A Focus on Cardiovascular Endocrinology

John P. Bilezikian, M.D.

Editor-in-Chief

A few months ago, I announced that the JCEM had begun a series on Cardiovascular Endocrinology, in keeping with the theme of this month’s Annual Meeting of The Endocrine Society. Recognizing that this important area of endocrinology has not received the attention it deserves, our President, John Baxter, asked each of The Endocrine Society Journals to highlight this theme for June. In 2003, the JCEM has already published two special feature articles in cardiovascular endocrinology: McFarlane S. I., and Sowers J. R.: Aldosterone function in diabetes mellitus—effects on cardiovascular and renal disease 88:516–523, 2003; and Goran M. I., Ball G. D. C., and Cruz M. L.: Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents 88:1417–1428, 2003. In the following pages, the special June section features 15 more articles on cardiovascular endocrinology. We are pleased to have received the cooperation of the most prominent investigators and thought leaders in this field to provide for you a compendium of information you should find refreshingly new and timely. Jonathan S. Williams and Gordon Williams’ historical perspective on the 50th anniversary of aldosterone is followed by an editorial by John Funder, in which he comments on the Ephesus Trial. Hypertension and cardiac function is a focus of the next three articles: Aldosterone in the heart (Perrin White); the cortisol-cortisone shuttle (Paul Stewart and Marcus Quinkler); and pregnancy (Ellen Seely and Caren G. Solomon). The metabolic syndrome is covered in three articles by Gerald Reaven (Insulin resistance, hypertension, and coronary artery disease), Monica Carr and John Brunzell (The emergence of the metabolic syndrome with menopause), and V. Krishna Chatterjee, Steve O’Rahilly, Mark Gurnell, and David B. Savage (Insulin resistance and dyslipidemia). The need for metabolic control in type 2 diabetes is reviewed by Paresh Dandona, Ahmad Alijada, Ajay Chaudhuri, and Arindam Bandyopadhyay, and by Irl Hirsch, Dace L. Trence, and Janet Kelly in the next two articles. Paul Ladenson and Anne R. Cappola write about hypothyroidism as a risk factor for atherosclerosis. Robert Kreisberg and Albert Oberman discuss the medical management of hyperlipidemia. David Weigle addresses issues related to the medical therapy of obesity. The last two articles in this series are new views related to markers of cardiovascular disease risk in women (Sonia Davison and Susan R. Davis) and how adult-onset growth hormone deficiency may be related to atherosclerosis (T. B. Twickler, M. J. M. Cramer, G. M. Dallinga-Thie, M. J. Chapman, D. W. Erkelens, and H. P. F. Koppeschaar).

The special June issue also contains 15 original research articles on cardiovascular endocrinology. Following the format of the invited reviews, the original articles contain information about aldosterone and corticosteroids (six articles); syndrome X, hypercholesterolemia, and lipoprotein metabolism (four articles). Three original articles emphasize the vasculature as a focus of endocrine control. The last two reports discuss growth hormone and body composition and the intriguing relationship between bone loss and atherosclerosis.

Expecting that you will continue to be interested in this theme in the coming months, we will be highlighting additional special feature articles on cardiovascular endocrinology throughout the year.





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