Imatra Health Centre (P.V.), Laukaa Health Centre (M.V.), Kuopio University; Department of Public Health and General Practice (E.K.), Kuopio University Hospital; General Practice (E.K.), Oulu University; and Department of Public Health Science and General Practice (P.V., S.K.-K.), Finland
Address correspondence to: Pasi Vanhala, M.D., Department of Public Health and General Practice, Oulu University, PL-5000, 90020 Oulu, Finland.
Abstract
The aim of the present study was to evaluate the predictive value
of QUICKI and fasting plasma insulin (FPI0 as predictors of the onset
of type 2 diabetes mellitus. We performed a five-year follow-up study
in a sample of middle-aged subjects with at least one of the following
risk factors; hypertension defined as systolic blood pressure 160
mmHg and/or diastolic blood pressure
90 mmHg or medication for
hypertensin, obesity defined as a body mass index
30
kg/m2 and/or a waist-to-hip ratio
1.00 in men and
0.88
in women, or a family history of type 2 DM. When the QUICKI index was
used to compare the tertile with the lowest risk to the tertile of the
highest risk of obese subjects. Odds Ratio (OR) for type 2 diabetes
was 7.77 (95% CI 1.39202.24). For FPI, the respective ORs were
2.84 (95% CI 0.829.82) and 3.96 (95% CI 1.0215.48). QUICKI and
fasting insulin did not have a statistically significant predictive
value among non-obese subjects. Concerning QUICKI, the subjects in the
tertiles at the medium and highest risk had a higher risk for type 2 DM
than the corresponding tertiles of FPI among obese subjects.
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