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Abstract |
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Key words: ESHRE/Europe/ICSI/IVF/register data
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Introduction |
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Data has been collected from 22 European countries and covers IVF, ICSI, frozen embryo replacements (FER) and oocyte donations (OD) initiated during 1999. Data from each participating country is sent to ESHRE yearly. A draft report is made and scrutinized by all consortium members, listed in the Appendix at the end of this paper.
A second Consortium meeting was held at the ESHRE meeting in Vienna in July 2002 with representatives from participating countries, where the present and future reporting system was discussed. Here it was noted that Germany reported a marked increased in the coverage in their register. Belgium, Hungary and Switzerland were planning to advance their registration systems from voluntary, non-governmental registers to mandatory registers run by the authorities. Additionally, it was noted that this year Ireland, Poland, Slovenia and Ukraine have joined the European IVF monitoring programme (EIM). Austria will be able to provide data for the year 2000.
The consortium noted that the quality of data still differs between countries. Data collection systems, coverage, definitions and validation are different. Definitions, as suggested by The International Committee on the Monitoring of ART (ICMART) will soon be published in a World Health Organization (WHO) IVF report. These definitions will be considered for adoption by the consortium.
The Consortium again noted that the data quality needs to be improved in the future. European countries still have different data collection systems with a variable degree of coverage, loss of follow-up and different definitions. The Consortium decided to continue to present annual reports and to try to improve the quality of the reports.
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Materials and methods |
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Data collection
The present report summarizes data from ART treatments started during 1999. The data include treatments from IVF, ICSI, OD and FER performed from January 1, 1999 to December 31, 1999. Follow-up data on pregnancies and deliveries are cohort data.
The data collection programmes vary considerably from one country to another. Registers from a number of countries have been unable to provide some of the data. Lack of such specific variables will appear in the tables as not available (NA).
The reporting principle used for the 1999 data is basically similar to the preceding year (ESHRE, 2001a,b
). The following eight countries reported data from all clinics in the country: Denmark, Finland, France, Iceland, The Netherlands, Norway, Sweden and Switzerland. In 1998 the UK also reported data from all clinics. In 1999 technical problems within the Human Fertilisation and Embryology Authority (HFEA) had the consequence that only data from a proportion of the clinics were incorporated, and some data were not available.
For 1999, the report includes summary data on complications such as ovarian hyperstimulation syndrome (OHSS), infection and bleeding. Furthermore, data on preimplantation genetic diagnosis (PGD) are also available.
In most countries reports of pregnancies are based on the presence of one or more intrauterine gestational sacs at sonography 5 weeks after embryo transfer. In some countries such as Denmark and The Netherlands, only pregnancies with a living fetus are recorded. Deliveries were normally reported within the same reporting system as for treatments and pregnancies. For the present report neither the definitions of pregnancies or births have been standardized.
As the data presented here is incomplete and generated through different methods using different definitions in different countries, interpretation of the data must be done with some caution.
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Results |
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Table VII shows that after ICSI the 21 916 pregnancies resulted from 78 452 embryo transfers. Thus the mean clinical pregnancy rate per embryo transfer was 27.9%, with a range from 18.535.2%. The delivery rates per embryo transfer after ICSI have not been summarized due to incomplete follow-up of pregnancies in many countries, as shown in Table VII
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Table VIII shows that after FER, 4950 pregnancies resulted from 31 482 transfers. Thus the mean clinical pregnancy rate per embryo transfer after FER was 15.7%. The delivery rates per embryo transfer after FER have not been summarized due to incomplete follow-up of pregnancies in many countries.
Table IX shows that after OD 1077 clinical pregnancies resulted from 2802 transfers, giving a pregnancy rate per transfer of 40.0%.
Singleton, twin, triplet and quadruplet deliveries
Table X shows the deliveries after IVF and ICSI in relation to singleton, twin, triplet and quadruplet deliveries. It can be seen that the distribution of the deliveries was: singleton 73.7%, twin 24.0%, triplet 2.2% and quadruplet 0.1%.
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Maternal death
One case of maternal death was recorded.
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Discussion |
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Four new countries have joined the EIMs consortium and contribute to the third report and now 22 countries participate, covering the whole of Western Europe with the exception of Austria (who plan to join next year) and Luxembourg where no IVF clinics exist.
Eight of the participating countries already have complete coverage in their reporting systems: Denmark, Finland, France, Iceland, The Netherlands, Norway, Sweden and Switzerland. Germany has improved its coverage, which is now estimated to include around 90% of the activities in that country. Belgium, Hungary and Switzerland have announced the plan to advance their systems into mandatory registers.
The number of reported cycles continues to grow. This year 538 clinics reported 258 460 cycles, which is an increase of 11% compared with 1998. From 1997 to 1998 the increase was 14%. Altogether this means an increase of 25% from 1997 to 1999. This marked increase over 2 years is partly due to a better coverage in the reporting systems but may also be due to a true expansion of activities in some countries. The latest World Report on IVF data (Adamson et al., 2002) from 1998, recorded 388 000 procedures world-wide, estimated to represent some 80% of all activities. This means that about 60% of recorded IVF activities globally come from Europe.
Within Europe the largest contributions come from Germany with 60 000 cycles followed by France with 52 000 cycles and the UK with 30 000 reported cycles. It should be noted that the figure from the UK is lower compared with previous years due to technical problems in their reporting system.
The proportion of standard IVF procedures to ICSI procedures remains the same this year compared with last year (56.6% standard IVF and 43.4% ICSI), but in some countries such as Belgium, Greece, Italy, Poland, Portugal, Spain and Switzerland ICSI is more prevalent than IVF. The number of FER cycles remained constant whereas the number of OD cycles showed a small decrease.
The availability of services remained highest in Denmark with 1659 cycles per million inhabitants. It was also high in the other Nordic countries, in The Netherlands and in France. The average number of treatment cycles per million inhabitants in those countries with complete coverage in their reporting was a little below 1000. The proportion of IVF children to all children born was again highest in the Nordic countries with Iceland at 3.6%, Denmark 3.2%, Finland 2.7% and Sweden 2.6%.
The number of embryos transferred in IVF and ICSI cycles differed substantially between countries. The mean number of single embryo transfers remained at about 12%, whereas the proportion of dual embryo transfers increased to 39.2% (compared with 37.2% and 35.7% for 1998 and 1997 respectively). The proportion of three embryo transfers was 39.6%, representing a small decrease from the previous year where it was 42.0%. Four embryo transfers or more remained constant at 9.3%. Finland, Sweden and Slovenia reported no embryo transfers of 4, and also a low proportion of three embryo transfers, whereas some other countries still reported very high proportions of
4 embryos transferred.
Pregnancy rates continued to increase slightly. For standard IVF the mean pregnancy rate per transfer was 27.7% (compared with 27.0% for 1998), for ICSI 27.9% (versus 26.8%), for FER cycles 15.7% (versus 14.9%) and for OD cycles 40.0% (versus 30.6% for 1998). Again there were quite large differences between different countries. As an example the pregnancy rate per transfer for IVF cycles varied between 22.742.3%.
Delivery rates showed similar trends but one problem remains: in some countries the lost to follow-up rate for deliveries is quite high. Therefore, delivery rates are less valid when compared with pregnancy rates.
One other possibility for reporting success rates would be to report on singleton delivery rates separately. The consortium plans to do so, as soon as the delivery rates are more valid. If only singleton pregnancies are accepted as a success, only 20% of transfers resulted in a successful outcome.
The occurrence of multiple deliveries did not change from 1998 (26.3%) to 1999 (26.3%). Neither did the twin or the triplet rate change from 1998 to 1999. The triplet rate remained at 2.2% of all deliveries, so the reduction seen from 1997 to 1998 did not continue.
The proportion of singleton deliveries after IVF and ICSI varied between countries within a range of 60.883.3%, twin rates from 10.832.5% and triplet rates from 0.36.4%.
The practice of fetal reduction is very different in different European countries. In some it is quite often practised whereas in others it is not practised at all. The consortium has not, so far, been able to collect reliable data on fetal reductions but is planning to do so in future reports. The proportion of infants (rather than deliveries) for singletons varied from 4279%, for twins between 1944% and for triplets between 0.615%. The proportion of quadruplets was very low.
Alternative ways of presenting success rates for the whole of Europe showed a pregnancy rate of 0.13 per embryo replaced and that 7.8 embryos needed to be replaced to obtain one pregnancy. These calculations include both singleton and multiple pregnancies.
In this report, for the first time, data on OHSS was collected. Data was not available from all countries. From those reporting, the overall proportion of OHSS was close to 1% with a high of 2.7% and a low of 0.3%. Of course various definitions and also various clinical policies make comparisons difficult.
Altogether 131 aspirations were followed by PGD, and of these 19 babies were delivered. It is expected that these activities will expand in the future. Certainly, a proportion of countries perform PGD, that are not reported within the EIM.
To summarize, this third ESHRE report on IVF cycles carried out in 1999 in Europe shows a continuing expansion of the register, both for participating countries, participating clinics and number of cycles reported. Trends are now becoming visible and there is a trend towards better efficacy. The combined multiple pregnancy rate was reduced from 1997 to 1998, but no further reduction was recorded from 1998 to 1999. With new knowledge on the safety of these procedures it becomes increasingly obvious that the proportion of multiple pregnancies is still much too high, although, at present, quite different in different European countries.
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Appendix I. |
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Belgium: Josiane Van Der Elst, Infertility Centre, University Hospital Gent, De Pintelaan 185, B 9000 Gent, Belgium. E-mail: josiane.vanderelst{at}rug.ac.be
Czech Republic: Pavel Ventruba, 1st Dept. of Obstetrics and Gynaecology, Masarik University of Brno, Obilni trh 11, 656 77 Brno, Czech Republic. E-mail: ventruba{at}fp-brno.cz
Denmark: Karin Erb, The Fertility Clinic, Odense University Hospital, DK 5000 Odense, Denmark. E-mail: karin. erb{at}ouh.fyns-amt.dk
Finland: Mika Gissler, Stakes, Stakes information. P.O.Box 220, 00531 Helsinki, Finland. E-mail: mika.gissler{at}stakes.fi
France: Jacques De Mouzon, Inserm U. 292, Hôpital de Bicêtre, 78 rue du Général Leclerc, F 75252, Kremlin Bicêtre, FRANCE. E-mail: demouzon{at}vjf.inserm.fr
Germany: Ricardo Felberbaum, Med. Univ. Ratzenburger Allee 160, D 23538 Lübeck, Germany. E-mail: rfelberbau{at}aol.com
Greece: Basil C.Tarlatzis, Infertility & IVF Centre, Geniki Kliniki, 2 Gravias Street,GR 54645 Thessaloniki, Greece. E-mail: tarlatzis{at}hol.gr
Hungary: Janos Urbancsek, 1st Dept. of Obstetrics and Gynaecology, SOTE, Baross utca 27, H 1088 Budapest, Hungary. E-mail: Urban{at}Noi1.sote.hu
Iceland: Hilmar Bjorgvinsson. IVF Unit, Depart. Obstet Gynecol, Natiaonal University Hospital. Landspitalinn, Reykjavik 101, Iceland. E-mail: Hilmar{at}rsp.is
Ireland: Edgar Mocanu. HARI Unit, Rotunda Hospital, Dublin1, Ireland. E-mail: emocanu{at}rcsi.ie
Italy: Anna Pia Ferraretti, S.I.S.M.E.R. s.r.l., Via Mazzini 12, I 40137 Bologna, Italy. E-mail: sismer{at}sismer.it
The Netherlands: Jan A.M. Kremer, Department of Obstetrics and Gynaecology, University Medical Centre St. Radboud, Nijmegen., Geert Grooteplein 10, P.O. Box 9101, NL 6500 HB Nijmegen, The Netherlands. E-mail: j.kremer{at}obgyn.umcn.nl
Norway: Johan T Hazehamp, Dept. of Reproductive Medicine, Volvat Medical Center, Postboks 5280, Majorstuea, Oslo 303, Norway. E-mail: Hazekamp{at}online.no
Poland: Waldermar Kuczynski, SP Szpital, Dept. Gynecology, MC Sklodowskiej 24 a, 15276 Bialystok, Poland. E-mail: kuczynsk{at}cksr.ac.bialystok.pl
Portugal: Carlos Calhaz-Jorge. Human Reproduction Unit, Dept. Obstet Gynecol, Hopital de Santa Maria, Av. Prof. Equs Monitz, 1649028 Lisboa, Portugal. E-mail: Calhazjorge{at}mail.telepac.pt
Russia: V.S.Korsak, IVF Centre, Ott Institute, Mendeleyevskay linia 3, 199034 St-Petersburg, Russia C.I.S. E-mail: ivf{at}mail.ott.ru
Slovenia: Irma-Virant Klun and Toma Tomaevic, University Medical Centre Ljubljana, Department fo Obstetrics and Gynecology, Ljubljana, Slovenia. E-mail: Irma.virant{at}kclj.si
Spain: Jose Luis Ballesca, Unidad de Repoduction, Hospital Clinic, E-08036 Barcelona, Spain.
Sweden: Per-Olof Karlstrom, Reproductive Center, Deopartment of Obstetrics and Gynecology, Academic Hospital, 751 85 Uppsala, Sweden. E-mail: per-olof. karlstrom{at}kk.uas.lul.se
Switzerland: Constanzo Limoni, Via Ceresio 6, 6826 Riva San Vitale, Switzerland. E-mail: alpha5{at}bluewin.ch
UK: Peter Parker, Human Fertilization and Embryology Authority, Paxton House, 30 Artillery Lane, E1 7LS London, UK. E-mail: Peter.Parker{at}hfea.gov.uk
Ukraine: Victor Veselovsky, Clinic Isida IVF, 28/1 Chornovilla Str. Kyiv, 01135, Ukraine. E-mail: vvv{at}isidaivf.com.ua
List of participating countries and centres
Belgium
Aalst: O.L.V. Ziekenhuis Gynaecologie en Verloskunde
Antwerp: Algemeen Ziekenhuis Middelheim Dienst Fertiliteit
Bonheiden: Imeldaziekenhuis I.V.F. Centrum Bonheiden
Brugge: Academisch Ziekenhuis Sint-Jan BIRTH Fertiliteitskliniek (In cooperation with : Sint-Lucas Ziekenhuis)
Brussels: Akademisch Ziekenhuis V.U.B. Centrum voor Reproductieve Geneeskunde; Centre Hospitalier Interrégional Edith Cavell Centre de Procréation Assistée; Cliniques Universitaires Saint-Luc UCL Unité de FIV; Hôpital Erasme U.L.B.- Centre de FIV Service de Gynécologie; Hôpital Universitaire Saint-Pierre U.L.B Clinique de Procréation Médicalement Assistée
Charleroi: Clinique Notre-Dame, Gynécologie et Obstétrique
Edegem: U.I.A Afdeling voor Infertiliteit
Genk: St.-Jansziekenhuis Centre for Reproductive Medicine
Gent: A.Z. Jan Palfijn Centrum voor Fertiliteitstherapie; Gynaecologisch Centrum; Universitair Ziekenhuis Gent R.U.G. Infertiliteitscentrum Vrouwenkliniek
Kortrijk: Sint-Niklaas Kliniek Fertiliteit, IVF en ET Dienst Gynaecologie
Leuven: Universitair Ziekenhuis Gasthuisberg K.U.L Dienst Gynaecologie; Medical Centre for Fertility IVF en ET
Libramont: Clinique Notre-Dame, Centre dInfertilité
Loverval: Institut de Morphologie Pathologique Laboratoire de F.I.V.
Namur: Centre Hospitalier Régional de Namur
Rocourt (Liège) : Clinique Saint Vincent Centre Liégeois pour lEtude et le Traitement de la Stérilité
Roeselare: Heilig Hartziekenhuis, Gynecologie
Vilvoorde: Van Helmontziekenhuis Fertiliteitscentrum SIMAF
Wilrijk: A.Z. St.-Camillus/St.-Augustinus Infertiliteit
Czech Republic
Brno: CAR 1 Dept. Ob/Gyn, Masaryk University; CAR 2 FN Brno; Laurea, Brno; Repromeda s.r.o.; Sanatorium Helios
eské Bud
jovice: Sanatorium ART
Hradec Králové: CAR SANUS
Olomouc: Fertimed; Palacky University, Department of Ob/Gyn
Ostrava: Gyncentrum
Plze: Dept. Ob/Gyn, Charles University Plzen
Praha: CAR Dept. Ob/Gyn, Charles University; CAR Dept. Ob/Gyn Charles University FN Motol; GEST Praha; ISCARE IVF; Sanatorium Pronata
Denmark
Aalborg: Fertilitetsklinikken Aalborg
Aarhus: Ciconia Vest; Fertilitetsklinikken Skejby Sygehus; Maigaards Fertilitetsklinik
Brædstup: Fertilitetsklinikken Brædstrup Sygehus
Copenhagen: Ciconia Øst; Dansk Fertilitetsklinik; Fertilitetsklinikken Helsehuset; Fertilitetsklinikken Herlev Sygehus; Fertilitetsklinikken Rigshospitalet; Fertilitetsklinikken Trianglen; Fertilitetsklinikken Hamlet
Horsens: Horsens Fertilitetsklinik
Odense: Fertilitetsklinikken Odense Universitetshospital; Odense IVF-Klinik
Skive: Fertilitetsklinikken Skive Sygehus
Finland
Helsinki: Diacor; Eira Hospital; Family Federation of Finland Helsinki; Felicitas; Helsinki University Central Hospital
Joensuu: Northern Carelia Central Hospital
Jyväskylä: Central Finland Central Hospital
Kuopio: In-Tiimi Kuopio; Kuopio University Central Hospital;
Lappeenranta Fermedi: Fermedi (pls note)
Oulu: Family Federation of Finland Oulu; Oulu University Central Hospital
Tampere: AVA Tampere; Tampere University Central Hospital
Turku: AVA Turku; Family Federation of Finland Turku; Koeputki Oy; Turku University Central Hospital
France
Amiens: Centre Picard; CHU
Angers: CHR
Aubervilliers: La Roseraie
Avignon: Urbain V
Bagnolet: La Dhuys
Bayonne: Lafargue
Besancon: CHU; Les Cigognes
Blanc Mesnil; Clinique
Bois-Guillaume: Saint Antoine
Bondy: Jean Verdier
Bordeaux: Pellegrin Fédération; Pellegrin Gynéco Obstétrique A
Brest: CHU; Pasteur
Bruges: Jean Villar
Caen: CHRU
Cayenne: CHG
Charleville-Mezieres: CH
Clamart: Antoine Béclère
Clermont-Ferrand: CHU
Cormeiller en Parisis: Clinique
Courbevoie: CH-La Défense
Dijon: Chenove; CHR
Epinal: Arc en ciel
Equeudreville: Cotentin
Grenoble: Belledonne; CHU
Guadeloupe-Les Abymes : Les Rosiers
Guilherands Granges: Pasteur
Le Chesnay: Parly II
Le Havre: CH
Le Mans: Tertre Rouge
Le Port: Jeanne dArc
Lille: Polyclinique du Bois; Jeanne de Flandres
Limoges: CHRU
Lorient : CH
Lyon Bron: Ste Marie-Thérèse
Lyon: Croix Rousse; Edouard Herriot; Montplaisir; Sainte Anne Lumière
Maisons-Laffitte: Sully
Marseille: Conception; Saint Joseph; Wulfran Puget
Martinique Fort de France: Sainte Marie
Metz: Sainte Croix
Montpellier: CHU; Saint Roch
Mulhouse: Diaconat
Nancy: A Pinard; Majorelle
Nantes: CHU; N.D. de Grâce; St Herblain / Atlantique
Neuilly: Chérest; Hôpital Américain
Nice: CHU; Saint Georges
Nimes: CHRU
Paris: Bichat; Cochin; Diaconesses; Les Bluets; La Muette; Montsouri; Pitié Salpétrière; Saint Vincent de Paul; Spontini; Tenon
Pau: Lagrange
Perigueux: Francheville
Perpignan: Saint Pierre
Poissy: CHI
Poitiers: CHU
Reims: CHU; Courlancy
Rennes: CHRU Sud; La Sagess
Roanne: CH
Rouen: CHU
Saint Etienne: Michelet
Saint-Jean: LUnion et le Vaurais
Saint-Saulve: Le Parc
Schiltigheim: CMCO
Sevres: J. Rostand
Toulon: Saint Michel
Toulouse: CHU; Saint Jean Languedoc
Tours: CHU; Parc Clinique
Vitry sur Seine: Les Noriets
Germany
Aachen: Universitätsklinikum der RWTH Aachen, Frauenklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin; Prof. Dr O. Bauer
Aalen: Dr R. Rau
Augsburg: Gemeinschaftspraxis Dr Warnecke, Dr Hiller, Dr Bauer, Dr Kraus
Bad Münder: Zentrum für IVF und Reproduktionsmedizin, Deutsche Klinik Bad Münder
Bayreuth: Klinikum Bayreuth
Bedburg/Erft: Praxis Dieter Struller
Berlin: Frauenklinik Charité, Abteilung für Endokrinologie und Reproduktionsmedizin; Praxisklinik für Fertilität, Gemeinschaftspraxis Dr D.J.Peet, Dr P.Sydow; Gemeinschaftspraxis Dr med. Detlef H.G.Temme, Dr med. Rolf Metzger; Gemeinschaftspraxis Dr M.Bloechle, Dr S.Marr, Dr G.Wilke; Charité, Med. Fakultät der Humboldt-Universität zu Berlin, Campus Virchow-Klinikum, Klinik für Frauenheilkunde und Geburtshilfe Reproduktionsmedizin; Fertility Center Berlin
Bielefeld: Frauenklinik Städtische Krankenanstalten
Bonn: Rheinische Friedrich-Wilhelms-Universität, Abteilung für
Klinische Endokrinologie und Reproduktionsmedizin
Bremen: Zentrum für Kinderwunschbehandlung; Evangelische Diakonissenanstalt, Klinik für Frauenheilkunde
Darmstadt: Frauenklinik Klinikum Darmstadt
Deggendorf: Institut für Reproduktionsmedizin
Dortmund: Gemeinschaftspraxis Dres. Med. S.Dieterle and A.Neuer
Dresden: Frauenarztpraxis Dr H.J.Held; Universitätsklinik Carl-Gustav-Carus, IVF Abteilung
Düsseldorf: Gemeinschaftspraxis Dr H.C.Verhoeven, Dr med. M.C.W.Scholtes, Dipl.-med. K.Marx, Dr med. M.Schulte; Frauenklinik der Heinrich-Heine-Universität; Krankenhaus Benrath
Erlangen: Gemeinschaftspraxis Prof. Dr Bregulla, Dr Hamori, Dr Behrens; Dr J.van Uem; Universitätsfrauenklinik
Essen: Gemeinschaftspraxis Dr Th. Katzorke, Dr D.Propping, Dr E.Willms; Universitätsklinikum
Esslingen: Partnerschaftsgesellschaft Dr P.Hermann, Dr J.E.Costea, und Partner; Städtische Frauenklinik
Frankfurt a. M.: Krankenhaus Nordwest
Freiburg: Gemeinschaftspraxis Dr Weitzell, Dr Thiemann, Prof. Dr F.Geisthövel; IVF-Ambulanz der Universitäts-Frauenklinik Freiburg
Gelsenkirchen: Wissenschaftsark Gelsenkirchen, Schwerpunkt Kinderwunschtherapie
Gießen: Gesellschaft zur Förderung der In-Vitro-Fertilisation und Reproduktionsmedizin GbR; Arbeitsgruppe Endokrino- logie, Fortpflanzungsmed. und Mikrochirurgie der Justus-Liebig-Universität
Göttingen: Frauenklinik Georg-August-Universität; Kinderwunschzentrum
Grevenbroich: Gemeinschaftspraxis Dr Kaiser, Dr Tigges, Dr Tuchel
Halle/Saale: Klinikum Kröllwitz, Klinik und Poliklinik für Geburtshilfe und Reproduktionsmedizin
Hamburg: Fertility Center Hamburg, Gemeinschaftspraxis Fischer, Naether, Rudolf; Universitätskrankenhaus Eppendorf, Klinik für Frauenheilkunde; Gemeinschaftspraxis Prof. Dr H.G.Bohnet, PD Dr U.A.Knuth; Gemeinschaftspraxis Dres. Leidenberger, Weise, Hinrichsen,
Graf and Partner GbR; Gemeinschaftspraxis Dr G.Bispink, Dr A.Horn, Dr Michel, Dr Seeler
Hannover: Frauenklinik der MHH am Oststadtkrankenhaus; Gynäkologische Gemeinschaftspraxis Dr K.Bühler, Dr Müseler-Albers, Dr H.P.Arendt
Heidelberg: Ruprecht-Karls-Universität, Gyn. Endokrinologie und Fertilitätsstörungen; Arbeitsgruppe Fortpflanzungsmedizin
Hildesheim: Gemeinschaftspraxis Dr F.-J.Algermissen, Dr P.F.Justus, Dr G.Wilke
Homburg: Universitätskliniken des Saarlandes, Frauenklinik und Poliklinik
Jena: Gemeinschaftspraxis PD Dr H.Fritzsche, Prof. Dr E.Günther
Karlsruhe: Karlsruher IVF-Programm, AG für Fortpflanzungsmedizin, Praxis Dr V.Wetzel
Kiel: Klinik für Gynäkologie der Christian-Albrechts-Universität zu Kiel
Köln: PAN Klinik am Neumarkt; Klinik für Frauenheilkunde und Geburtshilfe der Universitätsklinik zu Köln
Leipzig: Gemeinschaftspraxis Dres. F.A.Hmeidan, P.Jogschies, A.Gabert; Universitätsfrauenklinik Leipzig, Abteilung Reproduktionsmedizin
Lübeck: Universitätsklinikum Lübeck, Klinik für Frauenheilkunde und Geburtshilfe
Magdeburg: Klinik für Reproduktionsmedizin und Gyn. Endokrinologie
Mannheim: Universitätsfrauenklinik GmbH, Klinikum Mannheim
Marburg: Zentrum für Frauenheilkunde und Geburtshilfe Klinikum der Philipps-Universität
Minden: Dr O.P.Happel, Dr O.Buurman, Fachärzte für Frauenheilkunde
Mönchengladbach: Gemeinschaftspraxis Dr D.Döhmen, Dr Thomas Schalk
Mülheim: Evangelisches Krankenhaus, Klinik für Frauenheilkunde
München: Gemeinschaftspraxis Dr W.Bollmann, Dr Th.Brückner, Dr U.Noss, Dr M.Roemisch, Prof. Dr W.Albrich; Gemeinschaftspraxis Prof. Dr med. H.-K.Rjosk, PD Dr, med. A.Römmler, Dr med. H.Lacher, Frauenärzte; Frauenklinik Dr Krüsmann, IVF-Zentrum; Klinikum der Universität München-Großhadern, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
Münster: Dr L.D.Belkien; Klinik und Poliklinik für Geburtshilfe und Frauenheilkunde und des Instituts f. Reproduktionsmedizin des Zentrums für Frauenheilkunde Westf. Wilhelms-Universität, Bereich für Assistierte Reproduktionsmedizin
Mutlangen: Stauferklinik Schwäbisch-Gmünd
Neubrandenburg: Klinikum Neubrandenburg, Klinik für Frauenheilkunde und Geburtshilfe
Neuwied: Dr J.Beran
Oldenburg: Tagesklinik Dr E.Dewitt; Dr J.Hennefründ, Dr Ochs-Ring; Dr med. Saif Jibril
Osnabrück: Gemeinschaftspraxis Dr W. von der Burg, Dr I.Coordes
Pforzheim: Zentrum f. Reproduktionsmedizin in d. Zentralklinik
Prien: Gemeinschaftspraxis Dr M.Lehnert, PD Dr R.Steldinger
Regensburg: Gemeinschaftspraxis Dr med. A.F.Liebl, Prof. Dr med. B.Seifert
Remscheid: Gynäkologische Endokrinologie und Reproduktionsmedizin am Klinikum Dr Johannes Luckhaus
Rostock: Frauenklinik Rostock, Med. Fakultät der Universität
Saarbrücken: Gemeinschaftspraxis Dr J.Happel, Dr L.Happel, Dr M.Thaele
Schwerin: Medizinisches Zentrum der Landeshauptstadt Schwerin, Klinikum Schwerin
Stralsund: Klinikum der Hansestadt Stralsund GmbH, Klinik für Gynäkologie und Geburtshilfe
Stuttgart: Dr med. Mayer-Eichberger
Tübingen: Frauenklinik Eberhard-Karls-Universität
Ulm: Universitätsklinikum; Zentrum für Sterilitätsbetreuung
Wiesbaden: Zentrum für Reproduktionsmedizin
Würzburg: Gemeinschaftspraxis Dr R.Mai, Dr W.Schmitt; Universitätsfrauenklinik
Greece
No list
Hungary
Budapest: Jahn Ferenc Hospital, Department of OB/GYN; Nyiro Gyula Hospital, Department of OB/GYN; Semmelweis University of Medicine, 1st Department of OB/GYN; St. Johns Hospital, Department of OB/GYN
Debrecen: Medical University of Debrecen, Department of OB/GYN
Pécs: Medical University of Pécs, Department of OB/GYN
Iceland
Reykjavik: IVF-Unit, National University Hospital
Ireland
Dublin: Hari, Rotunda Hospital JMS
Galway: IVF Unit, UCH Galway
Italy
Abano Terme (Pd): Casa di Cura Abano Terme Centro Ripr. Assistita
Bari: Clinica S. Maria; Studio Medico San Luca; Studio Associato CECOS
Bologna: S.I.S.ME.R.; Tecnobios; Centro Sterilità e Fecondazione Assistita Università di Bologna
Bolzano: Ospedale di Bolzano
Brescia: Istituto Clinico Città di Brescia
Bressanone (Bz): Ospedale di Bressanone
Brunico (Bz): Ospedale di Brunico
Cagliari: Ospedale Regionale Microcitemie; Università di Cagliari
Cassano Murge (Ba): Casa Bianca
Catania: C.R.A.
Cittadella (Pd): Ospedale di Cittadella
Firenze: Centro Demetra; Centro Futura
Fossano (Cn): Ospedale di Fossano
Genova: Biotech; Università di Genova
Gragnano (Na): A.O.G.O.I.
Lecce: Centro di Fecondazione Assistita; Centro Studi Riproduzione Umana
Manduria (Ta): Ospedale M. Giannuzzi
Mantova: Ospedale C. Poma
Mercogliano (Av): Diagnostica Medica
Messina: Centro di Riproduzione Umana
Mestre (Ve): ARC-STER
Milano: Fondazione S. Raffaele del Monte Tabor; Polo Universitario S. Paolo
Modena: Università di Modena e Reggio Emilia
Monza (Mi): Centro Biogenesi
Motta di Livenza (Tv): Ospedale di Motta di Livenza
Napoli: Centro Mediterraneo di Fecondazione Assistita
Nardò (Le): Tecnomed Centro Medico Biologico
Padova: Studio Gemma; S.I.S.ME.R. Padova
Palermo: Centro Andros; Centro Biologia della Riproduzione
Parma: Università di Parma
Pesaro: Centro Salus
Pescara: Villa Serena
Pisa: Casa di Cura S. Rossore; Università di Pisa
Reggio Emilia: Studio Diagnostico Raul Palmer
Rimini: Ospedale di Rimini
Roma: European Hospital; Genesis
Rozzano (Mi): Istituto Clinico Humanitas
Salerno: C.M.R.; Human Fertilization Center
Sassari: Università di Sassari
Sora (Fr): Centro S.T.S.
Torino: Laparoscopy and Fertility Center; Centro LIVET; Ospedale S. Anna; Centro Diagnosi e Cura dellInfertilità di Coppia; Fertilab
Trieste: Ospedale Burlo Garofalo
Udine: S.I.S.ME.R. Udine
Varese: Centro Diagnostico Varesino
The Netherlands
Amsterdam: Academisch Medisch Centrum, Vrije Universiteit Medisch Centrum
Eindhoven: Catharina Ziekenhuis
Groningen: Academisch Ziekenhuis Groningen
Leiden: Leids Universitair Medisch Centrum, Stichting Medisch Centrum voor Geboorteregeling
Maastrict: Academisch Ziekenhuis Maastricht
Nijmegen: Universitair Medisch Centrum St Radboud
Rotterdam: Academisch Ziekenhuis Rotterdam
Tilburg: St. Elisabeth Ziekenhuis
Utrecht: Universitair Medisch Centrum
Voorburg: Reiner de Graaf Groep
Zwolle: Isala Klinieken
Norway
Bergen: Haukesund Sykehus, Universitetssykehus i Bergen
Haugesund. Fylkesykehuset i haugesund
Oslo: Rikshospitalet, Universitetssykehus. Ullevål Universitetssykehus, Volvat Medisinske Senter, Omnia Fertilitetssenteret
Tromsø: Universitetssykehuset Nord-Norge
Trondheim: St. Olavs Hospital, Universitetssykehus
Poland
Bialystok: Department of Gynecology, Medical Academy of Bialystok
Bytom: Department of Obstetrics and Gynecology, Silesian Medical University
Warsaw: Private Policlinic Ovum
Portugal
Guimarães: Hospital N. S. da Oliveira
Lisboa: CLIFER; CLINDIGO; Hospital de Santa Maria; Maternidade Dr Alfredo da Costa
Oporto: Centro de Genética Prof. Alberto Barros; Maternidade Júlio Dinis
Vila Nova de Gaia: Centro Hospitalar
Slovenia
Ljubljana: Medical Center Ljubljana
Maribor: Maribor Hospital
Postojna: Postojna Hospital
Spain
Alicante: Instituto Bernabeu; Unidad de Reproduccion Vistahermosa
Aravaca: Urh. Garcia del Real
Badajoz: Clinica Gonzalez Carrera
Baracaldo (Vizcaya): Hospital de Cruces
Barbera del Vallés: Centro de Reproduccion Humana del Valles Occidental
Barcelona: CIRH, Clinica de Reproduccion Asistida; Hospital Clinico de Barcelona; Hospital de la Santa Creu i Sant Pau; Instituto de Medicina Reproductiva; Instituto Marques; Instituto Universitario Dexeus
Bilbao: Clinica Euskalduna
Cordoba: Centro Mesa Dominguez; Clinica Bau
Godella: Instituto de Medicina Reproductiva
Granda: Centro de Reproduccion Asistida y Genética Reproductiva; Centro de reproduccion Humana; Hospital universitario Virgen de las Nieves
Llobregat: Hospital de Llobregat, Centre Tocoginecologico
La Flota: IVI Murcia
Lleida: CIRH Lleida
Madrid: Centro de Reproduccion Humana; Clinica Tambre; Fundacion Jimenez Diaz; Hospital Maternal La Paz; Instituto Ginecologico La Cigüena; IVI Madrid; Madrid FIV
Malaga: Centro Gutemberg
Oviedo: CEFIVA
Palma de Mallorca: Centro de Fecundation In Vitro Baleares; Instituto Balear de Infertilidad
Reus: Instituto de Infertilidad y Reproduccion Humana Conceptum
Sabadell: Centre Medic Fuster
San Sabastian: Clinica Quiron Donostria
Sevilla: Centro Hispalense de Reproduccion Asistida
Valencia: IVI Valencia
Russia
Cheboksary: Republican Center for Family Planning and Reproduction, Ministry of Health Chuvashia Republic. Director A.V.Samoilova
Krasnoyarsk: Center for Reproductive Medicine. Director A.V.Svetlakov
Moscow: IVF Department of Sechenov Medical Academia. Head of Dept. E.A.Kalinina
Medical Center for IVF. Director E.I.Pomeranceva. Center for Family Planning and Reproduction, IVF Department. Head of Dept. A.S.Kalugina Center for Infertility Treatment IVF. Director V.M.Zdanovsky
Center Lera. Director V.M.Zdanovsky, Medical Center for Infertility Treatment Embryon. Director K.N.Kechiayn Rostov-Don: Center of Human Reproducton and IVF. Medical Director A.V.Kuzmin
Samara: Medical Company IDK. Director V.I.Karnauch
Saratov: Region Center for Family Planning and Reproduction. Director N.P.Smirnova
St.Petersburg: International Center for Reproductive Medicine, Ob/Gyn Ott Institute. Medical Director Proffesor V.S.Korsak, Center for Family Planning, Pushkinsky District. Medical Director A.V.Ivanov Russian Finnish Medical Center AVA-Peter. Director N.V.Kornilov.
Baltic Institute of Human Reproductology. Director A.I.Nikitin
Tumen: Center for Reproductive Medicine Mercury. Medical Director E.V.Popenko, Medical Center Malish. Medical Director N.M.Kovalev
Voroneg: Region Center for Family Planning and Reproduction, IVF Department. Director N.N.Shemarinova
Vladivostok: Medical Center for IVF Santa Maria. Director V.A.Belikov
Sweden
Falun: IVF-enheten Falu lasarett
Göteborg: Fertilitetscentrum, Carlanderska sjukhemmet; Sahlgrenska universitetssjukhuset
Linköping: Universitetssjukhuset
Malmö: Curakliniken; Oeresundklinikken; Malmö allmänna sjukhus
Stockholm: Huddinge sjukhus; Karolinska sjukhuset; Lucinakliniken; Sophiahemmet
Umeå: Norrlands universitetssjukhus
Uppsala: Akademiska sjukhuset; Carl von Linnékliniken
Örebro: Regionsjukhuset
Switzerland
Baden: Reproduktionsmedizinisches Zentrum Kantonsspital
Basel: IVF-ICSI Zenter Institut Dr Viollier, Dr N. Pavic, Dr J-C. Spira; Universitäts-Frauenklinik, Abt. für gynäkologische Endokrinologie und Reproduktionsmedizin
Bellinzona: ProCrea, Centro Fertilità della Svizzera Italiana
Bern: Lindenhofspital, IVF-Labor; Universitätsfrauenklinik, Abt. für Gynäkologie, IVF und Reproduktionsmedizin, Inselspital
Frauenfeld-Kreuzlingen: IVF Zenter ILAMED
Genève: Centre Privé de Procréation Médicalement assistée de la Clinique de Champel Elysée; Hôpital Universitaire, Clinique et Policlinique de Stérilité et dEndocrinologie Gynécologique
Laufen: Dr A. Koller
Lausanne: Centre Vanderlick-Montchoisi; CHUV, Unité de Médecine de la Reproduction et dEndocrinologie Gynécologique
Locarno: Centro Cantonale di Infertilità, Servizio di Endocrinologia Ginecologica
Luzern: Kantonalspital, Sterilitätssprechstunde Frauenklinik, IVF-ICSI Labor
Schaffhausen-Zürich: Zentrum für Reproduktionsmedizin, Dr P Fehr, Dr Singer
Winterthur: Dr R. Köppel
Zollikerberg: IVF Zürich
Zürich: Universitätsspital, Klinik für Endocrinologie
Ukraine
Kharkiv: Center for Reproductive Medicine Implant
Kyiv: Institute of Reproductive Medicine; Isida IVF Clinic
Odessa: Center for Reproductive Medicine Remedi
UK
No list.
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Notes |
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* EIM subcommittee: Chairman, K.G.Nygren; co-ordinator, A.Nyboe Andersen; member, L.Gianaroli. See Appendix for contributing centres and contact persons representing the data collection programmes in the participating European countries.
Report prepared by K.G.Nygren and A.Nyboe Andersen
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References |
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ASRM/SART Registry (2002) Assisted reproductive technology in the United States: 1998 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil. Steril., 77, 1831.[ISI][Medline]
ESHRE (2001a) The European IVF-monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1997. Results generated from European registers by ESHRE. Hum. Reprod., 16, 384391.
ESHRE (2001b) The European IVF monitoring programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 1998. Results generated from European Registers by ESHRE. Hum. Reprod., 16, 24592471.