Departments of 1 Clinical Therapeutics and 2 Radiology, Medical School, University of Athens, Athens, Greece
* Correspondence to: Dr A. Bamias, 31 Komninon St, Haidari, 124 62 Athens, Greece. Tel: +30-210-3381546; Fax: +30-210-3381511; Email: abamias{at}med.uoa.gr
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Abstract |
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Patients and methods: A total of 381 patients with advanced urothelial carcinoma received CIMV (cisplatin, ifosphamide, methotrexate, vinblastine) (n=32), MVAC (methotrexate, vinblastine, doxorubicin, cisplatin) (n=105), DC (docetaxel, cisplatin) (n=174), CaG (carboplatin, gemcitabine) (n=64) or other regimes (n=6) and were included in this analysis.
Results: A total of 116 patients were 70 years. Elderly patients experienced more frequent neutropenia grade 3/4 (55% versus 37%, P=0.087) and renal toxicity (28% versus 10%, P=0.033) among patients treated with CIMV/MVAC, and neutropenic infections (4% versus 0%, P=0.019) among patients treated with DC. Median survival did not differ significantly between elderly and younger patients (9.3 versus 10.5 months, P=0.16). Eastern Cooperative Oncology Group performance status (PS) and haemoglobin were independently associated with prognosis. Patients with PS <2 and haemoglobin
10 g/dl had a median survival of 14 months as opposed to 5 months for patients with PS
2 or haemoglobin <10 g/dl (P <0.001).
Conclusion: Elderly patients with advanced urothelial cancer tolerate platinum-based chemotherapy well and derive the same benefit as their younger counterparts.
Key words: bladder cancer, chemotherapy, elderly, platinum
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Introduction |
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Carcinoma of the urothelial tract is a disease primarily of elderly people, since most patients are diagnosed beyond the age of 65 years [3]. Cisplatin-based chemotherapy is effective and prolongs survival of patients with advanced urothelial cancer [4
6
]. Nevertheless, the combination of MVAC (methotrexate, vinblastine, doxorubicin and cisplatin), which has long been considered as standard, as well as the recently established gemcitabine/cisplatin combination [7
], have been associated with bone marrow and renal toxicity. Therefore, cisplatin-based chemotherapy is offered to few elderly patients, because of age-related renal function impairment and frequent comorbidities preclude adequate hydration required for cisplatin administration [2
]. The non-nephrotoxic platinum analogue, carboplatin, has been frequently substituted for cisplatin in patients who are unfit to receive cisplatin [8
10
]. In both cases, there is limited information regarding the tolerability of treatment with cisplatin or carboplatin by elderly patients with advanced urothelial carcinoma and their outcome, since they form only a small percentage of patients included in clinical trials.
Between 1995 and 2003 we conducted four clinical studies in patients with advanced urothelial cancer. All patients included in these studies received first-line treatment with combinations containing cisplatin or carboplatin. We present here an analysis of our database from these studies in order to examine the relationship between age and the outcome in patients receiving platinum-based combination chemotherapy for advanced urothelial cancer. The purpose of this analysis was to determine whether elderly patients (70 years) do worse than their younger counterparts in terms of tolerance, disease control and survival.
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Patients and methods |
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Efficacy and toxicity analysis
Survival was calculated from the day of the initiation of treatment until date of death or last contact for patients still alive at the time of follow-up. Our database was updated in October 2003. Tumour assessment was performed every three cycles of treatment. Patients with bidimensionally measurable disease, who received protocol treatment and had at least one follow-up tumour assessment were eligible for response evaluation. Standard WHO criteria [16] were used for classifying response. In an intention-to-treat analysis all patients were included in the analysis; non-evaluable patients were considered as non-responders. Toxicity was evaluated at each chemotherapy visit according to National Cancer Institute Common Toxicity Criteria. All patients who received at least one cycle of chemotherapy were included in toxicity analysis. Relative dose intensity (RDI) was defined as the percentage of the expected dose administered to the patient (per unit of time expressed in mg/m2/week).
Statistical analysis
All analyses were performed using the SPSS statistical software (SPSS for Windows, version 10, SPSS Inc., Chicago, IL). Differences between elderly and younger patients were examined with a 2 test for categorical variables, whereas the t-test was used for continuous variables. Survival curves were produced with the KaplanMeier method and compared between arms with the stratified log-rank test. For univariate and multivariate analyses of survival, the Cox proportional hazards model was used. Throughout the analysis a level of 5% was used to denote statistical significance.
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Results |
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Chemotherapy administration and toxicity
RDI was analyzed for studies 3 and 4, since this parameter was not reported in the first two studies. The median number of cycles and RDI did not differ significantly between the two age groups irrespective of the treatment received (Table 2).
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The toxic death rates were similar between the two age groups: 1.7% in the elderly group (two patients) and 1.5% among younger patients (four patients). All deaths were due to neutropenic sepsis.
Response rates and survival
Complete and overall response rates were similar between the two groups for patients receiving MVAC, CIMV or CaG (Table 3). Complete response rate was significantly higher for younger patients among patients treated with DC (15% versus 2%, P=0.009). Nevertheless, the overall response rates did not differ between the two groups.
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Discussion |
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Data regarding the tolerability of chemotherapy by elderly patients have been contradictory. Several retrospective studies have shown that these patients can tolerate chemotherapy equally as well as younger patients [17, 18
], while other investigators have shown poor tolerance of chemotherapy [19
, 20
]. Advancing age has been associated with reduced bone marrow reserve and glomerular filtration rate (GFR) [2
]. Our analysis confirms these data, since elderly patients had more frequent anemia and significantly lower creatinine clearance. Renal toxicity was more frequent in elderly patients receiving MVAC or CIMV. In addition, higher grade 3 or 4 neutropenia was observed in patients receiving MVAC or CIMV, while neutropenic infections were exclusively observed in elderly patients among those treated with DC. In spite of these differences, bone marrow toxicity was acceptable and did not result in lower exposure to chemotherapy, as shown by a similar number of cycles and RDI between the two age groups. The lack of excessive bone marrow toxicity in elderly patients could be attributed to the routine use of granulocyte colony-stimulating factor in most patients included in this analysis (studies 2 and 3) [12
, 13
].
There is controversy regarding the efficacy of chemotherapy in elderly patients. Old age is a predictor of poor survival in non-Hodgkin's lymphoma [21] and ovarian cancer [22
]. Few data in patients with advanced urothelial cancer have been published. Our study showed that chemotherapy had similar efficacy in elderly and younger patients. This was true for cisplatin and carboplatin-based treatment, although the number of patients receiving carboplatin was too low for definite conclusions. Because our patients have been treated with different chemotherapy regimes, we stratified them according to treatment in all analyses of toxicity and efficacy. Again, no differences were detected between the two age groups. As expected, stratification lowered the statistical power of our results. Nevertheless, median survival of the two age groups was very similar in all subgroups, making the possibility of a true difference unlikely. Our results are in concert with other retrospective analyses [23
, 24
], which showed a lack of prognostic significance of age in patients with advanced urothelial cancer. Another study showed that patients older than 60 years had a better outcome than younger patients [25
]. Nevertheless, that result may have reflected the selection of elderly patients with physical condition and prognostic factors better than the average patient in this age group, in order to avoid excessive toxicity from MVAC administration.
Analysis of baseline characteristics of elderly patients showed that PS 2 or 3 and significant anaemia (haemoglobulin <10 g/dl) were independent predictors of poor prognosis. The prognostic significance of PS has been shown in all previous studies studying prognostic factors in advanced urothelial cancer [2325
], while anaemia was also shown to be an independent prognostic factor in one of these studies [23
]. Surprisingly, the presence of visceral metastases did not have a significant impact on survival in this analysis, although patients with visceral metastases had a shorter median survival (13 versus 8 months). Our study cannot specify whether this represents a true difference of this population compared with younger patients, or whether this is a result of the small number of patients included in this analysis. The first speculation is supported by the fact that the presence of visceral metastases was associated with poor prognosis in our phase III study, where elderly patients represented a small proportion of the population included [13
]. Although this study was included in this analysis, the prognostic significance of this factor was not maintained when only elderly patients were analysed. On the other hand, lack of prognostic significance was also shown in two other studies [24
, 25
]. One of these studies also included a relatively small number of patients (n=92) [25
], while the other study included a non-homogeneously treated population [24
]. On the contrary, both studies that showed the prognostic significance of the presence of visceral metastases included patients who had all received the same treatment (MVAC or GC) [23
, 26
].
The combination of the two prognostic factors defined two groups of distinctly different prognosis. The ability of identifying groups of different prognosis by combining prognostic factors has also been shown for patients treated with MVAC [23]. Patients who had one or two adverse prognostic factors had a median survival of only 5 months. It seems that these patients do not benefit from platinum-based combination chemotherapy and they should be candidates for symptomatic treatment, non-toxic monotherapy or novel non-chemotherapeutic agents.
Cisplatin-based chemotherapy is considered the standard treatment for patients with advanced urothelial cancer who have good PS, adequate renal function and no comorbidities precluding sufficient hydration [27]. In contrast, carboplatin-based chemotherapy has generally produced inferior results [28
30
] and is reserved for unfit patients. Survival was inferior for carboplatin-based chemotherapy among elderly patients in our study, although this did not reach statistical significance. This lack of significance may be due to the relatively small number of patients included in this analysis. Since elderly patients tolerated cisplatin-based chemotherapy equally as well as younger patients, we recommend that this treatment should be offered to elderly patients with good PS and no contraindications for cisplatin administration.
In conclusion, elderly patients with advanced urothelial cancer tolerate well and benefit from platinum-based chemotherapy and, therefore, should be offered this treatment option and should be included in clinical trials. Nevertheless, the use of prognostic factors is strongly recommended in order to select patients unlikely to benefit from combination chemotherapy and to avoid unnecessary toxicity.
Received for publication April 21, 2004. Revision received July 23, 2004. Accepted for publication August 26, 2004.
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