THE AUTHORS REPLY

Lucinda J. England1, Juliette S. Kendrick2 and Paul M. Gargiullo3

1 National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
2 Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30341
3 Cancer Surveillance Branch, Centers for Disease Control and Prevention, Atlanta, GA 30341

We thank Dr. Papoz for his observations (1) on our paper (2). His comments underscore the uncertainty that remains regarding the mechanism through which smoking affects fetal growth. As Dr. Papoz pointed out, maternal nutrition is hypothesized to mediate intrauterine growth restriction in infants born to smokers. While the extent of the role played by nutrition in fetal growth among smokers remains controversial, studies have shown that factors other than nutritional status are involved (3, 4).

In our study (2), we described the nature of the dose-response relation between tobacco exposure and birth weight as well as the relation between urine cotinine concentration and number of cigarettes smoked per day. We did not attempt to determine the mechanism through which smoking affects birth weight. It is true that we did not have information on dietary factors; however, it is unclear how these data would have contributed to our study. Because maternal nutrition status may be part of the causal pathway between smoking and fetal growth restriction, controlling for dietary factors in our analysis would have been inappropriate (5). Even controlling for prepregnancy body mass index (as we did) can potentially result in attenuation of the relation between smoking and infant birth weight. Therefore, we do not believe that the lack of data on dietary factors in our study prevented us from addressing our stated research questions.

We disagree with Dr. Papoz’s suggestion (1) that cigarette smoking and/or urine cotinine concentration in late pregnancy may not be useful measures of tobacco exposure for estimating the variation in birth weight due to smoking. Studies suggest that women who quit smoking during pregnancy deliver infants weighing as much as infants of never smokers (6, 72). This finding implies that tobacco exposure in late pregnancy is a more important determinant of birth weight than exposure in early pregnancy. Our data () also support this concept. We directly addressed the effects of changing tobacco exposure during pregnancy on infant birth weight in a later paper (8).

We agree with Dr. Papoz’s suggestion (1) that, in our study (2), the variability in birth weight explained by urine cotinine concentration and by cigarettes smoked per day may have been low because our study population consisted of only smokers and former smokers. Therefore, our findings are most relevant for populations of self-reported smokers. Cotinine concentration, for example, would undoubtedly be more useful in a population of women that included self-reported nonsmokers, where it would serve to both accurately categorize women as smokers or nonsmokers and quantify exposure.

Dr. Papoz (1) suggests that calorie supplementation may be an effective strategy to minimize fetal growth restriction in smokers. However, as Dr. Papoz acknowledges, studies addressing this issue have produced conflicting results (3, 4, 9, 10). In addition, reduced birth weight should be considered a surrogate for other adverse birth outcomes. While it is possible that calorie supplementation may offset some of the effects of smoking on fetal growth, the fetus is still exposed to toxins as long as the mother continues to smoke. Therefore, health care providers should continue to focus their efforts on helping pregnant women to quit smoking, because quitting is the most effective strategy for improving birth outcomes.

REFERENCES

  1. Papoz L. Re: "Measures of maternal tobacco exposure and infant birth weight at term." (Letter). Am J Epidemiol 2003;157:86–7.[Free Full Text]
  2. England LJ, Kendrick JS, Gargiullo PM, et al. Measures of maternal tobacco exposure and infant birth weight at term. Am J Epidemiol 2001;153:954–60.[Abstract/Free Full Text]
  3. Muscati SK, Koski KG, Gray-Donald K. Increased energy intake in pregnant smokers does not prevent human fetal growth retardation. J Nutr 1996;126:2984–9.[ISI][Medline]
  4. Hellerstedt WL, Himes JH, Story M, et al. The effects of cigarette smoking and gestational weight change on birth outcomes in obese and normal-weight women. Am J Public Health 1997;87:591–6.[Abstract]
  5. Rothman KJ, Sander S. Modern epidemiology. Philadelphia, PA: Lippincott-Raven Publishers, 1998:255.
  6. MacArthur C, Knox EG. Smoking and pregnancy: effects of stopping at different stages. Br J Obstet Gynecol 1988;95:551–5.[ISI][Medline]
  7. Ahlsten G, Cnattingius S, Lindmark G. Cessation of smoking during pregnancy improves foetal growth and reduces infant morbidity in the neonatal period. A population-based study. Acta Paediatr 1993;82:177–81.[ISI][Medline]
  8. England LJ, Kendrick JS, Wilson HG, et al. Effects of smoking reduction during pregnancy on the birth weight of term infants. Am J Epidemiol 2001;154:694–701.[Abstract/Free Full Text]
  9. Zaren B, Cnattingius S, Lindmark G. Fetal growth impairment from smoking—is it influenced by anthropometry? Acta Obstet Gynecol Scand Suppl 1997;165:30–4.[Medline]
  10. Metcoff J, Costiloe P, Crosby WM, et al. Effect of food supplementation during pregnancy on birth weight. Am J Clin Nutr 1985;41:933–47.[Abstract]




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