Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE
Report prepared by A Nyboe Andersen, L.Gianaroli, R. Felberbaum, J. de Mouzon and K.G.Nygren
The European IVF-monitoring programme (EIM)
, for the European Society of Human Reproduction and Embryology (ESHRE)1,2
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Abstract
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European results of assisted reproductive techniques from treatments initiated during 2001 are presented in this fifth report. Data were collected mainly from already existing national registers. From 23 countries, 579 clinics reported 289 690 cycles with: IVF 120 946, ICSI 114 378, frozen embryo transfer (FER) 47 195 and egg donation (ED) 7171. Overall this represents a 4% increase since the year 2000. For the first time, results on European data on intra-uterine inseminations (IUIs) were reported from 15 countries. A total of 67 124 cycles [IUI husband'sperm (IUI-H) 52 949 and IUI donor sperm (IUI-D) 14 185] were included. In 12 countries where all clinics reported to the register, a total of 108 910 cycles were performed in a population of 131.4 million, corresponding to 829 cycles per million inhabitants. For IVF, the clinical pregnancy rate per aspiration and per transfer was 25.1 and 29.0%, respectively. For ICSI, the corresponding rates were 26.2 and 28.3%. These figures are similar to the results from 2000. After IUI-H, the clinical pregnancy rate was 12.8% in women <40 and 9.7% in women
40 years of age. After IVF and ICSI, the distribution of transfer of one, two, three and
4 embryos was 12.0, 51.7, 30.8 and 5.5%, respectively. Compared with the year 2000, fewer embryos were transferred, but huge differences existed between countries. The distribution of singleton, twin and triplet deliveries for IVF and ICSI combined was 74.5, 24.0 and 1.5%, respectively. This gives a total multiple delivery rate of 25.5%, compared with 26.9% in the year 2000. The range of triplet deliveries after IVF and ICSI differed from 0.0 to 8.2% between countries. After IUI-H in women <40 years of age, 10.2% were twin and 1.1% were triplet gestations.
Key words:
Europe/ICSI/IUI/IVF/register data
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Introduction
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This report is the fifth annual ESHRE publication on European data on assisted reproduction technology (ART). The four previous reports, also published in Human Reproduction (ESHRE, 2001a
,b
, 2002
, 2004
), covered treatment cycles during 1997, 1998, 1999 and 2000.
Data have been collected from 23 European countries and cover IVF, ICSI, frozen embryo replacements (FERs), egg donations (EDs) and preimplantation genetic diagnosis (PGD) initiated during 2001. Additionally, for 2001, data on intra-uterine inseminations with husband semen (IUI-H) or donor semen (IUI-D) were also included from 15 countries. The number of clinics reporting IUI data may differ from the number of clinics presenting data on the in vitro techniques.
Data from each participating country are sent to ESHRE once a year. A draft report is made and then scrutinized by all consortium members, listed at the end of this paper.
A fourth Consortium meeting was held at the ESHRE meeting in Berlin in July 2004 with representatives from participating countries, where the present and future reporting systems were discussed. Here it was noted that Germany reported a marked increase in the coverage in their register. Austria and the Chez Republic would not be able to provide data for 2001. The consortium stressed that efforts should be made to include the Balkan countries and have better coverage in east Europe.
The consortium noted that the quality of data still differs between countries. Data collection systems, coverage, definitions and validation are different. At the Madrid Consortium meeting in 2003, it was decided that the EIM Consortium members should adapt to the definitions published in the WHO report (World Health Organization, 2002
). These definitions have also been adopted by ICMART (The International Committee on the Monitoring of ART) as well as WHO, ESHRE, IFFS and ASRM/SART. Some countries have been able to adjust the 2001 data sent to ESHRE to these definitions.
The consortium decided to continue to present annual reports and to try to improve the quality of the reports.
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Materials and methods
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National registers
A total of 15 countries already had existing data collection programmes for 2001, and therefore provided data directly from these sources. In Bulgaria, Greece, Ireland, Italy, Latvia, Poland, Slovenia and the Ukraine, where no such register existed, national data were collected de novo for the purpose of the EIM programme. Details regarding the registers have been described previously (ESHRE, 2001a
).
Data collection
The present report summarizes data from IVF treatments started during 2001. The data include treatments from IVF, ICSI, ED, FER, IUI-H and IUI-D performed from January 1, 2001 to December 31, 2001. Follow-up data on pregnancies and deliveries are cohort data. For IUI, only pregnancies, and not deliveries, were recorded.
Registers from a number of countries have been unable to provide some of the data. Lack of such specific variables will appear in the tables as not available (NA).
The reporting principle used for 2001 data is basically similar to preceding years (ESHRE, 2001a
,b
, 2002
, 2004
).
As the data presented here are incomplete and generated through different methods using different definitions in different countries, interpretation of the data must be done with some caution.
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Results
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Number of treatment cycles
Table I shows the number of all treatment cycles recorded in each country, the number of clinics in the country (if available) and the number of clinics reporting to the register. The cycles are subdivided into IVF, ICSI, FER and ED. In France and Iceland, the number of aspirations was used, as the number of initiated cycles was not available. Similarly the number of transfers rather than the number of thawings was used in Bulgaria and The Netherlands. In total, 579 clinics from 23 countries reported 289 690 cycles.
Table II shows data from those 12 countries where all clinics have reported to the register: the number of cycles is related to the total population in the country, and the number of infants born after ART is expressed as a percentage of the total number of live born in the country. Overall, 108 910 cycles were undertaken in a population of 131.4 million, giving a mean of 829 cycles per million. The percentage of infants born after ART ranged from 0.2 to 3.9%.
Size of the clinics
Table III shows the size distribution of the 579 reporting clinics. The size of a clinic (or unit) is based on all cycles performed per year. The size of the clinics is only related to the number of treatments with the in vitro techniques.
Age distribution
Table IV shows the age distribution of those women treated with IVF or ICSI in various countries.
Number of embryos transferred
Table V shows the number of embryos transferred after IVF and ICSI combined. The total number of single embryo transfers was 20 940 (12.0%), dual embryo transfers 90 364 (51.7%), triple embryo transfers 53 885 (30.8%) and
4 embryo transfers 9637 (5.5%). As indicated in the table, large differences were seen between countries. The range of triple embryo transfers was 2.149.8% and the range of transfer of
4 embryos was 0.052.0%.
Elective single embryo transfer (eSET) was only reported from France and from one clinic in Slovenia. The data from France indicated eSET in 1128 of 34 267 (3.3%) fresh IVF/ICSI transfers.
Pregnancies and deliveries after treatment
Table VIIX show the number of pregnancies and deliveries in relation to the number of initiated cycles, aspirations and transfers, for IVF (Table VI), ICSI (Table VII), FER (Table VIII) and ED (Table IX).
Table VI shows that after IVF, the 27 102 pregnancies resulted from 107 823 aspirations and 93 482 embryo transfers. Thus, the mean clinical pregnancy rate was 25.1% per aspiration and 29.0% per embryo transfer. The latter figure ranged from 20.4 to 36.9% between countries. The delivery rates per embryo transfer after IVF have not been summarized due to incomplete follow-up of pregnancies in many countries, as shown in Table X.
Table VII shows that after ICSI, the 27 156 pregnancies resulted from 103 538 aspirations and 95 919 transfers. Thus the mean clinical pregnancy rate was 26.2% per aspiration and 28.3% per embryo transfer. The latter figure ranged from 10.9 to 57.7%. The delivery rates per embryo transfer after ICSI have not been summarized due to incomplete follow-up of pregnancies in many countries, as shown in Table X.
Table VIII shows that after FER, 6821 pregnancies resulted from 41 583 transfers. Thus the mean clinical pregnancy rate per embryo transfer after FER was 16.4%. The delivery rates per embryo transfer after FER have not been summarized due to incomplete follow-up of pregnancies in many countries, as shown in Table XI.
Table IX shows that after ED, 2197 clinical pregnancies resulted from 6580 embryo transfers, giving a pregnancy rate per transfer of 33.4%, with a range from 17.2 to 50.4%. The delivery rates per embryo transfer after ED have not been summarized due to incomplete follow-up of pregnancies in many countries.
Singleton, twin, triplet and quadruplet deliveries
Table X shows the deliveries after IVF and ICSI in relation to singleton, twin and triplet deliveries. It is seen that the distribution of the deliveries was: singleton 27 920 (74.5%), twin 8975 (24.0%) and triplet 570 (1.5%). Quadruplets occurred in seven cases in 2001.
Table XI shows the deliveries after FER in relation to singleton, twin and triplet deliveries. It is seen that the distribution of the deliveries was: singleton 4060 (84.3%), twin 715 (14.8%) and triplet 39 (0.8%). No quadruplets occurred after FER in 2001.
Risks and fetal reductions
Table XII presents the incidence of ovarian hyperstimulation syndrome (OHSS) recorded from registers in 20 of the 23 countries. It is seen that 1851 cases of OHSS were recorded. The number of IVF and ICSI cycles in those 20 countries was 204 147, corresponding to a risk of OHSS of 0.9% of all stimulated cycles. Other complications are seen in the table.
Table XII also gives data on the number of recorded fetal reductions. In total, 397 fetal reductions were recorded.
One parameter of excellence, defined as the number of pregnancies per embryo transferred or the number of embryos replaced for each pregnancy, can be calculated. After IVF and ICSI, 21 countries replaced 401 871 embryos and this resulted in 54 258 pregnancies. The number of embryos transferred for each pregnancy was thus 7.4%.
Another parameter of excellence could be the number of singleton deliveries per transfer. After IVF and ICSI, 22 countries reported 27 920 singleton deliveries after 178 142 transfers. The singleton delivery rate per transfer was thus 15.7%. Considering this figure, it is important to know that a number of pregnancies are lost to follow-up, so the true singleton delivery rate remains unknown.
PGD was recorded in 10 countries: Belgium, Denmark, Finland, Greece, Hungary, Italy, Portugal, Russia, Spain and the UK. A total of 1145 aspirations and 859 transfers resulted in 218 pregnancies and 161 deliveries. This gives a clinical pregnancy rate of 25.3% and a delivery rate of 19.0% per transfer. The major countries were Italy, Belgium and Spain with 366, 321 and 309 aspirations, respectively.
Intra-uterine inseminations
Table XIII gives data on IUI-H divided into female age groups <40 years (upper panel) and
40 years (lower panel). For France, Hungary and Norway, no stratification for age was available, and the overall results are included in the group below 40 years of age.
It is seen that in women below 40 years of age, 50 912 treatments resulted in 6500 pregnancies, giving a pregnancy rate per procedure of 12.8%. In women at
40 years, the corresponding figures were 2027, 196 and 9.7%.
In women below 40 years of age, singleton, twin and triplet pregnancies accounted for 88.5, 10.2 and 1.1% of the pregnancies, respectively. In women above 40, the corresponding figures were 96.1, 3.8 and 0.0%.
Table XIV gives data on IUI-D divided into female age groups <40 years (upper panel) and
40 years (lower panel). For France, Hungary and Norway, no stratification for age was available, and the overall results are included in the group below 40 years of age.
It is seen that in women below 40 years of age, 12 811 treatments resulted in 2197 pregnancies, giving a pregnancy rate per insemination of 17.1%. In women at
40 years, the corresponding figures were 1374, 110 and 8.0%.
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Comments
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The present report is the fifth consecutive European report on IVF data covering treatment cycles from 1997, 1998, 1999, 2000 and 2001, respectively.
The number of countries reporting to the EIM's consortium and contributing to the fifth report has increased from 22 to 23, covering the whole of Western Europe with the exception of Austria who is due to join next year, and Luxembourg where there is no IVF clinic. In Eastern Europe, the Czech Republic who participated previously, was unable to provide data for 2001.
Twelve of the participating countries had a complete coverage in their reporting system: Belgium, Denmark, Finland, Hungary, Iceland, Latvia, Norway, Slovenia, Sweden, Switzerland, The Netherlands and the UK. For 2001,
10 000 cycle were missing from France. These data did not become available to the EIM in time for inclusion. Germany, the largest contributor to the EIM, with >70 000 cycles in 2001, is now very close to having complete coverage of all clinics in the country.
The number of reported cycles continues to grow. For this year, 579 clinics reported 289 690 cycles, which is an increase of 4% compared with 2000. As an estimated 10 000 cycles from France were missing for this year, the increase could have been similar to earlier years where it ranged from 8 to 14%. During the 5 year period of EIM reporting, the number of cycles has increased from 203 893 in 1997 to 289 690 in 2001, equivalent to an overall increase of 41%. This marked increase during the period is partly due to a better coverage in the reporting systems, but is also due to a true expansion of activities in some countries.
Within Europe, the largest contribution came from Germany with 72 000 cycles, followed by France with 54 000 cycles and the UK with 35 000 reported cycles. For comparison, the ASRM/SART registry reported 99 989 cycles from the USA in 2000 (ASRM/SART, 2004
).
In southern Europe, a number of countries have a low coverage, with 47 out of 182 (Spain), 59 out of 115 (Italy) and seven out of 46 (Greece) clinics reporting to the EIM.
The availability of services remained highest in Denmark with 1923 cycles per million inhabitants. It was also high in the other Nordic countries and in The Netherlands. The average number of treatment cycles per million inhabitants in those countries with complete coverage in their reporting was 829. The proportion of IVF children to all children born was again highest in the Nordic countries, but also very high in Slovenia.
The proportion of ICSI versus standard IVF procedures increased from 44% in 2000 to 49% in 2001 but, as indicated in Table I, there are many countries where ICSI is much more prevalent than IVF.
The number of embryos transferred in IVF and ICSI cycles differed substantially between countries, but there is a clear trend during the years towards transfer of fewer embryos. The mean number of single embryo transfers remained at
12%, whereas the proportion of two embryo transfers increased from 39.2% in 1999 to 46.6% in 2000 and to 51.7% in 2001. The proportion of three embryo transfers decreased from 39.6% in 1999 to 33.3% in 2000 and to 30.8% in 2001. Four embryo transfers also decreased from 9.3% in 1999 to 6.9% in 2000 and to 5.5% in 2001. Seven countries have completely abandoned transfer of four embryos.
The overall occurrence of multiple deliveries after IVF and ICSI was 25.5% in 2001 compared with 26.9% in 2000. During the 5 year period of the EIM, the most remarkable finding regarding multiples was that the incidence of triplet deliveries has been reduced from 3.6% in 1997, to 2.3% in 1998, 2.3% in 1999, 1.9% in 2000 and now to 1.5% in 2001. However, regarding triplet rates, huge differences still exist between countries. Regarding the multiple rates, the number of fetal reductions should also be considered. A total of 397 procedures were performed, the largest number being in Spain (93), France (80) and the UK (87).
Pregnancy rates for IVF, ICSI and FER remained fairly stable in 2001, compared with earlier years. For IVF, the mean pregnancy rate per transfer was 29.0% compared with 28.4% in 2000. For ICSI, this was 28.3% compared with 28.7% in 2000. For FER, the mean pregnancy rate was 16.4% compared with 16.5% in 2000. The figures from Europe remain lower than in the USA, where 62 881 IVF/ICSI retrievals in 2000 resulted in 22 567 pregnancies (35.9%). In the USA, however, multiple births occurred in 35.4% of all deliveries (ASRM/SART, 2004
).
One other possible way to report the success rate would be to report on singleton delivery rates, separately. At the present stage, where delivery rates are somewhat uncertain in many countries, we have only given an estimated overall figure of 15.8% singleton deliveries per transfer after IVF and ICSI.
Alternative ways of presenting the success rate within a single parameter of excellence was the number of fresh embryos replaced for each pregnancy. This figure was 7.4% in 2001, which is an improvement from 8.2% in 2000.
Altogether 882 embryo transfers after PGD were reported, compared with 543 in 2000 and 131 in 1999, suggesting an expansion of this activity in the coming years.
For the first time, the fifth report includes European data on 52 939 treatments with IUI-H and 14 185 treatments with IUI-D. The coverage of IUI activities is probably much less comprehensive than was seen regarding the in vitro techniques.
In women below 40 years of age, the pregancy rate was 12.8% for IUI-H and 17.1% for IUI-D. In women at
40 years, the corresponding figures were 9.7 and 8.0%.
After IUI-H in women below 40 years of age, twin pregnancies occurred in only 10.2% and triplet pregnancies in 1.1%. After IUI-D in women below 40, twin pregnancies occurred in 9.4% and triplet pregnancies in 1.2% of the cases. The data suggest that the twinning rates are less that half that is found with the in vitro techniques, and that the triplet rates are also lower.
To summarize, the present fifth ESHRE report on ART for Europe in 2001 shows a continuing expansion of the register regarding participating clinics, countries and number of cycles reported. The pregnancy rates per treatments remain fairly stable, but fewer embryos are transferred. The twinning rate remains stable, but the triplet rates have been reduced markedly from 3.6% in 1997 to 1.5% in 2001. eSET still had a minimal overall impact in 2001. Multiple gestations seem to be much less frequent after IUI-H and IUI-D compared with IVF and ICSI
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Appendix I. Contact persons representing data collection programmes in participating European countries, 2001
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- Belgium: Petra De Sutter, Infertility Center, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium. E-mail: petra.desutter{at}gent.be
- Bulgaria: Professor Stanimir Kyurkchiev, Institute of Biology and Immunology of Reproduction, Molecular Immunology, 73 Tzartgradsico shosse, 1113 Sofia, Bulgaria. E-mail: kyurkch{at}hotmail.com
- Denmark: Karin Erb, The Fertility Clinic, Odense University Hospital, DK-5000 Odense, Denmark. E-mail: karin.erb{at}ouh.fyns-amt.dk
- Finland: Mika Gissler, Stakes, Stakes Information. PO Box 220, 00531 Helsinki, Finland. E-mail: mika.gissler{at}stakes.fi
- France: Jacques De Mouzon, INSERM U 292, Hôpital de Bicêtre, 78 rue du Général Leclerc, F-75252, Kremlin Bicêtre, France. E-mail: demouzon{at}vjf.inserm.fr
- Germany: Ricardo Felberbaum, Med. Universität, Ratzenburger Allee 160, D-23538 Lübeck, Germany. E-mail: rfelberbau{at}netscape.net
- Greece: Basil C.Tarlatzis, Infertility and IVF Centre, Geniki Kliniki, 2 Gravias Street, GR-54645 Thessaloniki, Greece. E-mail: tarlatzis{at}hol.gr
- Hungary: Janos Urbancsek, 1st Department of Obstetrics and Gynaecology, SOTE, Baross utca 27, H-1088 Budapest, Hungary. E-mail: Urbjan{at}Noi1.sote.hu
- Iceland: Hilmar Bjorgvinsson. IVF Unit, Department of Obstetrics and Gynecology, Natiaonal University Hospital. Landspitalinn, Reykjavik 101, Iceland. E-mail: Hilmar{at}rsp.is
- Ireland (Republic of): Dr Robert Harrison, Human Assisted Reproduction Ireland Rotunda Hospital, RCSI Department of OB/GYN, Master's House, Parnell Square, Dublin 1, Ireland. E-mail: rfharrison{at}rcsi.ie
- Italy: Anna Pia Ferraretti, SISM s.r.l., Via Mazzini 12, I-40137 Bologna, Italy. E-mail: anna.ferraretti{at}sismer.it
- Latvia: Not available.
- The Netherlands: Jan A.M.Kremer, Department of Obstetrics and Gynaecology, A.Z.Nijmegen (St. Radboud), Geert Grooteplein 10, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands. E-mail: j.kremer{at}obgyn.azn.nl
- Norway: Johan T.Hazehamp, Department of Reproductive Medicine, Volvat Medical Center, Postboks 5280, Majorstuea, Oslo 303, Norway. E-mail: Hazekamp{at}online.no
- Poland: Waldermar Kuczynski, University Hospital, SP Szpital, Department of Gynecology, MC Sklodowskiej 24 a, 15-276 Bialystok, Poland. E-mail: kuczynsk{at}cksr.ac.bialystok.pl
- Portugal: Carlos Calhaz-Jorge. Human Reproduction Unit, Department of Obstetrics and Gynecology, Hopital de Santa Maria, Av. Prof. Equs Monitz, 1649-028 Lisboa, Portugal. E-mail: Calhazjorge{at}mail.telepac.pt
- Russia: V.S.Korsak, IVF Centre, Ott Institute, Mendeleyevskay linia 3, 199034 St-Petersburg, Russia CIS. E-mail: ivf{at}mcrm.ru
- Slovenia: Irma-Virant Klun, University Medical Centre Ljubljana, Department of Obstetrics and Gynecology, Ljubljana, Slovenia. E-mail: Irma.virant{at}kclj.sl
- Spain: Juana Hernandez, Department of Obstetrics and Gynaecology, Hospital San Milan, Avda. Autonoma de la Rioja 3, 26004 Logrono-La Rioja. Spain. E-mail: jhernandezh{at}meditex.es
- Sweden: P.O.Karlstroem, Department of Obstetrics and Gynaecology, 72189 Vesteraas, Sweden. E-mail: pok.red{at}swipnet.se
- Switzerland: Constanzo Limoni, Via Ceresio 6, 6826 Riva San Vitale, Switzerland. E-mail: alpha5{at}bluewin.ch
- UK: Richard Baranowski, Deputy Information Manager, Human Fertilization and Embryology Authority (HFEA), Bloomsbury Street, London WC1B 3HF, UK. E-mail: richard.baranowski{at}hfea.gov.uk
- Ukraine: Victor Veselovsky, Clinic Isida IVF, 28/1 Chornovilla Str. Kyiv, 01135, Ukraine. E-mail: 6vvv{at}isidaivf.com.ua
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List of participating centresEIM data collection 2001
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Belgium
- Antwerpen: Algemeen ziekenhuis Middelheim; Universitair ziekenhuis Antwerpen; AZ St.-Camillus/St.-Augustinus Wilrijk
- Brugge: Algemeen ziekenhuis Sint-Jan
- Brussel/Bruxelles: Institut médical Edith Cavell; Academisch ziekenhuis VUB; Hôpital universitaire St-Pierre; Hôpital Erasme
- Charleroi: Clinique Notre-Dame
- Genk: St-Jansziekenhuis
- Gent: Universitair ziekenhuis Gent; Algemeen ziekenhuis Jan Palfijn; Algemeen ziekenhuis St.-Lucas
- Kortrijk: Sint-Niklaaskliniek
- Leuven: Universitair ziekenhuis Gasthuisberg; Leuven Institute for Fertility and Embryology
- Liège: Clinique St Vincent Rocourt; Hôpital de la Citadelle
- Mont-sur-Sambre: Centre de PMA Sainte Thérèse
- Namur: Centre Hospitalier régional de Namur
- Roeselare: Heilig Hartziekenhuis
- Vilvoorde: Van Helmontziekenhuis
Bulgaria
- Sofia: ObGy Hospital Dr Shterev
- Sofia: IVF Department, 1st ObGy Hospital St Sofia
- Varna: Medical Centre Olimed
Denmark
- Aalborg: Fertilitetsklinikken Aalborg
- Aarhus: Ciconia Vest; Fertilitetsklinikken Skejby Sygehus; Maigaards Fertilitetsklinik
- Brædstup: Fertilitetsklinikken Brædstrup Sygehus
- Copenhagen: Ciconia Øst; Dansk Fertilitetsklinik; Fertilitetsklinikken Helsehuset; Fertilitetsklinikken Herlev Sygehus; Fertilitetsklinikken Hvidovre Hospital; Fertilitetsklinikken Rigshospitalet; Fertilitetsklinikken Trianglen; Gentofte Fertilitetsklinik; Speciallæge praksis, Lygten
- Holbæk: Fertilitetsklinikken Holbæk Sygehus
- Horsens: Horsens Fertilitetsklinik
- Odense: Fertilitetsklinikken Odense Universitetshospital; Odense IVF-Klinik
- Skive: Fertilitetsklinikken Skive Sygehus; Klinik for Kvindesygdomme og graviditet
Finland
- Helsinki: Diacor; Eira Hospital; Family Federation of Finland Helsinki; Felicitas; Fertinova; Helsinki University Central Hospital
- Joensuu: Northern Carelia Central Hospital
- Jyväskylä: In-Tiimi Jyväskylä
- Kuopio: In-Tiimi Kuopio; Kuopio University Central Hospital
- Lappeenranta: Fermedi
- Oulu: Family Federation of Finland Oulu; Oulu University Central Hospital
- Tampere: AVA Tampere; Tampere University Central Hospital
- Turku: AVA Turku; Family Federation of Finland Turku; Turku University Central Hospital
France
- Amiens: Centre Picard; CHU; CHR
- Aubervilliers: La Roseraie
- Avignon: Urbain V
- Bagnolet: La Dhuys
- Bayonne: Lafargue
- Besancon: CHU; Franche-Comté
- Blanc Mesnil: Clinique
- Bois-Guillaume: Saint Antoine
- Bondy: Jean Verdier
- Bordeaux: Pellegrin Fédération
- Brest: CHU; Pasteur
- Bruges: Jean Villar
- Caen: CHRU
- Cayenne: CHG
- Chambray-Les-Tours: Parc Clinique
- Charleville-Mezieres: CH
- Clamart: Antoine Béclère
- Clermont-Ferrand: CHU
- Cormeilles en Parisis: Clinique
- Courbevoie: CH-La Défense
- Dijon: CHR
- Dreux: CH
- Epinal: Arc en Ciel
- Equeudreville: Cotentin
- Grenoble: Belledonne; CHU
- Guilherand Granges: Pasteur
- Le Chesnay: Parly II
- Le Havre: CH
- Le Mans: Tertre Rouge
- Le Port: Jeanne d'Arc
- Lille: Polyclinique Du Bois; Jeanne De Flandres
- Limoges: CHRU
- Lorient: CH
- Lyon Bron: Ste Marie-Thérèse
- Lyon: Edouard Herriot; Montplaisir; Tonkin
- Marseille: Conception; Saint Joseph; IMR
- Martinique-Fort De France: Sainte Marie
- Metz: Sainte Croix
- Montpellier CHU; Saint Roch
- Mulhouse: Diaconat
- Nancy: A Pinard; Majorelle
- Nantes: CHU; ND De Grâce; St Herblain/Atlantique
- Neuilly: Chérest; Hôpital Américain
- Nice: CHU; Saint Georges
- Nimes CHRU
- Paris: Bichat; Cochin; Diaconesses; Les Bluets; La Muette; Montsouris; Pitié Salpétrière; Saint Vincent De Paul; Tenon
- Paulagrange
- Perigueux: Francheville
- Perpignan: Saint Pierre
- Poissy: CHI
- Poitiers: CHU
- Reims: CHU; Courlancy
- Rennes: CHRU Sud; La Sagesse
- Roanne: CH
- Rouen: CHU
- Saint Etienne: Michelet
- Saint-Jean: L'Union et le Vaurais
- Saint-Saulve: Le Parc
- Schiltigheim: CMCO
- Sevres: J.Rostand
- Toulon: Saint Michel
- Toulouse: CHU
- Toulouse: Saint Jean Languedoc
- Tours: CHU
- Vitry Sur Seine: Les Noriets
Germany
- Aachen: Frauenarztpraxis mit Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin an der Itertalklinik, Dr med. K.-M.Grunwald; Universitäts-Frauenklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, Medizinische Fakultät der RWTH Aachen, Prof. Dr med. J.Neulen
- Aalen: IVF-Zentrum Aalen, Dr med. Rainer Rau
- Augsburg: VF-Zentrum Augsburg, Gemeinschaftspraxis, Dr med. Dr rer. nat. Warnecke, Dr med. K.-F.Hiller, Dr med. T.H.Bauer, Dr med. H.Kraus
- Bad Münder: Zentrum für IVF und Reproduktionsmedizin, Deutsche Klinik Bad Münder, Drs Bispink, Chandra, Kast, Braulke, Schneider
- Bayreuth: IVF-Zentrum Bayreuth im Klinikum Bayreuth, Gemeinschaftspraxis Dr med. S.Todorow, Dr med. E.Schwarz
- Bedburg/Erft: Dr med. Dieter Struller, Facharzt für Frauenheilkunde und Geburtshilfe
- Berlin: Charité, Campus Virchow-Klinikum, Klinik für Frauenheilkunde und Geburtshilfe, Reproduktionsmedizin, Dr med. B.Pfüller, Dr med. A.Jantke, Dr H.Schmiady; Dr med. Matthias Bloechle, Dr med. Silke Marr; Dr med. M.Zaghloul-Abu Dakah, Kinderwunsch- und Privatpraxis; Fertility Center Berlin, Prof. Dr med. H.Kentenich, Dr med. G.Stief, Dr med. A.Tandler-Schneider; Gemeinschaftspraxis Drs med. A.Haase/P.Rott; Gemeinschaftspraxis im Lützow Center, Reproduktionsmedizinisches Zentrum, Dr med. Detlef H.G.Temme, Dr med. Rolf Metzger; Praxisklinik für Fertilität, Dr med. David J.Peet, Dr med. Peter Sydow, Dr med. Carmen Sydow; Praxis Dr med. Reinhard Hannen; Universitätsklinikum der Humboldt-Universität zu Berlin, Charité Campus Mitte, Klinik für Frauenheilkunde und Geburtshilfe, Abteilung für Reproduktionsmedizin und Endokrinologie, Dr med. B.Pfüller, Dr med. I.Scheiber
- Bielefeld: Bielefeld Fertility-Center, Gemeinschaftspraxis Paul A.Ebert, Dr med. Karl Völklein; BIF-Bielefelder Institut für Fortpflanzungsmedizin der Städtischen Kliniken Bielefeld-Rosenhöhe, Leitung: Dr med. Beate Harms
- Bonn: Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsklinikum Bonn, Prof. Dr med. Hans H.van der Ven; Praxisklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, PD Dr med. Gernot Prietl
- Bremen: Bremer Zentrum für Fortpflanzungsmedizin (BZF) in der Frauenklinik des Ev. Diakonie-Krankenhauses gGmbH, Prof. Dr Ernst Heinrich Schmidt, Dr Olaf Drost; Zentrum für Kinderwunschbehandlung Bremen, Dr A.von Stutterheim, Dr C.Clasing
- Cottbus: Carl-Thiem-Klinikum Cottbus, Bereich Reproduktionsmedizin und Gynäkologische Endokrinologie, Prof. Dr med. H.-H.Riedel
- Darmstadt: Reproduktionsmedizinisches und Endometriose Zentrum Darmstadt, Frauenklinik des Klinikum Darmstadt, Prof. Dr G.Leyendecker
- Deggendorf: Gemeinschaftspraxis Drs Kroiss und Bernhardt
- Dortmund: Gemeinschaftspraxis Drs med. S.Dieterle/A.Neuer
- Dresden: Praxis Dr med. H.J.Held; Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Prof. Dr med. W.Distler, Dr rer. nat. G.Keck
- Düsseldorf: Gemeinschaftspraxis Dr (B) Hugo Verhoeven, Dr med. Michael Scholtes, Dipl.-med. Kersten Marx, Dr med. Martina Behler, Dr med. Manfred Schulte; Städt. Kliniken Düsseldorf gGmbH, Frauenklinik Benrath, Abteilung für Reproduktionsmedizin und Gynäkologische Endokrinologie, Prof. Dr G.Freundl, Dr C.Gnoth, Dipl. Biol. E.Halbe; Universitätsfrauenklinik der Heinrich-Heine-Universität-Düsseldorf, Prof. Dr H.G.Bender
- Erlangen: Dr J.van Uem; Gemeinschaftspraxis der Frauenärzte Prof. Dr Dr K.-G.Bregulla, Dr M.Hamori, Dr R.Behrens; Universitätsfrauenklinik Erlangen, Prof. Dr med. Ludwig Wildt
- Essen: Gemeinschaftspraxis Dr med. Thomas Katzorke, Dr med. Dirk Propping, Dr med. Susanne Wohlers
- Esslingen: IVF-Zentrum Esslingen, Dr med. J.E.Costea
- Frankfurt/Main: IVF Zentrum Frankfurt, Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin, Universitäts Frauenklinik; Krankenhaus Nordwest, Frauenklinik/Zentrum für Reproduktionsmedizin, Prof. Dr E.Merz, Dr M.Amroni/Frau Dr S.Schuh
- Freiburg: Frauenklinik der Albert-Ludwigs-Universität, PD Dr med. C.Keck; Gemeinschaftspraxis Dr Weitzell, Dr M.Thiemann, Prof. Dr F.Geisthövel
- Gelsenkirchen: Schwerpunkt Kinderwunschtherapie, Wissenschaftspark Gelsenkirchen, Dr med. Ute Czeromin, Dr med. Ina Walter-Göbel
- Gie
en: Arbeitsgruppe Endokrinologie, Fortpflanzungsmedizin und Mikrochirurgie der Justus-Liebig-Universität, Prof. Dr W.Künzel, Prof. Dr W.Weidner; Gesellschaft zur Förderung der In-Vitro-Fertilisation und Reproduktionsmedizin GbR, Prof. Dr Gips
- Göttingen: Dr Monica Tobler, Fachärztin für Frauenheilkunde und Geburtshilfe; Georg-August-Universität, Klinik für Gynäkologie und Geburtshilfe, Prof. Dr med. Dr Bernd Hinney; Gemeinschaftspraxis, Dr Peter Böhm, Dr Sabine Hübner, Dr Rüdiger Moltrecht, Dr Christine Noeldechen, Dr Stephanie Mittmann
- Greifswald: Ernst-Moritz-Arndt-Universität, Frauen- und Poliklinik, Dr S.Möller
- Grevenbroich: Gemeinschaftspraxis Dr Tigges, Dr Kaiser, Dr Tuchel
- Haan: Gynäkologisch-Geburtshilfliche Abteilung für Gynäkologische Endokrino-logie/Reproduktionsmedizin, St Josef Krankenhaus GmbH, Dr med. Thomas Bremen, Dr rer. nat. Uwe Weidner
- Halle/Saale: Martin-Luther-Universität Halle-Wittenberg, Klinik und Poliklinik für Geburtshilfe und Reproduktionsmedizin, Prof. Dr med. habil. F.Röpke, Dr med. Petra Kaltwasser, Dr rer. nat. E. Seliger
- Hamburg: Fertility Center Hamburg; Gemeinschaftspraxis Bispink, Horn, Michel und Seeler; Praxisgemeinschaft Hinrichsen u. Partner GbR am Endokrinologikum Hamburg; Praxis BKS, Prof. Dr med. H.G.Bohnet, PD Dr med. U.A.Knuth, PD Dr med. M.A.Graf; Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin, Prof. Dr W.Braendle; Zentrum für Fertilitätsmedizin Kocak und Kollegen, Dr Semsettin Kocak
- Hannover: Frauenklinik der MHH am Oststadtkrankenhaus, Prof. Dr H.W.Schlösser; Gynäkologische Gemeinschaftspraxis, Dr M.Müseler-Albers, H.P.Arendt, Dr K.Bühler
- Heidelberg: Kinderwunschzentrum Heidelberg, Drs Maletz-Kehry, Parta, Hinderer,Tesarz; Universitätsklinikum Heidelberg, Abteilung für Gynäkologische Endokrinologie und Fertilisationsstörungen, Kinderwunsch-Sprechstunde, Prof. Dr T.Strowitzki, Dr Daniela Seehaus
- Hildesheim: Zentrum für Reproduktionsmedizin und Humangenetik Hildesheim, Dr F.-J.Algermissen, Dr P.F.Justus, Dr G.Wilke, Dr N.Graf
- Homburg: Universitätskliniken des Saarlandes, Frauenklinik und Poliklinik, Prof. Dr Drs h.c. mult. W.Schmidt, Dr P.Rosenbaum, Dr H.E.Hammadeh, Dr C.Clauèen, Dr K.Laufs, Dr D.Tigges
- Jena: Klinikum der FSU Jena, Klinik für Frauenheilkunde und Geburtshilfe, PD Dr med. W.Starker, Dr. rer. nat. I. Hoppe; Gemeinschaftspraxis Fritzsche-Reiher-Hoffmann
- Karlsruhe: Karlsruher IVF-Programm, Dr V.Wetzel, H.J.Gräber, E.Wetzel, Dr F.Tetens, Dr G.Zoulek
- Kiel: Universitäts-Frauenklinik der Christian-Albrechts-Universität Kiel, Prof. Dr med. L.Mettler, Dr med. A.Schmutzler
- Köln: Krankenhaus Porz am Rhein, Frauenklinik, Prof. Dr K.-H.Broer; PAN Klinik am Neumarkt, Dr S.Palm, Dr V.Sasse, Dr I.Pütz; Universitäts-Frauenklinik Köln, OA Dr Frank Nawroth
- Leipzig: Praxisklinik Reproduktionsmedizin und Gynäkologische Endokrinologie, Dr med. F.A.Hmeidan, Dr med. P.Jogschies, Dr med. A.Gabert; Universitätsfrauenklinik, Zentrum für Reproduktionsmedizin und Gynäkologische Endokrinologie, Prof. Dr med. H.Alexander
- Lübeck: Universitätsklinikum Lübeck, Klinik für Frauenheilkunde und Geburtshilfe
- Magdeburg: Klinik für Reproduktionsmedizin und Gynäkologische Endokrinologie, Otto-von-Guericke-Universität Magdeburg, Prof. Dr med. J.Kleinstein, Dr med. I.Nickel
- Marburg: Klinik für Gynäkologie, Gynäkologische Endokrinologie und Onkologie der Philipps-Universität Marburg, Prof. Dr Klaus-Dieter Schulz, Dr med. Karin Bock
- Mannheim: Universitätsfrauenklinik, Klinikum Mannheim gGmbH, Prof. Dr F.Melchert, PD Dr M.Weigel
- Minden: Gemeinschaftspraxis Dr med. Onno Buurman, Dr med. Michael Dumschat, Dr (YU) Akram El Harake, Fachärzte für Frauenheilkunde
- Mönchengladbach: Gemeinschaftspraxis Dr med. Georg Döhmen, Dr med. Thomas Schalk
- Mühlheim a. d. Ruhr: Ev. Krankenhaus Mühlheim an der Ruhr, Frauenklinik und Zentrum für Reproduktionsmedizin, Prof. Dr H.von Matthiessen
- München: Hormonzentrum München, PD Dr med. A. ömmler, Dr med. H Lacher, Dr med. J.Puchta, Dr med. M.Conrad; Kinderwunsch Centrum München an der Frauenklinik Dr Wilhelm Krüsmann, Gynäkologische Endokrinologie und Sterilitätsmedizin, Dr med. Klaus Fiedler, Dr med. Irene von Hertwig, Dr med. Gottfried Krüsmann, Prof. Dr med. Wolfgang Würfel; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Klinikum der Universität München-Grosshadern, Prof. Dr med. C.J.Thaler, Prof. Dr med. H.Hepp; Prof. Dr med. Dieter Berg, Dr med. Bernd Lesoine; Zentrum für Reproduktionsmedizin, Dr med. Walter Bollmann, Dr med. Thomas Brückner, Dr med. Ulrich Noss
- Münster: Gemeinschaftspraxis Dr Dr med. Lutz Belkien, PD Dr med. Bernd Krause; Universitätsklinikum Münster, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Dr med. Robert B.Greb, Prof. Dr Ludwig Kiesel; Institut für Reproduktionsmedizin, Prof. Dr med. Eberhard Nieschlag
- Neubrandenburg: Dietrich Bonhoeffer Klinikum Neubrandenburg; Klinik für Frauenheilkunde und Geburtshilfe, Prof. Dr med. R.Sudik
- Neuwied: Gemeinschaftspraxis Dr Beran und Dr Müller
- Nürnberg: Reproduktionsmedizinische Praxis Dr med. J.Neuwinger und Dr med. B.Munzer-Neuwinger
- Oldenburg: Dr med. Saif Jibril; Tagesklinik Oldenburg, Dr med. Jörg Hennefründ, Dr med. Heike Ochs-Ring, Dr med. Michael Heeder
- Osnabrück: Kinderwunschzentrum Osnabrück, Drs med. Irene Coordes, Doris Proffen, Manfred Schneider
- Pforzheim: Zentrum für Reproduktionsmedizin in der Centralklinik, Dr med. R.-P.Stein
- Prien am Chiemsee: Priener Zentrum für Reproduktionsmedizin, Dr med. Mathias Lehnert, PD Dr Dr med. Rainer Steldinger, Dr med. Susann Böhm, Dr med. (Univ. Izmir) Cenan Cevatli, Dr med. Wolfgang Lehnert
- Regensburg: Zentrum für Gynäkologische Endokrinologie und Reproduktionsmedizin, Prof. Dr med. Bernd Seifert, PD Dr med. Monika Bals-Pratsch, Dr med. Ute Hehr
- Remscheid: Gynäkologische Endokrinologie und Reproduktionsmedizin am Klinikum Remscheid
- Rostock: Universitäts-Frauenklinik Rostock, Reproduktionsmedizin, PD Dr med. H.Müller, Dr med. S.Hansch
- Saarbrücken: Dr med. Jens Happel, Dr med. Michael Thaele, Dr med. Lars Happel
- Schwäbisch Gmünd: Klinikum Schwäbisch Gmünd; Margariten Hospital, Geburtshilfe/Fortpflanzungsmedizin
- Schwerin: Medizinisches Zentrum der Landeshauptstadt Schwerin, Klinikum Schwerin, Prof. Dr med. E.Petri, Dr F.Thielemann
- Stuttgart: Dr. med. Fred Maleika; Praxis Dr D.B.Mayer-Eichberger; IVF-Zentrum, Univ.-Prof. Dr med. Ute Fuchs
- Tübingen: Universitätsklinikum Tübingen, Frauenklinik; Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin, PD Dr P.Licht, Dr R. Emig
- Ulm: IVF-Zentrum Ulm, Dr. med. Friedrich Gagsteiger, Prof. Dr med. Karl Sterzik; Universitätsklinikum Ulm, Zentrum für Reproduktionsmedizin und Gynäkologische Endokrinologie, Prof. Dr C.Brucker
- Wiesbaden: Zentrum für Reproduktionsmedizin, Dr med. Th.Hahn, Dr. med. M. Schorsch
- Würzburg: Dr med. R.Mai, Dr. med. Wolfgang Schmitt; Universitäts-Frauenklinik Würzburg, Prof. Dr T.Steck
Greece
- Athens: Fertility Institute, Center for Human Reproduction; Iatriki Erevna; IVF and Genetics; Neogenesis IVF Center; IVF Center Euromedica
- Thessaloniki: Infertility & IVF Center, Geniki Kliniki
Hungary
- Budapest: 1st Department of OB/GYN, Semmelweis University of Medicine; Department of OB/GYN, Jahn Ferenc Hospital; Department of OB/GYN, Nyiro Gyula Hospital; Department of OB/GYN, St John's Hospital, Kaali Institute, Devai Institute, Forgacs Institute
- Debrecen: Department of OB/GYN, Debrecen University of Medicine
- Gy
r: Kaali Institute
- Pécs: Department of OB/GYN, Pécs University of Medicine
- Szeged: Kaali Institute
- Tapolca: Pannon Institute for Reproduction
Iceland
- Reykjavik: IVF Unit, Department of. OB/GYN, National University Hospital, Landspitali
Ireland (Republic of)
- Clane: Assisted Conception Unit, Clane General Hospital
- Dublin: HARI Unit (Human Assisted Reproduction Ireland), Rotunda Hospital
- Galway: Galway Fertility Unit, University College Hospital
Italy
- Abano Terme (PD): Casa di Cura Abano Terme-Centro Ripr. Assistita
- Ancona: Ospedale Salesi
- Bari: Clinica S. Maria; Studio Medico San Luca; Studio Associato CECOS; University of Bari
- Bergamo: Ospedali Riuniti
- Bologna: SISMER; Tecnobios
- Bolzano: Ospedale di Bolzano
- Brescia: Istituto Citta di Brescia
- Bressanone (BZ): Ospedale di Bressanone
- Brunico (BZ): Ospedale di Brunico
- Cagliari: Ospedale Regionale Microcitemie
- Caserta: Centro Genesis
- Castellana Grotte: IRCCS
- Catania: CRA
- Fermo (AP): Istituto Palmatea
- Firenze: Universitá di Firenze
- Fossano (CN): Ospedale di Fossano
- Genova: Universitá di Genova
- Lecce: Centro Studi Riproduzione Umana
- Messina: Centro di Riproduzione Umana
- Mestre (VE): ARC-STER
- Milano: Fondazione S.Raffaele del Monte Tabor; Polo Universitario S.Paolo; Centro Cerva
- Modena: Universitá di Modena e Reggio Emilia
- Monza (MI): Centro di Medicina della Riproduzione Biogenesi
- Motta di Livenza (TV): Ospedale di Motta di Livenza
- Napoli: Centro Mediterraneo di Fecondazione Assistita; BDR
- Nardo' (LE): Tecnomed
- Padova: Studio Gemma; Euganea Medica
- Palermo: Centro Andros; Centro di Biologia della Riproduzione
- Parma: CIR Universitá di Parma
- Pesaro: Centro Salus
- Pescara: Villa Serena
- Pieve di Cadore (BL): Ospedale Civile
- Pisa: Casa di Cura S. Rossore; Universitá di Pisa
- Pordenone: Ospedale S.M. degli Angeli
- Roma: European Hospital; Centro RAPRUI; Universitá La Sapienza; CIPA
- Rozzano (MI): Istituto Clinico Humanitas
- Salerno: CMR
- Sassari: Universitá di Sassari
- Sora (FR): Centro STS
- Torino: Centro LIVET; Ospedale S.Anna; ARTES; Centro Diagnosi e Cura dell'Infertilitá di Coppia
- Varese: Centro Diagnostico Varesino
- Verona: Policlinico Borgoroma
Latvia
- Not available
The Netherlands
- Amsterdam: Academisch Medisch Centrum, Vrije Universiteit Medisch Centrum
- Eindhoven: Catharina Ziekenhuis
- Groningen: Academisch Ziekenhuis Groningen
- Leiden: Leids Universitair Medisch Centrum, Stichting Medisch Centrum voor Geboorteregeling
- Maastrict: Academisch Ziekenhuis Maastricht
- Nijmegen: Universitair Medisch Centrum St Radboud
- Rotterdam: Academisch Ziekenhuis Rotterdam
- Tilburg: St Elisabeth Ziekenhuis
- Utrecht: Universitair Medisch Centrum
- Voorburg: Reiner de Graaf Groep
- Zwolle: Isala Klinieken
Norway
- Bergen: Kvinneklinikken Helse-Bergen, Haukeland Sykehus
- Haugesund: Haugesund Sjukehus Helse Fonna
- Oslo: Fertilitetssenteret Omnia; Rikshospitalet; Ullevål
- Universitetssykehus; Volvat Medisinske Senter
- Trondheim: St Olavs Hospital HF
- Tromsø: Universitetssykehuset I Nord-Norge HF
Poland
- Bialystok: Department of Gynecology, Medical Academy of Bialystok; Center for Reproductive Medicine Kriobank
- Bytom: 1st Chair and Clinic of OB/GYN, Silesian Medical Academy
- Lodz: Gameta Fertility Center
- Lublin: AB OVO, NZOZ Centrum Zdrowia Rodziny
- Poznan: Division of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences; Clinic of Infertility Intermedica
- Szczecin: Clinic for Reproduction and Gynecology, Pomeranian Medical University
- Warsaw: 1st Deptartment of Gynecology and Obstetrics, University Hospital Warsaw; Private Infertility Clinic Novum; Private Gynaecological Clinic of Reproduction Germen
Portugal
- Guimarães: Hospital N.S. da Oliveira
- Lisboa: Ava Clinic; CLINDIGO; Hospital de Santa Maria; Maternidade Dr Alfredo da Costa
- Oporto: Centro de Genética Prof. Alberto Barros; CETI; Maternidade Júlio Dinis
- Vila Nova de Gaia: Centro Hospitalar
Russia
- Astrakhan: Center for Family Planning and Reproduction
- Voroneg: Region Center for Family Planning and Reproduction, IVF Department
- Vladivostok: Medical Center for IVF Santa Maria
- Vladikavkaz: Region Center for Family Planning and Reproduction
- Ekaterinburg: Center of Family Medicine, Center for rehabilitation of infringements of reproductive function
- Krasnoyarsk: Center for Reproductive Medicine
- Moscow: IVF Department of Sechenov Medical Academia; Medical Center for ART; Medical Center The Medicine; Center for Family Planning and Reproduction; IVF Department, Center for Infertility Treatment IVF; Center Lera; Medical clinic of reproduction MAMA; Clinic of reproduction Test tube baby; Medical Center for Infertility Treatment Embryon
- Nignekamsk: Center for Family Planning and Reproduction, IVF Department
- Nigny Novgorod: Center for Family Planning and Reproduction
- Novokuzneck: Zone Center of perinatology
- Novosibirsk: Medical Center Avicenna
- Rostov-Don: Center of Human Reproducton and IVF
- Samara: Medical Company IDK
- Saratov: Region Center for Family Planning and Reproduction
- St Petersburg: International Center for Reproductive Medicine; Ob/Gyn Ott Institute; Center for Family Planning, Pushkinsky District; Russian Finnish Medical Center AVA-Peter; Baltic Institute of Human Reproductology
- Tomsk: The Siberian Institute of Human Reproduction
- Tumen: Center for Reproductive Medicine Mercury; Medical Center Malysh
- Cheboksary: Republican Center for Family Planning and Reproduction, Ministry of Health Chuvashia Republic
Slovenia
- Ljubljana: Department of Obstetrics and Gynecology, Medical Centre Ljubljana
- Maribor: Department of Reproductive Medecine and Gynecologic Endocrinology, Hospital Maribor
- Postojna: Centre for Infertility Treatment, Hospital Postojna
Spain
- Albacete: Complejo Hospitalario de Albacete
- Alicante: Clínica Vista Hermosa de Alicante, Insituto Bernabeu
- America: IVI Almería
- Badajoz: IERA (Clínica Ginecológica González Carrera)
- Barcelona: CIRH (Centro de Infertilidad y Reproducción Humana, Dr Brassesco), Cetre Medic Fuster, FECUNMED, Hospital Clínico, Instituto Dexeus
- Canarias: Centro FIV Ángela Palumbo
- Cordoba: Clinica BAU
- Granada: Hospital Virgen de las Nieves, Clínica Sanabria
- Guipuzcoa: Policlínica de Gipozkoa
- La Rioja: Hospital San Millán-San Pedro de Logroño, Centro Ginecológico Manzanera
- Madrid: Fundación Jiménez Díaz, Hospital Maternal de La Paz; IVI Madrid; GINEFIV Madrid; FIV Madrid; Clínica Tambre; URH García del Real; Centro de Reproducción Humana; Centro Ginecológico Sojo; Hospital Madrid-Montepríncipe; Inst. Ginec. y Med Reprod. Dres Ordás y Palomo, Hospital Santa Cristina
- Malaga: Centro de Reproducción Asistida de Marbella
- Mallorca: Instituto Balear de Infertilidad; Fundación Hospital de Manacor
- Menorca: Hospital Verge del Toro
- Murcia: IVI Murcia
- Toledo: Hospital Virgen de la Salud
- Oviedo: CEFIVA, Hospital Central de Asturias
- Valencia: IVI Valencia; Hospital La Fe; IMER
- Vizcaya: Hospital de Cruces de Barakaldo; Hospital de Galdakao; Clinica Euskalduna
- Zaragoza: Hospital Miguel Servet; Clínica Quirón; Clínica Montpellier
Sweden
- Falun: IVF unit, Falun Hospital
- Göteborg: Fertility center, Carlanderska Hospital, Sahlgrenska University Hospital
- Linköping: IVF unit, Linköping University Hospital
- Malmö: Curakliniken, Öresundskliniken
- Stockholm: IVF Stockholm; St Görans Hospital; IVF unit, Huddinge University Hospital; IVF unit, Sophiahemmet; Lucinakliniken; Reproductive Medicine Center, Karolinska Univerity Hospital
- Umeå: IVF unit, Norrlands Universitetssjukhus
- Uppsala: Carl von Linne Kliniken; Reproduktionscentrum, Academic Hospital
- Örebro: IVF unit, Örebro University Hospital
Switzerland
- Baden: Reproduktionsmedizinisches Zentrum Kantonsspital
- Basel: IVF-ICSI Zenter Institut Dr Viollier; Universitäts-Frauenklinik, Abteilung für gynäkologische Endokrinologie und Reproduktionsmedizin
- Bellinzona: ProCrea, Centro Fertilità della Svizzera Italiana
- Bern: Lindenhofspital, IVF-Labor; Universitätsfrauenklinik, Abteilung für Gynäkologie, IVF und Reproduktionsmedizin, Inselspital
- Frauenfeld-Kreuzlingen: IVF Zenter ILAMED
- Genève: Centre Privé de Procréation Médicalement assistée de la Clinique de Champel Elysée; Hôpital Universitaire, Clinique et Policlinique de Stérilité et d'Endocrinologie Gynécologique
- Lausanne: CHUV, Unité de Médecine de la Reproduction et d'Endocrinologie Gynécologique; Centre Vanderlick-Montchoisi; Centre de Procréation Médicalement Assistée: Dr J.Dequesne
- Locarno: Centro Cantonale di Infertilità, Servizio di Endocrinologia Ginecologica
- Luzern: Kantonalspital, Sterilitätssprechstunde Frauenklinik, IVF-ICSI Labor
- Schaffhausen-Zürich: Zentrum für Reproduktionsmedizin, Dr P.Fehr, Dr Singer
- Winterthur: Dr R.Köppel
- Zollikerberg: IVF Zürich
- Zürich: Universitätsspital, Klinik für Endocrinologie
UK
- Aberdeen: University of Aberdeen
- Airdrie: Lanarkshire Acute Hospital NHS Trust
- Aldridge: Midland Fertility Services
- Bath: Bath Assisted Conception Clinic
- Belfast: Regional Fertility Centre, Belfast
- Birmingham: Birmingham Women's Hospital; BMI Priory Hospital
- Bishop Auckland: Bishop Auckland General Hospital
- Brentwood: Brentwood Fertility Centre
- Bristol: BUPA Hospital Bristol (now closed); Centre for Reproductive Medicine, University of Bristol; New Life Centre; Obstetrics and Gynaecology (Clinical Science at South Bristol); Southmead Hospital
- Buckhurst Hill: Essex Fertility Centre
- Burton Upon Trent: Burton Hospitals NHS Trust
- Cambridge: Bourn Hall Clinic; The Rosie Hospital
- Canterbury: BMI The Chaucer Hospital
- Cardiff: Cardiff Assisted Reproduction Unit
- Colchester: Isis Fertility Centre
- Coventry: Centre for Reproductive Medicine, Coventry
- Darlington: Cromwell IVF and Fertility Centre, Darlington
- Derby: Derby City General Hospital
- Dorchester: The Winterbourne Hospital
- Dundee: Ninewells Hospital
- Eastbourne: Eperance Private Hospital
- Edinburgh: Edinburgh Assisted Conception Unit; Western General Hospital NHS Trust (now closed)
- Exeter: Peninsular Centre for Reproductive Medicine
- Gateshead: Centre for Assisted Reproduction, Gateshead
- Glasgow: BMI Ross Hall Hospital (now closed); Glasgow Nuffield Hospital, Glasgow Royal Infirmary
- Goreleston on Sea: Subfertility Unit, James Paget Healthcare NHS Trust
- Great Missenden: The Chiltern Hospital Fertility Services Unit
- Hartlepool: Hartlepool General Hospital
- Hull: Hull IVF Unit
- Ilford: North East London Fertility Services
- Isleworth: West Middlesex University Hospital (now closed)
- Leeds: Assisted Conception Unit, St James University Hospital-Leeds; Clarendon Wing-Leeds
- Leicester: Leicester Royal Infirmary; Middle England Fertility Centre (now closed)
- Liverpool: Hewitt Centre for Reproductive Medicine; University Hospital Aintree (now closed)
- London: Assisted Conception Unit, King's College Hospital; Assisted Reproduction and Gynaecology Centre; Barts and the London Fertility Centre; Chelsea & Westminster Hospital; Cromwell IVF and Fertility Centre; Diana, Princess of Wales Centre for Reproductive Medicine (now closed); Guys Hospital; Homerton University Hospital; London Female and Male Fertility Centre; London Fertility Centre; London Women's Clinic/Hallam Medical Centre; Louis Hughes; Newham General; Reproductive Medicine Unit-UCL Hospitals NHS Trust; Seymour Clinic (now closed); Shirley Oaks Hospital; The Bridge Centre; The Hammersmith Hospital; The Harley Street Fertility Centre; The Lister Fertility Clinic; The Portland Hospital Fertility Unit (now closed); University College Hospital London
- Maidstone: Maidstone Fertility Centre (now closed)
- Manchester: CARE Manchester; Manchester Fertility Services Ltd; Salford Royal IVF and Fertility Centre (now closed); St Mary's Hospital
- Middlesbrough: Cleveland Gynaecology and Fertility Centre; The James Cook University Hospital
- Neath: Neath General Hospital
- Newcastle under Lyme: ACU, Lifestyle Sandy Lane Clinic
- Newcastle Upon Tyne: Newcastle Fertility Centre at Life
- Northampton: CARE Northampton
- Nottingham: CARE Nottingham; NURTURE; Queens Medical Centre Fertility Unit
- Orpington: BMI Chelsfield Park ACU
- Oxford: Oxford Fertility Unit
- Peterborough: The Fertility Unit, Peterborough District Hospital
- Plymouth: South West Centre for Reproductive Medicine
- Sheffield: CARE at The Sheffield Fertility Centre; Centre for Reproductive Medicine and Fertility, Sheffield
- Shrewsbury: Shropshire and Mid-Wales Fertility Centre
- Southampton: The Princess Anne Hospital Fertility Unit; Wessex Fertility Limited
- Sunderland: Sunderland Fertility Centre
- Swansea: Cromwell IVF and Fertility Centre, Swansea
- Watford: Watford General Hospital
- Wexham: Willow Suite, Thames Valley Nuffield Hospital
- Wigan: Billinge Hospital
- Wirral: CARE Wirral
- Woking: The Woking Nuffield Hospital
- Wolverhampton: St Jude's Clinic for Fertility & Gynaecology; Wolverhampton Assisted Conception Unit (now closed)
Ukraine
- Donetsk: Donetsk Regional Centre for Maternity and Child Care; Isida-Don IVF; UkrainianFrench Medical Centre of human reproductive function
- Kharkyv: Center for Reproductive Medicine Implant
- Kyiv: Institute of Genetic Reproduction; Institute of Reproductive Medicine; Isida IVF
- Odessa: Center for Reproductive Medicine REMEDI
- Simferopyl: Regional Center for Family Planning and Human Reproduction
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Notes
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1EIM Committee: Chairman, K.G.Nygren; co-ordinator, A. Nyboe Andersen; member L.Gianaroli, R.Felberbaum and J.de Mouzon. See Appendix for contributing centres and contact persons representing the data collection programmes in the participating European countries. 
2Address for correspondence: ESHRE Central Office, Meerstraat 60, B-1852 Grimbergen, Belgium.bruno.vandeneede{at}eshre.com 
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References
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ASRM/SART Registry (2004) Assisted reproductive technology in the United States: 2000 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril 81, 12071220.[CrossRef][ISI][Medline]
ESHRE (2001a) The European IVF-monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1997. Results generated from European registers by ESHRE. Hum Reprod 16, 384391.[Abstract/Free Full Text]
ESHRE (2001b) The European IVF monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1998. Results generated from European Registers by ESHRE. Hum Reprod 16, 24592471.[Abstract/Free Full Text]
ESHRE (2002) The European IVF monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1999. Results generated from European Registers by ESHRE. Hum Reprod 17, 32603274.[Abstract/Free Full Text]
ESHRE (2004) The European IVF monitoring programme (EIM), for the European Sociaty of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2000. Results generated from European Registers by ESHRE. Hum Reprod 19, 490503.[Abstract/Free Full Text]
World Health Organization (2002) In Vayena E, Rowe PJ, and Griffin PD (eds) Current practise and Controversies in Assisted Reproduction 2002. pp. 1922. World Health Organization, Geneva.
Submitted on December 13, 2004;
accepted on December 21, 2004.