Cancer, genes and gender

Aage Haugen

Department of Toxicology, National Institute of Occupational Health, P.O. Box 8149 Dep, 0033, Oslo, Norway

I appreciate the comments of Dr Meisel. In the letter, Dr Meisel has not expressed any concern about my commentary but argues that myeloperoxidase (MPO) and other enzymes involved in the metabolism of tobacco carcinogens regulated by hormones may contribute to sex-specific lung cancer risk. I share his view. We have demonstrated higher CYP1A1 expression levels in normal lung from females. There is also some animal data indicating a sex-difference in the abundance of detoxification enzymes (1).

Reference

  1. Singhal,S.S., Saxena,M., Ahmad,H. and Awathi,Y.C. (1992) Glutathione S-transferases of mouse liver: sex related differences in the expression of various isozymes. Biochem. Biophys. Acta, 1116, 622–627.
Received March 21, 2002; accepted April 2, 2002.





This Article
Extract
FREE Full Text (PDF)
Alert me when this article is cited
Alert me if a correction is posted
Services
Email this article to a friend
Similar articles in this journal
Similar articles in PubMed
Alert me to new issues of the journal
Add to My Personal Archive
Download to citation manager
Request Permissions
Google Scholar
Articles by Haugen, A.
PubMed
PubMed Citation
Articles by Haugen, A.