Measuring cancer prevalence in Europe: the EUROPREVAL Project

R. Capocaccia1,+, M. Colonna2,4, I. Corazziari1, R. De Angelis1, S. Francisci1, A. Micheli3 and E. Mugno3,§

1Istituto Superiore di Sanità, Rome, Italy; 2Isère Cancer Registry, Grenoble, France; 3Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy; 4FRANCIM, Toulose, France

Received 4 May 2001; revised 12 December 2001; accepted 13 December 2001.


    Abstract
 Top
 Abstract
 Introduction
 Estimation of total prevalence
 Standard errors of prevalence...
 Prevalence of all cancers...
 References
 
Cancer prevalence is the proportion of individuals in a population who at some stage during their lifetime have been diagnosed with cancer, irrespective of the date of diagnosis. Cancer prevalence statistics have generally been provided by a limited number of well established cancer registries that have been in existence for several decades. The advent of systematic follow-up of life status of incident cases and the availability of new statistical methodologies, now makes it possible for registries established during the 1970s or 1980s to provide prevalence data. The main problems encountered in the estimation of prevalence are the inclusion of: (i) cases lost to follow-up; (ii) cases known only from their death certificate; (iii) cases diagnosed before the start of registration; and (iv) the treatment of multiple tumours and migrations. The main aim of this paper was to review these problems and discuss, through the experience gained with EUROPREVAL, how they can be overcome. A method is presented for the calculation of prevalence of all cancers combined in the populations covered by the 45 cancer registries participating in EUROPREVAL. Prevalence of cancer is estimated to be 2% on average, with the highest values (3%) in Sweden and the lowest in Eastern Europe, with a minimum of ~1% in Poland.

Key words: epidemiology, Europe, methods, prevalence, tumours


    Introduction
 Top
 Abstract
 Introduction
 Estimation of total prevalence
 Standard errors of prevalence...
 Prevalence of all cancers...
 References
 
Cancer prevalence is the proportion of individuals in a population who at some stage during their lifetime have been diagnosed with cancer, irrespective of the date of diagnosis. This definition assumes that cancer is an irreversible disease and diagnosed individuals remain cancer cases until death. Such people make greater demands on the health system than the general population. They require treatment, follow-up for cancer recurrence, screening for independent secondary cancers and may be permanently impaired or disabled as a result of their cancer. However, prevalent cancer cases are a highly heterogeneous group in terms of health status, as they include patients undergoing clinical treatment and those diagnosed many years previously who may be considered cured of their cancer and require few if any additional health care resources. Time from diagnosis is therefore an essential qualifier of cancer prevalence data.

Unlike cancer incidence or mortality, prevalence has not been a major focus of epidemiological statistics; nevertheless, several methods have been developed to provide estimates of prevalence mainly as a by-product of some other activity. For example, health surveys sampling the general population [1] can provide prevalence estimates from persons reporting they have been diagnosed with cancer. However, health surveys are expensive, require very large samples to obtain data on rarer cancers, and are prone to bias, as the compliance of seriously ill persons is expected to differ from that of healthy individuals. Direct methods [24] employ incidence and follow-up data collected by population-based cancer registries (CRs). In essence, they calculate prevalence by counting how many incident cases are still alive at a given index date; however, cancer registration must have been carried out for long enough so that essentially all surviving cancer cases are registered, otherwise the prevalence estimate will be low.

Indirect methods estimate prevalence by modelling the mathematical relationships between incidence, prevalence, survival and mortality. Depending on what data are available—incidence and survival [5], incidence and mortality [6] or mortality and survival [7]—data can be used to obtain prevalence functions. Mortality data are usually obtained from national statistics, while incidence and survival data are provided by CRs.

Cancer prevalence data are not systematically available at the level of national populations. Some prevalence data pertaining to a few US states and some European countries that have been covered by cancer registration for many decades have been published [24, 813].

EUROPREVAL is the first Europe-wide project to estimate the prevalence of the most important cancers in the participating European countries. The first objective of the project was to use direct methods to calculate prevalence data for European populations covered by cancer registration. Data were available from the EUROCARE-2 Study [14], which collected data on cancer patients diagnosed from 1978 to 1992 from 56 participating population-based CRs in 17 European countries. In order to ensure that the cancer prevalence estimates from the numerous participating CRs were comparable across the board, it was necessary to solve some important methodological problems pertaining to data registration, consistency and comparability. The aim of this paper was to review these problems and discuss, through the experience gained with EUROPREVAL, how they can be overcome. We then applied these solutions to the basic prevalence calculations for all cancers combined in the populations covered by the 45 cancer registries participating in EUROPREVAL. The results of the study are more extensively presented in a companion paper appearing in this issue [15].

Problems arising from direct methods of calculating prevalence
The direct method used to calculate cancer prevalence in a population covered by cancer registration was simply to count all incident cases of cancer that were still alive at a given date (the index date). The procedure basically consists of allocating all incident cases still alive at the index date to cells in a two-dimensional matrix according to their age at the index date and the number of years since the cancer was diagnosed. When divided by the corresponding population sizes, they provide prevalence figures as proportions that are specific for age and disease duration. However, the figures thus produced are likely to be incomplete or inaccurate due to loss of cases during follow-up, cases known only from their death certificate (DCO), problems arising from the treatment of migration and multiple cancers, and lack of completeness due to surviving cases diagnosed before the registry came into existence. These problems are discussed below.

Cases lost to follow-up
Some cases are inevitably lost to follow-up and their vital status at the index date is therefore uncertain. For most European registries, the percentage of cases lost is <1% [16]. Higher percentages are the norm in US registries [13], because follow-up procedures differ and there is a relatively high rate of state-to-state migration.

Cases lost to follow-up are considered in the analysis by attributing an estimated survival probability. The approach of Feldman et al. [4] was to derive this probability from a single life table calculated for the whole set of patients not lost to follow-up, irrespective of age and period of diagnosis. A more recently published approach [12] estimates the survival probability of each lost case from the subset of followed patients belonging to the same age and period of diagnosis. The approach of Feldman et al. [4] gives more stable estimates; however, it can produce erroneous results in patients considerably younger or older than the average. The second approach [12], in theory, provides more accurate probability estimates, but is subject to random variability when the total number of patients in the age group considered is small. Whatever method is used, the number of lost cases estimated alive at the index date is added to the number of prevalent cases determined by the direct method.

Cases known only from the death certificate (DCO)
Some cases are notified to registries only when they die and the death certificate reports cancer as the underlying cause. Whether DCO cases should be included in prevalence counts is controversial, as is the method of their inclusion. It can be argued that such cancers are diagnosed very close to death; that patients were not actually treated as cancer patients and therefore only contribute to the prevalent population for a negligible time. On the other hand, some patients are DCO not because they were first diagnosed at death, but because an earlier diagnosis failed to reach the CR. These patients should be included in the prevalence count; however, this is not a simple task. The problem is to estimate the number of cancer cases not observed by the registry who actually had a cancer diagnosis at the prevalence date; these cases will be registered as DCO after this date. Specific studies of trends and survival times of DCO cases will have to be carried out in order to estimate the number of such cases. In any event, if they are not included, the proportion of DCO to registered cases should be reported to provide an indication of the extent to which prevalence may have been underestimated. We have done this when presenting the EUROPREVAL data.

Migration
People moving away after cancer diagnosis and registration are usually not lost to follow-up even if they move to a different health area, and although they no longer make demands on the health area where they were diagnosed, are still included in the prevalence data. Conversely, patients who move into another health area after diagnosis are not counted in the prevalence of that area even though they are treated there. In such situations the prevalence of a region or health area is underestimated when the net flow is into that area, and is overestimated in the opposite case. However, the resulting error is small in most European countries, where the net migration rate is usually between –1 and +1% per annum. Prevalence estimates should not therefore be substantially affected by migration, unless there is a net migration of cancer patients from one area to another. To our knowledge, this phenomenon has not been considered in any prevalence analysis, mainly because there is no systematic information on migration for health reasons. Migration was not considered when presenting the data from EUROPREVAL.

Multiple cancers
Prevalence can refer to the number of people with cancer or the number of cancers in the population. The difference lies in the way multiple primary malignant tumours are accounted for. Person prevalence considers only the first primary malignant cancer diagnosed in each person, and is a measure of the number of people actually making demands on health care resources for cancer. On the other hand, patients with two or more tumours are counted several times in tumour prevalence, which considers all primary malignant cancers in a person irrespective of whether they are the first or subsequent cancers. If the multiple cancers are treated independently, this second indicator is more pertinent to the demand for health care.

The difference between the two indicators may be substantial, particularly in older age groups. Inclusion of multiple tumours in comparative studies is complicated by a lack of uniformity among CRs in the application of cancer coding rules, particularly for tumours in paired organs [17]. Furthermore, the number of multiple tumours registered depends on the age of a CR: the older the registry, the greater the likelihood of registering previous diagnoses in multiple cancer patients. Recently established registries may know from clinical records that a given tumour is not the first primary, but may not have the resources or procedures necessary to access full information on previously diagnosed cancers. The EUROPREVAL project considered person prevalence only.

Completeness bias
Even when corrected to include DCO and lost-to-follow-up cases, prevalence measured on populations covered by CRs is still incomplete, as prevalent cases diagnosed before the registry began operating will not be recorded. Such unobserved cases are far from negligible, especially for recently established registries (<15 years) and for cancer sites with good prognoses [18]. It is vital, therefore, that these unobserved cases are estimated and included in the prevalence data. It is also essential, in a Europe-wide study involving numerous registries that have been operating for variable lengths of time (from only ~5 years to >=40 years), that a uniform and unbiased way of dealing with completeness is used, so as to provide comparable prevalence estimates for populations covered by cancer registration for different lengths of time.

We defined the observed prevalence as that produced by the counting method described above, to which various (small) corrections have been applied to take account of the cases lost to follow-up. We then applied an appropriate correction factor to the observed prevalence, the completeness index [18], which is an estimate of non-registered cases still alive. The figure thus produced is defined as the total prevalence. The completeness index will vary according to the length of the registration period and the characteristics of the cancer being considered. Completeness indices were estimated for the Connecticut Cancer Registry and the total prevalence figures thus calculated were compared with observed prevalence, which, since the registry has been operating for >50 years, should have been almost complete; concordances were found to be satisfactory [19]. The same method was applied to Italian prevalence data [20] and to EUROPREVAL data to improve European estimates of prevalence.


    Estimation of total prevalence
 Top
 Abstract
 Introduction
 Estimation of total prevalence
 Standard errors of prevalence...
 Prevalence of all cancers...
 References
 
In a population covered by cancer registration for L years, the total prevalence (Ntot) is given by the sum of the observed prevalence, Nobs (the proportion of patients diagnosed after the start of registry activity), plus the unobserved prevalence (Nunobs) of patients diagnosed before that date, whose value is unknown. Ntot is not directly measurable but can be estimated indirectly by dividing Nobs by the completeness index, R [18], which depends on L, the length of time the registry has been operating

Ntot = Nobs/R

R is an estimate of the extent to which the observed prevalence represents the total prevalence, and is defined by

R = Nobs(m)/Ntot(m)

where Nobs(m) and Ntot(m) are model-based estimates of observed and total prevalence, respectively, and are derived from parametric models of age-specific cancer incidence probability and relative survival probability [18]. The completeness index, R, takes the value of 1 when all prevalent cases are observed, and approaches 0 as the proportion of prevalent cases that are observed decreases. The value of Nobs(m)/Ntot(m) depends on the registration period (L), cancer site, sex and age class: all the factors that influence incidence and survival in the models.

Simple log-linear models can be used as incidence functions the major determinants of which are age at diagnosis and date of birth. These models are consistent, for a general class of cancers, with the multistage theory of carcinogenesis [21]. As shown by Capocaccia and De Angelis [18], R is not influenced by absolute incidence levels, but only by the age slope of incidence. R is larger for cancers the incidence of which rises steeply with age, e.g. prostate cancer, and is lower for cancers such as cervical cancer the incidence of which is largely independent of age.

Survival models with cure can be used as relative survival functions. This class of model assumes that only a proportion of patients, the so called fatal cases, have an excess death risk, while the remainder have the same mortality rate as the general population (not affected by the specific cancer) and can thus be regarded as cured [22]. Cure models allow estimation of long-term survival, which must be estimated accurately as it plays a crucial role in estimating prevalence. Survival has a direct influence on R: cancers with poor survival are characterised by high R values, as only recently diagnosed patients are likely to be alive at the prevalence date. In contrast, a high proportion of cancers patients with good prognosis who were diagnosed before a young registry started operating will still be alive at the index date, so R will be low.

Similarly, R can be used to estimate the partial prevalence for a period longer than the observation period; for instance, the 15-year prevalence in a population observed only for 10 years. This method is useful to decompose estimated total prevalence by duration of disease.


    Standard errors of prevalence estimates
 Top
 Abstract
 Introduction
 Estimation of total prevalence
 Standard errors of prevalence...
 Prevalence of all cancers...
 References
 
In cases where all prevalent cases are observed and followed from diagnosis to the index date, a simple Poisson distribution can be used to derive the standard error (SE) of the number of cases [5]:

SE (Ntot) = {surd}Ntot

The standard error of the prevalence as a proportion is obtained by dividing {surd}Ntot by the population count.

However, total prevalence is a composite estimator made up of: (i) a direct count, Nobs, of cases observed and followed; (ii) an estimated number (Nlost) of lost-to-follow-up cases surviving until the index date; and (iii) an estimated proportion 1/R of cases diagnosed before registration began. While the first term is Poisson distributed, the second term comes from an estimated life table—itself derived from the cases actually followed—and the last term is based on statistical models applied to the same or, in some cases, to an independent dataset. A formal theory of prevalence estimator sampling errors, that takes all these sources of variability and their interrelations into account, is being developed but is not yet available [23, 24].

A rough approximation to the SE of the total prevalence can be calculated assuming that the proportion of lost (Plost = Nlost/Nobs) and the completeness index, R, are without error:

SE (Ntot) = {surd}Nobs (1 + Plost )/R.

However, it is apparent that SEs calculated with this expression systematically underestimate the real variability of the prevalence figures, as potentially important sources of uncertainty are neglected and cannot be used for formal statistical testing.


    Prevalence of all cancers combined from European registry data
 Top
 Abstract
 Introduction
 Estimation of total prevalence
 Standard errors of prevalence...
 Prevalence of all cancers...
 References
 
In the EUROPREVAL Project, prevalence estimates for the most important cancer sites were produced for 17 European countries. The results of the study are extensively presented in a companion paper in this issue [15]. Here we report the methodological choices adopted in the study and present prevalence results in Europe for all cancers combined (Tables 1 and 2).


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Table 1. Calculation of prevalence for all cancers combined in European cancer registry areas (national registries are in capital letters)
 

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Table 2. Total prevalence decomposition by duration of disease for all cancers combined in European countries at the common index date of 31 December 1992 and prevalence proportions per 100 000 of population within 2, 5 and 10 years since diagnosis
 
The EUROPREVAL project used incidence and follow-up data provided by the EUROCARE project [14], collecting data from 56 participating population-based CRs from 17 European countries. The EUROCARE-2 database contains data on cancer patients diagnosed from 1978 to 1992, the minimum information for each patient being sex, date of birth, date of diagnosis, date of end of follow-up, tumour site, morphology and life status.

To calculate consistent prevalence figures at a given date, incidence and follow-up data must be complete at that date. The most recent date for which these data are available for all registries participating in EUROCARE is 31 December 1992, and this was taken as the index date for prevalence computation.

A certain fraction of the records (1–2% in most European registries) had wrong or missing values for some patient variables. Often the month of birth or month of diagnosis was missing, but in a few cases both the month and year were missing; in other cases the sex was not specified. The exclusion of such cases from calculations leads to underestimation of the prevalence. Automatic procedures to correct data incompatibilities or to impute missing values were therefore used whenever possible.

We used the direct approach to estimate the prevalence of all cancers in European registries at the index date of 31 December 1992. Specifically developed software [25] was used for the calculation of prevalence. The basic data are shown in Table 1 along with the main steps in the calculation, so as to illustrate the problems discussed above. Data from most participating CRs were included; data from specialised registries (concerned with digestive system or haematological cancers, etc.) were not included. For each CR, the following are reported in Table 1: (a) number of years of cancer registration, prior to the index date, available from EUROCARE-2 database; (b) the number of cancer cases collected during the period and included in the analysis; (c) the number of cases alive at the index date; (d) the number of lost cases; (e) the number of lost cases estimated alive at the index date; (f) the observed prevalent cases [= (c) + (e)] up to (a) years after diagnosis; (g) the completeness index; (h) the total prevalent cases [= (f)/(g)]; (i) the population count per 100 000; (j) the total prevalence per 100 000 [= (h)/(i)]; and (k) the average yearly DCO cases as a percentage of the total prevalence.

The incidence period considered ranged from 5 years (1998–1992) in several southern European registries to 23 years (1970–1992) in Iceland, Saarland and Geneva. Some registries, mainly in northern Europe, where cancer registration started during the 1950s, also provided a complete set of data covering their entire registration period. These data were used to check the estimates of the completeness index, R.

Cases lost to follow-up were considered in the analysis by assuming they had the same survival probability as cases not lost to follow-up of the same age at diagnosis and number of years passed since diagnosis. For each calendar period considered, the number of lost cases estimated alive was added to the number of prevalent cases. The contribution of lost cases estimated alive to the observed prevalence was highest in Somme, where they represent ~15% of the observed prevalent cases, followed by Warsaw (10%) and East Anglia (9%). Percentages ranging from 2% to 6% were observed in three registries: Geneva (a registry with good follow-up procedures, but with problems due to patient migration), Torino and Cracow. In all the other registries, lost cases contributed <2% to the observed prevalence.

As noted, migration was not considered as its influence on prevalence can be assumed to be negligible. Only first primary tumours were included; patients with multiple tumours were considered as one prevalent case. DCO cases were not included, but formed a small proportion of the total prevalence (always <3%, and in most cases <1%). Lack of completeness generally has a major influence on the prevalence estimations. Thus, the completeness index was only ~90% in registries with >20 years of follow-up, and fell to <50% in registries with only 5 years of follow-up. In the latter cases, half or more of the total prevalence had to be estimated.

In Table 2, registries are grouped by country, while prevalence proportions have been decomposed by time from diagnosis.

The average estimated prevalence in European countries was 2042 x 100 000, i.e. about two out of every 100 European citizens have had a previous cancer diagnosis. Sweden presents the highest estimated prevalence (3046). High levels were estimated also in Germany (2777), Italy and Switzerland (with >2500). Low prevalence was estimated in Eastern European countries, with the lowest levels in Poland (1169).

Approximately 20% (variable from 19% to 25% according to country) of total prevalent cases were diagnosed with cancer in the last 2 years, while ~40% (range 35–46%) and 60% (range 53–66%) were diagnosed in the last 5 and 10 years, respectively. The geographical variability of these proportions is lower than the absolute levels of prevalence, at least for all cancers combined. Indeed it is related to country-specific incidence distribution by cancer site and to survival levels, rather than to the length of follow-up.

Validation of total prevalence estimates
As statistical modelling is incorporated in total prevalence estimates, through the use of completeness index, validations against empirical-based estimates were carried out in EUROPREVAL study. To check the values of the completeness indices provided by the statistical models, we used data from the long-established CRs whose observation periods are long enough to have registered virtually all prevalent cases. We calculated figures for the 15-year prevalence, ignoring cases registered prior to that, and then corrected these data using the corresponding completeness index, R. The result (the estimated total prevalence) was then compared with the observed total prevalence. This method was also used to check prevalences estimated in SEER registries up to 1993, using data collected from 1940 to 1993 by the Connecticut cancer registry [19].

The results of the validation analysis are shown in Table 3. Total prevalence estimates for the 10 cancer sites included in the study were analysed separately. For the Finnish and Danish registries, the estimated total prevalence was slightly below the observed total prevalence. This is probably because the observed prevalence figures supplied by these registries refer to cancers rather than persons with cancer. In contrast, for the Eindhoven, Estonia and Saarland registries (with observation periods of 20–25 years) estimated total prevalence figures were more frequently above the observed total prevalence. Differences between estimated and observed values were generally less than ±10%; the only exceptions were cervical cancer and Hodgkin’s disease.


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Table 3. Comparison of the estimated total prevalence (calculated using the completeness index at 15 years) with the observed prevalence for registries established for >20 years, prevalence values (number of prevalent cases) are referred to the index date of 31 December 1992
 
For Hodgkin’s disease the estimated figures greatly exceeded the observed figures. For cervical cancer, the estimated total prevalence was lower than the observed prevalence in Finland and Denmark, but was >10% in all other registries except Iceland. These mismatches can be attributed to marked changes in the epidemiology of these two cancers. For Hodgkin’s disease the use of new more effective therapies became widespread; for cervical cancer screening became widespread. Our modelling approach was based on EUROCARE-2 data for the incidence period from 1978 to 1989, and did not take into account these developments. Thus the excess of estimated prevalent cases of Hodgkin’s disease can be explained by model-based overestimation of backward projections of survival; the lower prevalence estimates for cervical cancer in Finland and Denmark are the result of the high incidence levels in the pre-screening period that were not considered in the model.

Conclusions
As the population ages the proportion most at risk for developing cancer grows, while advances in cancer treatment are resulting in an increasing proportion of cancer patients living longer. Thus the demand for social services and especially health care by this sector of the population is growing, particularly in developed countries. Cancer prevalence is a vital indicator, as it is a measure of the number of cancer patients who require health and social services resources, and can be used to adequately plan future allocation of such resources. Providing and updating reliable and systematic prevalence statistics, obtained using uniform and validated methodologies such as we now have, on cancer incidence, survival and mortality is therefore important for all in European countries.

The breakdown of cancer prevalence figures according to time since diagnosis is an important first step towards the development of specific indicators of health care needs for specific sections of the population. A subsequent step will be to classify prevalent cases by disease stage at the index date. This will be even more informative for planning the allocation of health resources, as it will make it possible to identify four groups of patients: those recently diagnosed patients who are receiving primary treatment; those who can be considered cured of their cancer; those in the terminal phase of their illness; and the remainder with intermediate status, also referred to as ‘continuing-phase’ [26]. The groups thus identified are much more homogeneous in terms of predictable health needs than subgroups simply defined by time since diagnosis. Our approach to the estimation of the stage distribution of prevalence will be described in forthcoming papers from EUROPREVAL.


    Acknowledgements
 
We thank Donald Ward for the English revision of the manuscript. This research has been supported by the EUROPREVAL Biomed-2 Programme, Contract No. BMH4 98 3899.

Members of the EUROPREVAL Working Group: Austria, W. Oberaigner (Cancer Registry of Tyrol); Denmark, H. Storm, G. Engholm (Danish Cancer Society ‘Institute of Cancer Epidemiology’); Estonia, T. Aareleid (Estonian Cancer Registry); Finland, T. Hakulinen (Finnish Cancer Registry); France, G. Hédelin (Bas-Rhin Cancer Registry), H. Lefevre (Calvados Digestive Cancer Registry), J. Mace-Lesec’h (Calvados General Cancer Registry), J. Faivre (Côte d’Or Digestive Cancer Registry), G. Chaplain (Côte d’Or Gynaecologic Cancer Registry), P. M. Carli (Côte d’Or Malignant Haemopathies Registry), P. Arveux (Doubs Cancer Registry), J. Estève (University of Lyon), M. Colonna (Isère Cancer Registry), N. Raverdy, P. Jun (Somme Cancer Registry); Germany, J. Michaelis (German Registry of Childhood Malignancies), H. Ziegler, C. Stegmaier (Saarland Cancer Registry); Iceland, H. Tulinius (Icelandic Cancer Registry); Italy, R. Capocaccia (Project Leader), I. Corazziari, R. De Angelis, S. Francisci, S. Hartley, F. Valente, A. Verdecchia, A. Zappone (National Institute of Health, Rome), F. Berrino, G. Gatta, A. Micheli, E. Mugno, M. Sant (National Institute for the Study and Cure of Tumours, Milan), P. Crosignani (Lombardy Cancer Registry), E. Conti,V Ramazzotti (Latina Cancer Registry), M. Vercelli, C. Casella, A. Puppo (Liguria Cancer Registry, NCI, University of Genova, Genova), M. Federico (Modena Cancer Registry), M. Ponz De Leon (Modena Colorectal Cancer Registry), V. De Lisi (Parma Cancer Registry), R. Zanetti, S. Rosso (Piedmont Cancer Registry), C. Magnani (Piedmont Childhood Cancer Registry), L. Gafà, R. Tumino (Ragusa Cancer Registry), F. Falcini (Romagna Cancer Registry), E. Paci, E. Crocetti (Tuscany Cancer Registry), S. Guzzinati, P. Zambon (Venetian Cancer Registry); Poland, J. Rachtan (Cracow Cancer Registry), M. Bielska-Lasota (Warsaw Cancer Registry); Slovakia, I. Plesko (National Cancer Registry of Slovakia); Slovenia, V. Pompe-Kirn (Cancer Registry of Slovenia); Spain, I. Izarzugaza (Basque Country Cancer Registry), A. Izquierdo (Girona Cancer Registry), I. Garau (Mallorca Cancer Registry), E. Ardanaz, C. Moreno (Navarra Cancer Registry), J. Galceran (Tarragona Cancer Registry), V. Moreno (Catalan Institute of Oncologia); Sweden, T. Möller, H. Anderson (Southern Swedish Regional Tumour Registry); Switzerland, J. Torhorst (Basel Cancer Registry), C. Bouchardy, J. M. Lutz, M. Usel (Geneva Cancer Registry), J. E. Dowd (World Health Organisation, Geneva); The Netherlands, J. W. W. Coebergh, M. Janssen-Heijnen (Eindhoven Cancer Registry), R. A. M. Damuhis (Rotterdam Cancer Registry); Scotland, R. Black, V. Harris, D. Stockton (Scottish Cancer Intelligence Unit); UK, T. W. Davies (East Anglian Cancer Registry), M. P. Coleman, S. Harris (London School of Hygiene and Tropical Medicine), E. M. I. Williams (The Merseyside and Cheshire Cancer Registry), D. Forman, R. Iddenden (Northern and Yorkshire Cancer Registry and Information Service & Centre for Cancer Research), M. J. Quinn (Office for National Statistics), M. Roche (Oxford Cancer Intelligence Unit), J. Smith (South and West Cancer Intelligence Unit), H. Moller (Thames Cancer Registry), P. Silcocks (Trent Cancer Registry), G. Lawrence, K. Hemmings (West Midlands Cancer Intelligence Unit).


    Footnotes
 
+ Correspondence to: Dr R. Capocaccia, Istituto Superiore di Sanità, Laboratorio di Epidemiologia e Biostatistica, Viale Regina Elena 299, 00161 Roma, Italy. Tel: +39-06-499-02541; Fax: +39-06-499-02230; E-mail: rcap@iss.it Back

§ Members of the EUROPREVAL Working Group are listed in the Acknowledgements. Back


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 Abstract
 Introduction
 Estimation of total prevalence
 Standard errors of prevalence...
 Prevalence of all cancers...
 References
 
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