Cluain Mhuire Family Centre, Blackrock, Co. Dublin
Royal College of Surgeons of Ireland, Dublin
St John of God Hospital, Stillorgan, Co. Dublin
Cluain Mhuire Family Centre, Blackrock, Co. Dublin, Republic of Ireland
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Correspondence: Dr E. O'Callaghan, Stanley Foundation Research Unit, Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co. Dublin, Republic of Ireland
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ABSTRACT |
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Aims To identify the clinical correlates of QOL at the time of first presentation with schizophrenia.
Method Over two years, consecutive first-episode psychosis patients presenting to a catchment area psychiatric service underwent validated clinical assessments of premorbid adjustment, illness duration, symptoms and QOL.
Results At presentation, subjects already had a diminished QOL. Although independent of gender and age at onset of psychosis, QOL was influenced by premorbid adjustment, duration of untreated psychosis and symptoms.
Conclusions Reducing the duration of untreated psychosis may have a beneficial effect on the subsequent QOL of patients presenting with schizophrenia. First-episode patients with a protracted duration of untreated psychosis or impaired premorbid adjustment may warrant specific treatment interventions to prevent the development of secondary handicaps.
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INTRODUCTION |
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METHOD |
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Assessments
At presentation, patients were assessed using the Positive and Negative
Syndrome Scale (PANSS; Kay et al,
1987) and the Quality of Life Scale (QLS;
Heinrichs et al,
1984), a disease-specific instrument which provides
an external assessment of QOL based on patients' self-report and
the interviewer's assessment of their current life circumstances. When
patients were clinically stable, a DSM-IV diagnosis
(American Psychiatric Association,
1994) was ascertained using the up-dated version of the Structured
Clinical Interview for DSM-III-R - Patient Version (SCID-P;
Spitzer et al,
1987).
The patients were asked to consent to a parent being interviewed using the Premorbid Social Adjustment (PSA) scale (Foerster et al, 1991), which evaluates functioning from five to eleven (PSA-1) and from 12 to 16 (PSA-2) years of age. The DUP was defined as the time between the emergence of psychotic symptoms and the initiation of treatment. It was measured in two ways: first, during the SCID interview, patients dated the onset of the first psychotic symptom; second, a family member in regular contact with the patient was interviewed, using a check-list of behaviours describing the evolution of the illness (Beiser et al, 1993).
Interrater reliabilities
Intraclass correlation coefficients (ICCs) were 0.73 for the negative
syndrome subscale and in excess of 0.84 for the remaining sub-scales of the
PANSS. ICCs for the QLS sub-scale scores were in excess of 0.92, in excess of
0.88 for the PSA-1 and PSA-2 and in excess of 0.94 for the dating of the onset
of prominent psychotic symptoms.
Data analysis
Data were analysed by using Student's t-test, the
2 test or Pearson product-moment correlations (two-tailed).
Information from patients regarding the emergence of psychotic symptoms was
used to date their age at onset and to dichotomise them into long-term symptom
(DUP of one year or greater) and short-term symptom (DUP less than one year)
groups, using previously described criteria
(Haas & Sweeney, 1992).
Because the development of psychosis in adolescence restricts the evaluation
of premorbid adjustment, we only assessed the relationship between the QLS and
PSA scores in individuals aged 18 years or over at presentation.
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RESULTS |
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The subjects' total QLS score (mean 56.4, s.d.=20.6, median 57) was inversely correlated with the total PANSS score (r=-0.34, P=0.01) but independent of the Global Assessment of Functioning score (GAF; American Psychiatric Association, 1987) (r=0.09). Although there was no significant relationship with positive symptoms (r=-0.02), the QLS score was significantly correlated with the PANSS negative (r=-0.38, P<0.01) and general psychopathology (r=-0.31, P=0.02) syndrome scores. However, the severity of positive symptoms was positively correlated with the general psychopathology syndrome score (r=0.39, P<0.01). There was no significant difference in total QLS scores between male (mean 56.4, s.d.=20.1) and female (mean 56.5, s.d.=22.2) patients (t=-0.22, d.f.=51).
Age at onset of psychosis (mean 25.3 years, s.d.=8.8, range 13-45) was independent of the total QLS score (r=0.16) but positively correlated with the PANSS positive syndrome score (r=0.31, P=0.02). However, it was independent of the PANSS negative (r=0.001) and general psychopathology (r=-0.02) syndrome scores.
Although the mean DUP reported by patients was 22.7 months (s.d.=36.8,
median 6 months, range 1-240), their relatives reported a shorter DUP (mean
15.9, s.d.=34.5, median 3 months, range 0-240). Using the patients' dating, 23
individuals (43.3%) were classified as having a DUP of 12 months or more
(long-term symptom group). There were no significant gender differences
between the long-term and short-term symptom groups (2=2.24,
d.f.=1, P=0.13). However, there was a significant difference in the
QLS score (t=-2.89, d.f.=51, P<0.01) between the
long-term and short-term groups, but no significant differences between these
groups in the PANSS total or syndrome scores
(Table 1). A stepwise multiple
regression analysis indicated that a combination of a DUP of 12 months or
longer (t=-2.81, P=0.007) and the total PANSS score
(t=-2.41, P=0.02) accounted for a significant proportion of
the variance in the QOL of these individuals (adjusted
R2=19.9%, F=7.48, P=0.001).
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Of the 50 adults (age range 20-45 years) in this cohort, data relating to
premorbid adjustment were obtained for 46 individuals. There was a significant
relationship between the QLS, PSA-1 (r=-0.32, P=0.03) and
PSA-2 (r=-0.39, P<0.01) scores. Although there was
evidence that age at onset was related to the PSA-1 (r=-0.28,
P=0.06) and PSA-2 (r=-0.41, P<0.01) scores,
premorbid adjustment was independent of the PANSS total and syndrome scores
(0.04r
0.14). Furthermore, the long-term and short-term
symptom groups did not differ in terms of the PSA-1 (t=-0.68,
d.f.=44) and PSA-2 (t=-1.23, d.f.=44) scores.
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DISCUSSION |
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The QLS as a measure of quality of life
Recent reviews have produced somewhat conflicting recommendations regarding
the most appropriate instrument for evaluating QOL. However, fundamental
requirements of QOL measures include patient acceptability and the ability to
provide data relating to psychometrics. To date, QOL instruments have been
evaluated in terms of construct and convergent validity with other commonly
used scales. The QLS has been reported to be acceptable in terms of these
measures of validity (Lehman et
al, 1993; Lehman,
1996) and to reflect prospectively the effects of pharmacological
and psychosocial interventions (Rosenheck
et al, 1998). Regarding patient acceptability, only three
patients in this study declined to complete the QLS interview, in contrast to
the relatively high rate of incomplete data reported with self-rated
evaluations in in-patient samples (Kaiser
et al, 1996).
Since the QLS was initially devised as a measure of the schizophrenic deficit syndrome, it could be argued that it simply documents the presence of negative symptoms. However, the concept of the deficit syndrome has evolved to require evidence that negative symptoms persist longitudinally in the absence of psychosis, depression or side-effects (Carpenter et al, 1988), and the percentage of first-episode patients who meet these criteria appears to be minimal (Mayerhoff et al, 1994). Furthermore, in the present study, negative symptom severity only accounted for 15% of the variance in the QLS score. Although this finding may be interpreted in terms of measurement redundancy, there is little point in using a QOL instrument which fails to detect the impact of symptoms specific to schizophrenia (Awad et al, 1997). In fact, the pattern of symptoms appears to be a robust predictor of subjective QOL (Kaiser et al, 1996), and the deleterious effects of negative and general psychopathological symptoms have been previously demonstrated with self-rated instruments (Packer et al, 1997; Heslegrave et al, 1997). Although core psychotic symptoms were not found to influence QOL, it may be that they have an indirect effect mediated through general psychopathological symptoms.
Methodological issues in first-episode studies
The length of untreated illness prior to presentation is likely to be an
important determinant of outcome, since consecutive-admission studies indicate
that the best predictor of future chronicity is past chronicity. However,
there are difficulties in dating the onset of illness in first-episode
samples. For example, dating the onset of the prodrome is uniquely
problematic, because it is difficult to distinguish prodromal signs from the
social and academic impairments which are premorbidly evident in some patients
with schizophrenia.
Although our data confirm that some first-episode patients experience psychotic symptoms for a protracted period of time prior to referral, the mean DUP was greater than the median, indicating a significant effect of outliers. This reflects the difficulty in adequately defining what constitutes a first episode of schizophrenia. Furthermore, the reliability of patients' dating of psychosis onset may be questioned. However, this difficulty may be circumvented by interviewing patients when they are symptomatically stable and supplementing their report with collateral information from families (Keshevan & Schooler, 1992). The finding that family members reported a shorter DUP than patients may be due to the fact that psychotic symptoms are subjectively experienced phenomena and are not easily perceived by others.
Determinants of quality of life at presentation
The QOL of the individuals in this study was influenced by their
psychopathology, by how long they had psychosis prior to referral and by their
premorbid adjustment before the onset of psychotic symptoms. Since there was
no difference in premorbid functioning between the long- and short-term
symptom groups, it appears that the difference in QOL between these groups is
unlikely to have resulted from difficulties in the acquisition of life skills
prior to the onset of psychosis. Likewise, the effect of DUP on QOL appears to
be independent of the pattern of symptoms, including negative symptoms.
Consequently, it may be that a protracted DUP has an inherently detrimental
effect on an individual's QOL. However, it is possible that differences in the
mode of illness onset or in the environmental response to the emergence of
psychosis (for example, factors influencing treatment-seeking) may be an
alternative explanation for this finding.
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Clinical Implications and Limitations |
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LIMITATIONS
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Received for publication May 18, 1998. Revision received July 9, 1999. Accepted for publication July 9, 1999.