1 Address for correspondence: ESHRE Central Office, Meerstraat 60, B-1852 Grimbergen, Belgium. e-mail: bruno.vandeneede{at}eshre.com
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Abstract |
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Key words: ESHRE/Europe/ICSI/IVF/register data
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Introduction |
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Data have been collected from 22 European countries and cover IVF, ICSI, frozen embryo replacements (FER) and oocyte donations (OD) initiated during 2000. Data from each participating country were sent to ESHRE once a year. A draft report is made and then scrutinized by all consortium members, listed in the Appendix.
A Consortium meeting was held at the ESHRE meeting in Madrid in July 2003 with representatives from participating countries, where the present and future reporting systems were discussed. Here it was noted that Germany reported a marked increase in the coverage in their register. Belgium, Hungary and Switzerland were planning to advance their registration systems from voluntary, non-governmental registers to mandatory registers run by the authorities. Austria will be able to provide data for 2001.
The Consortium noted that the quality of data still differs between countries. Data collection systems, coverage, definitions and validation are different. At the Madrid meeting, it was decided that the EIM Consortium members should adapt to the definitions suggested by ICMART (The International Committee on the Monitoring of ART) and published by the World Health Organization (2002).
The Consortium again noted that the quality of data needs to be improved in the future. European countries still have different data collection systems with a variable degree of coverage, loss to follow-up and with different definitions. The Consortium decided to continue to present annual reports and to try to improve the quality of the reports.
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Materials and methods |
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Data collection
The present report summarizes data from IVF treatments performed from January 1, 2000 to December 31, 2000. Follow-up data on pregnancies and deliveries are cohort data.
Registers from a number of countries have been unable to provide some of the data. Lack of such specific variables will appear in the tables as not available (NA).
The reporting principle used for 2000 data is similar to preceding years (ESHRE, 2001a,b, 2002).
In most countries, reports of pregnancies are based on the presence of one or more intrauterine gestational sacs at sonography 5 weeks after embryo transfer. Deliveries were normally reported within the same reporting system as for treatments and pregnancies. For the present report, the definitions of pregnancies and births have not been standardized.
As the data presented here are incomplete and generated through different methods using different definitions in different countries, interpretation of the data must be done with some caution.
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Results |
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Pregnancies and deliveries after treatment
Table VIIX show the number of pregnancies and deliveries in relation to the number of initiated cycles, aspirations and transfers, for IVF (Table VI), ICSI (Table VII), FER (Table VIII) and OD (Table IX).
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Table VIII VII shows that after FER, 6663 pregnancies resulted from 40 155 transfers. Thus the mean clinical pregnancy rate per embryo transfer after FER was 16.6%. The delivery rates per embryo transfer after FER have not been summarized due to incomplete follow-up of pregnancies in many countries.
Table IX shows that after OD, 1951 clinical pregnancies resulted from 5925 transfers, giving a pregnancy rate per transfer of 32.9%, with a range from 14.0 to 46.8%.
Proportion of singleton, twin, triplet and quadruplet deliveries
Table X shows the deliveries after IVF and ICSI in relation to singleton, twin, triplet and quadruplet deliveries. It can be seen that the distribution of the deliveries was: singleton 25 336 (73.6%), twin 8396 (24.4%), triplet 674 (2.0%) and quadruplet 13 (0.04%).
Table XIXI shows the deliveries after FER in relation to singleton, twin, triplet and quadruplet deliveries. It can be seen that the distribution of the deliveries was: singleton 3632 (84.7%), twin 617 (14.4%), triplet 37 (0.9%) and quadruplet 2 (0.05%).
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Parameters of excellence
One parameter of excellence, defined as the number of deliveries per embryo transferred or the number of deliveries per embryo replaced, can be calculated. After IVF and ICSI, 20 countries replaced 398 952 embryos and this resulted in 35 928 deliveries. The number of embryos transferred for each delivery was thus 11.1. The number of deliveries per embryo replaced was 0.09. Considering these figures, it is important to realize that a number of pregnancies are lost to follow-up, so this remains an estimate.
Another parameter of excellence could be the number of singleton deliveries per transfer. After IVF and ICSI, 20 countries reported 25 336 singleton deliveries after 167 097 transfers. The singleton delivery rate per transfer was thus 15.2%. Considering this figure, it is important to realize that a number of pregnancies are lost to follow-up, so the true singleton delivery rate remains unknown.
Preimplantation genetic diagnosis (PGD)
PGD was recorded in seven countries: Belgium, Denmark, Greece, Hungary, Italy, Portugal and Russia. A total of 543 cycles, 533 aspirations and 362 transfers resulted in 106 pregnancies and 78 deliveries. This gives a clinical pregnancy rate of 19.5% per cycle, 19.9% per aspiration and 29.2 per transfer.
The main countries reporting PGD were Italy with 306 and Belgium with 198 cycles.
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Discussion |
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The number of countries that reported to the EIM consortium and contributed to the fourth report is unchanged from 1999 and constitutes 22 countries, covering the whole of Western Europe with the exception of Austria (who is likely to join next year) and Luxembourg (no IVF clinic).
Nine of the participating countries already have complete coverage in their reporting system: Denmark, Finland, France, Iceland, The Netherlands, Norway, Sweden, Switzerland and the UK. Germany has improved its coverage, now estimated to include close to 100% of the activities in the country.
The number of reported cycles continues to grow. In 2000, 569 clinics reported 279 267 cycles, which is an increase of 8% compared with 1999. From 1997 to 1998, the increase was 14% and from 1998 to 1999 it was 11%. Altogether this means an increase from 203 893 cycles in 1997 to 279 267 in 2000, equivalent to an increase of 37% over the 4 years. This marked increase during the period is partly due to a better coverage in the reporting systems but is also due to a true expansion of activities in some countries. The latest world report on IVF data (Adamson et al., 2002) from 1998 recorded 388 000 procedures world-wide, estimated to represent some 80% of all activities. In the USA, 88 077 cycles were recorded from 1999 (ASRM/SART Registry, 2002
). This means that
60% of recorded IVF activities globally come from Europe.
Within Europe, the largest contributions come from Germany with 63 000 cycles, followed by France with 57 000 cycles and the UK with 34 000 reported cycles. However, Italy, where the reporting is conducted in order to provide the EIM data on a voluntary basis, also reported close to 20 000 cycles in 2000. Spain, another of the large European countries, only has data from 36 of 180 clinics. Although it may primarily be the larger clinics that reported the 14 500 cycles from Spain, it is likely that only a minor proportion of the Spanish ART activity is being reported to the EIM consortium.
The proportion of standard IVF procedures to ICSI procedures remained the same in 2000 compared with the previous 2 years (56.0% standard IVF and 44% ICSI), but in some countries, such as Belgium, Greece, Hungary, Italy, Poland, Portugal, Slovenia, Spain and Switzerland, ICSI is more prevalent than IVF. The number of reported FER cycles as well as OD cycles showed a marked increase in 2000 compared with 1999.
The availability of services remained highest in Denmark, with 1830 cycles per million inhabitants. It was also high in the other Nordic countries and in The Netherlands and France. The average number of treatment cycles per million inhabitants in those countries with complete coverage in their reporting was 856. The proportion of IVF children to all children born was again highest in the Nordic countries, ranging from 2.1 to 3.8%.
The number of embryos transferred in IVF and ICSI cycles again differed substantially between countries. The mean number of single embryo transfers remained at 12%, whereas the proportion of dual embryo transfers increased from 39.2% in 1999 to 46.7% in 2000. The proportion of three embryo transfers decreased from 39.6% in 1999 to 33.3% in 2000. Four embryo transfers also decreased from 9.3% in 1999 to 6.8% in 2000. Denmark, Finland and Sweden report a low proportion of three embryo transfers.
For the first time, the data from 2000 included the number of eSETs. Data were only available from four countries reporting 2295 eSETs. National implementation of eSET has only occurred during recent years and, as discussed, the number of singleton deliveries was not changed in 2000, compared with earlier years.
It is noteworthy that the overall occurrence of multiple deliveries after IVF and ICSI (26.9%) in 2000 was similar to the figure 4 years earlier in 1997. There has been a change however, as the number of triplet deliveries has been reduced from 3.6% in 1997, to 2.3% in both 1998 and 1999 and to 2.0% in 2000. Regarding triplet rates, huge differences exist between countries.
This is the first report on the overall practice of fetal reduction in Europe. In total, 256 procedures were reported, but data are not available from a number of countries, so it is likely that far more procedures have been done.
Pregnancy rates for IVF, ICSI and FER continued to increase slightly. For IVF, the mean pregnancy rate per transfer is now 28.4% compared with 27.7% in 1999. For ICSI, it is 28.7% compared with 27.9% in 1999. For FER, it is 16.6% compared with 15.7% in 1999.
One other possibile way to report success rate would be to report on singleton delivery rates, separately. At the present stage where delivery rates are somewhat uncertain in many countries, we have only given the overall figure of 15.2% singleton deliveries per transfer after IVF and ICSI. Further emphasis will be put on this parameter in subsequent reports.
An alternative way of presenting success rate within a single parameter of excellence was the number of deliveries per embryo replaced (0.09) equivalent to the use of 11 embryos in order to achieve one delivery after IVF and ICSI.
Altogether, 543 cycles of PGD were reported, compared with 131 in 1999, suggesting an expansion of this activity in the coming years.
The benefit or success of ART for couples and for society needs to be monitored and described in terms of efficacy, safety, quality, availability and cost. The present report includes data on efficacy and availability and also on one very important aspect of safety, i.e. multiple pregnancies. The EIM and ESHRE are now planning to expand its ART monitoring activities to include also specific data on safety, quality and cost.
To summarize, the present fourth annual ESHRE report on ART in Europe in 2000 shows a continuing expansion of the register regarding participating clinics and number of cycles reported. Trends are now becoming visible and there is a trend towards better efficacy. Triplet deliveries were less frequent than in earlier years, but the combined multiple pregnancy rate (26.4%) was similar to the figure in 1997. Elective single embryo transfer had minimal overall impact in 2000.
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Appendix I. Contact persons representing data collection programmes in participating European countries, 2000 |
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Czech Republic: Pavel Ventruba, 1st Dept. of Obstetrics and Gynaecology, Masarik University of Brno, Obilni trh 11, 656 77 Brno, Czech Republic. E-mail: ventruba{at}fp-brno.cz
Denmark: Karin Erb, The Fertility Clinic, Odense University Hospital, DK-5000 Odense, Denmark. E-mail: karin.erb{at}ouh.fyns-amt.dk
Finland: Mika Gissler, Stakes, Stakes information, PO Box 220, 00531 Helsinki, Finland. E-mail: mika.gissler{at}stakes.fi
France: Jacques De Mouzon, INSERM U. 292, Hôpital de Bicêtre, 78 rue du Général Leclerc, F-75252, Kremlin Bicêtre, France. E-mail: demouzon{at}vjf.inserm.fr
Germany: Ricardo Felberbaum, Med. Univ. Ratzenburger Allee 160, D-23538 Lübeck, Germany. E-mail: rfelberbau{at}aol.com
Greece: Basil C.Tarlatzis, Infertility & IVF Centre, Geniki Kliniki, 2 Gravias Street, GR-54645 Thessaloniki, Greece. E-mail: tarlatzis{at}hol.gr
Hungary: Janos Urbancsek, 1st Department of Obstetrics and Gynaecology, SOTE, Baross utca 27, H-1088 Budapest, Hungary. E-mail: Urbjan{at}Noi1.sote.hu
Iceland: Hilmar Bjorgvinsson. IVF Unit, Department of Obstetrics and Gynecology, National University Hospital, Landspitalinn, Reykjavik 101, Iceland. E-mail: Hilmar{at}rsp.is
Ireland: Robert F.Harrison. HARI Unite, Rotunda Hospital, Dublin 1, Ireland. E-mail: rfharrison{at}rcsi.ie
Italy: Anna Pia Ferraretti, S.I.S.ME.R. s.r.l., Via Mazzini 12, I-40137 Bologna, Italy. E-mail: sismer{at}sismer.it
The Netherlands: Jan A.M.Kremer, Department of Obstetrics and Gynaecology, AZ Nijmegen (St. Radboud), Geert Grooteplein 10, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands. E-mail: j.kremer{at}obgyn.umcn.nl
Norway: Johan T.Hazehamp, Department of Reproductive Medicine, Volvat Medical Center, Postboks 5280, Majorstuea, Oslo 303, Norway. E-mail: Hazekamp{at}online.no
Poland: Waldermar Kuczynski, Department of Gynecology, University Hospital,MC Sklodowskiej 24 a, 15-276 Bialystok, Poland. E-mail: kuczynsk{at}cksr.ac.bialystok.pl
Portugal: Carlos Calhaz-Jorge, Human Reproduction Unit, Department of Obstetrics and Gynecology, Hopital de Santa Maria, Av. Prof. Equs Monitz, 1649-028 Lisboa, Portugal. E-mail: Calhazjorge{at}mail.telepac.pt
Russia: V.S.Korsak, IVF Centre, Ott Institute, Mendeleyevskay linia 3, 199034 St-Petersburg, Russia CIS. E-mail: ivf{at}mcrm.ru
Slovenia: Irma-Virant Klun, University Medical Centre Ljubljana, Department of Obstetrics and Gynecology, Ljubljana, Slovenia. E-mail: Irma.virant{at}kclj.sl
Spain: Juana Hernandez, Department of Obstetrics and Gynaecology, Hospital San Milan, Avda Autonoma de la Rioja 3, 26004 Logrono-La Rioja, Spain. E-mail: jhernandezh2meditex.es
Sweden: P.O.Karlström, Department of Obstetrics and Gynaecology, 72189 Vesteraas, Sweden. E-mail: pok.red{at}swipnet.se
Switzerland: Constanzo Limoni, Via Ceresio 6, 6826 Riva San Vitale, Switzerland. E-mail: alpha5{at}bluewin.ch
UK: A.McNab, Human Fertilization and Embryology Authority, Paxton House, 30 Artillery Lane, London E1 7LS, UK. E-mail: angela.mcnab{at}hfea.gov.uk
Ukraine: Victor Veselovsky, Clinic Isida IVF, 28/1 Chornovilla Str. Kyiv, 01135, Ukraine. E-mail: vvv{at}isidaivf.com.ua
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List of participating countries and centres |
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Brugge: Algemeen Ziekenhuis Sint-Jan
Brussel: Institut médical Edith Cavell; Akademisch Ziekenhuis VUB; Hôpital Universitaire St-Pierre ULB; Höpital Erasme
Charleroi: Clinique Notre-Dame
Genk: St-Jansziekenhuis
Gent: Universitair Ziekenhuis Gent; Algemeen Ziekenhuis Jan Palfijn; Algemeen Ziekenhuis St-Lucas
Kortrijk: St-Niklaaskliniek
Liège: Clinique St-Vincent; Hôpital de la Citadelle
Leuven: Universitair Ziekenhuis Gasthuisberg; Leuven Institute for Fertility and Embryology
Mont sur Sambre: Centre de PMA Sainte Thérèse
Namur: Centre Hospitalier Régional de Namur
Roeselare: Heilig Hartziekenhuis
Vilvoorde: Van Helmontziekenhuis
Czech Republic
List not available
Denmark
Aalborg: Fertilitetsklinikken Aalborg
Aarhus: Ciconia Vest; Fertilitetsklinikken Skejby Sygehus; Maigaards Fertilitetsklinik
Brædstup: Fertilitetsklinikken Brædstrup Sygehus
Copenhagen: Ciconia Øst; Dansk Fertilitetsklinik; Fertilitetsklinikken Helsehuset; Fertilitetsklinikken Herlev Sygehus; Fertilitetsklinikken Rigshospitalet; Fertilitetsklinikken Trianglen; Fertilitetsklinikken, Institut for Human Reproduktion; Gentofte Fertilitetsklinik
Horsens: Horsens Fertilitetsklinik
Odense: Fertilitetsklinikken Odense Universitetshospital; Odense IVF-Klinik
Skive: Fertilitetsklinikken Skive Sygehus
Finland
Helsinki: Diacor Health Services; Eira Hospital; Felicitas Clinic; Helsinki University Central Hospital; The Family Federation of Finland Helsinki Clinic
Joensuu: Northern Karelia Central Hospital
Jyväskylä: In-Tiimi Clinic Jyväskylä
Kuopio: In-Tiimi Clinic Kuopio; Kuopio University Central Hospital
Lappeenranta: Fermedi Clinic
Oulu: Oulu University Central Hospital; The Family Federation of Finland Oulu Clinic
Tampere: AVA Clinic Tampere; Tampere University Central Hospital
Turku: AVA Clinic Turku; Turku University Central Hospital; The Family Federation of Finland Turku Clinic
France
Amiens: CHU; Centre Picard
Angers: CHR
Avignon: Urbain V
Bayonne: Lafargue
Besançon: CHU; les Cigognes
Bois Guillaume: St Antoine
Bordeaux: Pellegrin Fédération; Pellegrin Gynéco-Obstétrique A; Saint Sernin/Jean Villard
Brest: CHU; Pasteur
Caen: CHRU
Charleville-Mézières: CH
Clermont-Ferrand: CH
Dijon: CHU; Chenove
Epinal: Arc en ciel
Equeurdreville: Cotentin
Grenoble: Belledonne; CHU
Guadeloupe: Les Abymes-Les Rosiers
Guilherand-Granges: Pasteur
Guyane: Cayenne CHG
La Réunion: Le Port-Jeanne dArc
La Rochelle: Le Mail
Le Havre: CH
Le Mans: Tertre Rouge
Lens: CH
Lille: Polyclinique du Bois; Jeanne de Flandres
Limoges: CHU
Lorient: CH
Lyon: Bron Ste Marie-Thérèse; Croix Rousse; Edouard Herriot; Montplaisir; Sainte Anne Lumière
Marseille: CHU Conception; Renaissance; Saint Joseph; Wulfran-Puget
Martinique: Fort de France-Sainte Marie
Metz: Ste Croix
Montpellier: CHU; Saint Roch
Mulhouse: Diaconat
Nancy: A.Pinard; Majorelle
Nantes; Atlantique; CHU; Notre Dame de Grâce
Nice: Saint Georges; CHU
Nîmes: CHRU; Grand Sud
Paris (area): Aubervilliers La Roseraie; Bagnolet La Dhuys; Blanc Mesnil Clinique; Bondy Jean Verdier; Clamart Béclère; Cormeille-en-Parisis Clinique; Courbevoie-La Défense CH; Dreux CH; Le Chesnay Parly 2 Clinique; Maisons-Laffite Sully; Neuilly Cherest; Neuilly Hôpital Américain; Paris Bichat; Paris Les Bluets; Paris Cochin; Paris Diaconesses; Paris La Muette; Paris Montsouris; Paris Pitié Salpétrière; Paris Spontini; Paris St Vincent de Paul; Paris Tenon; Poissy CHI; Sèvres J. Rostand; Vitry sur Seine Les Noriets
Pau: Lagrange
Périgueux: Francheville
Perpignan: Saint-Pierre
Poitiers: CHU
Reims: CHU; Courlancy
Rennes: CHU Sud/Hôtel Dieu; la Sagesse
Roanne: CH
Rouen: CHU
Saint-Jean: LUnion et le Vaurais
Saint-Saulve: le Parc
Schiltigheim: CMCO
St Etienne: Michelet
Toulon: Saint Michel
Toulouse: CHU; St Jean Languedoc
Tours: CHU; Parc
Germany
Aachen: Frauenarztpraxis mit Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin an der Itertalklinik; Universitäts-Frauenklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin Medizinische Fakultät der RWTH Aachen
Aalen: Dr med. Rainer Rau
Augsburg: Gemeinschaftspraxis Drs Warnecke, Hiller, Bauer, Kraus
Bad Münder: Zentrum für IVF und Reproduktionsmedizin Deutsche Klinik Bad Münder
Bayreuth: IVF-Zentrum Bayreuth im Klinikum Bayreuth
Bedburg: Praxis Dr Dieter Struller
Berlin: Fertility Center Berlin; Gemeinschaftspraxis Dr med. Matthias Bloechle/Dr med. Silke Marr; Gemeinschaftspraxis Drs med. A.Haase/P.Rott; Gemein schaftspraxis im Lützow Center Reproduktions medizinisches Zentrum; Praxis Dr med. Reinhard Hannen; Praxisklinik für Fertilität; Universitätsklinikum der Humboldt-Universität zu Berlin Charité Campus Mitte; Universitätsklinikum der Humboldt-Universität zu Berlin Charité Campus Virchow-Klinikum
Bielefeld: BIF Bielefelder Institut für Fortpflanzungsmedizin der Städtischen Kliniken Bielefeld-Rosenhöhe
Bonn: Universitätsklinikum Bonn
Bremen: Bremer Zentrum für Fortpflanzungsmedizin (BZF) in der Frauenklinik des Ev. Diakonie-Krankenhauses gGmbH; Zentrum für Kinderwunschbehandlung Bremen
Darmstadt: Reproduktionsmedizinisches und Endometriose Zentrum Darmstadt
Deggendorf: Gemeinschaftspraxis Drs Kroiss und Bernhardt
Dortmund: Gemeinschaftspraxis Drs med. S.Dieterle/A.Neuer
Dresden: Praxis Dr med. H.J.Held; Universitätsklinikum Carl Gustav Carus
Düsseldorf: Gemeinschaftspraxis Dr (B) Hugo Verhoeven/Dr med. Michael Scholtes/Dipl. med. Kersten Marx/Dr med. Martina Behler; Städt. Kliniken Düsseldorf gGmbH Frauenklinik Benrath; Universitätsfrauenklinik der Heinrich-Heine-Universität-Düsseldorf
Erlangen: Dr J.van Uem; Gemeinschaftspraxis der Frauenärzte Prof. Dr Dr K.-G.Bregulla/Dr M.Hamori/Dr R.Behrens; Universitätsfrauenklinik Erlangen
Essen: Gemeinschaftspraxis Dr med. Thomas Katzorke/Dr med. Dirk Propping/Dr med. Susanne Wohlers
Esslingen: IVF-Zentrum Esslingen
Frankfurt am Main: Krankenhaus Nordwest
Freiburg: Frauenklinik der Albert-Ludwigs-Universität; Gemeinschaftspraxis Dr Weitzell/Dr M.Thiemann/Prof. Dr F.Geisthövel
Gelsenkirchen: Schwerpunkt Kinderwunschtherapie Wissen schaftspark Gelsenkirchen
Gießen: Arbeitsgruppe Endokrinologie, Fortpflanzungsmedi zin und Mikrochirurgie der Justus-Liebig-Universität; Gesellschaft zur Förderung der In-Vitro-Fertilisation und Reproduktionsmedizin GbR
Göttingen: Dr Monica Tobler; Gemeinschaftspraxis Dr Peter Böhm, Dr Sabine Hübner Dr Rüdiger Moltrecht, Dr Christine Noeldechen; Klinik für Gynäkologie und Geburtshilfe Georg-August-Universität
Greifswald: Ernst-Moritz-Arndt-Universität
Grevenbroich: Gemeinschaftspraxis Dr Tigges/Dr Kaiser/Dr Tuchel
Haan: Gynäkologisch-Geburtshilfliche Abteilung Gynä kologische Endokrino-logie/Reproduktionsmedizin St Josef Krankenhaus GmbH
Halle: Martin-Luther-Universität Halle-Wittenberg
Hamburg: Fertility Center Hamburg; Gemeinschaftspraxis Bispink/Horn/Michel and Seeler; Kocak und Kollegen; Praxis BKS; Praxisgemeinschaft Hinrichsen u. Partner GbR am Endokrinologikum Hamburg; Universitätsklinikum Hamburg-Eppendorf
Hannover: Gynäkologische Gemeinschaftspraxis Dr M.Müseler-Albers/H.P.Arendt/Dr.K.Bühler; Frauenklinik der MHH am Oststadtkrankenhaus
Heidelberg: Universitätsklinikum Heidelberg Abt. Gynäkologische Endokrinologie und Fertilisationsstörungen Kinderwunsch-Sprechstunde; Kinderwunschzentrum Heidel berg
Hildesheim: Zentrum für Reproduktionsmedizin und Human genetik Hildesheim
Homburg: Universitätskliniken des Saarlandes
Jena: Gemeinschaftspraxis Fritzsche/Reiher/Hoffmann; Klinikum der FSU Jena
Karlsruhe: Karlsruher IVF-Programm
Kiel: Universitäts-Frauenklinik der Christian-Albrechts-Universität
Köln: PAN Klinik am Neumarkt; Krankenhaus Porz am Rhein; Universitäts-Frauenklinik Köln
Leipzig: Praxisklinik; Universitätsfrauenklinik
Lübeck: Universitätsklinikum Lübeck
Magdeburg: Otto-von-Guericke-Universität Magdeburg
Mannheim: Universitätsfrauenklinik Klinikum Mannheim gGmbH
Marburg: Klinik für Gynäkologie, Gynäkologische Endo krinologie und Onkologie Der Philipps-Universität Marburg
Minden: Gemeinschaftspraxis Dr med. Onno Buurman/Otto P.Happel
Mönchengladbach: Gemeinschaftspraxis Dr med. Georg Döhmen/Dr med. Thomas Schalk
Mühlheim: Ev. Krankenhaus Mühlheim an der Ruhr Frauenklinik und Zentrum für Reproduktionsmedizin
München: Hormonzentrum München; Kinderwunsch Centrum München an der Frauenklinik Dr Wilhelm Krüsmann; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe Klinikum der Universität München-Grosshadern; Prof. Dr med. Dieter Berg/Dr med. Bernd Lesoine; Zentrum für Repro duktionsmedizin Dr med. Walter Bollmann/Dr med. Thomas Brückner/Dr med. Ulrich Noss
Münster: Gemeinschaftspraxis Dr Dr med. Lutz Belkien/PD Dr med. Bernd Krause; Universitätsklinikum Münster Klinik und Poliklinik für Frauenheilkunde und GeburtshilfeInstitut für Reproduktionsmedizin
Neubrandenburg: Dietrich Bonhoeffer Klinikum Neubranden burg
Neuwied: Gemeinschaftspraxis Dr Beran and Dr Müller
Nürnberg: Dr med. J.Neuwinger and Dr med. B.Munzer-Neuwinger Reproduktionsmedizinische Praxis
Oldenburg: Dr med. Saif Jibril; Tagesklinik Oldenburg
Osnabrück: Kinderwunschzentrum Osnabrück
Pforzheim: Zentrum für Reproduktionsmedizin in der Centralklinik
Prien am Chiemsee: Priener Zentrum für Reproduktions-medizin
Regensburg: Zentrum für Gynäkologische Endokrinologie und Reproduktionsmedizin
Remscheid: Gynäkologische Endokrinologie und Repro duktionsmedizin am Klinikum Remscheid
Rostock: Universitäts-Frauenklinik Rostock Reproduktions medizin
Saarbrücken: Dr med. Jens Happel/Dr med. Michael Thaele/Dr med. Lars Happel
Schwäbisch Gmünd: Klinikum Schwäbisch Gmünd Margariten Hospital
Schwerin: Medizinisches Zentrum der Landeshauptstadt Schwerin Klinikum Schwerin
Stralsund: Klinikum am Sund Frauenklinik IVF-Zentrum Stralsund
Stuttgart: Praxis Dr D.B.Mayer-Eichberger IVF-Zentrum
Tübingen: Universitätsklinikum Tübingen Frauenklinik Schwerpunkt Gynäkologische Endokrinologie und Repro duktionsmedizin
Ulm: IVF-Zentrum Ulm; Universitätsklinikum Ulm
Wiesbaden: Zentrum für Reproduktionsmedizin
Würzburg: Dr med. R.Mai/Dr med. Wolfgang Schmitt, medizinische Genetik; Universitäts-Frauenklinik Würzburg
Greece
Athens: Institute of Gynaecology and Assisted Reproduction; Iatriki Erevna; Euromedica IVF; Fertility Institute; Embryogenesis
Ioannina: IVF Center of Ioannina,
Thessaloniki: Infertility and IVF Center, Geniki Kliniki; Intrabalkan Medical Center
Hungary
Budapest: 1st Department of OB/GYN, Semmelweis University of Medicine; Department of OB/GYN, Jahn Ferenc Hospital; Department of OB/GYN, Nyiro Gyula Hospital; Department of OB/GYN, St. Johns Hospital
Debrecen: Department of OB/GYN, Medical University of Debrecen
Pécs: Department of OB/GYN, Medical University of Pécs
Tapolca: Pannon Institut for Reproduction
Iceland
Reykjavik: IVF Unit, Department of OB/GYN, National University Hospital, Landspitali.
Ireland
Dublin: Human Assisted Reproduction Ireland, Rotunda Hospital
Galway: Galway Fertility Clinic
Kildare: Clane Fertility Clinic
Italy
Abano Terme (PD): Casa di Cura Abano Terme-Centro Ripr. Assistita
Ancona: Ospedale Salesi
Bari: Clinica S. Maria; Studio Medico San Luca; Studio Associato CECOS; University of Bari
Bergamo: Ospedali Riuniti
Bologna: S.I.S.ME.R.; Tecnobios
Bolzano: Ospedale di Bolzano
Bressanone (BZ): Ospedale di Bressanone
Brunico (BZ): Ospedale di Brunico
Cagliari: Ospedale Regionale Microcitemie
Campobasso: Villa Maria
Caserta: Centro Genesis
Catania: C.R.A.
Cittadella (PD): Ospedale di Cittadella
Fermo (AP): Istituto Palmatea
Firenze: Centro P.M.A. Futura Diagnostica
Fossano (CN): Ospedale di Fossano
Genova: Biotech; Università di Genova
Gragnano (NA): A.O.G.O.I.
Lecce: Centro Studi Riproduzione Umana
Manduria (TA): Ospedale M.Giannuzzi
Mantova: Centro Medicina della Riproduzione Ospedale C.Poma
Mercogliano (AV): Diagnostica Medica
Messina: Centro di Riproduzione Umana
Mestre (VE): ARC-STER
Milano: Fondazione S. Raffaele del Monte Tabor; Polo Universitario S. Paolo; Centro Cerva
Modena: Università di Modena e Reggio Emilia
Monza (MI): Centro Medicina della Riproduzione Biogenesi
Motta di Livenza (TV): Ospedale di Motta di Livenza
Napoli: Centro Mediterraneo di Fecondazione Assistita; Villa del Sole
Nardò (LE): Tecnomed-Centro Medico Biologico
Padova: Studio Gemma; Euganea Medica
Palermo: Centro Andros; Centro Biologia della Ripro duzione; Centro Genesis
Parma: C.I.R. Università di Parma
Pesaro: Centro Salus
Pescara: Villa Serena
Pieve di Cadore (BL): Ospedale Civile
Pisa: Casa di Cura S. Rossore; Università di Pisa; CE.S.CO.
Pordenone: Ospedale S. M. degli Angeli
Reggio Emilia: Studio Diagnostico Raul Palmer
Rimini: Ospedale Infermi
Roma: European Hospital; Centro Genesis; Centro R.A.P.R.U.I.; Villa Margherita; Universitá La Sapienza; C.I.P.A.; C.I.D.
Rozzano (MI): Istituto Clinico Humanitas
Salerno: C.M.R.; Human Fertilization Center
Sassari: Università di Sassari
Sora (FR): Centro S.T.S.
Torino: Laparoscopy and Fertility Center; Centro LIVET; Ospedale S. Anna; Centro Diagnosi e Cura dellInfertilità di Coppia; Fertilab
Trecenta (RO): Ospedale S. Luca
Trieste: Ospedale Burlo Garofalo
Varese: Centro Diagnostico Varesino
Verona: Policlinico Borgoroma
The Netherlands
Amsterdam: Academisch Medisch Centrum, Vrije Universiteit Medisch Centrum
Eindhoven: Catharina Ziekenhuis
Groningen: Academisch Ziekenhuis Groningen
Leiden: Leids Universitair Medisch Centrum, Stichting Medisch Centrum voor Geboorteregeling
Maastrict: Academisch Ziekenhuis Maastricht
Nijmegen: Universitair Medisch Centrum St Radboud
Rotterdam: Academisch Ziekenhuis Rotterdam
Tilburg: St. Elisabeth Ziekenhuis
Utrecht: Universitair Medisch Centrum
Voorburg: Reiner de Graaf Groep
Zwolle: Isala Klinieken
Norway
Bergen: Kvinneklinikken Helse-Bergen
Haugesund: Haugesund sjukehus Helse Fonna
Oslo: Fertilitetssenteret Omnia på Røde Kors Klinikk; Rikshospitalet; Ullevål Universitetssykehus; Volvat Medisinske Senter
Trondheim: St Olavs Hospital HF
Tromsø; Universitetssykehuset i Nord-Norge HF
Poland
Bialystok: Department of Gynecology, Medical Academy of Bialystok Bialystok: Center for Reproductive Medicine Kriobank
Bytom: I Katedra i Klinika Poloznictwa i Ginekologii
Lodz: Gameta Fertility Center
Lublin: AB OVO, NZOZ Centrum Zdrowia Rodziny
Myslowice: Novomedica, Klinika Leczenia Nieplodnosci
Poznan: Division of Infertility and Reproductive Endocrinology
Poznan: Health Centre Intermedica, IVF Clinic
Szczecin: Clinic for Reproduction and Gynecology, Pomeranian Medical University
Warsaw: I Clinic of Obstetrics and Gynecology, University Medical School of Warsaw
Warsaw: Private Policlinic Novum
Warsaw: Private Gynaecological Clinic of Reproduction Germen
Portugal
Guimarães: Hospital N. S. da Oliveira
Lisboa: Ava Clinic; Centro de Medicina da Reprodução-Instituto de Urologia; CLIFER; Hospital de Santa Maria; Maternidade Dr Alfredo da Costa
Oporto: Centro de Genética Prof. Alberto Barros; CETI; Hospital de S. João; Maternidade Júlio Dinis
Vila Nova de Gaia: Centro Hospitalar
Russia
Cheboksary: Republican Center for Family Planning and Reproduction, Ministry of Health Chuvashia Republic
Krasnoyarsk: Center for Reproductive Medicine
Moscow: Center Lera; Center for Family Planning and Reproduction, IVF Department; Center for Infertility Treatment IVF; IVF Department of Sechenov Medical Academia; Medical Center for ART; Medical Center for Infertility Treatment Embryon; Scientific Center for Obstetrics, Gynecology and Perinatology of Russian Academy of Medical Science
Rostov-Don: Center of Human Reproducton and IVF
Samara: Medical Company IDK
Saratov: Region Center for Family Planning and Reproduction
St Petersburg: Baltic Institute of Human Reproductology; Center for Family Planning, Pushkinsky District; International Center for Reproductive Medicine, Ob/Gyn Ott Institute; Russian Finnish Medical Center AVA-Peter
Tumen: Center for Reproductive Medicine Mercury; Medical Center Malish, Medical Director N.M.Kovalev
Vladivostok: Medical Center for IVF Santa Maria
Voroneg: Region Center for Family Planning and Reproduction, IVF Department
Slovenia
Ljubljana: Department of Obstetrics and Gynaecology, Medical Centre Ljubljana
Maribor: Department of Reproductive Medicine and Gynecologic Endocrinology, Hospital Maribor
Postojna: Centre for Infertility Treatment, Hospital Postojna
Spain
List not available
Sweden
Falun: Falu lasarett
Göteborg: Fertilitetscentrum; Sahlgrenska sjukhuset
Huddinge: Huddinge sjukhus
Linköping: Universitetssjukhuset
Malmö: Curakliniken; Ideonkliniken
Örebro: Regionsjukhuset
Stockholm: Karolinska sjukhuset; Lucinakliniken; S:t Görans sjukhus; Sophiahemmet
Umeå: Norrlands universitetssjukhus
Uppsala: Akademiska sjukhuset, Carl von Linné kliniken
Switzerland
Baden: Reproduktionsmedizinisches Zentrum Kantonsspital
Basel: IVF-ICSI Zenter Institut Dr Viollier, Dr N.Pavic, Dr J.-C.Spira; Universitäts-
Frauenklinik, Abt. für gynäkologische Endokrinologie und Reproduktionsmedizin
Bellinzona: ProCrea, Centro Fertilità della Svizzera Italiana
Bern: Lindenhofspital, IVF-Labor; Universitätsfrauenklinik, Abt. für Gynäkologie, IVF und Reproduktionsmedizin, Inselspital
Frauenfeld-Kreuzlingen: IVF Zenter ILAMED
Genève: Centre Privé de Procréation Médicalement assistée de la Clinique de Champel Elysée; Hôpital Universitaire, Clinique et Policlinique de Stérilité et dEndocrinologie Gynécologique
Lausanne: CHUV, Unité de Médecine de la Reproduction et dEndocrinologie Gynécologique; Centre Vanderlick-Montchoisi
Locarno: Centro Cantonale di Infertilità, Servizio di Endocrinologia Ginecologica
Luzern: Kantonalspital, Sterilitätssprechstunde Frauenklinik, IVF-ICSI Labor
Schaffhausen-Zürich: Zentrum für Reproduktionsmedizin, Dr P.Fehr, Dr Singer
Winterthur: Dr R.Köppel
Zollikerberg: IVF Zürich
Zürich: Universitätsspital, Klinik für Endocrinologie
UK
Aberdeen: University of Aberdeen
Aldridge: Midland Fertility Services
Basingstoke: The Hampshire Clinic
Bath: Bath Assisted Conception Clinic
Belfast: Regional Fertility Centre, Belfast
Birmingham: Birmingham Womens Hospital; BMI Priory Hospital
Bristol: Centre for Reproductive Medicine, University of Bristol; Southmead Hospital
Burton Upon Trent: Burton Hospitals NHS Trust
Cambridge: Bourn Hall Clinic
Cardiff: University Hospital of Wales
Chingford: Essex Fertility Centre
Colchester: Isis Fertility Centre
Coventry: Centre for Reproductive Medicine, Coventry
Darlington: Cromwell IVF and Fertility Centre, Darlington
Dorchester: The Winterbourne Hospital
Dundee: Ninewells Hospital
Eastbourne: Esperance Private Hospital
Edinburgh: Edinburgh Assisted Conception Unit
Exeter: Peninsular Centre for Reproductive Medicine
Gateshead: Centre for Assisted Reproduction, Gateshead
Glasgow: BMI Ross Hall Hospital; Glasgow Nuffield Hospital; Glasgow Royal Infirmary
Great Missenden: The Chiltern Hospital Fertility Services Unit
Hartlepool: Hartlepool General Hospital
Hull: Hull IVF Unit
Ilford: The Bupa Roding Hospital
Kent: BMI The Chaucer Hospital
Leeds: Assisted Conception Unit, St James University Hospital-Leeds; Clarendon Wing-Leeds
Leicester: BUPA Hospital Leicester; Leicester Royal Infirmary
Liverpool: Liverpool Womens Hospital; University Hospital Aintree
London: Assisted Conception Unit, Kings College Hospital; Assisted Reproduction and Gynaecology Centre; Barts and the London Fertility Centre; Chelsea & Westminster Hospital; Cromwell IVF and Fertility Centre, London; Diana, Princess of Wales Centre for Reproductive Medicine; Guys Hospital; Homerton University Hospital NHS Trust; London Female and Male Fertility Centre; London Fertility Centre; London Womens Clinic/Hallam Medical Centre; Newham General; The Bridge Centre; The Hammersmith Hospital; The Harley Street Fertility Centre; The Lister Fertility Clinic; The Portland Hospital Fertility Unit; UCH London
Manchester: CARE at the Alexandra Victoria Park; Manchester Fertility Services Ltd; St Marys Hospital
Middlesborough: The James Cook University Hospital
Newcastle: Newcastle Fertility Centre at Life
Newcastle-under-Lyme: Lifestyle
Northampton: CARE at the Three Shires Hospital
Nottingham: CARE at the Park Hospital; NURTURE
Orpington: BMI Chelsfield Park ACU
Oxford: Oxford Fertility Unit
Plymouth: South West Centre for Reproductive Medicine
Salford: Salford Royal IVF and Fertility Centre
Sheffield: CARE at The Sheffield Fertility Centre
Slough: Willow Suite, Thames Valley Nuffield Hospital
Southampton: BUPA Hospital Southampton
Swansea: Cromwell IVF and Fertility Centre, Swansea
Wirral: Wirral Fertility Centre
Woking: The Woking Nuffield Hospital
Wolverhampton: Wolverhampton Assisted Conception Unit
Ukraine
Donetsk: Donetsk Regional Centre for Maternity and Child Care; Isida-Don IVF
Kharkyv: Center for Reproductive Medicine Implant
Kyiv: Institut Genetics Reproduction; Institute Reproduction Medicine; Isida IVF
Odessa: Center for Reproductive Medicine REMEDI
Simferopyl: Regional Center for Family Planning and Human Reproduction
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References |
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ASRM/SART Registry (2002) Assisted reproductive technology in the United States: 1999 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril 78,918927.[CrossRef][ISI][Medline]
ESHRE (2001a) The European IVF-monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1997. Results generated from European registers by ESHRE. Hum Reprod 16,384391.
ESHRE (2001b) The European IVF-monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1998. Results generated from European registers by ESHRE. Hum Reprod 16,24592471.
ESHRE (2002) The European IVF-monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1999. Results generated from European registers by ESHRE. Hum Reprod 17,32603274.
World Health Organization (2002) Current Practise and Controversies in Assisted Reproduction 2002. Vayena E, Rowe PJ and Griffin PD (eds). World Health Organization, Geneva, pp. 1922.
Submitted on November 14, 2003;