Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE

Report prepared by A Nyboe Andersen, L.Gianaroli, R. Felberbaum, J. de Mouzon and K.G.Nygren

The European IVF-monitoring programme (EIM) , for the European Society of Human Reproduction and Embryology (ESHRE)1,2


    Abstract
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Comments
 Appendix I. Contact persons...
 List of participating...
 References
 
European results of assisted reproductive techniques from treatments initiated during 2001 are presented in this fifth report. Data were collected mainly from already existing national registers. From 23 countries, 579 clinics reported 289 690 cycles with: IVF 120 946, ICSI 114 378, frozen embryo transfer (FER) 47 195 and egg donation (ED) 7171. Overall this represents a 4% increase since the year 2000. For the first time, results on European data on intra-uterine inseminations (IUIs) were reported from 15 countries. A total of 67 124 cycles [IUI husband'sperm (IUI-H) 52 949 and IUI donor sperm (IUI-D) 14 185] were included. In 12 countries where all clinics reported to the register, a total of 108 910 cycles were performed in a population of 131.4 million, corresponding to 829 cycles per million inhabitants. For IVF, the clinical pregnancy rate per aspiration and per transfer was 25.1 and 29.0%, respectively. For ICSI, the corresponding rates were 26.2 and 28.3%. These figures are similar to the results from 2000. After IUI-H, the clinical pregnancy rate was 12.8% in women <40 and 9.7% in women ≥40 years of age. After IVF and ICSI, the distribution of transfer of one, two, three and ≥4 embryos was 12.0, 51.7, 30.8 and 5.5%, respectively. Compared with the year 2000, fewer embryos were transferred, but huge differences existed between countries. The distribution of singleton, twin and triplet deliveries for IVF and ICSI combined was 74.5, 24.0 and 1.5%, respectively. This gives a total multiple delivery rate of 25.5%, compared with 26.9% in the year 2000. The range of triplet deliveries after IVF and ICSI differed from 0.0 to 8.2% between countries. After IUI-H in women <40 years of age, 10.2% were twin and 1.1% were triplet gestations.

Key words: Europe/ICSI/IUI/IVF/register data


    Introduction
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Comments
 Appendix I. Contact persons...
 List of participating...
 References
 
This report is the fifth annual ESHRE publication on European data on assisted reproduction technology (ART). The four previous reports, also published in Human Reproduction (ESHRE, 2001aGo,bGo, 2002Go, 2004Go), covered treatment cycles during 1997, 1998, 1999 and 2000.

Data have been collected from 23 European countries and cover IVF, ICSI, frozen embryo replacements (FERs), egg donations (EDs) and preimplantation genetic diagnosis (PGD) initiated during 2001. Additionally, for 2001, data on intra-uterine inseminations with husband semen (IUI-H) or donor semen (IUI-D) were also included from 15 countries. The number of clinics reporting IUI data may differ from the number of clinics presenting data on the in vitro techniques.

Data from each participating country are sent to ESHRE once a year. A draft report is made and then scrutinized by all consortium members, listed at the end of this paper.

A fourth Consortium meeting was held at the ESHRE meeting in Berlin in July 2004 with representatives from participating countries, where the present and future reporting systems were discussed. Here it was noted that Germany reported a marked increase in the coverage in their register. Austria and the Chez Republic would not be able to provide data for 2001. The consortium stressed that efforts should be made to include the Balkan countries and have better coverage in east Europe.

The consortium noted that the quality of data still differs between countries. Data collection systems, coverage, definitions and validation are different. At the Madrid Consortium meeting in 2003, it was decided that the EIM Consortium members should adapt to the definitions published in the WHO report (World Health Organization, 2002Go). These definitions have also been adopted by ICMART (The International Committee on the Monitoring of ART) as well as WHO, ESHRE, IFFS and ASRM/SART. Some countries have been able to adjust the 2001 data sent to ESHRE to these definitions.

The consortium decided to continue to present annual reports and to try to improve the quality of the reports.


    Materials and methods
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Comments
 Appendix I. Contact persons...
 List of participating...
 References
 
National registers
A total of 15 countries already had existing data collection programmes for 2001, and therefore provided data directly from these sources. In Bulgaria, Greece, Ireland, Italy, Latvia, Poland, Slovenia and the Ukraine, where no such register existed, national data were collected de novo for the purpose of the EIM programme. Details regarding the registers have been described previously (ESHRE, 2001aGo).

Data collection
The present report summarizes data from IVF treatments started during 2001. The data include treatments from IVF, ICSI, ED, FER, IUI-H and IUI-D performed from January 1, 2001 to December 31, 2001. Follow-up data on pregnancies and deliveries are cohort data. For IUI, only pregnancies, and not deliveries, were recorded.

Registers from a number of countries have been unable to provide some of the data. Lack of such specific variables will appear in the tables as ‘not available’ (NA).

The reporting principle used for 2001 data is basically similar to preceding years (ESHRE, 2001aGo,bGo, 2002Go, 2004Go).

As the data presented here are incomplete and generated through different methods using different definitions in different countries, interpretation of the data must be done with some caution.


    Results
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Comments
 Appendix I. Contact persons...
 List of participating...
 References
 
Number of treatment cycles
Table I shows the number of all treatment cycles recorded in each country, the number of clinics in the country (if available) and the number of clinics reporting to the register. The cycles are subdivided into IVF, ICSI, FER and ED. In France and Iceland, the number of aspirations was used, as the number of initiated cycles was not available. Similarly the number of transfers rather than the number of thawings was used in Bulgaria and The Netherlands. In total, 579 clinics from 23 countries reported 289 690 cycles.


View this table:
[in this window]
[in a new window]
 
Table I. ART in European countries in 2001

 
Table II shows data from those 12 countries where all clinics have reported to the register: the number of cycles is related to the total population in the country, and the number of infants born after ART is expressed as a percentage of the total number of live born in the country. Overall, 108 910 cycles were undertaken in a population of 131.4 million, giving a mean of 829 cycles per million. The percentage of infants born after ART ranged from 0.2 to 3.9%.


View this table:
[in this window]
[in a new window]
 
Table II. ART in 2001 in those countries where all clinics reported to the national register

 
Size of the clinics
Table III shows the size distribution of the 579 reporting clinics. The size of a clinic (or unit) is based on all cycles performed per year. The size of the clinics is only related to the number of treatments with the in vitro techniques.


View this table:
[in this window]
[in a new window]
 
Table III. Size of the IVF clinics reporting to the register

 
Age distribution
Table IV shows the age distribution of those women treated with IVF or ICSI in various countries.


View this table:
[in this window]
[in a new window]
 
Table IV. Age distribution (years) of women treated with IVF and ICSI

 
Number of embryos transferred
Table V shows the number of embryos transferred after IVF and ICSI combined. The total number of single embryo transfers was 20 940 (12.0%), dual embryo transfers 90 364 (51.7%), triple embryo transfers 53 885 (30.8%) and ≥4 embryo transfers 9637 (5.5%). As indicated in the table, large differences were seen between countries. The range of triple embryo transfers was 2.1–49.8% and the range of transfer of ≥4 embryos was 0.0–52.0%.


View this table:
[in this window]
[in a new window]
 
Table V. Number of embryos transferred after IVF and ICSI

 
Elective single embryo transfer (eSET) was only reported from France and from one clinic in Slovenia. The data from France indicated eSET in 1128 of 34 267 (3.3%) fresh IVF/ICSI transfers.

Pregnancies and deliveries after treatment
Table VIIX show the number of pregnancies and deliveries in relation to the number of initiated cycles, aspirations and transfers, for IVF (Table VI), ICSI (Table VII), FER (Table VIII) and ED (Table IX).


View this table:
[in this window]
[in a new window]
 
Table VI. Pregnancies and deliveries after IVF

 

View this table:
[in this window]
[in a new window]
 
Table IX. Pregnancies and deliveries after oocyte donation

 

View this table:
[in this window]
[in a new window]
 
Table VII. Pregnancies and deliveries after ICSI

 

View this table:
[in this window]
[in a new window]
 
Table VIII. Pregnancies and deliveries after FER

 
Table VI shows that after IVF, the 27 102 pregnancies resulted from 107 823 aspirations and 93 482 embryo transfers. Thus, the mean clinical pregnancy rate was 25.1% per aspiration and 29.0% per embryo transfer. The latter figure ranged from 20.4 to 36.9% between countries. The delivery rates per embryo transfer after IVF have not been summarized due to incomplete follow-up of pregnancies in many countries, as shown in Table X.


View this table:
[in this window]
[in a new window]
 
Table X. Singleton, twin, triplet and quadruplet deliveries after IVF and ICSI

 
Table VII shows that after ICSI, the 27 156 pregnancies resulted from 103 538 aspirations and 95 919 transfers. Thus the mean clinical pregnancy rate was 26.2% per aspiration and 28.3% per embryo transfer. The latter figure ranged from 10.9 to 57.7%. The delivery rates per embryo transfer after ICSI have not been summarized due to incomplete follow-up of pregnancies in many countries, as shown in Table X.

Table VIII shows that after FER, 6821 pregnancies resulted from 41 583 transfers. Thus the mean clinical pregnancy rate per embryo transfer after FER was 16.4%. The delivery rates per embryo transfer after FER have not been summarized due to incomplete follow-up of pregnancies in many countries, as shown in Table XI.


View this table:
[in this window]
[in a new window]
 
Table XI. Singleton, twin, triplet and quadruplet deliveries after FER

 
Table IX shows that after ED, 2197 clinical pregnancies resulted from 6580 embryo transfers, giving a pregnancy rate per transfer of 33.4%, with a range from 17.2 to 50.4%. The delivery rates per embryo transfer after ED have not been summarized due to incomplete follow-up of pregnancies in many countries.

Singleton, twin, triplet and quadruplet deliveries
Table X shows the deliveries after IVF and ICSI in relation to singleton, twin and triplet deliveries. It is seen that the distribution of the deliveries was: singleton 27 920 (74.5%), twin 8975 (24.0%) and triplet 570 (1.5%). Quadruplets occurred in seven cases in 2001.

Table XI shows the deliveries after FER in relation to singleton, twin and triplet deliveries. It is seen that the distribution of the deliveries was: singleton 4060 (84.3%), twin 715 (14.8%) and triplet 39 (0.8%). No quadruplets occurred after FER in 2001.

Risks and fetal reductions
Table XII presents the incidence of ovarian hyperstimulation syndrome (OHSS) recorded from registers in 20 of the 23 countries. It is seen that 1851 cases of OHSS were recorded. The number of IVF and ICSI cycles in those 20 countries was 204 147, corresponding to a risk of OHSS of 0.9% of all stimulated cycles. Other complications are seen in the table.


View this table:
[in this window]
[in a new window]
 
Table XII. Complications and fetal reductions

 
Table XII also gives data on the number of recorded fetal reductions. In total, 397 fetal reductions were recorded.

One ‘parameter of excellence’, defined as the number of pregnancies per embryo transferred or the number of embryos replaced for each pregnancy, can be calculated. After IVF and ICSI, 21 countries replaced 401 871 embryos and this resulted in 54 258 pregnancies. The number of embryos transferred for each pregnancy was thus 7.4%.

Another ‘parameter of excellence’ could be the number of singleton deliveries per transfer. After IVF and ICSI, 22 countries reported 27 920 singleton deliveries after 178 142 transfers. The singleton delivery rate per transfer was thus 15.7%. Considering this figure, it is important to know that a number of pregnancies are lost to follow-up, so the true singleton delivery rate remains unknown.

PGD was recorded in 10 countries: Belgium, Denmark, Finland, Greece, Hungary, Italy, Portugal, Russia, Spain and the UK. A total of 1145 aspirations and 859 transfers resulted in 218 pregnancies and 161 deliveries. This gives a clinical pregnancy rate of 25.3% and a delivery rate of 19.0% per transfer. The major countries were Italy, Belgium and Spain with 366, 321 and 309 aspirations, respectively.

Intra-uterine inseminations
Table XIII gives data on IUI-H divided into female age groups <40 years (upper panel) and ≥40 years (lower panel). For France, Hungary and Norway, no stratification for age was available, and the overall results are included in the group below 40 years of age.


View this table:
[in this window]
[in a new window]
 
Table XIII. Intra-uterine insemination with husband's semen (IUI-H)

 
It is seen that in women below 40 years of age, 50 912 treatments resulted in 6500 pregnancies, giving a pregnancy rate per procedure of 12.8%. In women at ≥40 years, the corresponding figures were 2027, 196 and 9.7%.

In women below 40 years of age, singleton, twin and triplet pregnancies accounted for 88.5, 10.2 and 1.1% of the pregnancies, respectively. In women above 40, the corresponding figures were 96.1, 3.8 and 0.0%.

Table XIV gives data on IUI-D divided into female age groups <40 years (upper panel) and ≥40 years (lower panel). For France, Hungary and Norway, no stratification for age was available, and the overall results are included in the group below 40 years of age.


View this table:
[in this window]
[in a new window]
 
Table XIV. Intra-uterine insemination with donor semen (IUI-D)

 
It is seen that in women below 40 years of age, 12 811 treatments resulted in 2197 pregnancies, giving a pregnancy rate per insemination of 17.1%. In women at ≥40 years, the corresponding figures were 1374, 110 and 8.0%.


    Comments
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Comments
 Appendix I. Contact persons...
 List of participating...
 References
 
The present report is the fifth consecutive European report on IVF data covering treatment cycles from 1997, 1998, 1999, 2000 and 2001, respectively.

The number of countries reporting to the EIM's consortium and contributing to the fifth report has increased from 22 to 23, covering the whole of Western Europe with the exception of Austria who is due to join next year, and Luxembourg where there is no IVF clinic. In Eastern Europe, the Czech Republic who participated previously, was unable to provide data for 2001.

Twelve of the participating countries had a complete coverage in their reporting system: Belgium, Denmark, Finland, Hungary, Iceland, Latvia, Norway, Slovenia, Sweden, Switzerland, The Netherlands and the UK. For 2001, ~10 000 cycle were missing from France. These data did not become available to the EIM in time for inclusion. Germany, the largest contributor to the EIM, with >70 000 cycles in 2001, is now very close to having complete coverage of all clinics in the country.

The number of reported cycles continues to grow. For this year, 579 clinics reported 289 690 cycles, which is an increase of 4% compared with 2000. As an estimated 10 000 cycles from France were missing for this year, the increase could have been similar to earlier years where it ranged from 8 to 14%. During the 5 year period of EIM reporting, the number of cycles has increased from 203 893 in 1997 to 289 690 in 2001, equivalent to an overall increase of 41%. This marked increase during the period is partly due to a better coverage in the reporting systems, but is also due to a true expansion of activities in some countries.

Within Europe, the largest contribution came from Germany with 72 000 cycles, followed by France with 54 000 cycles and the UK with 35 000 reported cycles. For comparison, the ASRM/SART registry reported 99 989 cycles from the USA in 2000 (ASRM/SART, 2004Go).

In southern Europe, a number of countries have a low coverage, with 47 out of 182 (Spain), 59 out of 115 (Italy) and seven out of 46 (Greece) clinics reporting to the EIM.

The availability of services remained highest in Denmark with 1923 cycles per million inhabitants. It was also high in the other Nordic countries and in The Netherlands. The average number of treatment cycles per million inhabitants in those countries with complete coverage in their reporting was 829. The proportion of IVF children to all children born was again highest in the Nordic countries, but also very high in Slovenia.

The proportion of ICSI versus standard IVF procedures increased from 44% in 2000 to 49% in 2001 but, as indicated in Table I, there are many countries where ICSI is much more prevalent than IVF.

The number of embryos transferred in IVF and ICSI cycles differed substantially between countries, but there is a clear trend during the years towards transfer of fewer embryos. The mean number of single embryo transfers remained at ~12%, whereas the proportion of two embryo transfers increased from 39.2% in 1999 to 46.6% in 2000 and to 51.7% in 2001. The proportion of three embryo transfers decreased from 39.6% in 1999 to 33.3% in 2000 and to 30.8% in 2001. Four embryo transfers also decreased from 9.3% in 1999 to 6.9% in 2000 and to 5.5% in 2001. Seven countries have completely abandoned transfer of four embryos.

The overall occurrence of multiple deliveries after IVF and ICSI was 25.5% in 2001 compared with 26.9% in 2000. During the 5 year period of the EIM, the most remarkable finding regarding multiples was that the incidence of triplet deliveries has been reduced from 3.6% in 1997, to 2.3% in 1998, 2.3% in 1999, 1.9% in 2000 and now to 1.5% in 2001. However, regarding triplet rates, huge differences still exist between countries. Regarding the multiple rates, the number of fetal reductions should also be considered. A total of 397 procedures were performed, the largest number being in Spain (93), France (80) and the UK (87).

Pregnancy rates for IVF, ICSI and FER remained fairly stable in 2001, compared with earlier years. For IVF, the mean pregnancy rate per transfer was 29.0% compared with 28.4% in 2000. For ICSI, this was 28.3% compared with 28.7% in 2000. For FER, the mean pregnancy rate was 16.4% compared with 16.5% in 2000. The figures from Europe remain lower than in the USA, where 62 881 IVF/ICSI retrievals in 2000 resulted in 22 567 pregnancies (35.9%). In the USA, however, multiple births occurred in 35.4% of all deliveries (ASRM/SART, 2004Go).

One other possible way to report the success rate would be to report on singleton delivery rates, separately. At the present stage, where delivery rates are somewhat uncertain in many countries, we have only given an estimated overall figure of 15.8% singleton deliveries per transfer after IVF and ICSI.

Alternative ways of presenting the success rate within a single ‘parameter of excellence’ was the number of fresh embryos replaced for each pregnancy. This figure was 7.4% in 2001, which is an improvement from 8.2% in 2000.

Altogether 882 embryo transfers after PGD were reported, compared with 543 in 2000 and 131 in 1999, suggesting an expansion of this activity in the coming years.

For the first time, the fifth report includes European data on 52 939 treatments with IUI-H and 14 185 treatments with IUI-D. The coverage of IUI activities is probably much less comprehensive than was seen regarding the in vitro techniques.

In women below 40 years of age, the pregancy rate was 12.8% for IUI-H and 17.1% for IUI-D. In women at ≥40 years, the corresponding figures were 9.7 and 8.0%.

After IUI-H in women below 40 years of age, twin pregnancies occurred in only 10.2% and triplet pregnancies in 1.1%. After IUI-D in women below 40, twin pregnancies occurred in 9.4% and triplet pregnancies in 1.2% of the cases. The data suggest that the twinning rates are less that half that is found with the in vitro techniques, and that the triplet rates are also lower.

To summarize, the present fifth ESHRE report on ART for Europe in 2001 shows a continuing expansion of the register regarding participating clinics, countries and number of cycles reported. The pregnancy rates per treatments remain fairly stable, but fewer embryos are transferred. The twinning rate remains stable, but the triplet rates have been reduced markedly from 3.6% in 1997 to 1.5% in 2001. eSET still had a minimal overall impact in 2001. Multiple gestations seem to be much less frequent after IUI-H and IUI-D compared with IVF and ICSI


    Appendix I. Contact persons representing data collection programmes in participating European countries, 2001
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Comments
 Appendix I. Contact persons...
 List of participating...
 References
 

Belgium: Petra De Sutter, Infertility Center, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium. E-mail: petra.desutter{at}gent.be
Bulgaria: Professor Stanimir Kyurkchiev, Institute of Biology and Immunology of Reproduction, Molecular Immunology, 73 Tzartgradsico shosse, 1113 Sofia, Bulgaria. E-mail: kyurkch{at}hotmail.com
Denmark: Karin Erb, The Fertility Clinic, Odense University Hospital, DK-5000 Odense, Denmark. E-mail: karin.erb{at}ouh.fyns-amt.dk
Finland: Mika Gissler, Stakes, Stakes Information. PO Box 220, 00531 Helsinki, Finland. E-mail: mika.gissler{at}stakes.fi
France: Jacques De Mouzon, INSERM U 292, Hôpital de Bicêtre, 78 rue du Général Leclerc, F-75252, Kremlin Bicêtre, France. E-mail: demouzon{at}vjf.inserm.fr
Germany: Ricardo Felberbaum, Med. Universität, Ratzenburger Allee 160, D-23538 Lübeck, Germany. E-mail: rfelberbau{at}netscape.net
Greece: Basil C.Tarlatzis, Infertility and IVF Centre, Geniki Kliniki, 2 Gravias Street, GR-54645 Thessaloniki, Greece. E-mail: tarlatzis{at}hol.gr
Hungary: Janos Urbancsek, 1st Department of Obstetrics and Gynaecology, SOTE, Baross utca 27, H-1088 Budapest, Hungary. E-mail: Urbjan{at}Noi1.sote.hu
Iceland: Hilmar Bjorgvinsson. IVF Unit, Department of Obstetrics and Gynecology, Natiaonal University Hospital. Landspitalinn, Reykjavik 101, Iceland. E-mail: Hilmar{at}rsp.is
Ireland (Republic of): Dr Robert Harrison, Human Assisted Reproduction Ireland Rotunda Hospital, RCSI Department of OB/GYN, Master's House, Parnell Square, Dublin 1, Ireland. E-mail: rfharrison{at}rcsi.ie
Italy: Anna Pia Ferraretti, SISM s.r.l., Via Mazzini 12, I-40137 Bologna, Italy. E-mail: anna.ferraretti{at}sismer.it
Latvia: Not available.
The Netherlands: Jan A.M.Kremer, Department of Obstetrics and Gynaecology, A.Z.Nijmegen (St. Radboud), Geert Grooteplein 10, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands. E-mail: j.kremer{at}obgyn.azn.nl
Norway: Johan T.Hazehamp, Department of Reproductive Medicine, Volvat Medical Center, Postboks 5280, Majorstuea, Oslo 303, Norway. E-mail: Hazekamp{at}online.no
Poland: Waldermar Kuczynski, University Hospital, SP Szpital, Department of Gynecology, MC Sklodowskiej 24 a, 15-276 Bialystok, Poland. E-mail: kuczynsk{at}cksr.ac.bialystok.pl
Portugal: Carlos Calhaz-Jorge. Human Reproduction Unit, Department of Obstetrics and Gynecology, Hopital de Santa Maria, Av. Prof. Equs Monitz, 1649-028 Lisboa, Portugal. E-mail: Calhazjorge{at}mail.telepac.pt
Russia: V.S.Korsak, IVF Centre, Ott Institute, Mendeleyevskay linia 3, 199034 St-Petersburg, Russia CIS. E-mail: ivf{at}mcrm.ru
Slovenia: Irma-Virant Klun, University Medical Centre Ljubljana, Department of Obstetrics and Gynecology, Ljubljana, Slovenia. E-mail: Irma.virant{at}kclj.sl
Spain: Juana Hernandez, Department of Obstetrics and Gynaecology, Hospital San Milan, Avda. Autonoma de la Rioja 3, 26004 Logrono-La Rioja. Spain. E-mail: jhernandezh{at}meditex.es
Sweden: P.O.Karlstroem, Department of Obstetrics and Gynaecology, 72189 Vesteraas, Sweden. E-mail: pok.red{at}swipnet.se
Switzerland: Constanzo Limoni, Via Ceresio 6, 6826 Riva San Vitale, Switzerland. E-mail: alpha5{at}bluewin.ch
UK: Richard Baranowski, Deputy Information Manager, Human Fertilization and Embryology Authority (HFEA), Bloomsbury Street, London WC1B 3HF, UK. E-mail: richard.baranowski{at}hfea.gov.uk
Ukraine: Victor Veselovsky, Clinic Isida IVF, 28/1 Chornovilla Str. Kyiv, 01135, Ukraine. E-mail: 6vvv{at}isidaivf.com.ua


    List of participating centres—EIM data collection 2001
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Comments
 Appendix I. Contact persons...
 List of participating...
 References
 
Belgium

Antwerpen: Algemeen ziekenhuis Middelheim; Universitair ziekenhuis Antwerpen; AZ St.-Camillus/St.-Augustinus Wilrijk
Brugge: Algemeen ziekenhuis Sint-Jan
Brussel/Bruxelles: Institut médical Edith Cavell; Academisch ziekenhuis VUB; Hôpital universitaire St-Pierre; Hôpital Erasme
Charleroi: Clinique Notre-Dame
Genk: St-Jansziekenhuis
Gent: Universitair ziekenhuis Gent; Algemeen ziekenhuis Jan Palfijn; Algemeen ziekenhuis St.-Lucas
Kortrijk: Sint-Niklaaskliniek
Leuven: Universitair ziekenhuis Gasthuisberg; Leuven Institute for Fertility and Embryology
Liège: Clinique St Vincent Rocourt; Hôpital de la  Citadelle
Mont-sur-Sambre: Centre de PMA Sainte Thérèse
Namur: Centre Hospitalier régional de Namur
Roeselare: Heilig Hartziekenhuis
Vilvoorde: Van Helmontziekenhuis

Bulgaria

Sofia: ObGy Hospital ‘Dr Shterev’
Sofia: IVF Department, 1st ObGy Hospital ‘St Sofia’
Varna: Medical Centre ‘Olimed’

Denmark

Aalborg: Fertilitetsklinikken Aalborg
Aarhus: Ciconia Vest; Fertilitetsklinikken Skejby Sygehus; Maigaards Fertilitetsklinik
Brædstup: Fertilitetsklinikken Brædstrup Sygehus
Copenhagen: Ciconia Øst; Dansk Fertilitetsklinik; Fertilitetsklinikken Helsehuset; Fertilitetsklinikken Herlev Sygehus; Fertilitetsklinikken Hvidovre Hospital; Fertilitetsklinikken Rigshospitalet; Fertilitetsklinikken Trianglen; Gentofte Fertilitetsklinik; Speciallæge praksis, Lygten
Holbæk: Fertilitetsklinikken Holbæk Sygehus
Horsens: Horsens Fertilitetsklinik
Odense: Fertilitetsklinikken Odense Universitetshospital; Odense IVF-Klinik
Skive: Fertilitetsklinikken Skive Sygehus; Klinik for  Kvindesygdomme og graviditet

Finland

Helsinki: Diacor; Eira Hospital; Family Federation of Finland Helsinki; Felicitas; Fertinova; Helsinki University Central Hospital
Joensuu: Northern Carelia Central Hospital
Jyväskylä: In-Tiimi Jyväskylä
Kuopio: In-Tiimi Kuopio; Kuopio University Central Hospital
Lappeenranta: Fermedi
Oulu: Family Federation of Finland Oulu; Oulu University Central Hospital
Tampere: AVA Tampere; Tampere University Central Hospital
Turku: AVA Turku; Family Federation of Finland Turku; Turku University Central Hospital

France

Amiens: Centre Picard; CHU; CHR
Aubervilliers: La Roseraie
Avignon: Urbain V
Bagnolet: La Dhuys
Bayonne: Lafargue
Besancon: CHU; Franche-Comté
Blanc Mesnil: Clinique
Bois-Guillaume: Saint Antoine
Bondy: Jean Verdier
Bordeaux: Pellegrin Fédération
Brest: CHU; Pasteur
Bruges: Jean Villar
Caen: CHRU
Cayenne: CHG
Chambray-Les-Tours: Parc Clinique
Charleville-Mezieres: CH
Clamart: Antoine Béclère
Clermont-Ferrand: CHU
Cormeilles en Parisis: Clinique
Courbevoie: CH-La Défense
Dijon: CHR
Dreux: CH
Epinal: Arc en Ciel
Equeudreville: Cotentin
Grenoble: Belledonne; CHU
Guilherand Granges: Pasteur
Le Chesnay: Parly II
Le Havre: CH
Le Mans: Tertre Rouge
Le Port: Jeanne d'Arc
Lille: Polyclinique Du Bois; Jeanne De Flandres
Limoges: CHRU
Lorient: CH
Lyon Bron: Ste Marie-Thérèse
Lyon: Edouard Herriot; Montplaisir; Tonkin
Marseille: Conception; Saint Joseph; IMR
Martinique-Fort De France: Sainte Marie
Metz: Sainte Croix
Montpellier CHU; Saint Roch
Mulhouse: Diaconat
Nancy: A Pinard; Majorelle
Nantes: CHU; ND De Grâce; St Herblain/Atlantique
Neuilly: Chérest; Hôpital Américain
Nice: CHU; Saint Georges
Nimes CHRU
Paris: Bichat; Cochin; Diaconesses; Les Bluets; La Muette; Montsouris; Pitié Salpétrière; Saint Vincent De Paul; Tenon
Paulagrange
Perigueux: Francheville
Perpignan: Saint Pierre
Poissy: CHI
Poitiers: CHU
Reims: CHU; Courlancy
Rennes: CHRU Sud; La Sagesse
Roanne: CH
Rouen: CHU
Saint Etienne: Michelet
Saint-Jean: L'Union et le Vaurais
Saint-Saulve: Le Parc
Schiltigheim: CMCO
Sevres: J.Rostand
Toulon: Saint Michel
Toulouse: CHU
Toulouse: Saint Jean Languedoc
Tours: CHU
Vitry Sur Seine: Les Noriets

Germany

Aachen: Frauenarztpraxis mit Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin an der Itertalklinik, Dr med. K.-M.Grunwald; Universitäts-Frauenklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, Medizinische Fakultät der RWTH Aachen, Prof. Dr med. J.Neulen
Aalen: IVF-Zentrum Aalen, Dr med. Rainer Rau
Augsburg: VF-Zentrum Augsburg, Gemeinschaftspraxis, Dr med. Dr rer. nat. Warnecke, Dr med. K.-F.Hiller, Dr med. T.H.Bauer, Dr med. H.Kraus
Bad Münder: Zentrum für IVF und Reproduktionsmedizin, Deutsche Klinik Bad Münder, Drs Bispink, Chandra, Kast, Braulke, Schneider
Bayreuth: IVF-Zentrum Bayreuth im Klinikum Bayreuth, Gemeinschaftspraxis Dr med. S.Todorow, Dr med. E.Schwarz
Bedburg/Erft: Dr med. Dieter Struller, Facharzt für Frauenheilkunde und Geburtshilfe
Berlin: Charité, Campus Virchow-Klinikum, Klinik für Frauenheilkunde und Geburtshilfe, Reproduktionsmedizin, Dr med. B.Pfüller, Dr med. A.Jantke, Dr H.Schmiady; Dr med. Matthias Bloechle, Dr med. Silke Marr; Dr med. M.Zaghloul-Abu Dakah, Kinderwunsch- und Privatpraxis; Fertility Center Berlin, Prof. Dr med. H.Kentenich, Dr med. G.Stief, Dr med. A.Tandler-Schneider; Gemeinschaftspraxis Drs med. A.Haase/P.Rott; Gemeinschaftspraxis im Lützow Center, Reproduktionsmedizinisches Zentrum, Dr med. Detlef H.G.Temme, Dr med. Rolf Metzger; Praxisklinik für Fertilität, Dr med. David J.Peet, Dr med. Peter Sydow, Dr med. Carmen Sydow; Praxis Dr med. Reinhard Hannen; Universitätsklinikum der Humboldt-Universität zu Berlin, Charité Campus Mitte, Klinik für Frauenheilkunde und Geburtshilfe, Abteilung für Reproduktionsmedizin und Endokrinologie, Dr med. B.Pfüller, Dr med. I.Scheiber
Bielefeld: Bielefeld Fertility-Center, Gemeinschaftspraxis Paul A.Ebert, Dr med. Karl Völklein; BIF-Bielefelder Institut für Fortpflanzungsmedizin der Städtischen Kliniken Bielefeld-Rosenhöhe, Leitung: Dr med. Beate Harms
Bonn: Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsklinikum Bonn, Prof. Dr med. Hans H.van der Ven; Praxisklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, PD Dr med. Gernot Prietl
Bremen: Bremer Zentrum für Fortpflanzungsmedizin (BZF) in der Frauenklinik des Ev. Diakonie-Krankenhauses gGmbH, Prof. Dr Ernst Heinrich Schmidt, Dr Olaf Drost; Zentrum für Kinderwunschbehandlung Bremen, Dr A.von Stutterheim, Dr C.Clasing
Cottbus: Carl-Thiem-Klinikum Cottbus, Bereich Reproduktionsmedizin und Gynäkologische Endokrinologie, Prof. Dr med. H.-H.Riedel
Darmstadt: Reproduktionsmedizinisches und Endometriose Zentrum Darmstadt, Frauenklinik des Klinikum Darmstadt, Prof. Dr G.Leyendecker
Deggendorf: Gemeinschaftspraxis Drs Kroiss und Bernhardt
Dortmund: Gemeinschaftspraxis Drs med. S.Dieterle/A.Neuer
Dresden: Praxis Dr med. H.J.Held; Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Prof. Dr med. W.Distler, Dr rer. nat. G.Keck
Düsseldorf: Gemeinschaftspraxis Dr (B) Hugo Verhoeven, Dr med. Michael Scholtes, Dipl.-med. Kersten Marx, Dr med. Martina Behler, Dr med. Manfred Schulte; Städt. Kliniken Düsseldorf gGmbH, Frauenklinik Benrath, Abteilung für Reproduktionsmedizin und Gynäkologische Endokrinologie, Prof. Dr G.Freundl, Dr C.Gnoth, Dipl. Biol. E.Halbe; Universitätsfrauenklinik der Heinrich-Heine-Universität-Düsseldorf, Prof. Dr H.G.Bender
Erlangen: Dr J.van Uem; Gemeinschaftspraxis der Frauenärzte Prof. Dr Dr K.-G.Bregulla, Dr M.Hamori, Dr R.Behrens; Universitätsfrauenklinik Erlangen, Prof. Dr med. Ludwig Wildt
Essen: Gemeinschaftspraxis Dr med. Thomas Katzorke, Dr med. Dirk Propping, Dr med. Susanne Wohlers
Esslingen: IVF-Zentrum Esslingen, Dr med. J.E.Costea
Frankfurt/Main: IVF Zentrum Frankfurt, Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin, Universitäts Frauenklinik; Krankenhaus Nordwest, Frauenklinik/Zentrum für Reproduktionsmedizin, Prof. Dr E.Merz, Dr M.Amroni/Frau Dr S.Schuh
Freiburg: Frauenklinik der Albert-Ludwigs-Universität, PD Dr med. C.Keck; Gemeinschaftspraxis Dr Weitzell, Dr M.Thiemann, Prof. Dr F.Geisthövel
Gelsenkirchen: Schwerpunkt Kinderwunschtherapie, Wissenschaftspark Gelsenkirchen, Dr med. Ute Czeromin, Dr med. Ina Walter-Göbel
Gie{beta}en: Arbeitsgruppe Endokrinologie, Fortpflanzungsmedizin und Mikrochirurgie der Justus-Liebig-Universität, Prof. Dr W.Künzel, Prof. Dr W.Weidner; Gesellschaft zur Förderung der In-Vitro-Fertilisation und Reproduktionsmedizin GbR, Prof. Dr Gips
Göttingen: Dr Monica Tobler, Fachärztin für Frauenheilkunde und Geburtshilfe; Georg-August-Universität, Klinik für Gynäkologie und Geburtshilfe, Prof. Dr med. Dr Bernd Hinney; Gemeinschaftspraxis, Dr Peter Böhm, Dr Sabine Hübner, Dr Rüdiger Moltrecht, Dr Christine Noeldechen, Dr Stephanie Mittmann
Greifswald: Ernst-Moritz-Arndt-Universität, Frauen- und Poliklinik, Dr S.Möller
Grevenbroich: Gemeinschaftspraxis Dr Tigges, Dr Kaiser, Dr Tuchel
Haan: Gynäkologisch-Geburtshilfliche Abteilung für Gynäkologische Endokrino-logie/Reproduktionsmedizin, St Josef Krankenhaus GmbH, Dr med. Thomas Bremen, Dr rer. nat. Uwe Weidner
Halle/Saale: Martin-Luther-Universität Halle-Wittenberg, Klinik und Poliklinik für Geburtshilfe und Reproduktionsmedizin, Prof. Dr med. habil. F.Röpke, Dr med. Petra Kaltwasser, Dr rer. nat. E. Seliger
Hamburg: Fertility Center Hamburg; Gemeinschaftspraxis Bispink, Horn, Michel und Seeler; Praxisgemeinschaft Hinrichsen u. Partner GbR am Endokrinologikum Hamburg; Praxis BKS, Prof. Dr med. H.G.Bohnet, PD Dr med. U.A.Knuth, PD Dr med. M.A.Graf; Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin, Prof. Dr W.Braendle; Zentrum für Fertilitätsmedizin Kocak und Kollegen, Dr Semsettin Kocak
Hannover: Frauenklinik der MHH am Oststadtkrankenhaus, Prof. Dr H.W.Schlösser; Gynäkologische Gemeinschaftspraxis, Dr M.Müseler-Albers, H.P.Arendt, Dr K.Bühler
Heidelberg: Kinderwunschzentrum Heidelberg, Drs Maletz-Kehry, Parta, Hinderer,Tesarz; Universitätsklinikum Heidelberg, Abteilung für Gynäkologische Endokrinologie und Fertilisationsstörungen, Kinderwunsch-Sprechstunde, Prof. Dr T.Strowitzki, Dr Daniela Seehaus
Hildesheim: Zentrum für Reproduktionsmedizin und Humangenetik Hildesheim, Dr F.-J.Algermissen, Dr P.F.Justus, Dr G.Wilke, Dr N.Graf
Homburg: Universitätskliniken des Saarlandes, Frauenklinik und Poliklinik, Prof. Dr Drs h.c. mult. W.Schmidt, Dr P.Rosenbaum, Dr H.E.Hammadeh, Dr C.Clauèen, Dr K.Laufs, Dr D.Tigges
Jena: Klinikum der FSU Jena, Klinik für Frauenheilkunde und Geburtshilfe, PD Dr med. W.Starker, Dr. rer. nat. I. Hoppe; Gemeinschaftspraxis Fritzsche-Reiher-Hoffmann
Karlsruhe: Karlsruher IVF-Programm, Dr V.Wetzel, H.J.Gräber, E.Wetzel, Dr F.Tetens, Dr G.Zoulek
Kiel: Universitäts-Frauenklinik der Christian-Albrechts-Universität Kiel, Prof. Dr med. L.Mettler, Dr med. A.Schmutzler
Köln: Krankenhaus Porz am Rhein, Frauenklinik, Prof. Dr K.-H.Broer; PAN Klinik am Neumarkt, Dr S.Palm, Dr V.Sasse, Dr I.Pütz; Universitäts-Frauenklinik Köln, OA Dr Frank Nawroth
Leipzig: Praxisklinik Reproduktionsmedizin und Gynäkologische Endokrinologie, Dr med. F.A.Hmeidan, Dr med. P.Jogschies, Dr med. A.Gabert; Universitätsfrauenklinik, Zentrum für Reproduktionsmedizin und Gynäkologische Endokrinologie, Prof. Dr med. H.Alexander
Lübeck: Universitätsklinikum Lübeck, Klinik für Frauenheilkunde und Geburtshilfe
Magdeburg: Klinik für Reproduktionsmedizin und Gynäkologische Endokrinologie, Otto-von-Guericke-Universität Magdeburg, Prof. Dr med. J.Kleinstein, Dr med. I.Nickel
Marburg: Klinik für Gynäkologie, Gynäkologische Endokrinologie und Onkologie der Philipps-Universität Marburg, Prof. Dr Klaus-Dieter Schulz, Dr med. Karin Bock
Mannheim: Universitätsfrauenklinik, Klinikum Mannheim gGmbH, Prof. Dr F.Melchert, PD Dr M.Weigel
Minden: Gemeinschaftspraxis Dr med. Onno Buurman, Dr med. Michael Dumschat, Dr (YU) Akram El Harake, Fachärzte für Frauenheilkunde
Mönchengladbach: Gemeinschaftspraxis Dr med. Georg Döhmen, Dr med. Thomas Schalk
Mühlheim a. d. Ruhr: Ev. Krankenhaus Mühlheim an der Ruhr, Frauenklinik und Zentrum für Reproduktionsmedizin, Prof. Dr H.von Matthiessen
München: Hormonzentrum München, PD Dr med. A. ömmler, Dr med. H Lacher, Dr med. J.Puchta, Dr med. M.Conrad; Kinderwunsch Centrum München an der Frauenklinik Dr Wilhelm Krüsmann, Gynäkologische Endokrinologie und Sterilitätsmedizin, Dr med. Klaus Fiedler, Dr med. Irene von Hertwig, Dr med. Gottfried Krüsmann, Prof. Dr med. Wolfgang Würfel; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Klinikum der Universität München-Grosshadern, Prof. Dr med. C.J.Thaler, Prof. Dr med. H.Hepp; Prof. Dr med. Dieter Berg, Dr med. Bernd Lesoine; Zentrum für Reproduktionsmedizin, Dr med. Walter Bollmann, Dr med. Thomas Brückner, Dr med. Ulrich Noss
Münster: Gemeinschaftspraxis Dr Dr med. Lutz Belkien, PD Dr med. Bernd Krause; Universitätsklinikum Münster, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Dr med. Robert B.Greb, Prof. Dr Ludwig Kiesel; Institut für Reproduktionsmedizin, Prof. Dr med. Eberhard Nieschlag
Neubrandenburg: Dietrich Bonhoeffer Klinikum Neubrandenburg; Klinik für Frauenheilkunde und Geburtshilfe, Prof. Dr med. R.Sudik
Neuwied: Gemeinschaftspraxis Dr Beran und Dr Müller
Nürnberg: Reproduktionsmedizinische Praxis Dr med. J.Neuwinger und Dr med. B.Munzer-Neuwinger
Oldenburg: Dr med. Saif Jibril; Tagesklinik Oldenburg, Dr med. Jörg Hennefründ, Dr med. Heike Ochs-Ring, Dr med. Michael Heeder
Osnabrück: Kinderwunschzentrum Osnabrück, Drs med. Irene Coordes, Doris Proffen, Manfred Schneider
Pforzheim: Zentrum für Reproduktionsmedizin in der Centralklinik, Dr med. R.-P.Stein
Prien am Chiemsee: Priener Zentrum für Reproduktionsmedizin, Dr med. Mathias Lehnert, PD Dr Dr med. Rainer Steldinger, Dr med. Susann Böhm, Dr med. (Univ. Izmir) Cenan Cevatli, Dr med. Wolfgang Lehnert
Regensburg: Zentrum für Gynäkologische Endokrinologie und Reproduktionsmedizin, Prof. Dr med. Bernd Seifert, PD Dr med. Monika Bals-Pratsch, Dr med. Ute Hehr
Remscheid: Gynäkologische Endokrinologie und Reproduktionsmedizin am Klinikum Remscheid
Rostock: Universitäts-Frauenklinik Rostock, Reproduktionsmedizin, PD Dr med. H.Müller, Dr med. S.Hansch
Saarbrücken: Dr med. Jens Happel, Dr med. Michael Thaele, Dr med. Lars Happel
Schwäbisch Gmünd: Klinikum Schwäbisch Gmünd; Margariten Hospital, Geburtshilfe/Fortpflanzungsmedizin
Schwerin: Medizinisches Zentrum der Landeshauptstadt Schwerin, Klinikum Schwerin, Prof. Dr med. E.Petri, Dr F.Thielemann
Stuttgart: Dr. med. Fred Maleika; Praxis Dr D.B.Mayer-Eichberger; IVF-Zentrum, Univ.-Prof. Dr med. Ute Fuchs
Tübingen: Universitätsklinikum Tübingen, Frauenklinik; Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin, PD Dr P.Licht, Dr R. Emig
Ulm: IVF-Zentrum Ulm, Dr. med. Friedrich Gagsteiger, Prof. Dr med. Karl Sterzik; Universitätsklinikum Ulm, Zentrum für Reproduktionsmedizin und Gynäkologische Endokrinologie, Prof. Dr C.Brucker
Wiesbaden: Zentrum für Reproduktionsmedizin, Dr med. Th.Hahn, Dr. med. M. Schorsch
Würzburg: Dr med. R.Mai, Dr. med. Wolfgang Schmitt; Universitäts-Frauenklinik Würzburg, Prof. Dr T.Steck

Greece

Athens: Fertility Institute, Center for Human Reproduction; Iatriki Erevna; IVF and Genetics; Neogenesis IVF Center; IVF Center Euromedica
Thessaloniki: Infertility & IVF Center, Geniki Kliniki

Hungary

Budapest: 1st Department of OB/GYN, Semmelweis University of Medicine; Department of OB/GYN, ‘Jahn Ferenc’ Hospital; Department of OB/GYN, ‘Nyiro Gyula’ Hospital; Department of OB/GYN, St John's Hospital, Kaali Institute, Devai Institute, Forgacs Institute
Debrecen: Department of OB/GYN, Debrecen University of Medicine
Gyor: Kaali Institute
Pécs: Department of OB/GYN, Pécs University of Medicine
Szeged: Kaali Institute
Tapolca: Pannon Institute for Reproduction

Iceland

Reykjavik: IVF Unit, Department of. OB/GYN, National University Hospital, Landspitali

Ireland (Republic of)

Clane: Assisted Conception Unit, Clane General Hospital
Dublin: HARI Unit (Human Assisted Reproduction Ireland), Rotunda Hospital
Galway: Galway Fertility Unit, University College Hospital

Italy

Abano Terme (PD): Casa di Cura Abano Terme-Centro Ripr. Assistita
Ancona: Ospedale Salesi
Bari: Clinica S. Maria; Studio Medico ‘San Luca’; Studio Associato CECOS; University of Bari
Bergamo: Ospedali Riuniti
Bologna: SISMER; Tecnobios
Bolzano: Ospedale di Bolzano
Brescia: Istituto Citta di Brescia
Bressanone (BZ): Ospedale di Bressanone
Brunico (BZ): Ospedale di Brunico
Cagliari: Ospedale Regionale Microcitemie
Caserta: Centro Genesis
Castellana Grotte: IRCCS
Catania: CRA
Fermo (AP): Istituto Palmatea
Firenze: Universitá di Firenze
Fossano (CN): Ospedale di Fossano
Genova: Universitá di Genova
Lecce: Centro Studi Riproduzione Umana
Messina: Centro di Riproduzione Umana
Mestre (VE): ARC-STER
Milano: Fondazione S.Raffaele del Monte Tabor; Polo Universitario S.Paolo; Centro Cerva
Modena: Universitá di Modena e Reggio Emilia
Monza (MI): Centro di Medicina della Riproduzione ‘Biogenesi’
Motta di Livenza (TV): Ospedale di Motta di Livenza
Napoli: Centro Mediterraneo di Fecondazione Assistita; BDR
Nardo' (LE): Tecnomed
Padova: Studio ‘Gemma’; Euganea Medica
Palermo: Centro ‘Andros‘; Centro di Biologia della Riproduzione
Parma: CIR Universitá di Parma
Pesaro: Centro Salus
Pescara: Villa Serena
Pieve di Cadore (BL): Ospedale Civile
Pisa: Casa di Cura S. Rossore; Universitá di Pisa
Pordenone: Ospedale S.M. degli Angeli
Roma: European Hospital; Centro RAPRUI; Universitá ‘La Sapienza‘; CIPA
Rozzano (MI): Istituto Clinico Humanitas
Salerno: CMR
Sassari: Universitá di Sassari
Sora (FR): Centro STS
Torino: Centro LIVET; Ospedale S.Anna; ARTES; Centro Diagnosi e Cura dell'Infertilitá di Coppia
Varese: Centro Diagnostico Varesino
Verona: Policlinico Borgoroma

Latvia

Not available

The Netherlands

Amsterdam: Academisch Medisch Centrum, Vrije Universiteit Medisch Centrum
Eindhoven: Catharina Ziekenhuis
Groningen: Academisch Ziekenhuis Groningen
Leiden: Leids Universitair Medisch Centrum, Stichting Medisch Centrum voor Geboorteregeling
Maastrict: Academisch Ziekenhuis Maastricht
Nijmegen: Universitair Medisch Centrum St Radboud
Rotterdam: Academisch Ziekenhuis Rotterdam
Tilburg: St Elisabeth Ziekenhuis
Utrecht: Universitair Medisch Centrum
Voorburg: Reiner de Graaf Groep
Zwolle: Isala Klinieken

Norway

Bergen: Kvinneklinikken Helse-Bergen, Haukeland Sykehus
Haugesund: Haugesund Sjukehus Helse Fonna
Oslo: Fertilitetssenteret Omnia; Rikshospitalet; Ullevål
Universitetssykehus; Volvat Medisinske Senter
Trondheim: St Olavs Hospital HF
Tromsø: Universitetssykehuset I Nord-Norge HF

Poland

Bialystok: Department of Gynecology, Medical Academy of Bialystok; Center for Reproductive Medicine ‘Kriobank’
Bytom: 1st Chair and Clinic of OB/GYN, Silesian Medical Academy
Lodz: ‘Gameta’ Fertility Center
Lublin: ‘AB OVO’, NZOZ Centrum Zdrowia Rodziny
Poznan: Division of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences; Clinic of Infertility ‘Intermedica’
Szczecin: Clinic for Reproduction and Gynecology, Pomeranian Medical University
Warsaw: 1st Deptartment of Gynecology and Obstetrics, University Hospital Warsaw; Private Infertility Clinic ‘Novum’; Private Gynaecological Clinic of Reproduction ‘Germen’

Portugal

Guimarães: Hospital N.S. da Oliveira
Lisboa: Ava Clinic; CLINDIGO; Hospital de Santa Maria; Maternidade Dr Alfredo da Costa
Oporto: Centro de Genética Prof. Alberto Barros; CETI; Maternidade Júlio Dinis
Vila Nova de Gaia: Centro Hospitalar

Russia

Astrakhan: Center for Family Planning and Reproduction
Voroneg: Region Center for Family Planning and Reproduction, IVF Department
Vladivostok: Medical Center for IVF ‘Santa Maria’
Vladikavkaz: Region Center for Family Planning and Reproduction
Ekaterinburg: Center of Family Medicine, Center for rehabilitation of infringements of reproductive function
Krasnoyarsk: Center for Reproductive Medicine
Moscow: IVF Department of Sechenov Medical Academia; Medical Center for ART; Medical Center ‘The Medicine’; Center for Family Planning and Reproduction; IVF Department, Center for Infertility Treatment ‘IVF’; Center ‘Lera’; Medical clinic of reproduction ‘MAMA’; Clinic of reproduction ‘Test tube baby’; Medical Center for Infertility Treatment ‘Embryon’
Nignekamsk: Center for Family Planning and Reproduction, IVF Department
Nigny Novgorod: Center for Family Planning and Reproduction
Novokuzneck: Zone Center of perinatology
Novosibirsk: Medical Center ‘Avicenna’
Rostov-Don: Center of Human Reproducton and IVF
Samara: Medical Company ‘IDK’
Saratov: Region Center for Family Planning and Reproduction
St Petersburg: International Center for Reproductive Medicine; Ob/Gyn Ott Institute; Center for Family Planning, Pushkinsky District; Russian Finnish Medical Center ‘AVA-Peter’; Baltic Institute of Human Reproductology
Tomsk: The Siberian Institute of Human Reproduction
Tumen: Center for Reproductive Medicine ‘Mercury’; Medical Center ‘Malysh’
Cheboksary: Republican Center for Family Planning and Reproduction, Ministry of Health Chuvashia Republic

Slovenia

Ljubljana: Department of Obstetrics and Gynecology, Medical Centre Ljubljana
Maribor: Department of Reproductive Medecine and Gynecologic Endocrinology, Hospital Maribor
Postojna: Centre for Infertility Treatment, Hospital Postojna

Spain

Albacete: Complejo Hospitalario de Albacete
Alicante: Clínica Vista Hermosa de Alicante, Insituto Bernabeu
America: IVI Almería
Badajoz: IERA (Clínica Ginecológica González Carrera)
Barcelona: CIRH (Centro de Infertilidad y Reproducción Humana, Dr Brassesco), Cetre Medic Fuster, FECUNMED, Hospital Clínico, Instituto Dexeus
Canarias: Centro FIV Ángela Palumbo
Cordoba: Clinica BAU
Granada: Hospital Virgen de las Nieves, Clínica Sanabria
Guipuzcoa: Policlínica de Gipozkoa
La Rioja: Hospital San Millán-San Pedro de Logroño, Centro Ginecológico Manzanera
Madrid: Fundación Jiménez Díaz, Hospital Maternal de La Paz; IVI Madrid; GINEFIV Madrid; FIV Madrid; Clínica Tambre; URH García del Real; Centro de Reproducción Humana; Centro Ginecológico Sojo; Hospital Madrid-Montepríncipe; Inst. Ginec. y Med Reprod. Dres Ordás y Palomo, Hospital Santa Cristina
Malaga: Centro de Reproducción Asistida de Marbella
Mallorca: Instituto Balear de Infertilidad; Fundación Hospital de Manacor
Menorca: Hospital Verge del Toro
Murcia: IVI Murcia
Toledo: Hospital Virgen de la Salud
Oviedo: CEFIVA, Hospital Central de Asturias
Valencia: IVI Valencia; Hospital La Fe; IMER
Vizcaya: Hospital de Cruces de Barakaldo; Hospital de Galdakao; Clinica Euskalduna
Zaragoza: Hospital Miguel Servet; Clínica Quirón; Clínica Montpellier

Sweden

Falun: IVF unit, Falun Hospital
Göteborg: Fertility center, Carlanderska Hospital, Sahlgrenska University Hospital
Linköping: IVF unit, Linköping University Hospital
Malmö: Curakliniken, Öresundskliniken
Stockholm: IVF Stockholm; St Görans Hospital; IVF unit, Huddinge University Hospital; IVF unit, Sophiahemmet; Lucinakliniken; Reproductive Medicine Center, Karolinska Univerity Hospital
Umeå: IVF unit, Norrlands Universitetssjukhus
Uppsala: Carl von Linne Kliniken; Reproduktionscentrum, Academic Hospital
Örebro: IVF unit, Örebro University Hospital

Switzerland

Baden: Reproduktionsmedizinisches Zentrum Kantonsspital
Basel: IVF-ICSI Zenter Institut Dr Viollier; Universitäts-Frauenklinik, Abteilung für gynäkologische Endokrinologie und Reproduktionsmedizin
Bellinzona: ProCrea, Centro Fertilità della Svizzera Italiana
Bern: Lindenhofspital, IVF-Labor; Universitätsfrauenklinik, Abteilung für Gynäkologie, IVF und Reproduktionsmedizin, Inselspital
Frauenfeld-Kreuzlingen: IVF Zenter ILAMED
Genève: Centre Privé de Procréation Médicalement assistée de la Clinique de Champel Elysée; Hôpital Universitaire, Clinique et Policlinique de Stérilité et d'Endocrinologie Gynécologique
Lausanne: CHUV, Unité de Médecine de la Reproduction et d'Endocrinologie Gynécologique; Centre Vanderlick-Montchoisi; Centre de Procréation Médicalement Assistée: Dr J.Dequesne
Locarno: Centro Cantonale di Infertilità, Servizio di Endocrinologia Ginecologica
Luzern: Kantonalspital, Sterilitätssprechstunde  Frauenklinik, IVF-ICSI Labor
Schaffhausen-Zürich: Zentrum für Reproduktionsmedizin, Dr P.Fehr, Dr Singer
Winterthur: Dr R.Köppel
Zollikerberg: IVF Zürich
Zürich: Universitätsspital, Klinik für Endocrinologie

UK

Aberdeen: University of Aberdeen
Airdrie: Lanarkshire Acute Hospital NHS Trust
Aldridge: Midland Fertility Services
Bath: Bath Assisted Conception Clinic
Belfast: Regional Fertility Centre, Belfast
Birmingham: Birmingham Women's Hospital; BMI Priory Hospital
Bishop Auckland: Bishop Auckland General Hospital
Brentwood: Brentwood Fertility Centre
Bristol: BUPA Hospital Bristol (now closed); Centre for Reproductive Medicine, University of Bristol; New Life Centre; Obstetrics and Gynaecology (Clinical Science at South Bristol); Southmead Hospital
Buckhurst Hill: Essex Fertility Centre
Burton Upon Trent: Burton Hospitals NHS Trust
Cambridge: Bourn Hall Clinic; The Rosie Hospital
Canterbury: BMI The Chaucer Hospital
Cardiff: Cardiff Assisted Reproduction Unit
Colchester: Isis Fertility Centre
Coventry: Centre for Reproductive Medicine, Coventry
Darlington: Cromwell IVF and Fertility Centre, Darlington
Derby: Derby City General Hospital
Dorchester: The Winterbourne Hospital
Dundee: Ninewells Hospital
Eastbourne: Eperance Private Hospital
Edinburgh: Edinburgh Assisted Conception Unit; Western General Hospital NHS Trust (now closed)
Exeter: Peninsular Centre for Reproductive Medicine
Gateshead: Centre for Assisted Reproduction, Gateshead
Glasgow: BMI Ross Hall Hospital (now closed); Glasgow Nuffield Hospital, Glasgow Royal Infirmary
Goreleston on Sea: Subfertility Unit, James Paget Healthcare NHS Trust
Great Missenden: The Chiltern Hospital Fertility Services Unit
Hartlepool: Hartlepool General Hospital
Hull: Hull IVF Unit
Ilford: North East London Fertility Services
Isleworth: West Middlesex University Hospital (now closed)
Leeds: Assisted Conception Unit, St James’ University Hospital-Leeds; Clarendon Wing-Leeds
Leicester: Leicester Royal Infirmary; Middle England Fertility Centre (now closed)
Liverpool: Hewitt Centre for Reproductive Medicine; University Hospital Aintree (now closed)
London: Assisted Conception Unit, King's College Hospital; Assisted Reproduction and Gynaecology Centre; Barts and the London Fertility Centre; Chelsea & Westminster Hospital; Cromwell IVF and Fertility Centre; Diana, Princess of Wales Centre for Reproductive Medicine (now closed); Guys Hospital; Homerton University Hospital; London Female and Male Fertility Centre; London Fertility Centre; London Women's Clinic/Hallam Medical Centre; Louis Hughes; Newham General; Reproductive Medicine Unit-UCL Hospitals NHS Trust; Seymour Clinic (now closed); Shirley Oaks Hospital; The Bridge Centre; The Hammersmith Hospital; The Harley Street Fertility Centre; The Lister Fertility Clinic; The Portland Hospital Fertility Unit (now closed); University College Hospital London
Maidstone: Maidstone Fertility Centre (now closed)
Manchester: CARE Manchester; Manchester Fertility Services Ltd; Salford Royal IVF and Fertility Centre (now closed); St Mary's Hospital
Middlesbrough: Cleveland Gynaecology and Fertility Centre; The James Cook University Hospital
Neath: Neath General Hospital
Newcastle under Lyme: ACU, Lifestyle Sandy Lane Clinic
Newcastle Upon Tyne: Newcastle Fertility Centre at Life
Northampton: CARE Northampton
Nottingham: CARE Nottingham; NURTURE; Queens Medical Centre Fertility Unit
Orpington: BMI Chelsfield Park ACU
Oxford: Oxford Fertility Unit
Peterborough: The Fertility Unit, Peterborough District Hospital
Plymouth: South West Centre for Reproductive Medicine
Sheffield: CARE at The Sheffield Fertility Centre; Centre for Reproductive Medicine and Fertility, Sheffield
Shrewsbury: Shropshire and Mid-Wales Fertility Centre
Southampton: The Princess Anne Hospital Fertility Unit; Wessex Fertility Limited
Sunderland: Sunderland Fertility Centre
Swansea: Cromwell IVF and Fertility Centre, Swansea
Watford: Watford General Hospital
Wexham: Willow Suite, Thames Valley Nuffield Hospital
Wigan: Billinge Hospital
Wirral: CARE Wirral
Woking: The Woking Nuffield Hospital
Wolverhampton: St Jude's Clinic for Fertility & Gynaecology; Wolverhampton Assisted Conception Unit (now closed)

Ukraine

Donetsk: Donetsk Regional Centre for Maternity and Child Care; Isida-Don IVF; Ukrainian–French Medical Centre of human reproductive function
Kharkyv: Center for Reproductive Medicine ‘Implant’
Kyiv: Institute of Genetic Reproduction; Institute of Reproductive Medicine; Isida IVF
Odessa: Center for Reproductive Medicine REMEDI
Simferopyl: Regional Center for Family Planning and Human Reproduction


    Notes
 
1EIM Committee: Chairman, K.G.Nygren; co-ordinator, A. Nyboe Andersen; member L.Gianaroli, R.Felberbaum and J.de Mouzon. See Appendix for contributing centres and contact persons representing the data collection programmes in the participating European countries. Back

2Address for correspondence: ESHRE Central Office, Meerstraat 60, B-1852 Grimbergen, Belgium.bruno.vandeneede{at}eshre.com Back


    References
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Comments
 Appendix I. Contact persons...
 List of participating...
 References
 
ASRM/SART Registry (2004) Assisted reproductive technology in the United States: 2000 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril 81, 1207–1220.[CrossRef][ISI][Medline]

ESHRE (2001a) The European IVF-monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1997. Results generated from European registers by ESHRE. Hum Reprod 16, 384–391.[Abstract/Free Full Text]

ESHRE (2001b) The European IVF monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1998. Results generated from European Registers by ESHRE. Hum Reprod 16, 2459–2471.[Abstract/Free Full Text]

ESHRE (2002) The European IVF monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1999. Results generated from European Registers by ESHRE. Hum Reprod 17, 3260–3274.[Abstract/Free Full Text]

ESHRE (2004) The European IVF monitoring programme (EIM), for the European Sociaty of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2000. Results generated from European Registers by ESHRE. Hum Reprod 19, 490–503.[Abstract/Free Full Text]

World Health Organization (2002) In Vayena E, Rowe PJ, and Griffin PD (eds) Current practise and Controversies in Assisted Reproduction 2002. pp. 19–22. World Health Organization, Geneva.

Submitted on December 13, 2004; accepted on December 21, 2004.