1Department of Cardiology, Rm B2-240, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
2Department of Cardiology, University Hospital Nijmegen, Nijmegen, The Netherlands
3Department of Internal Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands
4Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands
Received 5 August 2004; revised 2 November 2004; accepted 25 November 2004; online publish-ahead-of-print 28 January 2005.
* Corresponding author. Tel: +31 20 5662193; fax: +31 20 5666809. E-mail address: b.j.mulder{at}amc.uva.nl
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Abstract |
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Methods and results Between 1993 and 2004 127 women with Marfan syndrome were prospectively followed; 61 women had one or more children; in 23 women, 33 pregnancies could be followed prospectively for aortic dimensions. Only one woman had suffered an aortic complication, a type A dissection (limited to the ascending aorta), before pregnancy. Out of 66 childless women a comparison group of 22 women was selected and individually matched. Mean initial aortic root diameter just before pregnancy was 37±5 mm (range 2545). Before, during, and after pregnancy the overall individual aortic root diameter change (in 31 pregnancies) was not significant (P=0.77). Only the woman with a previous type A dissection developed an aortic complication (type B dissection) during her second pregnancy. No cardiac complications occurred in the other 22 women during their pregnancies. During a median follow-up of 6.4 years, no significant difference in growth of the aortic root was observed between the pregnancy group and the matched childless group (0.28 vs. 0.19 mm/year, P=0.08, respectively).
Conclusion Pregnancy in women with Marfan syndrome seems to be relatively safe up to an aortic root diameter of 45 mm, at least as far as our observed diameter range of 2545 mm is concerned.
Key Words: Marfan syndrome Pregnancy Aortic root diameter Aortic root growth Guidelines Aortic complication
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Introduction |
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Recently, new guidelines for women with Marfan syndrome and pregnancy were established.10,11 They were based on three studies in which it became apparent that the risk for dissection was low in women with minimal cardiac involvement and an aortic root diameter smaller than 40 mm.68 Currently, there is still debate regarding the aortic root diameter above which pregnancy should be discouraged in women with Marfan syndrome. The aim of this study was to evaluate the effect of pregnancy on growth of the aortic root in women with Marfan syndrome.
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Methods |
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Out of the 127 women, 66 remained childless up to the end of this study and 61 women had one or more children before 2004 (Figure 1). Among these 61 women, complete clinical data and aortic dimensions were available for 33 of 47 pregnancies in 23 women [mean age 27 (1837) years]. The remaining 38 women with children were excluded from further analysis because the diagnosis of Marfan syndrome was only established after they had completed their pregnancies and therefore no data of aortic dimensions were available during their pregnancies.
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Out of the 66 childless women, a group of 22 was selected for the purpose of long-term comparison. These women were individually matched with the 22 women in the pregnancy group. In order of importance, the match was formed on the basis of family history, initial aortic root diameter, duration of follow-up, and age (Table 1). Family history had to match exactly. The differences for initial aortic root diameter (last echo before pregnancy or echo at first visit in the childless group) between women varied from 0 to 3 mm, the age differences varied from 0.3 to 10 years, and follow-up differences varied from 0.5 to 8 years.
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Statistical analysis
Data were illustrated by estimating a linear regression line for each woman separately, and aortic root growth (mm/year) was quantified by using the regression slope. Data are described as frequencies or as means with standard deviations. Time intervals are expressed in medians and interquartile ranges (25th75th percentiles).
We first compared aortic root diameters before, during, and after pregnancy. The average aortic root diameter was used when more points were available in a given time interval. The three time intervals were defined as follows: before pregnancy ranged from 125 weeks before conception until conception; during pregnancy ranged from conception till delivery; and after pregnancy ranged from delivery until 125 weeks after conception. The aortic root diameter change was analysed using a linear mixed effect model with aortic root diameter as a dependent variable, time as a fixed effect, and patient as random effect.
Secondly, to exclude the influence of previous pregnancies on aortic root growth, we analysed aortic root growth before and after the first pregnancy of a woman separately. However, only for 10 first pregnancies were multiple echocardiograms available both before and after pregnancy. We again used a linear mixed effects regression model for the aortic root diameter on time (weeks), pregnancy status (before/after start pregnancy), and their interaction. Patient was the random effect. Before pregnancy was, in this model, defined as from 125 weeks before conception until conception and after pregnancy was defined as time from conception until 125 weeks after conception.
In the last analyses we compared the long-term impact of pregnancy, aortic root growth, and aortic complications between the pregnancy group and the matched childless group. Growth of the aortic root diameter with increasing age was analysed statistically with a linear mixed effects regression model of the dependent variable aortic root diameter on the independent variables age, pregnancy status (ever/never), and their interaction. Since each pregnant woman was in a separate stratum matched individually to a non-pregnant woman, and since aortic root diameters were repeatedly measured in all women, we included a random intercept per woman, and a random stratum effect in the model to take account of the correlation between the repeated diameter measurements and between the pregnant and non-pregnant women in the same stratum. We only tested the interaction between age and pregnancy status because this is a test for the null hypothesis that the diameter growth with age is the same in pregnant and non-pregnant women. Both random effects were assumed to follow a normal distribution, as were the residual terms, and the appropriateness of this assumption was checked visually by inspection of the histograms. We made no distinction between women with one or two pregnancies, and we included in this analysis all available diameter measurements.
Differences between patient subgroups with respect to proportions were tested with the 2 test and differences on continuous variables with the (paired) Student's t-test. A two-sided level of 0.05 was used for each statistical test.
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Results |
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Echocardiographic measurements of the aortic root diameter were obtained throughout 31 of the 47 pregnancies carried through the third trimester. Two of these women were pregnant at the time of enrolment. Mean initial aortic root diameter at the echocardiogram just before or at pregnancy was 37±5 mm (range 2545). Twelve women used beta-blockers during 15 pregnancies.
Nine women had an initial aortic root diameter of 40 mm (range 4045 mm) during 11 pregnancies and beta-blockers were used during six of these pregnancies. Of these nine women, five were known with a positive family history for Marfan, two with a positive history for dissection, and two had a negative family history.
Over the time period studied (before, during, and after pregnancy) the overall individual aortic root diameter change (in 31 pregnancies) was not significant (P=0.77). Evolution of aortic root diameter is visualized in Figure 3, which shows individual regression lines of 31 pregnancies.
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One woman developed a type B dissection during pregnancy. She had had an acute type A dissection (limited to the ascending aorta) 7 years before her first pregnancy for which she underwent emergency aortic root replacement. Against the advice of the cardiologist, she became pregnant twice. During her pregnancies she was followed with serial MRI scans. No cardiovascular complications or aortic growth were observed during her first pregnancy. In spite of normal aortic diameters she developed a type B dissection at 27 weeks gestation of her second pregnancy. She was initially treated conservatively and at 34 weeks gestation a healthy infant was born by a caesarean section. Repair of the thoraco-abdominal aorta was accomplished 10 days after pregnancy.
Pregnancy group versus matched childless group
Out of the childless group, 22 patients were selected and individually matched with the 22 pregnant patients for family history, initial aortic root diameter, duration of follow-up, and age (Table 1).
During a median follow-up of 6.4 years, no significant difference in aortic root growth was observed between the pregnancy group and the matched childless group (Figure 4 and Table 3). However, within the pregnancy group, a small but significant difference in aortic root growth was observed between nine women with an initial aortic root diameter 40 mm and 13 women with a diameter <40 mm. There was no significant difference in family history between these two subgroups (P=0.3). Moreover, in women with an aortic root diameter
40 mm, aortic root growth was significantly increased in the pregnancy group compared with nine matched women in the childless group.
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Discussion |
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During pregnancy, important maternal cardiovascular changes occur, such as an increase in blood volume, heart rate, stroke volume, cardiac output, left ventricular wall mass, and end-diastolic dimensions.16 In addition, hormonal changes occur which lead to histological changes in the aorta. Fragmentation of the reticulum fibres, a diminished amount of acid mucopolysaccharides, and loss of the normal corrugation of elastic fibres have been observed in the aortic wall of pregnant patients.17 So, both haemodynamic and hormonal mechanisms have been suggested to play an important role in the increased susceptibility to dissection in women during pregnancy. Three previous studies reported on aortic complications during pregnancy in women with Marfan syndrome. In a prospective study of 21 patients, two out of four women with aortic root diameter of between 40 and 43 mm at pregnancy developed an aortic complication (type B dissection and progressive aortic root dilation).8 Another woman with an aortic root replacement before pregnancy had extension of her chronic dissection 1 week postpartum.
In a retrospective study in 36 patients, six aortic complications (three type A dissections, one type B dissection, and two progressive aortic dilations) occurred, in four women with aortic root diameters of between 40 and 45 mm and in two women in whom the diagnosis of Marfan syndrome was not established until the aortic event occurred.6 However, the prevalence of women with an aortic root diameter of >40 mm was unknown in this study. In another retrospective study of 26 patients, one woman with cardiac impairment before conception developed endocarditis and died several weeks later of congestive heart failure.7 All patients had aortic root diameters of <42 mm, although individual preconception diameters were not provided.
From the results of these studies it was suggested that women with an aortic root diameter of >40 mm were at increased risk of aortic dissection. However, in these studies very few patients were included with aortic root diameters of >40 mm.
Therefore, the aortic root diameter above which pregnancy should be discouraged in women with Marfan syndrome is still a matter of debate. The Canadian guidelines recommend that women with an aortic root diameter beyond 44 mm should strongly be discouraged from becoming pregnant; the European guidelines discourage pregnancy above an aortic root diameter of 40 mm.10,11 In the literature and in our study, there are still insufficient data available on pregnancy in women with Marfan syndrome with aortic root diameters larger then 45 mm. Of course it is well known that the risk of aortic dissection increases with increasing aortic root diameters. However, our findings indicate that women without previous cardiac complications seem to tolerate pregnancy well, up to an aortic root diameter of 45 mm.
Not much is known about the long-term effect of pregnancy on the cardiovascular status of women with Marfan syndrome. After 6 years of follow-up, Rossiter et al.8 observed no apparent worsening of cardiovascular status in 18 women with Marfan syndrome after pregnancy compared with 18 women with Marfan syndrome without children. This is consistent with our study; aortic root growth was almost similar in the pregnancy group compared with the control group during a median follow-up of 6 years. However, in a subgroup of women with an aortic root diameter of 40 mm, pregnancy had a small but significant influence on long-term growth of the aortic root. In 20 years these women would have an average growth of 7 against 3 mm in childless women with similar initial aortic root diameters. In our opinion, for women with an aortic root diameter up to 45 mm, this does not need to be a major objection to having children, because the short- and long-term results of prophylactic aortic root surgery are excellent.18,19 However, in all women, especially in women with enlarged aortic root diameters, the pros and cons of pregnancy should be fully discussed as well as the alternatives (childlessness, adoption, and surrogate pregnancy). Women with previous aortic dissection are at high risk of aortic complications during pregnancy.
Limitations of the study
A limitation of this study is the inherent absence of randomization. Patients who, after receiving counselling explaining their pregnancy-related risks, choose to proceed with pregnancy may represent a subset of the Marfan syndrome population at lower risk for cardiovascular complications. The 22 childless women who were matched with the 22 women prospectively followed during pregnancy, cannot strictly be considered a control group, because of occult biases in why those patients may have elected not to have any pregnancies. However, objective measures show similarities between the two groups. The proportions of patients with a family history of aortic dissection, a predictor of an individual's risk of dissection, were similar in the two groups.
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Conclusion |
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References |
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