Academic Urology Unit, Royal Marsden Hospital, Downs Road, Sutton SM2 5PT, UK
* Email: alison_birtle{at}hotmail.com
Bleomycin is an antibiotic complex derived from Streptomyces verticullis culture and excreted by the kidneys. Bleomycin toxicity, predominately skin and pulmonary, has been described since the drug's introduction into testicular cancer management in the 1960s [1]. Previous data from the Royal Marsden have described a 6.8% rate of pulmonary toxicity in an 835-patient series, with increased risk occurring in patients >40 years old, those with impaired glomerular filtration rate (GFR) (<80 ml/min) or with stage IV disease, or if a cumulative dose >300 000 IU was given [2
]. No relation to bleomycin batch has been described previously.
At the end of 2003/early 2004, we encountered a number of patients with bleomycin toxicity and decided to investigate whether there was an identifiable cause. We identified 19 patients treated at least in part from the same bleomycin batch (435000 Kyowa). Cumulative bleomycin dose, schedule, prognostic group and bleomycin risk factors were reviewed. Five out of 19 patients (26%) developed grade 3 skin or lung toxicity at total doses of 90 000300 000 IU, requiring cessation of drug ± corticosteroids. Pulmonary toxicity was observed in three out of 19 (15.8%), a much higher rate than that seen in our previous series [2
]. When stratified for stage, GFR, age, prognostic group and chemotherapy schedule, no apparent causal relationship was seen in the patients with toxicity (Table 1). This association may be due to chance, but given that the only common factor among the group was of the shared bleomycin batch, we are suspicious that this was the causal element.
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2. O'Sullivan JM, Huddart RA, Norman AR et al. Predicting the risk of bleomycin lung toxicity in patients with germ-cell tumours. Ann Oncol 2003; 14: 9196.
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