Factor V Leiden and recurrent miscarriage

Raj Rai

Department of Reproductive Science and Medicine, Imperial College School of Medicine at St Mary's Mint Wing, South Wharf Road, London W2 1PG, UK E-mail: r.rai{at}ic.ac.uk


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Dear Sir,

All women attending the St Mary's Hospital Recurrent Miscarriage Clinic are investigated according to our published protocol (Clifford et al., 1994Go) which is also described in the Methods section of our manuscript. No cause to account for their pregnancy losses was identified and the only difference between the two groups of women was in Factor V Leiden status.

We agree with Bohlmann et al. that the role of other thrombophilic defects and adverse pregnancy outcome at all gestational ages deserves further investigation. This is a field that we ourselves are actively pursuing and in particular we are examining the role of the fetal genotype in determining pregnancy outcome.

There is a typographical error in the Abstract. The number of women with recurrent early miscarriage is 16 and not 19 as stated in the Abstract. This error is not repeated elsewhere in our manuscript and all analyses were performed correctly.


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Clifford, K., Rai, R., Watson, H. and Regan, L. (1994) An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases. Hum. Reprod., 9, 1328–1332.[Abstract]





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