Division of Psychiatry, General Hospital of Rogaland, Stavanger
Ullevål University Hospital, Oslo
Institute of Psychology, University of Oslo, Norway
Roskilde Psychiatric University Hospital Fjorden, Roskilde, Denmark
Department of Behavioural Sciences in Medicine, University of Oslo, Norway
Yale University School of Medicine, New Haven, Connecticut, USA
Correspondence: Dr Jan Olav Johannessen, Division of Psychiatry, General Hospital of Rogaland, Armauer Hanssens vei 20,4000 Stavanger Norway.E-mail: jojo{at}sir.no
Declaration of interest Supporters included Lundbeck Pharma, Eli Lilly and Janssen-Cilag Pharmaceuticals; full details in Acknowledgements.
* Paper presented at the Third International Early Psychosis Conference,
Copenhagen, Denmark, September 2002.
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ABSTRACT |
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Aims To determine whether those with first-episode psychosis in an early detection healthcare area with existing referral channels differ from those who access care via detection teams.
Method Those with first-episode psychosis recruited via detection teams were compared with those accessing treatment via conventional channels, at baseline and after 3 months of acute treatment.
Results Patients recruited via detection teams are younger males with a longer DUP, a less dramatic symptom picture and better functioning; however they recover more slowly, and have more symptoms at 3-month follow-up.
Conclusions After establishing low threshold active case-seeking detection teams, we found clear differences between those patients entering treatment via detection teams v. those obtaining treatment via the usual channels. Such profiling may be informative for early detection service development.
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INTRODUCTION |
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We know little about how organisational structures in the health services influence important parameters, such as DUP. In Germany, Fuchs & Steinert (2002) found that patients with a first-episode psychosis who came to treatment via a general practitioner had the shortest DUP. However, only 24% of the patients entered psychiatric services via this route. In Australia, Lincoln et al (1998) reported that 50% of people developing a first-episode psychosis experienced psychotic symptoms before approaching any service. The general practitioner played a key role, with 50% of people having had this contact at some point prior to commencing effective treatment. Where an individuals own efforts to seek early help failed, the role of relatives and others was subsequently vital. DUP via these different pathways is not accounted for in that study. de Haan et al (2002) carried out a survey on European families concerning their priorities and satisfaction with the services provided in a first-episode psychosis. The respondents emphasised the need for early intervention through outreach. Drake et al (2000) found that longer DUP results from a pattern of symptoms and social functioning that reduces the concern of the sufferer and relevant others. Long DUP was predicted by poor insight and social isolation but preserved basic coping skills.
In a previous study on pathways to care for first-episode psychosis (Larsen et al, 1998) we found that patients with a long DUP (>1 year) were young males with a poor social network, social withdrawal and a more deteriorating course, compared with patients with a short duration of untreated psychosis (<1 year).
In this paper we review those patients with first-episode psychosis obtaining treatment in a healthcare sector with an established early detection system of public education about psychosis and easy access to care through active outreach. We also investigate the differences, at first admission and following 3 months of acute treatment, between those patients obtaining treatment via the teams and those obtaining help via existing referral systems.
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METHOD |
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The experimental sectors are characterised by a comprehensive education and detection system designed to enhance knowledge about early signs of psychosis among the general public, schools and health professionals. Early detection teams have been established in the experimental sectors in order to lower the threshold of entry to specialised psychiatric services, and to recruit appropriate patients as early as possible in the illness course. The teams comprise psychiatrists, psychologists, psychiatric nurses and social workers. They are on call from 08.00 h until 16.00 h, Monday to Friday. The teams are mobile and work with a dynamic outreach attitude. Details of the programme have been described elsewhere (Johannessen et al, 2001; Larsen et al, 2001). The active period of inclusion was 19972000, with follow-up planned at 3 months, 1, 2, 5 and 10 years.
In the early detection area, mean DUP was reduced to 25.3 weeks (median 4.5, s.d.=61.7) in the period 19972000, compared with 114.2 weeks (median 26.0, s.d.=173.6) before the project started (19931994) (Larsen et al, 2001). These results indicate that the early detection strategies are successful in changing the attitude to obtaining help.
Study population
The sample consists of patients recruited to first treatment in the early
detection sectors, Rogaland County, Norway in the TIPS study. The population
of the County is 370 000.
Our clinical hypothesis is that the lowered threshold to treatment and active case-seeking, as carried out by the detection teams, would facilitate the help-seeking process for those patient groups that we had earlier found to be recruited into treatment late in the illness development. These are usually young males with a long DUP, a weak social network and a less dramatic symptomatology (Larsen et al, 1998). As a result we would expect a higher percentage of such patients among those recruited through the teams.
The criteria for inclusion were: (a) a first episode of a non-affective psychosis, i.e. schizophrenia, schizophreniform, schizoaffective and delusional disorder, brief psychosis, affective disorder with mood incongruent, delusions, and psychotic disorder not otherwise specified; non-narrow schizophrenia or spectrum disorder (non-NSSD); (b) living in the catchment area; (c) age 1565 years; (d) IQ>470 and (e) a first episode of psychosis. The exclusion criteria were a history of an earlier treated first psychosis, receiving adequate prior neuroleptic treatment and organic or substance-induced psychosis. Written informed consent was obtained from all the individuals and the study was approved by the Regional Committee for Medical Research Ethics and the Data Inspectorate.
Instruments
Diagnosis was identified using the Structured Clinical Interview for the
DSMIV Axis I Disorders (SCIDI;
First et al, 1995). Symptom levels were measured with the Positive and Negative Syndrome Scale
(PANSS; Kay et al,
1987). Global functioning was measured by the Global Assessment of
Functioning Scale (GAF; American
Psychiatric Association, 1994), the scores were split into symptom
scores (GAFS) and function scores (GAFF) to improve psychometric
properties. The DUP was measured as the time from the first onset of positive
psychotic symptoms (the first week with a PANSS score of 4 or more on Positive
Scale items 1, 3, 5, 6 or General Scale item 9) to the start of first adequate
treatment of psychosis, i.e. admission to the study. Multiple sources,
including personal interviews with patients and relatives, were used to
ascertain the length of this period. Premorbid functioning was measured by the
Premorbid Assessment of Functioning Scale (PAS;
Cannon-Spoor et al,
1982). Drug and alcohol use was measured by the Clinician Rating
Scale (Drake et al,
1990). Social functioning (number of friends and participation in
meaningful activities) during the year before the start of treatment was
measured with the StraussCarpenter scale
(Strauss & Carpenter,
1974).
All raters were trained in the use of study instruments by rating pre-prepared case notes and audio/videotapes before entering the study assessment teams. The rating of essential variables, such as diagnosis and DUP, was achieved by consensus with experienced clinical researchers. Reliability for the PANSS scores was measured by the rating of videotaped interviews of patients with first-episode psychosis by all raters. Reliability for diagnosis, GAF and DUP was measured by the rating of actual case notes by masked raters with long clinical research experience. Reliability of measurements was fair to very good (for details see Friis et al, 2003). For the PAS, a testretest was carried out with a masked rater in 19931994. As it showed good reliability with intraclass correlation between 0.84 and 0.87, no specific reliability test was carried out for the PAS in the TIPS study, but all raters were experienced.
Statistics
Analyses were performed with the Statistical Package for the Social
Sciences (version 11.0) for Windows. Mean values are reported with standard
deviations in parentheses, and median values are reported for skewed
variables. The t-test is used for comparison between groups, with
dichotomised data the 2 test and the Fishers exact test
were used. Non-parametric tests are used for data without normal distribution.
All tests are two-tailed. As noted in several other studies, DUP is not
normally distributed, although its natural logarithm has a normal
distribution. All analyses that include DUP are thus non-parametric where
possible. In parametric analysis, the DUP has been transformed to its natural
logarithm. In order to determine which characteristics contributed to the
patients being identified by the detection teams, a logistic regression
analysis was performed.
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RESULTS |
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For the 4-year period of active inclusion, the contacts with the detection teams were about one per day. Out of 1921 contacts, 107 individuals had a first-episode psychosis (Table 1).
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The pattern of referral for treatment in the early detection sector changed, with about 50% of the referrals coming from the patients family, or the patients themselves via the detection team. This is in contrast to before the project began, when all the referrals were made by general practitioners.
Patient characteristics at baseline
The samples recruited via the detection teams v. conventional
channels did not differ at baseline diagnostically (i.e. percentage
schizophrenia, schizophreniform disorder, schizoaffective disorder, psychotic
disorder not otherwise specified, mood incongruent affective psychosis,
delusional disorder, brief psychosis), premorbidly (PAS), neuropsychologically
(executive function, verbal learning, working memory, impulsivity), or
functionally according to the StraussCarpenter scale (work, meaningful
activity, friends and hospitalisation in the past year, and symptoms in the
past month). Differences between the samples recruited via the detection teams
v. existing channels are shown in
Table 2.
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We found the detection team sample to be younger with a mean age at start of treatment of 22.5 years (s.d. 5.4) (males 21.8; females 24.3) as opposed to the non-detection team sample with a mean age at start of treatment of 26.3 years (s.d. 8.6). The teams recruited more males (73%) as opposed to non-team patients (53%).
DUP was longer in the detection team sample, with a median of 18.0 weeks (mean 53.4; s.d. 97.3) v. median 4 weeks (mean 31.9; s.d. 97.3) in the non-team sample. The detection team sample had a higher score on drug use, but no differences on alcohol use.
At admission, the detection team group was found to be better functioning as measured by the Global Assessment of Functioning Scale (GAF). On the Positive and Negative Symptom Scale (PANSS) there were no significant differences between the two groups.
Patient characteristics at 3-month follow-up
A higher percentage of the detection team sample was treated on an
out-patient basis: 25% in the team group v. 7.6% in the non-team
group. Although there were no differences on admission, the non-detection team
patients had a total PANSS score of 47.7 after 3 months, the detection team
patients 54.2. This difference was also apparent as measured on the GAF, with
the non-detection team group showing a much higher degree of symptomatic
improvement after 3 months, and also a higher level of social functioning at 3
months (GAFS 52.2 v. 46.1, and GAFF 52.3 v.
48.8) (Table 3).
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DISCUSSION |
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A major aim of the early detection sector is to make the entry to treatment more straightforward for people developing psychotic disorders. After 4 years experience with detection teams, we found that the teams recruited young males with longer DUP, who had better functioning but more substance misuse. They were also more frequently treated on an out-patient basis. However, they proved to be less responsive to treatment during the acute phase. This could be interpreted as the non-detection team group showing a more dramatic spectrum of symptoms resulting in more conventional admission, whereas the detection team group had a more insidious onset, with a symptom profile that did not alarm the patients and/or their relatives sufficiently to initiate contact with the treatment system via the usual channels. It appears that detection teams may be required in order to net patients with fewer symptoms and longer DUP.
At 3-month follow-up, the detection team group was characterised by social withdrawal to a higher degree than the non-team group, which probably is one of the basic characteristics of these patients. The main factors associated with their less robust response to treatment appears to be longer DUP and younger age. The patients identified by the teams seem to be similar to the patients with a long DUP found in our previous study (Larsen et al, 1998). We have since reported that those early detected patients as a group are less ill at the start of treatment (Larsen et al, 2001). This also seems to be the case for the patients with a long DUP. Is the poorer response to treatment in the acute phase for the detection team group in this study a result of long DUP, or is DUP only a confounding factor? We hope that we will have more information about this when we report the long-term follow-up results from the TIPS study.
The main advantage of a detection team is rapid response and a high level of mobility, including the possibility of visiting the patients in their homes, schools, etc. The teams have a relaxed attitude towards patients using drugs, which could be a possible explanation why the detection team patients have a higher level of substance misuse than those accessing the treatment system via existing channels.
To our knowledge, this is the first study to measure the characteristics of patients contacted by detection teams in an early detection programme. For a population of about 400 000, a team comprising four people appears to be adequate for detection and screening purposes, depending on geography and communications.
Our findings suggest that early intervention systems that include outreach case-seeking structures with easy access to treatment will recruit a younger but more chronically disordered subgroup of patients with first-episode psychosis. This is an important and often difficult to reach group. This is also reinforced by our finding that patients contacted by a detection team were more reluctant to join the TIPS project with its comprehensive treatment programme. Understanding the different patterns of response to specific early detection system elements can aid in the construction of effective early detection and intervention public health systems.
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Clinical Implications and Limitations |
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LIMITATIONS
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ACKNOWLEDGMENTS |
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From the Department of Psychiatry, Yale University, New Haven, Connecticut, USA; Ruskide County Psychiatric Hospital Fjorden, Roskilde, Denmark; Rogaland Psychiatric Hospital, Haugesund Hospital, Ullevål University Hospital and the Departments of Psychiatry, Psychology and Behavioural Sciences, University of Oslo, Norway.
This study was supported by the Norwegian National Research Council (nos 133897/320 and 154642/320), the Norwegian Department of Health and Social Affairs, the National Council for Mental Health/Health and Rehabilitation (nos 1997/41 and 2002/306), Rogaland County and Oslo County (P.V., J.O.J., S.F., T.K.L., I.M. and S.O.). Also funded by the Theodore and Vada Stanley Foundation, the Regional Health Research Foundation for Eastern Region, Denmark; Roskilde County, Denmark, Helsefonden Lundbeck Pharma, Eli Lilly and Janssen-Cilag Pharmaceuticals (E.S.). Also supported by a National Alliance for Research on Schizophrenia and Depression (NARSAD) Distinguished Investigator Award and National Institute of Mental Health grant MH-01654 (T.H.McG) and NARSAD Young Investigator Award (T.K.L.).
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