1. Review the existing experimental data for the gene and the SNPs.
2. Review existing epidemiologic evidence about disease association.
3. Look at the nucleic acid sequence.
4. Look at evolutionary conservation of protein regions and amino acids.
5. If structural information is available for the protein or a related one, look at where the SNPs lie in the structure.
6. Use population genetics information about distribution of the SNPs.
Related News Article in JNCI
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