Endocrinology Research and Development, Ipsen International, 24, rue Erlanger, 75781 Paris Cedex 16, France. E-mail: ernest.loumaye{at}ipsen.com
Dear Sir,
We read Dr Hos letter with interest. Although it is difficult to draw any conclusion from one case report, we acknowledge his comments.
We investigated anovulatory patients treated with relatively low dose of FSH, and with LH alone in several groups. We did not investigate ovulatory patients undergoing controlled ovarian stimulation with a relatively high dose of FSH for assisted reproduction techniques. Defining the dose of LH, the LH/FSH ratio and the optimal timing for LH administration which would produce a ceiling effect in the population considered by Dr Ho is certainly worth further investigation