Istituto di Anestesiologia e Rianimazione, University of Rome La Sapienza, Azienda Ospedaliera Policlinico Umberto I, Viale del Policlinico 155, I-00161 Rome, Italy *Corresponding author: C.so Trieste 169/A, I-00198 Rome, Italy
Accepted for publication: November 1, 2001
![]() |
Abstract |
---|
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
---|
Methods. We compared two methods of intermittent CO measurements in patients during liver transplantation: COpa, regarded as the current clinical standard, and an aortic transpulmonary thermodilution technique (COart) performed with the PiCCO system. We also compared CCO and PCCO. Measurements were made in 62 patients at three stages: after the induction of anaesthesia, after caval clamping phase, and at the end of surgery. We used BlandAltman and correlation analysis.
Results. We found close agreement between the techniques. Mean bias between COart and COpa and PCCO and CCO was 0.15 (2SD of differences between methods=1.74) litre min1 and 0.03 (1.75) litre min1, respectively. Mean bias between CCO and COpa and PCCO and COpa was 0.02 (1.48) litre min1 and 0.04 (1.69) litre min1, respectively.
Conclusions. Measurement with the aortic transpulmonary thermodilution technique gives continuous and intermittent values that agree with the pulmonary thermodilution method.
Br J Anaesth 2002; 88: 3506
Keywords: heart, cardiac output; measurement techniques, pulse contour analysis, measurement techniques, thermodilution; anaesthesia; liver, transplantation
![]() |
Introduction |
---|
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
---|
|
![]() |
Patients and methods |
---|
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
---|
Anaesthesia and mechanical ventilation
We applied a lead II/V5 ECG to measure the heart rate and a pulse oximeter and placed a radial artery catheter to measure arterial pressure (AP) (PCM SpaceLabs, Inc., Redmond, WA USA). Anaesthetic management was standardized.
Intermittent positive-pressure ventilation and analysis of inspired gases and end-tidal CO2 were done with a volumetric anaesthesia ventilator (CATO, Drager Werk HG. Lübeck, Germany). Liver transplantation was done without veno-venous bypass, using the Piggy-back technique. Cathecholamines were used, if needed, to stabilize the circulation during graft reperfusion. Body temperature was controlled to avoid hypothermia, using a warming blanket (Gaymar Meditherm, Orchard Park, NY, USA) and warm intravenous fluids (HOT LINE, SIMS Medical System, Graseby Ltd, UK).
PiCCO monitoring
In all patients, a 4-French gauge thermistor-tipped catheter (Pulsiocath PV2014L, Pulsion Medical System, Munich, Germany) was placed via a 5-French gauge introducer (Adam Spence Europe Ltd, Abbeytown, Boyle, CR, Ireland) through the right femoral artery, and connected to the PiCCO System (version 4.1) for clinical monitoring of AP, PCCO measurements derived from the AP wave, and COart.
Cardiopulmonary monitoring
A modified 7.5-French gauge PAC for SvO2 and CCO was inserted via an introducer (8.5Fr Baxter Edwards Laboratories, Irvine, CA, USA) into the right internal jugular vein using the Seldinger technique and connected to the Vigilance system (Baxter Edwards Laboratories, Irvine, CA, USA) for COpa and CCO monitoring.
Experimental procedure
COart was calculated from the thermodilution curves using the StewartHamilton principle. The pulse contour device was calibrated after induction of anaesthesia by the mean values of three consecutive COart measurements randomized within the respiratory cycle. These were performed by injection of 15 ml cold saline solution, at a temperature lower than 10°C, via a central venous catheter with subsequent detection by the thermistor embedded into the wall of the arterial catheter. An enhanced version of the Wesseling algorithm, not yet published by the manufacturer, was used to analyse the pulse contour, with a correction factor to reduce the effects of mean AP on arterial impedance as described elsewhere.6 9 10 PCCO was calculated by multiplying stroke volume by heart rate and presented on the monitor as a moving average of the preceding 12 s. We passed the modified PAC into the pulmonary artery by monitoring the pressure waveform from the distal port of the catheter. Intermittent CO measurements were done by manual injection of 10 ml cold saline solution into the superior vena cava through the atrial port. Three consecutive boluses were injected without regard to the phase of respiratory cycle, over a 2-min period. To avoid variation between operators, the injection was always performed by the same person. The plot of the washout curve was examined for stable baseline temperature, undisturbed rapid upstroke, and exponential decay without signs of early recirculation. If an injection had to be rejected, more injections were made to obtain three measurements after rejecting the lowest and the highest. The setting of the ventilator remained the same during the measurements. Intracardiac and pulmonary AP were monitored continuously to ensure that the catheter was in the correct position. Other intravenous fluids were infused at a constant slow rate during the measurements.
After the induction of anaesthesia and achievement of stable cardiovascular conditions, calibration of the pulse contour analysis system was done before induction of anaesthesia. Intermittent CO measurements were then obtained at specific times during the study period: after induction of anaesthesia (T1), after caval clamping phase (T2) and at the end of surgery (T3). Each set of measurements was made in a steady-state period, that is, at least 15 min after change in dosage of catecholamine or sedatives, infusion rate, or ventilator settings. At each time a single set of haemodynamic measurements was collected when the cardiovascular system was stable. The CO data (bolus and continuous) obtained for calibration and immediately following the calibration are not included in the analysis of PCCO results. At each time, PCCO and CCO were measured immediately before and after intermittent CO measurements and the mean of these PCCO and CCO data pairs recorded. To assess the influence of haemodynamic status on bias, two sets of data pairs were considered according to CO (<8 and >8 litre min1).
![]() |
Statistical analysis |
---|
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
---|
Bias between COpaCOart, COpaCCO, and COpa PCCO at each stage (T1, T2, T3) was analysed using the paired Student t test. CO, mean AP and systemic vascular resistance index (SVRI) were analysed using ANOVA for repeated measurements and the paired Student t test with Bonferroni correction. All statistical analysis was computed by SPSS for Windows (Version 8.0, 1997, SPSS Inc., Chicago, IL). Statistical significance was considered to be at P<0.05.
![]() |
Results |
---|
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
---|
|
|
|
|
|
|
|
|
|
|
![]() |
Discussion |
---|
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
---|
To our knowledge, this is the first study that compares continuous and intermittent CO measurement obtained with two different devices, the PiCCO System and a modified PAC (Intellicath) in patients undergoing liver transplantation. We confirmed that COart and PCCO measurements agree with COpa, the current clinical standard, and that PCCO agreed well with CCO, showing that measurements of continuous CO can be made successfully by PCCO during transplant surgery. In this study we used the COpa technique as the reference method for all comparisons because it is the current clinical standard.
Previous studies in critically ill patients have reported a small mean difference (bias) and limit of agreement (bias±2SD), considered clinically acceptable, between CCO, based on the pulsed warm thermodilution technique, and COpa measurements.2 14 15 Our results support the findings of others.3 Bottiger and colleagues report a bias of 0.24 and a degree of precision of 1.789 litre min1. In the early phase of transplantation, after inferior vena cava clamping and after graft reperfusion, the accuracy (bias 0.78 litre min1) and precision (4.3 litre min1) were markedly decreased.3 When we compared CCO and COpa after caval clamping phase we found a bias (2SD) of 0.12 (1.43) litre min1 (Table 6). These differences could be because we do not usually use drug support during inferior vena cava cross-clamping and we carefully avoid hypothermia during liver transplantation so that hypothermia before and immediately after graft reperfusion is prevented.
Nowadays the transpulmonary indicator thermodilution technique allows intermittent CO measurement without the need to use a PAC. Animal experiments1618 and clinical studies7 1921 found a good correlation between pulmonary thermodilution and the transpulmonary thermodilution technique. However, COpa is a measure of right ventricular output whereas COart also measures left ventricular output. Previous studies have found that transpulmonary CO is greater than the corresponding COpa. There may be loss of the cold, and right heart CO may be less than left heart CO because heart rate can be reduced by the cold injection. Approximately 34% of the indicator could be lost during passage in the pulmonary circulation, with overestimation of COart.17 18 Lewis and co-workers22 described a 9% loss of the injected thermal indicator before femoral detection. Since other studies did not find an indicator loss,23 24 the transient reduction in heart rate by the cold injection, which has less influence on the COart because of the longer appearance time, is more likely to be responsible for the somewhat lower values of COpa.25 In the present study COart was higher than COpa, which supports results from other authors.2225 Which CO is the true CO cannot be detected by this study. In any case a good agreement between the different techniques was observed. Our results comparing the two intermittent techniques (bias 0.15 [1.59 to 1.89] litre min1) are similar to those reported by Gödje and co-workers who studied patients undergoing coronary artery bypass grafting (bias 0.29 [1.60 to 1.02] litre min1).7 In the present study we found a mean difference of 0.04 litre min1 with a level of agreement of 1.69 litre min1 between PCCO and COpa, similar to the results reported by Gödje and colleagues (bias [2SD] 0.07 [1.40] litre min1 and 0.10 [0.42] litre min1).7 26 Excellent results (0.003 [1.26] litre min1) were obtained during cardiac surgery in 12 patients.27
Rödig and co-workers showed that changes in vascular tone of approximately 20% did not affect the pulse contour method but large changes in AP may affect PCCO measurements, and re-calibration of the PCCO device may be necessary.6 The finding that moderate changes in SVR did not necessarily affect the accuracy of PCCO support a study by Irlbeck and colleagues.28 These authors studied PCCO and COpa in patients in the intensive care unit and concluded that PCCO is valid for clinical purposes only if the initial calibration is repeated every 4 h.28 We found no evidence that PCCO was not accurate even with substantial changes in SVR. The changes in vascular tone in our patients were probably less and had no effect on the pulse contour method. The site of pulse contour detection may be important. The pressure in peripheral arteries (such as the radial artery) may be influenced by the reflection of pulse waves and greater transit time, which can interfere with the calculation of PCCO. In this study, PCCO was always measured with a catheter in the abdominal aorta, passed from the femoral artery. Problems with arterial catheters in the radial or brachial artery during periods of low CO were avoided. We did not observe a decrease in PCCO and/or CCO after injection of cold saline at any time during the procedures, despite giving large volumes of fluids that could affect the reliability of the continuous thermodilution CO measurements.3 At greater values of CO (>8 litre min1) the limits of agreement between PCCO COpa and between CCOCOpa were 1.37 to 1.73 litre min1 and 1.98 to 2.36 litre min1, respectively (Table 5).29 Clinically the response to haemodynamic changes is more accurate with PCCO based on AP waveform than CCO because the latter method requires measurement over 3 min, being a semicontinuous method.
The risks of PAC have been recently discussed.30 The transpulmonary thermodilution method performed with the PiCCO or COLD system requires a central venous cannula to inject cold saline, and a femoral arterial cannula, and avoids the use of a PAC.9 21 22 27 Given the closer correlation between the methods, the pulse contour method for determination of CO can be calibrated and made using COart, which would avoid unnecessary insertion of a PAC.7 26 27 A central venous cannula is necessary in most surgical patients anyway, and femoral artery catheterization, which allows continuous haemodynamic monitoring and blood sampling, is safe in critically ill patients.31
In conclusion, PAC insertion seems to be justified only when continuous measurement of SvO2 is needed, or in patients with pulmonary hypertension. The PiCCO system is very useful in high-risk patients if less invasive monitoring is required.
![]() |
References |
---|
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
---|
2 Boldt J, Menges T, Wollbruck M, Hammermann H, Hempelmann G. Is continuous cardiac output measurement using thermodilution technique reliable in the critically ill patients? Crit Care Med 1994; 22: 19138[ISI][Medline]
3 Bottiger BW, Sinner B, Motsch J, Bach A, Bauer H, Martin E. Continuous versus intermittent thermodilution cardiac output measurement during orthotopic liver transplantation. Anaesthesia 1997; 52: 207214[ISI][Medline]
4 Yeldermann ML. Continuous measurement of cardiac output with the use of stochastic system identification techniques. J Clin Monit 1990; 6: 32232[ISI][Medline]
5 Greim CA, Roewer N, Thiel H, Laux Gand Schulte J. Continuous cardiac output during adult liver transplantation: thermal filament technique versus bolus thermodilution. Anesth Analg 1997; 85: 4838[Abstract]
6
Rödig G, Prasser C, Keyl C, Liebold A, Hobbhahn J. Continuous cardiac output measurement: pulse contour analysis vs thermodilution technique in cardiac surgical patients. Br J Anaesth 1999; 82: 52530
7 Gödje O, Höeke K, Lichtwarck-Aschoff M, Faltchauser A, Lamm P, Reichart B. Continuous cardiac output by femoral arterial thermodilution calibrated pulse contour analysis: comparison with pulmonary arterial thermodilution. Crit Care Med 1999; 27: 240712[ISI][Medline]
8 Hourani JM, Bellamy PE, Tashkin DP, Batra P, Simmons MS. Pulmonary dysfunction in advanced liver disease: frequent occurrence of an abnormal diffusing capacity. Am J Med 1991; 90: 693700[ISI][Medline]
9 Falthauser A, Erhardt W, Gödje O, Reichart B, Pfeiffer UJ. Accuracy of a less invasive device for rapid beat-to-beat continuous cardiac output monitoring. Intensive Care Med 1996; 22 (Suppl 3): 506
10 Rauch H, Bottiger BW, Motsch J, Müller M, Fleischer F, Martin E. Pulse contour cardiac output measurement corresponds better with standard dilution technique than continuous thermodilution technique after hypothermic by-pass. Br J Anaesth 1997; 78 (Suppl 2): 16
11 Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurements. Lancet 1986; 1: 30710[ISI][Medline]
12 Spiess BD, McCarthy R, Tuman KJ, Ivankovich AD. Bioimpedance hemodynamics compared to pulmonary artery catheter monitoring during orthotopic liver transplantation. J Surg Res 1993; 54: 526[ISI][Medline]
13 Stelzer H, Blazek G, Gabriel A, et al. Two-dimensional transesophageal echocardiography in early diagnosis and treatment of hemodynamic disturbances during liver transplantation. Transplant Proc 1991; 23: 19578[ISI][Medline]
14 Bottiger BW, Soder M, Rauch H, et al. Semi-continuous versus injectate cardiac output measurement in intensive care patients after cardiac surgery. Intensive Care Med 1996; 22: 3128[ISI][Medline]
15 Jakobsen CJ, Melsen NC, Andresen EB. Continuous cardiac output measurement in the postoperative period. Acta Anaesthesiol 1995; 39: 4858[ISI]
16 Wickets CJ, Jakobsson J, Frostell C, Hedenstierna G. Measurement of extravascular lung water by thermal-dye technique: mechanisms of cardiac output dependence. Intensive Care Med 1990; 16: 11520[ISI][Medline]
17 Bock JC, Barker BC, Mackersie RC, Tranbaugh RF. Cardiac output measurements using femoral artery thermodilution in patients. J Crit Care 1989; 4: 10611[ISI]
18
Bock JC, Deuflhard P, Hoeft A, et al. Thermal recovery after passage of the pulmonary circulation assessed by deconvolution. J Appl Physiol 1988; 64: 121016
19
Gödje O, Peyerl M, Seebauer T, Dewald O, Reichart B. Reproducibility of double indicator dilution measurements of intrathoracic blood volume compartments, extravascular lung water and liver function. Chest 1998; 113: 10707
20 Sakka SG, Reinhart K, Meier-Hellmann A. Comparison of pulmonary artery and arterial thermodilution cardiac output in critically ill patients. Intensive Care Med 1999; 25: 8436[ISI][Medline]
21 Sakka SG, Reinhart K, Wegscheider K, Meier-Hellmann A. Is the placement of a pulmonary artery catheter still justified solely for the measurement of cardiac output? J Cardiothorac Vasc Anesth 2000; 14: 11924[ISI][Medline]
22 Lewis FR, Elings VB, Hill SL, Christensen JM. The measurement of extravascular lung water by thermal-green dye indicator dilution. Ann N Y Acad Sci 1982; 384: 394410[Abstract]
23
Carlile PV, Beckett RC, Gray BA. Relationship between CO and transit times for dye and thermal indicators in central circulation. J Appl Physiol 1986; 60: 136372
24 Arfors KE, Malmberg P, Pavek K. Conservation of thermal indicator in lung circulation. Cardiovasc Res 1971; 5: 5304[ISI][Medline]
25 Harris AP, Miller CF, Beattie C, Rosenfeld GI, Rogers MC. The slowing of sinus rhythm during thermodilution cardiac output determination and the effect of altering injectate temperature. Anesthesiology 1985; 63: 5401[ISI][Medline]
26
Gödje O, Thiel C, Lamm P, et al. Less invasive, continuous hemodynamic monitoring during minimally invasive coronary surgery. Ann Thorac Surg 1999; 68: 15326
27 Burhe W, Weyland A, Kazmaier S, et al. Comparison of cardiac output by pulse-contour analysis and thermodilution in patients undergoing minimally invasive direct coronary artery bypass grafting. J Cardiothorac Vasc Anesth 1999; 13: 43740[ISI][Medline]
28 Irlbeck M, Forst H, Briegel J, Haller M, Peter K. Continuous measurement of cardiac output with pulse contour analysis. Anaësthesist 1995; 44: 493500[ISI][Medline]
29 Lefrant JY, Bruelle P, Ripart J, et al. Cardiac output measurement in critically ill patients: comparison of continuous and conventional thermodilution techniques. Report of investigation. Can J Anaesth 1995; 42: 9726[Abstract]
30 Cusack RJ, Rhodes A. Pulmonary artery catheter to use or not to use; that is the question? Clin Intensive Care 2000; 11: 1179
31 Gurman GM, Kriemerman S. Cannulation of big arteries in critically ill patients. Critical Care Med 1985; 13: 21720[ISI][Medline]