Department of Psychiatry, University Medical Centre, The Netherlands
Parnassia Psychiatric Centre, The Hague, The Netherlands
Department of Clinical Epidemiology, University Medical Centre, Utrecht, The Netherlands
Correspondence: Dr J. P. Selten, Department of Psychiatry, University Hospital, PO Box 85500, 3508 GA Utrecht, The Netherlands. Tel: 00 31 30 250 8180; fax: 00 31 30 2505443; e-mail: j.p.selten{at}psych.azu.nl
Declaration of interest Supported by the Stanley Foundation.
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ABSTRACT |
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Aims To compare the incidence of psychotic disorders in the immigrant groups to that in natives.
Method Two-year first-contact incidence study in The Hague.
Results The risks of schizophrenia, schizophreniform or schizoaffective disorder (DSM-IV criteria) were increased for subjects born in Morocco (gender and age-adjusted relative risk=4.5; 95% Cl 1.4-8.5), Surinam (relative risk=3.2; 1.8-5.7), The Netherlands Antilles (relative risk=2.9; 0.9-9.5) and other non-Western countries (relative risk=2.4; 1.3-4.7). This risk was also increased for Moroccans (relative risk=8.0; 2.6-24.5) and Surinamese (relative risk=5.5; 2.5-11.9) of the second generation. The risks for Turkish immigrants, first or second generation, and for immigrants from Western countries were not significantly increased.
Conclusions This study indicates that the incidence of schizophrenia is increased in several, but not all, immigrant groups to The Netherlands. It is possible that factors associated with a process of rapid westernisation precipitate schizophrenia in people who are genetically at risk.
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INTRODUCTION |
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METHOD |
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A recent survey provided evidence of a tripartition of Dutch society. Educational levels and income were found to be lowest for Turkish and Moroccan immigrants. Surinamese and Antillean immigrants were found to take an intermediate position. In The Hague, the proportions of children growing up in single-parent families were lowest for Moroccans (5%) and Turks (10%) and highest for Hindustanis (28%), other Surinamese (38%) and Antilleans (47%). For natives (see Statistical analysis) this figure was 18% (Martens, 1999).
Recruitment of patients
The criteria for inclusion and exclusion were similar to those used in the
World Health Organization (WHO) Ten-Country Study
(Jablensky et al,
1992). Subjects whose residence in The Hague was shorter than 6
months or who stayed there illegally were excluded. Collaboration was
established with local general practitioners (GPs) and psychiatrists. A team
of researchers (N.V., W.F., J.D.B.) tried to interview all subjects aged 15-54
years who made first contact with a physician for a (suspected) psychotic
disorder during the period 1 April 1997 to 1 April 1999. The physician
responsible made contact between the patient and the team. The researchers
asked for written informed consent for: (a) a diagnostic interview; (b) an
interview with a key informant; and (c) access to the medical file. Some
patients gave consent for only one or two parts of the study. When the patient
refused contact with the team, the researchers asked the physician for
detailed clinical information, but not the patient's name, date of birth or
address. The study was approved by all relevant ethical committees.
Assessment
Residents in psychiatry (J.D.B./N.V.) interviewed patients using the Dutch
translation of the Comprehensive Assessment of Symptoms and History (CASH)
(Andreasen et al,
1992). They screened the medical file and asked patients from
Surinam (first- and second-generation) to assign themselves to an ethnic group
(African, Hindustani or other). A research nurse (W.F.) interviewed key
informants (usually a spouse or a close relative), using the Instrument for
the Retrospective Assessment of the Onset of Schizophrenia (IRAOS)
(Häfner
et al, 1992). She also asked the key informants of first-
and second-generation immigrants whether they considered the most prominent
symptoms normal within the patient's culture. An official interpreter was
asked to help in the administration of CASH or IRAOS, if necessary. The
residents and the nurse were of Dutch origin. They compiled a narrative
history of the patient's illness omitting any clue to the patient's ethnicity
(e.g. sibship size). During a diagnostic meeting two psychiatrists (J.P.S. and
D.S./J.O./W.C./M.V.), who remained blind to ethnicity, made a consensus DSM-IV
diagnosis (American Psychiatric
Association, 1994). They noted whether the presence of a psychotic
disorder was possible, very likely or certain and determined the time of onset
of psychosis. The latter was impossible in nine patients, because the
information was of insufficient quality.
Study subjects
One hundred and ninety-seven subjects made first contact for a (suspected)
psychotic disorder. Thirty-eight (19.3%) refused contact with the team, but
their anonymised data could be assessed. The proportion of refusers among
Surinamese (22.2%), Antillean (28.6%) and Turkish subjects (30.0%) was higher
than among natives (18.3%), but the reverse was true for Moroccans (13.8%) and
others (18.2%). Logistic regression analysis, controlling for gender and age,
showed that the differences were not significant (two-tailed P for
odds ratios > 0.25). Diagnostic interviews were conducted in 152 of 197
cases (77.2%) and interviews with key informants in 121 of 197 cases (61.4%).
From the total of 197 patients, 12 were excluded on the basis of being
diagnosed with a substance-induced psychotic disorder or a non-psychotic
disorder. A further four patients were excluded because the presence of
psychosis was dubious. The patients with a very likely (n=4) or
certain (n=177) diagnosis of a psychotic disorder constituted the
study sample.
Statistical analysis
The municipality of The Hague classifies its citizens according to country
of birth, not race or ethnicity. If a citizen was born abroad, he or she is
assigned to the group of people born in the same country (e.g. Turkey,
first-generation). The Hague divided people born in countries other than The
Netherlands, Surinam, The Netherlands Antilles, Turkey or Morocco into a group
of people born in Western or Westernised countries (western, northern and
southern Europe (including the former Yugoslavia), the USA, Canada, Australia,
New Zealand, Japan and Israel) and a group of people born in non-Western
countries (all other countries, including the previously communist countries
in Eastern Europe). A Dutch-born citizen is considered a second-generation
immigrant if at least one parent was born abroad (e.g. Turkey,
second-generation). If the parents were born in different foreign countries,
the country of birth of the mother is decisive for assignment to a particular
group. Natives are Dutch-born citizens whose parents were also born in The
Netherlands (see Table 1).
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The country of birth of the parents of 10 Dutch-born patients was uncertain, but since these latter conveyed the impression of being culturally Dutch, they were classified as natives. The municipality of The Hague provided population figures, divided according to the above criteria, 5-year age-group and gender, for 1 January 1997, 1998 and 1999. In order to derive person-years at risk for the period of the study (1 April 1997 to 1 April 1999) the population figures for 1997, 1998 and 1999 were multiplied by 0.75, 1.0 and 0.25, respectively, and then added together. First-contact rates were calculated by dividing the number of cases by the number of person-years. In order to compute 95% confidence intervals (95% CIs) for these rates a Poisson distribution was assumed (MacMahon & Trichopoulos, 1996). First-contact rates were computed for all psychotic disorders (DSM-IV: schizophrenia, schizophreniform disorder, schizoaffective disorder, mood disorder with psychotic features, delusional disorder, brief psychotic disorder, shared psychotic disorder or psychotic disorder, not otherwise specified) and for schizophrenic disorders (DSM-IV: schizophrenia, schizophreniform disorder, schizoaffective disorder). Standardised first-contact rates were derived by direct standardisation for age and gender to the total population of The Netherlands as at 1 January 1998. The risks for the following population groups were compared to the risks for natives:
Gender and (5-year) age-adjusted relative risks were calculated by Poisson regression analysis, using EGRET (Cytel Software, 1999).
Research into the inverse relationship between schizophrenia and socio-economic status has shown that social selection processes (downward mobility of the genetically predisposed) are more important than social causation processes (development of the disorder promoted by adversity and stress associated with low socio-economic status) (e.g. Dohrenwend et al, 1992). This means that a modest role for the social causation mechanism has not been ruled out.
Consequently, we made an attempt to adjust for possible confounding by socio-economic status. We had obtained the addresses of 142 patients (78%) with a psychotic disorder and of 89 (81%) with a schizophrenic disorder (not the addresses of those who refused contact with the research team). The 40 neighbourhoods of The Hague are divided into five socio-economic levels, based on disposable income, quality of housing and rates of long-term unemployment. The population figures in each neighbourhood for 1 January 1998, by 5-year age-group, gender and country of birth of citizen and parents, were made available by the city of The Hague. Using these data we calculated the gender- and (5-year) age-adjusted relative risks for the population groups described in (a). We then examined whether further adjustment for the socio-economic status of the neighbourhoods influenced the results.
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RESULTS |
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First-generation
The risks of any psychotic disorder were significantly increased for
immigrants from Surinam, The Netherlands Antilles, Morocco and other
non-Western countries, but not for immigrants from Turkey, Western or
Westernised countries. The same pattern emerged for the risks of a
schizophrenic disorder (except for the non-significant elevation in the risk
for Netherlands Antilleans). The high risk for Moroccan immigrants was due to
a large number of cases among males, not females. The patients from
non-Western countries had been born in Africa (n=13), Asia
(n=5), Central or South America (n=2) or Eastern Europe
(n=2).
Second-generation
There were no Turkish or Antillean subjects who made first contact, but the
risks for Moroccans and Surinamese were greatly increased.
Socio-economic status of neighbourhood
Adjustment for this variable had a minor effect
(Table 4).
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Interval between psychosis onset and first contact with
physician
This interval was not shorter for the immigrant groups than for natives
(Table 5).
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Additional analyses
At the time of referral to the research team only a minority of the
patients were hospitalised: Surninamese 10% (3/31), Antilleans 33% (2/6),
Moroccans 21% (6/28), Turks 40% (4/10), natives 29% (19/65) and others 34%
(14/41).
Most immigrants had been brought to The Netherlands by their parents. For example, the median ages at arrival of the Surinamese and Moroccan patients diagnosed with a schizophrenic disorder were 9 years (interquartile range: 4-19) and 15 years (9-24), respectively. For people from other countries than Surinam, the Antilles, Turkey and Morocco the median age was 25 (9-33). The majority of key informants regarded the patients' most prominent symptoms as abnormal within his or her culture. In only one case were these symptoms considered normal. Most Surinamese patients were Hindustanis (23/31=74.2%).
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DISCUSSION |
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Validity
The findings for the immigrant groups are not due to a low incidence in
natives. The first-contact rate for schizophrenic disorders among natives in
The Hague is normal (e.g.
Jablensky et al,
1992). The absence of Antillean and Turkish patients of the second
generation may be due to the small size of the population at risk. Lack of
power could account for the normal risk for Turkish immigrants of the first
generation, although, consistent with our findings, a low or normal risk for
these people has also been found in Germany (e.g.
Weyerer &
Häfner, 1992).
There was no evidence of a shorter interval between psychosis onset and contact with medical services in the immigrant groups. The small proportion of patients admitted to hospital at the time of referral to the study excludes hospital bias as an explanation for the results. The excess of psychotic disorders in the immigrant groups was not explained by the socio-economic status of their neighbourhood.
Ideas that appear to be delusional in one culture (e.g. sorcery and witchcraft) may be commonly held in another psychiatrists, when assessing symptoms of schizophrenia, should take these cultural differences into account (American Psychiatric Association, 1994). One could suggest, therefore, that psychiatrists who are blind to ethnicity are unable to make a diagnosis, but the large majority of key informants viewed the symptoms as clearly abnormal. Significantly, when the psychiatrists were informed of the patients' origins, they never considered a change of diagnosis.
The denominators of our study, which are derived from municipal registries, not from voluntary door-to-door surveys or interviews with heads of households, can be regarded as highly reliable. Registration with the municipal authorities is a compulsory requirement for legal residence in The Netherlands and a prerequisite for obtaining essential documents and possible aid (e.g. income support). In sum, this study confirms the results of both previous studies based on the Dutch registry (Selten & Sijben, 1994; Selten et al, 1997).
Interpretation
Some possible explanations are the following: (a) increased incidence of
schizophrenia in country of origin; (b) selective migration of people who are
genetically at risk; (c) environmental factors in Western Europe precipitate
schizophrenia in those who are genetically at risk.
Although there have been no first-contact incidence studies in Surinam, The Netherlands Antilles, Turkey or Morocco, the first explanation is the least plausible. The WHO Ten-Country study found no significant differences in the incidence of schizophrenia, narrowly defined, and studies in the Caribbean found a normal incidence (Jablensky et al, 1992; Mahy et al, 1999).
Although selective migration could explain many of the findings reported here, there are reasons to question this interpretation, particularly for immigrants from Surinam. First, migration from Surinam was on a very large scale. Second, there is no evidence that all subjects at risk for schizophrenia have left Surinam. A chart review found 56 first admissions for DSM-III-R schizophrenia (American Psychiatric Association, 1987) in the single psychiatric hospital in Surinam in 1992 and 1993. Consequently, the average annual first admission rate for people aged 15-54 years was 1.24 per 10 000 (M. Hanoeman, personal communication, 2000). Third, most immigrants recruited for this study were brought to The Netherlands by their parents and any selective mechanisms should have applied to the latter. A problem for an interpretation in terms of environmental factors is how to explain the increased risk in both first- and second-generation immigrants. One could speculate, for instance, that female immigrants have not been exposed to certain viruses in Europe and that these women, when pregnant, produce an abnormal immune response that damages the foetal brain. But this hypothesis does not explain the high incidence in first-generation immigrants. The stress of acculturation, which is highest for immigrants from developing countries, operates across both generations and one should consider the possibility that a process of rapid Westernisation precipitates schizophrenia in individuals who are genetically at risk. Subjects at risk perform worse on tests that measure the processing of complex information, problem-solving ability and mental flexibility (Cannon et al, 1994) and probably do best when they live in a structured environment. However, since a process of Westernisation will often lead to a break-down of social bonds and previously consensual world views, many immigrants live in a highly unstructured environment. It is conceivable, therefore, that the interaction between a specific genetic make-up (e.g. reduced capacity to cope with contradictory information) and specific environmental factors (e.g. conflict between traditional and Western culture) leads to high rates of schizophrenia in some immigrant groups. The normal rates for Turkish people in The Netherlands and Asians in the UK could be due to a protective effect of their strong social and family networks. The Turkish community in The Netherlands is highly organised and has founded many bodies to assist its members (Landman, 1992). Given the long history of conflict in the Rif mountains, it is not surprising that the Moroccan community is more divided and less organised (van Gemert, 1998). The high proportion of Hindustani children growing up in single-parent families in The Netherlands suggests that the cohesion in this section of the population is not as strong as in the Asian communities in the UK. Evidence for a greater social stability in the Turkish community is also provided by the crime rates, which are significantly lower for Turkish people than for Moroccan, Antillean and Surinamese subjects in The Netherlands (Leuw, 1997). A stressful Westernisation hypothesis, however, is not without its problems. There is a dearth of evidence that psychosocial stress leads to schizophrenia (Norman & Malla, 1993) and it is possible that other factors associated with Westernisation explain the findings. Perhaps a parallel could be drawn with the putative rise in schizophrenia in 19th-century Europe (Hare, 1983) and the reports that schizophrenia was relatively uncommon in non-Western societies prior to contact with European-American civilisation (Torrey, 1980).
Limitations
Three limitations are mentioned below, the most important of which concerns
the small numbers of cases in some immigrant groups. The reliability of the
assessment of the time of onset of psychosis was not examined. Finally,
adjustment for socio-economic status of neighbourhood is a crude strategy to
control for inequalities.
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Clinical Implications and Limitations |
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LIMITATIONS
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ACKNOWLEDGMENTS |
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REFERENCES |
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American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSMIV). Washington, DC: APA.
Andreasen, N. C., Flaum, M. & Arndt, S. (1992) The comprehensive assessment of symptoms and history (CASH): an instrument for assessing diagnosis and psychopathology. Archives of General Psychiatry, 49, 615 -623.[Abstract]
Cannon, T. D., Zorrilla, L. E., Shtasel, D., et al (1994) Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Archives of General Psychiatry, 51, 651 -661.[Abstract]
Cytel Software (1999) EGRET for Windows. Cambridge, MA: Cytel Software.
Dohrenwend, B. P. (1999) Epidemiology of schizophrenia: discussion. In Search for the Causes of Schizophrenia, vol. IV (eds W.F. Gattaz & H. Häfner), pp. 81 -88. Darmstadt: Springer.
Dohrenwend, B. P., Levav, I., Shrout, P. E., et al (1992) Socioeconomic status and psychiatric disorders; the causationselection issue. Science, 255, 946 -952.[Medline]
van Gemert, F. (1998) Everybody for Himself. Opportunities, Culture and Criminality of Moroccan Boys. Amsterdam: Spinhuis.
Häfner, H., Riecher-Rössler, A., Hambrecht, K., et al (1992) IRAOS: an instrument for the retrospective assessment of the onset of schizophrenia. Schizophrenia Research, 6, 209 -223.[CrossRef][Medline]
Hare, E. (1983) Was insanity on the increase? The fifty-sixth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1982. British Journal of Psychiatry, 142, 439 -455.[Medline]
Harrison, G., Glazebrook, C., Brewin, J., et al (1997) Increased incidence of psychotic disorders in migrants from the Caribbean to the United Kingdom. Psychological Medicine, 27, 799 -806.[CrossRef][Medline]
Jablensky, A., Sartorius, N., Ernberg, G., et al (1992) Schizophrenia: manifestations, incidence and course in different cultures. Psychological Medicine, Monograph Supplement 20.
Landman, N. (1992) The Islamic Institutions in the Netherlands. Amsterdam: Free University Press.
Leuw, E. (1997) Criminality and Ethnic Minorities. The Hague: Scientific Centre for Research and Documentation.
MacMahon, B. & Trichopoulos, D. (1996) Epidemiology. Principles and Method, pp. 202 -203. Boston, MA: Little.
Mahy, G. E., Mallett, R., Leff, J., et al (1999) First-contact incidence rate of schizophrenia on Barbados. British Journal of Psychiatry, 175, 28-33.[Abstract]
Martens, E. P. (1999) Focus on Ethnic Minorities. Rotterdam: Institute for Socio-Economic Research.
Martens, E. P. & Verweij, A. O. (1997) Surinamese in the Netherlands. Rotterdam: Institute for Socio-Economic Research.
Norman, R. M. G. & Malla, A. K. (1993) Stressful life events and schizophrenia. I: A review of the research. British Journal of Psychiatry, 162, 161 -166.[Abstract]
Selten, J. P. & Sijben, A. E. S. (1994) First admission rates for schizophrenia in immigrants to the Netherlands. Social Psychiatry and Psychiatric Epidemiology, 29, 71-77.[Medline]
Selten, J. P., Slaets, J. P. J. & Kahn, R. S. (1997) Schizophrenia in Surinamese and Dutch Antillean immigrants to the Netherlands: evidence of an increased incidence. Psychological Medicine, 27, 807 -811.[CrossRef][Medline]
Torrey, E. F. (1980) Schizophrenia and Civilization. New York: Aronson.
Weyerer, S. & Häfner, H. (1992) The high incidence of psychiatrically treated disorders in the inner city of Mannheim. Susceptibility of German and foreign residents. Social Psychiatry and Psychiatric Epidemiology, 27, 142 -146.[Medline]
Received for publication May 30, 2000. Revision received October 12, 2000. Accepted for publication October 13, 2000.