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Fig. 2. Schematic presentation of tumors and mutations found in the kidneys of patient 4. Of 18 tumors examined, 15 tumors, 11 from the left kidney and four from the right kidney, exhibited a somatic second hit. Tumors with two colors depict those in which areas of different histologic type were microdissected separately from frozen sections; these tumors are categorized from formalin-fixed sections as oncocytic hybrid tumors. Mutations or LOH were observed in all histologic type and in both kidneys.
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