9989760	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"9989760"},"DateCreated":{"Year":{"$":"1999"},"Month":{"$":"02"},"Day":{"$":"25"}},"DateCompleted":{"Year":{"$":"1999"},"Month":{"$":"02"},"Day":{"$":"25"}},"DateRevised":{"Year":{"$":"2005"},"Month":{"$":"11"},"Day":{"$":"16"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0022-2143"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"133"},"Issue":{"$":"2"},"PubDate":{"Year":{"$":"1999"},"Month":{"$":"Feb"}}},"Title":{"$":"The Journal of laboratory and clinical medicine"},"ISOAbbreviation":{"$":"J. Lab. Clin. Med."}},"ArticleTitle":{"$":"Vitamin D3 derivatives (deltanoids) in the treatment of tumor cell invasion."},"Pagination":{"MedlinePgn":{"$":"95-7"}},"AuthorList":{"@CompleteYN":"Y","Author":{"@ValidYN":"Y","LastName":{"$":"Keski-Oja"},"ForeName":{"$":"J"},"Initials":{"$":"J"}}},"Language":{"$":"eng"},"PublicationTypeList":{"PublicationType":[{"$":"Comment"},{"$":"Editorial"},{"$":"Review"}]}},"MedlineJournalInfo":{"Country":{"$":"UNITED STATES"},"MedlineTA":{"$":"J Lab Clin Med"},"NlmUniqueID":{"$":"0375375"},"ISSNLinking":{"$":"0022-2143"}},"ChemicalList":{"Chemical":{"RegistryNumber":{"$":"67-97-0"},"NameOfSubstance":{"$":"Cholecalciferol"}}},"CitationSubset":[{"$":"AIM"},{"$":"IM"}],"CommentsCorrectionsList":{"CommentsCorrections":{"@RefType":"CommentOn","RefSource":{"$":"J Lab Clin Med. 1999 Feb;133(2):120-8"},"PMID":{"@Version":"1","$":"9989763"}}},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Animals"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Cholecalciferol"},"QualifierName":[{"@MajorTopicYN":"N","$":"analogs & derivatives"},{"@MajorTopicYN":"Y","$":"therapeutic use"}]},{"DescriptorName":{"@MajorTopicYN":"N","$":"Extracellular Matrix"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Lung Neoplasms"},"QualifierName":[{"@MajorTopicYN":"Y","$":"drug therapy"},{"@MajorTopicYN":"N","$":"secondary"}]},{"DescriptorName":{"@MajorTopicYN":"N","$":"Melanoma, Experimental"},"QualifierName":[{"@MajorTopicYN":"Y","$":"drug therapy"},{"@MajorTopicYN":"N","$":"secondary"}]},{"DescriptorName":{"@MajorTopicYN":"N","$":"Mice"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Neoplasm Invasiveness"},"QualifierName":{"@MajorTopicYN":"N","$":"prevention & control"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Skin Neoplasms"},"QualifierName":[{"@MajorTopicYN":"Y","$":"drug therapy"},{"@MajorTopicYN":"N","$":"pathology"}]}]},"NumberOfReferences":{"$":"11"}}
998985	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"998985"},"DateCreated":{"Year":{"$":"1977"},"Month":{"$":"01"},"Day":{"$":"29"}},"DateCompleted":{"Year":{"$":"1977"},"Month":{"$":"01"},"Day":{"$":"29"}},"DateRevised":{"Year":{"$":"2000"},"Month":{"$":"12"},"Day":{"$":"18"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0003-2697"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"76"},"Issue":{"$":"2"},"PubDate":{"Year":{"$":"1976"},"Month":{"$":"Dec"}}},"Title":{"$":"Analytical biochemistry"},"ISOAbbreviation":{"$":"Anal. Biochem."}},"ArticleTitle":{"$":"Double-label autoradiography on polyacrylamide gels with 3H and 14C."},"Pagination":{"MedlinePgn":{"$":"452-7"}},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Gruenstein"},"ForeName":{"$":"E I"},"Initials":{"$":"EI"}},{"@ValidYN":"Y","LastName":{"$":"Pollard"},"ForeName":{"$":"A L"},"Initials":{"$":"AL"}}]},"Language":{"$":"eng"},"PublicationTypeList":{"PublicationType":{"$":"Journal Article"}}},"MedlineJournalInfo":{"Country":{"$":"UNITED STATES"},"MedlineTA":{"$":"Anal Biochem"},"NlmUniqueID":{"$":"0370535"},"ISSNLinking":{"$":"0003-2697"}},"ChemicalList":{"Chemical":[{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Carbon Radioisotopes"}},{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Neoplasm Proteins"}},{"RegistryNumber":{"$":"10028-17-8"},"NameOfSubstance":{"$":"Tritium"}}]},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Autoradiography"},"QualifierName":{"@MajorTopicYN":"Y","$":"methods"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Carbon Radioisotopes"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Cell Line"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Electrophoresis, Polyacrylamide Gel"},"QualifierName":{"@MajorTopicYN":"Y","$":"methods"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Fluorometry"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Neoplasm Proteins"},"QualifierName":{"@MajorTopicYN":"N","$":"analysis"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Neoplasms, Experimental"},"QualifierName":{"@MajorTopicYN":"N","$":"analysis"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Neuroblastoma"},"QualifierName":{"@MajorTopicYN":"N","$":"analysis"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Tritium"}}]}}
9989878	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"9989878"},"DateCreated":{"Year":{"$":"1999"},"Month":{"$":"04"},"Day":{"$":"15"}},"DateCompleted":{"Year":{"$":"1999"},"Month":{"$":"04"},"Day":{"$":"15"}},"DateRevised":{"Year":{"$":"2005"},"Month":{"$":"11"},"Day":{"$":"16"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0301-2115"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"81"},"Issue":{"$":"2"},"PubDate":{"Year":{"$":"1998"},"Month":{"$":"Dec"}}},"Title":{"$":"European journal of obstetrics, gynecology, and reproductive biology"},"ISOAbbreviation":{"$":"Eur. J. Obstet. Gynecol. Reprod. Biol."}},"ArticleTitle":{"$":"Some genetic aspects of ovarian tumors."},"Pagination":{"MedlinePgn":{"$":"283-7"}},"Affiliation":{"$":"Centre for Human Genetics and Flanders Institute of Biotechnology, University of Leuven, Belgium. rita.logist@med.KULEUVEN.ac.be"},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Van den Berghe"},"ForeName":{"$":"H"},"Initials":{"$":"H"}},{"@ValidYN":"Y","LastName":{"$":"Dal Cin"},"ForeName":{"$":"P"},"Initials":{"$":"P"}}]},"Language":{"$":"eng"},"PublicationTypeList":{"PublicationType":[{"$":"Journal Article"},{"$":"Review"}]}},"MedlineJournalInfo":{"Country":{"$":"IRELAND"},"MedlineTA":{"$":"Eur J Obstet Gynecol Reprod Biol"},"NlmUniqueID":{"$":"0375672"},"ISSNLinking":{"$":"0301-2115"}},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Chromosome Aberrations"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Female"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Genes, BRCA1"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Genetic Predisposition to Disease"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Humans"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Loss of Heterozygosity"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Ovarian Neoplasms"},"QualifierName":{"@MajorTopicYN":"Y","$":"genetics"}}]},"NumberOfReferences":{"$":"65"}}
9989922	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"9989922"},"DateCreated":{"Year":{"$":"1999"},"Month":{"$":"03"},"Day":{"$":"18"}},"DateCompleted":{"Year":{"$":"1999"},"Month":{"$":"03"},"Day":{"$":"18"}},"DateRevised":{"Year":{"$":"2006"},"Month":{"$":"11"},"Day":{"$":"15"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0195-6663"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"32"},"Issue":{"$":"1"},"PubDate":{"Year":{"$":"1999"},"Month":{"$":"Feb"}}},"Title":{"$":"Appetite"},"ISOAbbreviation":{"$":"Appetite"}},"ArticleTitle":{"$":"Predicting the intent to purchase unfamiliar and familiar cheeses: the effects of attitudes, expected liking and food neophobia."},"Pagination":{"MedlinePgn":{"$":"113-26"}},"Abstract":{"AbstractText":{"$":"The attitude model of the theory of reasoned action (TRA) has been applied mainly to predicting the choice of familiar foods; however, the choice of unfamiliar foods may be governed by distinct factors. In the present study, 92 females rated their attitudes and subjective norms about the purchase intentions of two familiar and two unfamiliar cheeses, and the expected and actual pleasantness of them. They also completed the food neophobia scale, which measures the tendency to avoid novel foods. Neophobic persons rated the attitudes and expected and actual taste pleasantness lower than neophilics for all cheeses, except for the most familiar, mild cheese. This suggests that food neophobia also indicates the tendency not only to avoid, but also to dislike novel foods. Before tasting, attitudes and subjective norms together predicted the intent to purchase familiar cheeses better (R2=0.54 and 0.58) than for novel cheeses (R2=0.24 and 0.35); thus, the basic TRA model was not as useful in predicting intent to purchase unfamiliar as familiar cheeses. The predictions especially for the novel cheeses were clearly improved by including expected pleasantness ratings in the model. The usefulness of the food neophobia score as an additional predictor was not clearly supported. Attitudes and subjective norms measured before tasting were poor predictors of purchase intents after tasting, which implies the importance of taste and direct product experience in food choice."},"CopyrightInformation":{"$":"Copyright 1999 Academic Press."}},"Affiliation":{"$":"Department of Food Technology, University of Helsinki, Finland."},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Arvola"},"ForeName":{"$":"A"},"Initials":{"$":"A"}},{"@ValidYN":"Y","LastName":{"$":"Lähteenmäki"},"ForeName":{"$":"L"},"Initials":{"$":"L"}},{"@ValidYN":"Y","LastName":{"$":"Tuorila"},"ForeName":{"$":"H"},"Initials":{"$":"H"}}]},"Language":{"$":"eng"},"PublicationTypeList":{"PublicationType":[{"$":"Journal Article"},{"$":"Research Support, Non-U.S. Gov't"}]}},"MedlineJournalInfo":{"Country":{"$":"ENGLAND"},"MedlineTA":{"$":"Appetite"},"NlmUniqueID":{"$":"8006808"},"ISSNLinking":{"$":"0195-6663"}},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Adult"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Attitude"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Cheese"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Consumer Satisfaction"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Female"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Food Preferences"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Forecasting"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Humans"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Middle Aged"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Phobic Disorders"}}]}}
9990263	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"9990263"},"DateCreated":{"Year":{"$":"1999"},"Month":{"$":"02"},"Day":{"$":"25"}},"DateCompleted":{"Year":{"$":"1999"},"Month":{"$":"02"},"Day":{"$":"25"}},"DateRevised":{"Year":{"$":"2009"},"Month":{"$":"11"},"Day":{"$":"19"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0001-5547"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"41"},"Issue":{"$":"4 Suppl"},"PubDate":{"MedlineDate":{"$":"1997 Jul-Aug"}}},"Title":{"$":"Acta cytologica"},"ISOAbbreviation":{"$":"Acta Cytol."}},"ArticleTitle":{"$":"Porocarcinoma detected by fine needle aspiration biopsy of a node metastasis. A case report."},"Pagination":{"MedlinePgn":{"$":"1305-9"}},"Abstract":{"AbstractText":[{"@Label":"BACKGROUND","@NlmCategory":"BACKGROUND","$":"Porocarcinomas were first reported by Pinkus and Meherengan in 1963 as uncommon malignant adnexal tumors of the skin characterized by epidermotropism with pagetoid diffusion within the epidermis."},{"@Label":"CASE","@NlmCategory":"METHODS","$":"The cytologic findings of an eccrine porocarcinoma lymph node metastasis in a 65-year-old female and histologic features of the skin recurrence are reported. Metastasis was firstly identified by fine needle aspiration biopsy (FNAB) performed on one inguinal lymph node. Cytologically the tumor was characterized by atypical malignant cells showing clear granular or keratinized cytoplasm and vesicular nuclei, with prominent nucleoli, which were irregularly dispersed or forming nests or cords, sometimes harboring central necrosis. The skin metastasis, detected after the cytologic FNAB diagnosis, showed superficial dissemination within the epidermis and dermal invasion."},{"@Label":"CONCLUSION","@NlmCategory":"CONCLUSIONS","$":"Cytologic diagnosis of porocarcinoma metastases by FNAB is important for adequate treatment, but adherence to strict diagnostic criteria is necessary. The tumor cells could be histogenetically related to the intraepidermal duct cells of the eccrine sweat glands, and pagetoid diffusion is considered a sort of homing phenomenon."}]},"Affiliation":{"$":"Institute of Anatomic Pathology, University of Padua, Italy."},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Blandamura"},"ForeName":{"$":"S"},"Initials":{"$":"S"}},{"@ValidYN":"Y","LastName":{"$":"Altavilla"},"ForeName":{"$":"G"},"Initials":{"$":"G"}},{"@ValidYN":"Y","LastName":{"$":"Antonini"},"ForeName":{"$":"C"},"Initials":{"$":"C"}},{"@ValidYN":"Y","LastName":{"$":"Marchetti"},"ForeName":{"$":"M"},"Initials":{"$":"M"}},{"@ValidYN":"Y","LastName":{"$":"Piazza"},"ForeName":{"$":"M"},"Initials":{"$":"M"}}]},"Language":{"$":"eng"},"PublicationTypeList":{"PublicationType":[{"$":"Case Reports"},{"$":"Journal Article"}]}},"MedlineJournalInfo":{"Country":{"$":"UNITED STATES"},"MedlineTA":{"$":"Acta Cytol"},"NlmUniqueID":{"$":"0370307"},"ISSNLinking":{"$":"0001-5547"}},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Acrospiroma"},"QualifierName":[{"@MajorTopicYN":"N","$":"diagnosis"},{"@MajorTopicYN":"Y","$":"pathology"}]},{"DescriptorName":{"@MajorTopicYN":"N","$":"Aged"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Biopsy, Needle"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Female"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Humans"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Lymphatic Metastasis"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Recurrence"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Sweat Gland Neoplasms"},"QualifierName":[{"@MajorTopicYN":"N","$":"diagnosis"},{"@MajorTopicYN":"Y","$":"pathology"}]}]}}
9990425	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"9990425"},"DateCreated":{"Year":{"$":"1999"},"Month":{"$":"02"},"Day":{"$":"25"}},"DateCompleted":{"Year":{"$":"1999"},"Month":{"$":"02"},"Day":{"$":"25"}},"DateRevised":{"Year":{"$":"2006"},"Month":{"$":"11"},"Day":{"$":"15"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0914-9465"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"61"},"Issue":{"$":"5"},"PubDate":{"Year":{"$":"1998"},"Month":{"$":"Dec"}}},"Title":{"$":"Archives of histology and cytology"},"ISOAbbreviation":{"$":"Arch. Histol. Cytol."}},"ArticleTitle":{"$":"Postnatal development of the rat sublingual glands. A morphometric and radioautographic study."},"Pagination":{"MedlinePgn":{"$":"417-26"}},"Abstract":{"AbstractText":{"$":"The postnatal development of rat sublingual glands was analyzed by morphometric and radioautographic studies. The absolute number of each cell type was evaluated by the Aherne II morphometric method for cell counting and labeling indices of these cell types were determined in radioautographs from animals injected with 3H-thymidine. The quantitative cell population kinetic studies were accompanied by morphologic analysis of the modifications in each gland structure. The data concerning evolution of number of each cell type were submitted to analysis by least squares fit-exponential curve. The exponential equations duplication times for the acinar, serous demilune, intercalated duct, striated duct and stroma cells from 2 to 30 days of age were 7.5, 9.0, 10.8 and 9.5 days, respectively. On the other hand, the mean labeling indices for the same cell types during the same period were 9.5%, 5.8%, 7.2%, 3.3% and 4.3%, respectively. Thus, the intercalated duct cells exhibited the second highest labeling index and the slowest growth rate, while the striated duct cells showed the lowest labeling index and the third highest duplication time. The fact that the striated duct cell labeling index does not explain the relatively short duplication time of these cells, suggests that cells from other neighboring morphologic compartments, probably from intercalated duct, migrate and differentiate into striated ducts cells."}},"Affiliation":{"$":"Department of Morphology, Faculty of Dentistry of Bauru, São Paulo University, Brazil."},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Taga"},"ForeName":{"$":"R"},"Initials":{"$":"R"}},{"@ValidYN":"Y","LastName":{"$":"Sesso"},"ForeName":{"$":"A"},"Initials":{"$":"A"}}]},"Language":{"$":"eng"},"PublicationTypeList":{"PublicationType":[{"$":"Journal Article"},{"$":"Research Support, Non-U.S. Gov't"}]}},"MedlineJournalInfo":{"Country":{"$":"JAPAN"},"MedlineTA":{"$":"Arch Histol Cytol"},"NlmUniqueID":{"$":"8806082"},"ISSNLinking":{"$":"0914-9465"}},"ChemicalList":{"Chemical":{"RegistryNumber":{"$":"9007-49-2"},"NameOfSubstance":{"$":"DNA"}}},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Aging"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Animals"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Autoradiography"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Cell Count"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Cell Differentiation"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Cell Movement"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"DNA"},"QualifierName":{"@MajorTopicYN":"N","$":"biosynthesis"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Female"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Male"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Rats"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Rats, Wistar"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Stromal Cells"},"QualifierName":[{"@MajorTopicYN":"N","$":"cytology"},{"@MajorTopicYN":"N","$":"metabolism"}]},{"DescriptorName":{"@MajorTopicYN":"N","$":"Sublingual Gland"},"QualifierName":[{"@MajorTopicYN":"N","$":"cytology"},{"@MajorTopicYN":"Y","$":"growth & development"},{"@MajorTopicYN":"N","$":"metabolism"}]}]}}
999263	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"999263"},"DateCreated":{"Year":{"$":"1977"},"Month":{"$":"01"},"Day":{"$":"28"}},"DateCompleted":{"Year":{"$":"1977"},"Month":{"$":"01"},"Day":{"$":"28"}},"DateRevised":{"Year":{"$":"2006"},"Month":{"$":"11"},"Day":{"$":"15"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0003-5637"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"21"},"Issue":{"$":"9"},"PubDate":{"Year":{"$":"1976"},"Month":{"$":"Sep"}}},"Title":{"$":"Antibiotiki"},"ISOAbbreviation":{"$":"Antibiotiki"}},"ArticleTitle":{"$":"[Study of the penicillinase of the plague microbe, the synthesis of which is determined by the R-episome]."},"Pagination":{"MedlinePgn":{"$":"800-5"}},"Abstract":{"AbstractText":{"$":"Penicillinase produced by a culture of the plague microbe with episomic resistance to benzylpenicillin was isolated and purified. Comparative investigation of the substrate spectrum, Michaelis constant and antigenic properties of the enzymes from the plague and dysentery microbes (R-factor donor) showed that transfer of the R-episome to the new host did not affect the investigated properties of penicillinase the synthesis of which was controlled by this episome."}},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Rozhkov"},"ForeName":{"$":"K K"},"Initials":{"$":"KK"}},{"@ValidYN":"Y","LastName":{"$":"Mishan'kin"},"ForeName":{"$":"B N"},"Initials":{"$":"BN"}}]},"Language":{"$":"rus"},"PublicationTypeList":{"PublicationType":[{"$":"English Abstract"},{"$":"Journal Article"}]},"VernacularTitle":{"$":"Izuchenie penitsillinazy chumnogo mikroba, sintez kotoroĭ determinirovan R-épisomoĭ"}},"MedlineJournalInfo":{"Country":{"$":"USSR"},"MedlineTA":{"$":"Antibiotiki"},"NlmUniqueID":{"$":"0375020"},"ISSNLinking":{"$":"0003-5637"}},"ChemicalList":{"Chemical":[{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Culture Media"}},{"RegistryNumber":{"$":"EC 3.5.2.-"},"NameOfSubstance":{"$":"Penicillinase"}}]},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Culture Media"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Drug Resistance, Microbial"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Extrachromosomal Inheritance"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Kinetics"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Penicillinase"},"QualifierName":[{"@MajorTopicYN":"Y","$":"biosynthesis"},{"@MajorTopicYN":"N","$":"isolation & purification"}]},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Plasmids"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"R Factors"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Recombination, Genetic"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Shigella"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Yersinia pestis"},"QualifierName":{"@MajorTopicYN":"Y","$":"enzymology"}}]}}
999425	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"999425"},"DateCreated":{"Year":{"$":"1977"},"Month":{"$":"01"},"Day":{"$":"25"}},"DateCompleted":{"Year":{"$":"1977"},"Month":{"$":"01"},"Day":{"$":"25"}},"DateRevised":{"Year":{"$":"2006"},"Month":{"$":"11"},"Day":{"$":"15"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0003-9055"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"30"},"Issue":{"$":"4"},"PubDate":{"Year":{"$":"1976"}}},"Title":{"$":"Archiv für experimentelle Veterinärmedizin"},"ISOAbbreviation":{"$":"Arch Exp Veterinarmed"}},"ArticleTitle":{"$":"[Single and complex effect of ammonia and hydrogen sulfide in the air on small laboratory animals (rats) under various environmental conditions 2. Effect of hydrogen sulfide alone and hydrogen sulfide with ammonia and dust]."},"Pagination":{"MedlinePgn":{"$":"541-5"}},"Abstract":{"AbstractText":{"$":"The maximum tolerable concentrations per animal position of hydrogen sulphide alone (5 ppm) and with ammonia (5 ppm H2S; 30 ppm NH3) were established by model experiments under defined environmental conditions. The normal values of the contaminant gas combination were found to be acceptable even with additional dust load on the experimental animals. TGL 29084 should stipulate 5 ppm hydrogen sulphide as the new maximum concentration per animal position."}},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Stolpe"},"ForeName":{"$":"J"},"Initials":{"$":"J"}},{"@ValidYN":"Y","LastName":{"$":"Sedlag"},"ForeName":{"$":"R"},"Initials":{"$":"R"}},{"@ValidYN":"Y","LastName":{"$":"Bresk"},"ForeName":{"$":"B"},"Initials":{"$":"B"}}]},"Language":{"$":"ger"},"PublicationTypeList":{"PublicationType":[{"$":"English Abstract"},{"$":"Journal Article"}]},"VernacularTitle":{"$":"Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen 2. Mitteilung: Die Wirkung von Schwefelwasserstoff sowie Schwefelwasserstoff, Ammoniak und Staub"}},"MedlineJournalInfo":{"Country":{"$":"GERMANY, EAST"},"MedlineTA":{"$":"Arch Exp Veterinarmed"},"NlmUniqueID":{"$":"0372410"},"ISSNLinking":{"$":"0003-9055"}},"ChemicalList":{"Chemical":[{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Dust"}},{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Environmental Pollutants"}},{"RegistryNumber":{"$":"7664-41-7"},"NameOfSubstance":{"$":"Ammonia"}},{"RegistryNumber":{"$":"7783-06-4"},"NameOfSubstance":{"$":"Hydrogen Sulfide"}}]},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Ammonia"},"QualifierName":{"@MajorTopicYN":"Y","$":"pharmacology"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Animal Feed"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Animals"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Body Temperature Regulation"},"QualifierName":{"@MajorTopicYN":"N","$":"drug effects"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Body Weight"},"QualifierName":{"@MajorTopicYN":"N","$":"drug effects"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Dust"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Environmental Pollutants"},"QualifierName":{"@MajorTopicYN":"Y","$":"pharmacology"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Hydrogen Sulfide"},"QualifierName":{"@MajorTopicYN":"Y","$":"pharmacology"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Rats"}}]}}
999876	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"999876"},"DateCreated":{"Year":{"$":"1977"},"Month":{"$":"02"},"Day":{"$":"26"}},"DateCompleted":{"Year":{"$":"1977"},"Month":{"$":"02"},"Day":{"$":"26"}},"DateRevised":{"Year":{"$":"2005"},"Month":{"$":"11"},"Day":{"$":"17"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0006-3002"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"453"},"Issue":{"$":"1"},"PubDate":{"Year":{"$":"1976"},"Month":{"$":"Nov"},"Day":{"$":"26"}}},"Title":{"$":"Biochimica et biophysica acta"},"ISOAbbreviation":{"$":"Biochim. Biophys. Acta"}},"ArticleTitle":{"$":"Conformational changes in two neurotoxic proteins from snake venoms."},"Pagination":{"MedlinePgn":{"$":"121-32"}},"Abstract":{"AbstractText":{"$":"alpha-Neurotoxin from Naja nigricollis and erabutoxin b from Laticauda semifasciata, two homologous neurotoxic proteins, are studied by circular dichroism, ultraviolet spectroscopy and fluorescence in various water/trifluoroethanol mixtures. The data obtained show that the beta structure of alpha-neurotoxin is conserved in water as well as in the organic solvent. By contrast, erabutoxin b changes from the beta-structure in water to the helix type in trifluoroethanol. The latter induces similarly for both toxins a structural modification around tryptophan 29, a residue common to all neurotoxins known to date. The vicinity of tyrosine 25, another common amino acid, is also altered by the presence of the organic solvent as demonstrated by the sudden increase of reactivity of the phenolic ring towards iodine. The present work affords some evidence for the presence of a particular structure located around the two aromatic residues, which is common to all neurotoxins and able to rearrange independently from the rest of the molecule. Biological importance of this peculiar region is highly probable."}},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Menez"},"ForeName":{"$":"A"},"Initials":{"$":"A"}},{"@ValidYN":"Y","LastName":{"$":"Bouet"},"ForeName":{"$":"F"},"Initials":{"$":"F"}},{"@ValidYN":"Y","LastName":{"$":"Tamiya"},"ForeName":{"$":"N"},"Initials":{"$":"N"}},{"@ValidYN":"Y","LastName":{"$":"Fromageot"},"ForeName":{"$":"P"},"Initials":{"$":"P"}}]},"Language":{"$":"eng"},"PublicationTypeList":{"PublicationType":{"$":"Journal Article"}}},"MedlineJournalInfo":{"Country":{"$":"NETHERLANDS"},"MedlineTA":{"$":"Biochim Biophys Acta"},"NlmUniqueID":{"$":"0217513"},"ISSNLinking":{"$":"0006-3002"}},"ChemicalList":{"Chemical":[{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Disulfides"}},{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Snake Venoms"}},{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Toxins, Biological"}},{"RegistryNumber":{"$":"55520-40-6"},"NameOfSubstance":{"$":"Tyrosine"}}]},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Animals"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Circular Dichroism"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Disulfides"},"QualifierName":{"@MajorTopicYN":"N","$":"analysis"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Protein Binding"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Protein Conformation"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Snake Venoms"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Spectrophotometry, Ultraviolet"}},{"DescriptorName":{"@MajorTopicYN":"Y","$":"Toxins, Biological"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Tyrosine"},"QualifierName":{"@MajorTopicYN":"N","$":"analysis"}}]}}
999920	{"@Owner":"NLM","@Status":"MEDLINE","PMID":{"@Version":"1","$":"999920"},"DateCreated":{"Year":{"$":"1977"},"Month":{"$":"02"},"Day":{"$":"16"}},"DateCompleted":{"Year":{"$":"1977"},"Month":{"$":"02"},"Day":{"$":"16"}},"DateRevised":{"Year":{"$":"2004"},"Month":{"$":"11"},"Day":{"$":"17"}},"Article":{"@PubModel":"Print","Journal":{"ISSN":{"@IssnType":"Print","$":"0006-3002"},"JournalIssue":{"@CitedMedium":"Print","Volume":{"$":"455"},"Issue":{"$":"2"},"PubDate":{"Year":{"$":"1976"},"Month":{"$":"Dec"},"Day":{"$":"2"}}},"Title":{"$":"Biochimica et biophysica acta"},"ISOAbbreviation":{"$":"Biochim. Biophys. Acta"}},"ArticleTitle":{"$":"Effects of incorporated trypsin on anion exchange and membrane proteins in human red blood cell ghosts."},"Pagination":{"MedlinePgn":{"$":"353-70"}},"Abstract":{"AbstractText":{"$":"Varying concentrations of trypsin were sealed into human red cell ghosts and the effects on membrane proteins and sulfate equilibrium exchange were studied. After incubation for 45 min at 37 degrees C, pH 7.2, the following observations were made: above 10 ng/ml the ghosts undergo fragmentation without lysis. Dodecyl sulfate gel electrophoresis shows that the digestion of spectrin and of the protein in band 2.1 (nomenclature of Steck (1974) J. Cell. Biol. 62, 1-19) is nearly complete at 50 ng/ml, that of the protein in band 3 at 25 mug/ml. After digestion at 25 mug/ml, about 60% of the total protein of the membrane is released and the original bands of conventional dodecyl sulfate gel electropherograms of the remaining protein are nearly completely abolished. In their place three new bands appear representing peptides with molecular weights of 58 000, 48 000 and 34 000, respectively. Sometimes a fourth peptide with a molecular weight of approx. 13 000 is also observed. Using a radioactive labeling technique it is shown that the two peptides with the highest molecular weights are derived from the protein in band 3. Labeling with diazo[35S]sulfanilic acid indicates that in addition to the peptides in the described four Coomassie blue-stainable bands, other peptides with molecular weights up to 100 000 are still present in the exhaustively trypsinized ghosts. External trypsin has no effect on the sulfate equilibrium exchange in ghosts while internal trypsin causes inhibition. Inhibition becomes apparent at trypsin concentration exceeding those required to produce a complete digestion of spectrin. It remains incomplete, even at the highest intracellular concentrations which cause maximal effects on all membrane proteins, including the protein in band 3. Under these conditions strong further inhibition can be produced by agents which are known to inhibit anion transport in untreated red cells and ghosts. These agents include the penetrating 1-fluoro-2,4-dinitrobenzene and the nonpenetrating phlorizin, 4-acetamido-4'-isothiocyanato stilbene-2,2'-disulfonic acid, 4,4'-diacetamido stilbene-2,2'-disulfonic acid, and 2-(4'-aminophenyl)-6-methylbenzenethiazol-3',7-disulfonic acid (APMB). Unlike the other nonpenetrating inhibitors APMB is not only capable of inhibiting at the outer but also at the inner membrane surface. Treatment with internal trypsin does not significantly reduce the inhibition by incorporated APMB. The described observations suggest that after exhaustive tryptic digestion of the major membrane proteins, the receptor sites for typical inhibitors of anion transport continue to exert their function."}},"AuthorList":{"@CompleteYN":"Y","Author":[{"@ValidYN":"Y","LastName":{"$":"Lepke"},"ForeName":{"$":"S"},"Initials":{"$":"S"}},{"@ValidYN":"Y","LastName":{"$":"Passow"},"ForeName":{"$":"H"},"Initials":{"$":"H"}}]},"Language":{"$":"eng"},"PublicationTypeList":{"PublicationType":{"$":"Journal Article"}}},"MedlineJournalInfo":{"Country":{"$":"NETHERLANDS"},"MedlineTA":{"$":"Biochim Biophys Acta"},"NlmUniqueID":{"$":"0217513"},"ISSNLinking":{"$":"0006-3002"}},"ChemicalList":{"Chemical":[{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Blood Proteins"}},{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Membrane Proteins"}},{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Sulfanilic Acids"}},{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Sulfates"}},{"RegistryNumber":{"$":"0"},"NameOfSubstance":{"$":"Sulfonic Acids"}},{"RegistryNumber":{"$":"EC 3.4.21.4"},"NameOfSubstance":{"$":"Trypsin"}}]},"CitationSubset":{"$":"IM"},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@MajorTopicYN":"N","$":"Biological Transport"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Blood Proteins"},"QualifierName":{"@MajorTopicYN":"N","$":"metabolism"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Erythrocyte Membrane"},"QualifierName":[{"@MajorTopicYN":"N","$":"drug effects"},{"@MajorTopicYN":"Y","$":"metabolism"},{"@MajorTopicYN":"N","$":"ultrastructure"}]},{"DescriptorName":{"@MajorTopicYN":"N","$":"Erythrocytes"},"QualifierName":{"@MajorTopicYN":"Y","$":"metabolism"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Humans"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Kinetics"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Membrane Proteins"},"QualifierName":{"@MajorTopicYN":"Y","$":"blood"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Molecular Weight"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Sulfanilic Acids"},"QualifierName":{"@MajorTopicYN":"N","$":"blood"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Sulfates"},"QualifierName":{"@MajorTopicYN":"N","$":"blood"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Sulfonic Acids"},"QualifierName":{"@MajorTopicYN":"N","$":"blood"}},{"DescriptorName":{"@MajorTopicYN":"N","$":"Trypsin"},"QualifierName":[{"@MajorTopicYN":"Y","$":"blood"},{"@MajorTopicYN":"N","$":"pharmacology"}]}]}}