A News story in the February 2 issue of the Journal ("Missingthe Target: Ubiquitin Ligase Drugs Stall," Vol. 97, No. 3, p.166) omitted the context of the Nobel Prizewinning accomplishmentsof Avram Hershko, M.D., Ph.D., and Aaron Ciechanover, M.D.,D.Sc., failing to mention their key experimental and extensiveconceptual work done between 1978 and 1983. Attacking an obscureproblem, ATP-dependent proteolysis, Hershko and Ciechanover,partially in collaboration with Irwin A. Rose, Ph.D., elucidatedall the major elements of the ubiquitinproteasome systemand their basic cellular role in proteolysis, now recognizedas fundamental to biology. A more detailed explanation of theirwork was reported in the Journal in 2002 (Vol. 94, No. 8, p.550).