnitude of the left shoulder muscle torque was less than that of
the right shoulder, whereas the magnitude of the left elbow muscle
torque was larger than that of the right elbow (see Figs. 6-8).
Strength differences between the arms could not account for such muscle
torque patterns. Instead, such differences in muscle joint torque must
result from interlimb differences in patterns of neural activation of muscles.
The hypothesis that control of the two limbs is mediated by distinct
neural mechanisms is consistent with previous work indicating different
neural contributions to unilateral movements of right and left arms.
The landmark studies by Kuypers and colleagues established that,
although trunk and limb girdle musculatures are controlled through
bilateral projections, control of arm musculature for reach and
prehension arises primarily from contralateral cortex, either directly
through descending corticospinal projections, or indirectly through
brain stem pathways (Holstege and Kuypers 1982,
1987
; Kuypers 1982
; Kuypers and
Brinkman 1970
; Kuypers and Laurence 1967
;
Kuypers and Maisky 1975
; Kuypers et al.
1962
; Lawrence and Kuypers 1968a
,b
). Subsequent
electrophysiological and neural imaging studies have revealed
substantial activation of ipsilateral motor cortex during unimanual arm
and finger movements (Chen et al. 1997a
,b
;
Dassonville et al. 1997
; Gitelman et al.
1996
; Kawashima et al. 1994
,
1996
-1998
; Kim et al. 1993
; Kutas
and Donchin 1974
; Macdonell et al. 1991
;
Matsunami and Hamada 1981
; Salmelin et al.
1995
; Taniguchi et al. 1998
; Tanji et al.
1988
; Urbano et al. 1996
; Viviani et al.
1998
; Volkmann et al. 1998
). However, activation
of left and right hemispheres during unilateral upper limb movements
are not symmetrical for movements of the dominant and nondominant arms
(Amunts et al. 1996
; Dassonville et al.
1997
; Gitelman et al. 1996
; Kawashima et
al. 1997
; Kim et al. 1993
; Taniguchi et
al. 1998
; Tanji et al. 1988
; Urbano et
al. 1996
; Viviani et al. 1998
; Volkmann
et al. 1998
). Furthermore, handedness has been associated with
morphological asymmetries in motor cortex, basal ganglia, and
cerebellum (Amunts et al. 1996
; Kooistra and Heilman 1988
; Snyder et al. 1995
). Such
physiological and morphological asymmetries are consistent with the
idea that voluntary movement of the two arms is achieved through
independent controllers.
The differences in coordination between the limbs reported in this
study may reflect the more extensive, lifelong, practice and experience
that is often associated with dominant limb use. This hypothesis is
supported by previous reports indicating that accurate coordination of
muscle forces with intersegmental and environmental forces is dependent
on proprioceptive information (Ghez and Sainburg 1995;
Sainburg et al. 1993
, 1995
) and learning (Lackner and Dizio 1994
; Sainburg et al.
1999
; Shadmehr and Mussa-Ivaldi 1994
), and that
such coordination develops over the first few years of life
(Thelen et al. 1983
, 1993
;
Zernicke and Schneider 1993
). Alternatively, it has been
proposed that the behavioral effects of handedness are determined by
physiological asymmetries that are present before the opportunity for
such experience develops (Annett 1992
; Clark et
al. 1996
; Coryell 1985
; Drea et al.
1995
; McManus 1985
; Melsbach et al.
1996
; Tan 1990
). According to this idea,
handedness emerges from unique neural circuits in each hemisphere that
are specialized for controlling different aspects of limb movements.
This hypothesis is supported by evidence of handedness in human fetuses
and newborns (Caplan and Kinsbourne 1976
; Coryell 1985
; Futagi et al. 1995
; Hepper et al.
1998
, 1991
; Konishi et al. 1986
,
1997
; Ottaviano et al. 1989
; Tan
et al. 1992
). At present, however, there is insufficient data
to distinguish between these alternatives.
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ACKNOWLEDGMENTS |
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The authors thank G. Johnson, Columbia University College of Physicians and Surgeons, for design of the air jets used in this study. Fabrication of these air jets was done by One of A Kind Ltd., Lincoln Park, NJ.
This research was supported by National Institute of Child Health and Human Development Grants 1k01HD-0118601 and T32HD-07423.
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FOOTNOTES |
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Address for reprint requests: R. L. Sainburg, 90 Farber Hall, Main St. Campus, State University of New York at Buffalo, Buffalo, NY 14214.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Received 21 June 1999; accepted in final form 26 January 2000.
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REFERENCES |
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