The decision of who to treatthe issue of allocation of scarce resourceswas the doctors dilemma that formed the substance of George Bernard Shaws play first performed in 1906. The excerpts reproduced here come from the Preface on Doctors which Shaw added as a commentary to the play in 1911. Shaw develops a number of themesof particular note is his championing of a socialized system of medicine to avoid the perverse incentives to investigate and treat patients needlessly that were (and probably still are) rampant in a largely private health care system. Shaw also notes the inconsistencies in clinical practice in which different doctors will consider their own treatments superior to those of other doctors, even when not a shred of evidence exists to choose between them. Systematic reviews of randomized controlled trials conducted by the Cochrane Collaboration are now improving this situation and hopefully contributing to reducing the humbug and paternalism in medicine lamented by Shaw.
Randomization is the theme of the series of papers on Ronald Aylmer Fisher and Austin Bradford Hill. Both appreciated the importance of randomization in experimental design, although in Bradford Hills case he emphasized its value as a means of concealing allocation, and thereby avoiding selection bias. Fishers emphasis was different. He saw randomization as a means of ensuring that valid tests of significance of differences between comparison groups could be conducted. The commentaries published here give intriguing insights into the personalities, relationships and, importantly, the immense contributions both men made to medical science.
This issues theme is mental health. Are psychological factors, such as vital exhaustion, causally linked to increased risk of cardiovascular disease?1 Does smoking cause suicide?2 The implications for health promotion of the answers to these questions are profoundly important. Our commentators note that non-causal associations arise through mechanisms of reporting bias, reverse causality, and through psychological factors acting as ciphers for material deprivation.3 Few studies are capable of excluding this range of explanations and ultimately the answer lieswhere possiblein conducting randomized controlled trials. The ENRICHD trial4 of psychological interventions after myocardial infarction failed to show any benefit in terms of recurrence of cardiovascular events suggesting that the psychological factors are not causally related to disease. However, the accompanying commentary in the Journal of the American Medical Association5 called for further trials of more powerful treatments and large enough to detect smaller effect sizesdespite the confidence intervals of the estimate from ENRICHD excluding an effect as small as a 14% reduction in events. It is understandably hard for some investigators to let such hypotheses die.
The smoking and suicide relationship was originally used to illustrate that even strong associations can be seriously confounded6 but many investigators believe the association is causal. In this issue we publish Hemmingsson and colleagues paper2 showing that the association is attenuated by adjustment for heavy alcohol consumption and mental problems among smokers which they interpret as providing evidence against the causal hypothesis. Our commentator thinks the relationship is indeed causal and that Hemmingssons analysis is spurious as it has overadjusted for factors on the causal pathway between smoking and suicide.7 This debate will doubtless continue.
References
1 Prescott E, Holst C, Grønbæk M, Schnohr P, Jensen G, Barefoot J. Vital exhaustion as a risk factor for ischaemic heart disease and all-cause mortality in a community sample. A prospective study of 4084 men and 5479 women in the Copenhagen City Heart Study. Int J Epidemiol 2003;32:99097.
2 Hemmingsson T, Kriebel D. Smoking at age 1820 and suicide during 26 years of follow-uphow can the association be explained? Int J Epidemiol 2003;32:100005.
3 Macleod J, Carroll D. Commentary: What should we make of associations between vital exhaustion and heart disease? Int J Epidemiol 2003;32:99799.
4 Writing Committee for the ENRICHD Investigators. Effects of treating depression and low perceived social support on clinical events after myocardial infarction: The Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) randomized trial. JAMA 2003;289:310616.
5 Frasure-Smith N, Lespérance F. Depressiona cardiac risk factor in search of a treatment. JAMA 2003;289:317173.
6 Davey Smith G, Phillips AN, Neaton JD. Smoking as an independent risk factor for suicide: illustration of an artefact from observational epidemiology? Lancet 1992;340:70912.[ISI][Medline]
7 Leistikow B. Commentary: Questionable premises, overadjustment, and a smoking/suicide association in younger adult men. Int J Epidemiol 2003;32:100506.