The second point advocated by Alliot and co-workers is related to EGFR mutations that can be predictive of response to EGFR targeted therapies. We agree with the view that some EGFR mutations may favour the activity of anti-EGFR drugs, but for the moment these mutations are essentially reported in lung cancer patients [7]. Recent data exclude the presence of such mutations in colorectal cancer patients [8
]. In conclusion, efforts must be made to evaluate how we can optimise patient selection for EGFR targeting, especially for colorectal cancer patients. As we underlined in a recently published study [9
], other biomarkers are necessary to be evaluated besides EGFR expression itself and, as mentioned by Alliot and co-workers, p-AKT expression, MAPK expression or EGFR amplification are all good candidates for this purpose.
1 SOMPS, Université Pierre et Marie Curie, Paris; 2 Laboratoire d'Oncopharmacologie, CAC Antoine Lacassagne, Nice, France
(* Email: jean-philippe.spano{at}psl.ap-hop-paris.fr)
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