1Department of Anaesthesiology and Critical Care Medicine, Meir Hospital, 44281, Kfar Saba, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel, and 2Department of Otolaryngology, Head and Neck Surgery, Meir Hospital, 44281, Kfar Saba, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel*Corresponding author
Accepted for publication: April 16, 2000
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Abstract |
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Br J Anaesth 2000; 85: 4079
Keywords: anaesthetics i.v., propofol; anaesthetic techniques; complications, myotonic; ventilation
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Introduction |
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Anaesthetic management of these patients is challenging and may pose a serious problem to the anaesthesiologist. Myotonia may be precipitated by hypothermia, shivering, and mechanical or electrical stimulation. Furthermore, sensitivity to sedative, anaesthetic and neuromuscular blocking agents may result in intraoperative and early postoperative cardiovascular and respiratory complications, as well as prolonged recovery from anaesthesia. We therefore performed a study to assess the adequacy of an anaesthetic regimen based on i.v. propofol in myotonic dystrophy patients undergoing oropharyngeal and neck surgery.
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Patients and methods |
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The study was approved by the Institutional Ethics Committee and consent was obtained from all patients or their parents. No pre-anaesthetic medication was administered. Prior to induction of anaesthesia, with the patient in the supine position, vital capacity and tidal volume were measured using an Ohmeda Modulus II anaesthetic machine pneumotachograph with a tight-fitting face mask. Intraoperative monitoring included electrocardiogram, non-invasive arterial pressure, pulse oximeter, capnograph, nerve stimulator and rectal temperature. The highest and lowest intraoperative arterial pressure and heart rate were documented. Anaesthesia was induced with fentanyl 0.05 mg, propofol 2.5 mg kg1 and atracurium 0.5 mg kg1. After intubation of the trachea, the patients lungs were ventilated with 70% N2O in oxygen and anaesthesia was maintained with a continuous infusion of propofol 6 mg kg1 h1, bolus fentanyl 2 µg kg1 and incremental doses of atracurium 0.2 mg kg1. After patients had regained consciousness and four equal train of four twitches were observed, the trachea was extubated. A 20% or greater decrease in systolic blood pressure was treated with i.v. ephedrine (5 mg).
Duration of anaesthesia (start of anaesthesiaextubation), recovery time (end of surgeryextubation), post-extubation tidal volume and vital capacity were recorded. Patients were admitted for 23 h to the post-anaesthetic care unit (PACU) prior to being discharged to the ward. On admission to PACU, ECG, NIBP, SpO2 as well as the occurrence of postoperative nausea and vomiting were recorded. Postoperative respiratory and cardiac complications and length of hospital admission were noted.
The mean highest and lowest intraoperative heart rate, systolic blood pressure, post-extubation tidal volume and vital capacity, and lowest postoperative SpO2were compared to baseline values and analysed using the MannWhitney U-test. A P-value of <0.05 was considered significant.
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Results |
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There was no difference between mean preoperative and postoperative tidal volumes (334 (119) ml versus 330 (122) ml) (P=0.97). However, there was a significant decrease in mean postoperative vital capacity (965 (349) ml) from the preoperative value (1664 (566) ml) (P=0.0028). There were no perioperative respiratory or cardiac complications and bronchial secretions were not a problem. Only two patients complained of nausea and vomiting, but no treatment was required. Similarly, muscular hypertonia and shivering were not observed.
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Discussion |
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Etomidate was used successfully in a myotonic dystrophy patient undergoing maxillo-facial surgery.8 However, because etomidate has been shown to cause adrenal suppression, its use by continuous infusion is now questioned.9
The use of propofol as an induction and maintenance agent in myotonic dystrophy is controversial. Milligan was the first to report the uneventful use of propofol as an induction agent in myotonic dystrophy,10 while White and Smyth administered a continuous infusion of propofol in a case undergoing prolonged oral surgery without mishap.11 Speedy found that less than 1 mg kg1 of propofol was sufficient to induce hypnosis and permit tracheal intubation.12 However, when isoflurane was added to maintain anaesthesia, the patient developed severe intraoperative hypotension and prolonged postoperative unconsciousness and apnoea. Similarly, in a patient in whom a target-controlled propofol infusion system was used, recovery was prolonged for 1 h after the completion of surgery.13 A generalized myotonic state was also reported after the i.v. administration of propofol.14 As with thiopental, the cause of these variable exaggerated physiological responses to propofol can be associated with the severity of the disease.
Inhalation agents may be deleterious in patients suffering from myotonic dystrophy and should be used with caution. Deep inhalation anaesthesia may further risk the already compromised cardiovascular and respiratory systems of these patients, while postoperative shivering may precipitate myotonia. However, large concentrations of volatile anaesthetics have been shown to resolve myotonic contractions albeit at the expense of cardiorespiratory depression.2
Neuromuscular blocking drugs pose a particular problem in myotonic dystrophy. These patients are particularly sensitive to succinylcholine. Succinylcholine has an initial stimulating action on muscle.15 16 This may result in the development of myotonia leading to difficulty in intubation and ventilation. Therefore, the use of succinylcholine is not recommended in myotonic dystrophy patients.2 7 17
In contrast, the non-depolarizing neuromuscular blocking drugs usually evoke a normal response. However, if muscle wasting exists, a prolonged response may occur necessitating the reversal of the muscle relaxant. The anticholinesterase drugs used for this purpose may also precipitate myotonia, presumably a result of increased sensitivity to the stimulatory effect of acetylcholine.18 19 Although neostigmine has been found to be safe in some instances,16 20 it would be prudent to rather use short-acting non-depolarizing muscle relaxants which do not require antagonism. In this context, atracurium, an intermediate-acting muscle relaxant, which is metabolized by Hoffman degradation may be the most suitable. Spontaneous recovery from atracurium has been shown to occur in under an hour.17 2123
We found the combination of a continuous propofol infusion, fentanyl, atracurium and nitrous oxide in oxygen to be successful for patients undergoing oropharyngeal and neck surgery. Exaggerated reactions to drugs and myotonia were not observed. The recovery period was smooth and relatively short (12 min), and only two patients had nausea and vomiting. There were no serious postoperative respiratory or cardiac complications.
Anaesthetic and surgical complication rates range between 8.2 and 42.9%.57 The stable intraoperative period, uneventful recovery and lack of postoperative complications in our study may be explained by two factors. Firstly, our patients were young (median age 21 yr) and only had minor symptoms of the disease. Myotonic dystrophy is a slowly progressing multi-system disease with death occurring usually in the sixth decade of life.17 Secondly, the surgical procedures in this study were peripheral. The prevalence of postoperative pulmonary complications has been reported to be as high as 38.1% after upper abdominal surgery in patients with myotonic dystrophy.5 However, in none of these cases was propofol used as the main anaesthetic. In contrast, White and Smyth reported an uneventful perioperative period in a patient anaesthetized using a continuous infusion of propofol for abdominal hysterectomy.11 Therefore, the effect of propofol-based anaesthesia on the surgical outcome in myotonic dystrophy patients undergoing major surgery needs further clarification.
In conclusion, the combination of propofol infusion, fentanyl, and atracurium with nitrous oxide in oxygen appears to be a suitable anaesthetic technique for young myotonic dystrophy patients undergoing peripheral surgery. Further studies are required to evaluate this anaesthetic technique in elderly patients suffering from myotonic dystrophy as well as those undergoing major surgery.
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References |
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